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炎症显像剂^(99)Tc^m-LVFX的标记与动物实验研究

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核技术 2004年第11期27卷 858-860页

作者：袁志斌 Keiko koyama Tetsuya HIGUCHI Noboru ORIUCHI Keigo ENDO 上海交通大学附属第六人民医院上海200233 日本群马大学医学部

核医学影像检查对炎症疾病的诊断有独特的价值,标记抗生素是近来新开发的一类炎症显像剂。本文用Tc标记了左旋氧氟沙星(LVFX),研究其生物分布和动物模型的显像结果。使用酒石酸亚锡作为还原剂,快速标记LVFX。研究了99Tcm-LVFX在炎症动... 详细信息

核医学影像检查对炎症疾病的诊断有独特的价值,标记抗生素是近来新开发的一类炎症显像剂。本文用Tc标记了左旋氧氟沙星(LVFX),研究其生物分布和动物模型的显像结果。使用酒石酸亚锡作为还原剂,快速标记LVFX。研究了99Tcm-LVFX在炎症动物模型内的生物分布和炎症动物模型注射99Tcm-LVFX后的显像结果。结果表明标记方法简单迅速,标记物稳定。生物分布和显像结果均表明99Tcm-LVFX在炎症组织内有较高的摄取。研究提示99Tcm-LVFX是一种潜在的炎症显像剂。

关键词：左旋氧氟沙星炎症大白鼠核素显像

Global distributions of storm-time ionospheric currents as seen in geomagnetic field variations

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Advances in Polar Science 2013年第4期24卷 296-314页

作者： Atsuki Shinbori Tomoaki Hori Yoshimasa Tanaka Yukinobu koyama Takashi Kiku-chi Tsutomu Nagatsuma Research Institute for Sustainable Humanosphere GokashoUjiKyoto 611-0011Japan Solar-Terrestrial Environment Laboratory Nagoya UniversityFurou-choChikusa-kuNagoyaAichi 464-8614Japan National Institute of Polar Research 10-3 Midori-choTachikawaTokyo 190-8518Japan Data Analysis Center for Geomagnetism and Space Magnetism Graduate School of ScienceKyoto UniversityKitashi-rakawa-Oiwake ChoSakyo-kuKyoto 606-8502Japan National Institute of Information and Communications Technology 4-2-1NukuikitamachiKoganeiTokyo 184-0015Japan

To investigate temporal and spatial evolution of global geomagnetic field variations from high-latitude to the equator during geomagnetic storms, we analyzed ground geomagnetic field disturbances from high latitudes to the magnetic equator. The daytime ionospheric equivalent current during the storm main phase showed that twin-vortex ionospheric currents driven by the Region 1 field-aligned currents （R1 FACs） are intensified significantly and expand to the low-latitude region of-30~ magnetic latitude. Centers of the currents were located around 70~ and 65~ in the morning and afternoon, respectively. Corresponding to intensification of the R1 FACs, an enhancement of the eastward/westward equatorial electrojet occurred at the daytime/nighttime dip equator. This signature suggests that the enhanced convection electric field penetrates to both the daytime and nighttime equa- tor. During the recovery phase, the daytime equivalent current showed that two new pairs of twin vortices, which are different from two-cell ionospheric currents driven by the R1 FACs, appear in the polar cap and mid latitude. The former led to enhanced north- ward Bz （NBZ） FACs driven by lobe reconnection tailward of the cusps, owing to the northward interplanetary magnetic field （IMF）. The latter was generated by enhanced Region 2 field-aligned currents （R2 FACs）. Associated with these magnetic field variations in the mid-latitudes and polar cap, the equatorial magnetic field variation showed a strongly negative signature, produced by the westward equatorial electrojet current caused by the dusk-to-dawn electric field.

