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Morphological and structural study of Native Kidneys in Chronic Kidney Disease Patients on Dialysis Compared to Non-Dialysis Patients

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Open Journal of Nephrology 2020年第4期10卷 348-360页

作者： Jacques Vigan Patricia Ahouansou Yekpe sonia Adjanohoun séraphin ahoui Bruno Leopold Agboton Hosana Kpoviessi sM Olivier Biaou Nephrology and Hemodialysis Academic Clinic National University Hospital Center Hubert K Maga (CNHU-HKM) of Cotonou Cotonou Benin CNHU-HKM Medical Imaging Center Cotonou Benin Nephrology Healthcare Center Borgou Regional Hospital Parakou Benin

Whether on dialysis or not, native kidneys in chronic kidney disease (CKD) patients undergo morphological and structural changes. Objective: To study native kidney morphometric and structural aspects in CKD patients o... 详细信息

Whether on dialysis or not, native kidneys in chronic kidney disease (CKD) patients undergo morphological and structural changes. strong>Objective:strong> To study native kidney morphometric and structural aspects in CKD patients on dialysis and non-dialysis patients. strong>Methods:strong> It was a descriptive, analytical, and cross-sectional study conducted from May to December 2018. The study enrolled CKD patients on dialysis or not followed at CNHU-HKM in Cotonou. Renal ultrasound was performed to locate cysts and uroscanner completed in the presence of atypical cysts. Through logistic regression, associated factors were determined. strong>Results:strong> The sample size was 240 patients, of which 151 (62.9%) were receiving dialysis and 89 (37.1%) non-dialysis patients. Male subjects were predominant (sex ratio = 1.5). The average size of the right kidney, expressed in mm in patients on dialysis was: pole-to-pole length = 78.56;width = 42.06;cortical thickness = 11.80;and the left kidney: pole-to-pole length = 79.76;width = 41.53;cortical thickness = 12.6. For non-dialysis patients, the following size was recorded for the right kidney: pole-to-pole length = 92.35;width = 47.61;cortical thickness = 15.64;and left kidney: length = 92.13;width = 47.82;cortical thickness = 15.43. Predictive factors for the occurrence of acquired renal cysts were: old age (p = 0.0001), dialysis (p strong>Conclusion:strong> CKD patients on dialysis have small kidneys and are more likely to develop acquired renal cysts. There is a need to carry out an annual ultrasound screening for native kidneys in patients receiving dialysis.

关键词： Chronic Kidney Disease Dialysis Acquired Renal Cysts

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Frequency and Factors Associated with Gender-Based Violence in the Northern Region of Benin from 2016 to 2022

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Open Journal of Internal Medicine 2024年第3期14卷 287-298页

作者： Comlan Albert Dovonou Cossi Adébayo Alassani Khadidjatou saké Alassan sero Tamou Cossi Angelo Attinsounon séraphin ahoui Finangnon Armand Wanvoegbe Departmental University Hospital Center of Borgou and Alibori Parakou Benin Departmental University Hospital Center of Oum and Plateau Porto-Novo Benin

Introduction: Gender-based violence constitutes a public health problem. The objective of this study is to determine the frequency and factors associated with gender-based violence. study Framework and Method: This was a retrospective, descriptive, cross-sectional study with an analytical aim over the period from January 2016 to December 2022. The study took place in the Integrated support Center for Victims and survivors of Gender-Based Violence located in the Departmental University Hospital Center of Borgou and Alibori. The study population consisted of people who were victims of gender-based violence in the northern region of Benin, regardless of their age and gender. Results: The study population consisted of 1198 subjects. The average age of the victims was 21.76 ± 10.02;female victims represented 96.4%, with a sex ratio equal to 0.037 (43/1155). sexual violence was the most represented (50.25%), followed by psychological (29.30%), physical (24.37%), economic (13.77%) and property (2%). The factors associated with violence were married people and monthly income (physical violence), minors, female gender and single people (sexual violence), polygamous households and monthly income (economic violence), the absence of children burden, married people and monthly income (psychological violence), married people (property violence). Conclusion: Gender-based violence is frequent in the North of Benin and is dominated by sexual violence. The victims are mainly female.

关键词： Frequency Gender-Based Violence North Benin

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Hemodialysis patients’ satisfaction and associated factors in National Teaching Hospital Hemodialysis Center, Cotonou (Benin)

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Open Journal of Nephrology 2019年第4期9卷 127-138页

作者： séraphin ahoui Jacques Vigan Bruno Léopold Agboton Evariste Eteka Francis Tchegnonsi Tognon A. Anselme Djidonou Prosper Gandaho Leonard Fourn Department of Nephrology Borgou Regional Teaching Hospital Parakou Benin Nephrology-Hemodialysis University Clinic (CUNH) Hubert Koutoukou Maga National Teaching Hospital Cotonou (CNHU-HKM) Benin Department of Psychiatry Borgou Regional Teaching Hospital Parakou Benin Faculty of Health sciences University of Abomey-Calavi Abomey-Calavi Benin