关键词： solar wind interplanetary magnetic field geomagnetic storm convection electric field field-alignedcurrents equatorial electrojet NBZ FAC system

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远场涡流技术的特性

无损检测 1992年第12期14卷 356-358页

作者： H.Hoshikawa K.koyama 李文娟

通过实验和有限元分析研究了检测磁性管用的远场涡流技术.管子内壁周围磁场因远场区的缺陷而明显变化.采用远场涡流技术可以相同的灵敏度从管子内壁同时检测到管子内、外壁缺陷,检测缺陷深度用缺陷信号的相位较幅度更为合适。缺陷信号... 详细信息

通过实验和有限元分析研究了检测磁性管用的远场涡流技术.管子内壁周围磁场因远场区的缺陷而明显变化.采用远场涡流技术可以相同的灵敏度从管子内壁同时检测到管子内、外壁缺陷,检测缺陷深度用缺陷信号的相位较幅度更为合适。缺陷信号幅度指示随测试频率的加大而减小,而相位指示则在某个频率上达到最大.文中阐述了管子电磁特性对远场涡流的影响,这对测试频率的选择将起到指导作用.

关键词：涡流检验远场涡流技术特性

Genomic characterization of esophageal squamous cellcarcinoma:insights from next-generation sequencing

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World Journal of Gastroenterology 2016年第7期22卷 2284-2293页

作者： Yasushi Sasaki Miyuki Tamura Ryota koyama Takafumi Nakagaki Yasushi Adachi Takashi Tokino Department of Medical Genome Sciences Research Institute for Frontier MedicineSapporo Medical UniversitySapporo 060-8556Japan Department of Gastroenterology Rheumatology and Clinical ImmunologySapporo Medical University School of MedicineSapporo 060-8543Japan

Two major types of cancer occur in the esophagus: squamous cell carcinoma, which is associated with chronic smoking and alcohol consumption, and adenocarcinoma, which typically arises in gastric reflux-associated Barrett's esophagus. Although there is increasing incidence of esophageal adenocarcinoma in Western counties, esophageal squamous cell carcinoma(ESCC) accounts for most esophageal malignancies in East Asia, including China and Japan. Technological advances allowing for massively parallel, high-throughput next-generation sequencing(NGS) of DNA have enabled comprehensive characterization of somatic mutations in large numbers of tumor samples. Recently, several studies were published in which whole exome or whole genome sequencing was performed in ESCC tumors and compared with matched normal DNA. Mutations were validated in several genes, including in TP53, CDKN2 A, FAT1, NOTCH1, PIK3 CA, KMT2 D and NFE2L2, which had been previously implicated in ESCC. Several new recurrent alterations have also been identified in ESCC. Combining the clinicopathological characteristics of patients with information obtained from NGS studies may lead to the development of effective diagnostic and therapeutic approaches for ESCC. As this research becomes more prominent, it is important that gastroenterologist become familiar with the various NGS technologies and the results generated using these methods. In the present study, we describe recent research approaches using NGS in ESCC.

关键词： esophageal squamous cell carcinoma next-generation sequencing somatic mutation Drivermutation copy number variant

结合长度对悬浮液中电子注射效率和CA(Carotenoic Acid)-TiO_2纳米粒子体系构成的太阳能电池中太阳能转化成电能的效率的依赖性(英文)

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光散射学报 2005年第3期17卷 292-294页

作者： Yasushi koyama Faculty of Science and Technology Kwansei Gakuin University Sanda Hyogo 669-1337 Japan

The electron-injection mechanisms determined for TiO2-carotenoic acid （CA） suspensions. Subpicosecond time-resolved absorption spectra were recorded for retinoic and carotenoic acids, i.e., RA5, CA6, CA7, CA8, CA9 and CA11 （hereafter, collectively referred to ‘CAs’） having the number of conjugated double bonds, n = 5, 6, 7, 8, 9 and 11, respectively, free in ethanol solution and bound to TiO2 nano-particles. The time-resolved spectra were analyzed by singular-value decomposition followed by global fitting based on an energy diagram consisting of the 3Ag-, 1Bu-, 1Bu+ and 2Ag- states that were extrapolated from those in carotenoids with n = 9 - 13 （K. Furuichi, T. Sashima, Y. koyama, Chem. Phys. Lett. 356 （2002） 547 - 555）. The scheme and the time constants of internal conversion and electron injection, in the very initial stage after excitation, were determined; here, the time constants of internal conversion that were determined for CAs in solution were transferred to the case of CAs bound to TiO2. It was found that electron injection took place from both the 1Bu+ and 2Ag- states in RA5, CA6, CA7 and CA8, whereas only from the 1Bu+ state in CA9 and CA11. The electron-injection efficiencies were determined by the use of the relevant time constants as follows: RA5 37%, CA6 92%, CA7 98%, CA8 94%, CA9 60% and CA11 29%; the electron-injection efficiency in CA7 was almost unity. In the final stage, both the D 0 and T1 states remained and then decayed.