Background: Patients’ satisfaction is a relevant component in assessing healthcare services. The objective of this study was to study the level of satisfaction of chronic hemodialysis patients and the associated factors in Cotonou CNHU-HKM dialysis center. Patients and Methods: It was a cross-sectional, descriptive and analytical study conducted by administering a questionnaire on days off dialysis. It was carried out from 1st November 2015 to 1st January 2016 in CNHU-HKM Nephrology University Clinic of Cotonou. Hemodialysis patients aged 18 years and above having given their informed consent were included in the study. Patients’ recruitment was comprehensive. Likert scale was used in assessing the level of satisfaction with 4 as “very satisfied” and 1 for “very dissatisfied”. satisfaction was evaluated on the basis of Ware dimensions. The threshold for satisfaction was 50. Outcomes: Overall, 377 patients were included in the study. Respondents’ mean age was 51.5 ± 13.3 years with 1.37 as sex ratio. Arteriovenous fistula was used for 80.1% of hemodialysis patients. 77.7% of the patients underwent dialysis twice a week while 45.9% were administered a four-hour dialysis. The overall average proportion of “satisfied” was 76.5%. The level of satisfaction was 52% for healthcare environment, 61% for service delivery, 73.9% for healthcare accessibility, 76.1% for healthcare structure, 77.5% for healthcare management, 90.3% for quality of healthcare, 88.3% for interpersonal relationship and 93.2% for efficiency and continuum of healthcare. Factors associated with satisfaction included age (p = 0.02), vascular access (p = 0.04) and urea reduction ratio (p = 0.01). In addition, the degree of satisfaction of hemodialysis patients was not statistically associated with sex, marital status, educational level, history of the disease, age of dialysis, number of sessions per week, and duration per session. Conclusion: The overall level of hemodialysis patients’ satisfaction is above

关键词： satisfaction Chronic Hemodialysis Cotonou

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Acute Renal Failure during Progressive systemic sclerosis in the Regional University Teaching Hospital of Brest-La Cavale Blanche (France)

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第3期7卷 158-166页

作者： Comlan Albert Dovonou Cossi Adébayo Alassani séraphin ahoui Lauren Gueguen Arthur Capdeville Elie Cornec-Le Gall Laurent Doucet Yannick Le Meur Borgou Regional University Teaching Hospital Parakou Benin Regional University Teaching Hospital of Brest-La Cavale Blanche Brest France

systemic scleroderma is a rare disease in which visceral manifestations occur, particularly peripheral vascular, digestive, cardiopulmonary and renal. It is pathology with a predilection for women. The present clinical case is that of a man with the renal complications of scleroderma and the difficulties of the treatment even in the developed countries like France. In the present case, the management of this disease required a high dose of corticosteroid therapy and extra-renal purification. Early detection of complications through a minimal clinical examination supplemented with paraclinic tests has proved necessary.

关键词： systemic sclerosis Acute Renal Failure Brest France

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Epidemiology of Anemia at the Internal Medicine Department in Borgou Departmental Hospital Center(DHC)in Parakou(Benin)

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Open Journal of Internal Medicine 2018年第2期8卷 123-130页

作者： Comlan Albert Dovonou Adébayo Alassani Cossi Angelo Attinsounon serge Ade Kadidjatou sake Jivaterd Degla séraphin ahoui Moise Adegbindin Prosper Gandaho Djimon Marcel Zannou Fabien Houngbe Isidore Zohoun Medicine Department and Medical specialities Medical FacultyParakou UniversityParakouBenin Internal Medicine Department Borgou Departmental Teaching HospitalParakouBenin Medicine Department and Medical specialities of Cotonou Health science ParakouBenin

Objective: To describe clinical and biological characteristics of anemia in the Internal Medicine department of Borgou Departmental Hospital Center (DHC). Methods: This was a transversal and descriptive study for an analytic purpose. All patients hospitalized in the Internal Medicine department of Borgou DHC who had a hemogram for their care were included in the study. Anemia was defined as a hemoglobin level lower than 12 g/dL for men and lower than 11.5 g/dL for women. Results: Frequency of anemia was 61.8% (76 of 123 patients). Anemia was moderate in 47.4% of the cases and severe in 27.6% of the cases. Basing on the mean corpuscular volume, microcytic anemia accounted for 36.8%, anemia was normocytic in 46.1% and macrocytic in 17.1% of cases. According to the mean corpuscular hemoglobin concentration, normochromic anemia accounted for 81.6% of the series and hypochromic in 18.4%. The most common pathologies found in anemic patients came from digestive origin (17%), the renal causes were also found in 17% of the cases. Cardiac pathologies were responsible for anemia in 13% of cases. Malaria and pulmonary pathologies were responsible for anemia in respectively 12% and 9%. The main factors associated with anemia were young age (young adult) and neurological pathologies. Conclusion: Anemia hospital prevalence is very high in the Internal Medicine Department of Borgou DHC. Awareness of populations and practitioners for the early management of various pathologies which provide anemia could improve this presentation.

关键词： Anemia Internal Medicine Parakou

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Quality of Life of Chronic Haemodialytic Patients at Cotonou Teaching Hospital (BENIN)

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Open Journal of Nephrology 2014年第4期4卷 131-141页

作者： Elhadji Fary Ka Jacques Vigan Ahmed Tall Lemrabott Noriace Excelle Zohoun Mohamedou Moustapha Cissé séraphin ahoui Maria Faye Younoussa Keita Khodia Fall Bruno Léopold Agboton Abdou Niang Boucar Diouf Nephrology Department Aristide Le Dantec Hospital Dakar Senegal Nephrology and Hemodialysis Clinic Hubert Koutoukou Maga Teaching Hospital Cotonou Benin

Introduction: The objectives of this work were to assess haemodialytic patients’ quality of life (QoL) and to identify factors affecting this QoL. Patients and Methods: It was a three (03) month monocentric and transversal study (from October 24, 2011 to January 27, 2012) conducted in the haemodialysis unit at Hubert Koutoukou Maga Teaching Hospital (CNHU-HKM) in Cotonou. Patients included were residents of Benin, aged 18 years and above, chronic haemodialysis in this unit for over 3 months, and willfully gave their consent. Quality of life was evaluated using questionnaire on Kidney Disease Quality of Life short-Form French version 1.2 (KDQoL-sF 36). Epidemiological data, nephropathy etiologies and purification parametres were recorded in patients files. Data statistical analysis was performed using sPss software 11.5. Results: In total 131 patients were involved in the study. The average age was 50.27 ± 12.17 years with a sex ratio of 1.69. Nephroangiosclerosis was the 1st cause. Most patients 128 (97.71 %) received two haemodialysis sessions on weekly basis. The Average Overall score (AOs) based respectively on sF 36 and KDQoL was 48.55 and 58.55. The average of both sF 36 and KDQoL AOs was 53.55. Factors affecting hemodialytic patients quality of life were vitality, limitations related to mental health and physical condition, burden of kidney disease, effect of the disease on daily life and occupational status. The study revealed that: Patients education level was correlated with vitality

关键词： Quality of Life Haemodialysis Patients Chronic Kidney Disease Benin

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Factors Associated with Non-Compliance among Patients with Chronic Kidney Disease at the Departmental University Hospital of Borgou and Alibori in Parakou (Benin)

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Open Journal of Nephrology 2023年第4期13卷 420-434页

作者： Coovi Nonwanou Ignace Tokpanoude séraphin ahoui Damien Barikissou Georgia Elvire s. E. Djossou sayo Djibo Gottfried Agballa Ireti Nethania Elie Ataigba Ismaël Landry Paraiso Omer Adjibode Benoit s. Agossoukpe Rodrigue s. Kakpo-Zannou Badirou Aguemon Unité de santé Publique de la Faculté des sciences de la santé (Fss) Université d’Abomey-Calavi (UAC) Cotonou Bénin Association des Médecins Communautaires du Bénin (AMCB) Parakou Bénin service de Néphrologie Centre Hospitalier Universitaire Départemental du Borgou Alibori (CHUD/B-A) Parakou Bénin Faculté de Médecine (FMP) Institut de Formation en Soins Infirmiers et Obstétricaux (IFSIO) Parakou Bénin service de Psychiatrie Centre Hospitalier Universitaire Départemental du Borgou Alibori (CHUD/B-A) Parakou Bénin

Introduction: Therapeutic compliance in chronic kidney disease (CKD) represents a major challenge for the prevention of this condition, which is both a non-communicable disease (NCD) and a complication of other NCDs. Non-adherence to treatment (NOT) is a factor in the poor prognosis of CKD in developing countries, particularly in Benin. The aim of this study was to evaluate therapeutic compliance (TC) and determine the factors associated with non-compliance in patients with chronic kidney disease undergoing treatment at the Departmental University Hospital of Borgou and Alibori in Parakou (CHUD/B-A). Patients and Methods: This study was carried out in the Nephrology Department of CHUD/B-A. It was a cross-sectional, descriptive study with analytical aims that ran from December 25, 2022 to March 15, 2023 and covered data from 2017 to 2022. It involved 345 patient records meeting the diagnosis of CKD according to the KDIGO 2012 criteria. NOT was defined by a Girerd score evaluation greater than or equal to 3. Data processing and analysis were performed with R software version 4.3.0. Results: The mean age (sD) of patients was 50 years (±14.9). The prevalence of NOT was 57.1%. Potential predictors of non-adherence were: monthly revenue (p = 0.009), mode of admission (p = 0.001), phytotherapy (p = 0.040), traditional treatment (p = 0.049) and quantity of drugs (p = 0.042). Conclusion: Therapeutic compliance among chronic kidney patients still needs to be improved through awareness-raising sessions.

关键词： Chronic Kidney Disease Therapeutic Non-Adherence Girerd Assessment Chronic Renal Failure Benin

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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