关键词：悬浮液电子注射效率 TiO2 纳米粒子太阳能电池

NEPTUNIUM CO-RECOVERY WITH URANIUM AND PLUTONIUM IN NEXT PROCESS

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NEPTUNIUM CO-RECOVERY WITH URANIUM AND PLUTONIUM IN NEXT PRO...

Budd-Chiari syndrome: A case with a combination of hepatic vein and superior vena cava occlusion

International Solvent Extraction Conference 2005

作者： Yuichi SANO Masayoshi KAMIYA Atsuhiro SHIBATA Tsutomu KOIZUMI Tomozo koyama Japan Nuclear Cycle Development Institute Ibaraki Japan Japan Nuclear Cycle Development Institute Ibaraki Japan Japan Nuclear Cycle Development Institute Ibaraki Japan Japan Nuclear Cycle Development Institute Ibaraki Japan Japan Nuclear Cycle Development Institute Ibaraki Japan

来源： cnki会议评论

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World Journal of Gastroenterology 2005年第24期11卷 3797-3799页

作者： Yoshio Araki Chikara Sakaguchi Izumi Ishizuka Masaya Sasaki Tomoyuki Tsujikawa Shigeki koyama Akira Furukawa Yoshihide Fujiyama Department of Internal Medicine Department of Radiology

We here report a recent, rare case of Budd-Chiari syndrome, associated with a combination of hepatic vein and superior vena cava occlusion. A young female, who had been ingood health, was admitted to our hospital because of massive ascites. The patient had used no oral contraceptives. Tests for coagulation disorders, hematological disorders, and antiphospholipid syndrome were all negative. BuddChiari syndrome was diagnosed by radiographic examination. The patient was suffering from a combination of hepatic vein and superior vena cava occlusion. In particular, the venous flow returned from the liver mainly through a right accessory hepatic vein, and stenosis was recognized at the orifice of this collateral vein into the vena ***, the patient underwent percutaneous balloon dilatation therapy for this stenosis. After this treatment, the massive ascites was gradually reduced, and she was discharged from our hospital. It has now been one year since discharge, and the patient has been doing well. If deteriorating liver function or intractable ascites occur again, a liver transplantation may be anticipated. This is the first case report of Budd-Chiari syndrome associated with a superior vena cava occlusion.

关键词：肝静脉血管闭塞病理机制临床表现并发症

Tumor Segmentation on <sup>18</sup>F FDG-PET Images Using Graph Cut and Local Spatial Information

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Open Journal of Medical Imaging 2015年第3期5卷 174-181页

作者： Mizuho Nishio Atsushi K. Kono Kazuhiro Kubo Hisanobu koyama Tatsuya Nishii Kazuro Sugimura Clinical PET Center Institute of Biomedical Research and Innovation Kobe Japan Division of Functional and Diagnostic Imaging Research Department of Radiology Kobe University Graduate School of Medicine Kobe Japan Division of Radiology Department of Radiology Kobe University Graduate School of Medicine Kobe Japan Center for Radiology and Radiation Oncology Kobe University Hospital Kobe Japan

The purpose of this study was to develop methodology to segment tumors on 18F-fluorodeoxyg- lucose (FDG) positron emission tomography (PET) images. Sixty-four metastatic bone tumors were included. Graph cut was used for tumor segmentation, with segmentation energy divided into unary and pairwise terms. Locally connected conditional random fields (LCRF) were proposed for the pairwise term. In LCRF, three-dimensional cubic window with length L was set for each voxel, and voxels within the window were considered for the pairwise term. Three other types of segmentation were applied: region-growing based on 35%, 40%, and 45% of the tumor maximum standardized uptake value (RG35, RG40, and RG45, respectively), SLIC superpixels (SS), and region-based active contour models (AC). To validate the tumor segmentation accuracy, dice similarity coefficients (DSC) were calculated between the result of each technique and manual segmentation. Differences in DSC were tested using the Wilcoxon signed-rank test. Mean DSCs for LCRF at L = 3, 5, 7, and 9 were 0.784, 0.801, 0.809, and 0.812, respectively. Mean DSCs for the other techniques were: RG35, 0.633;RG40, 0.675;RG45, 0.689;SS, 0.709;and AC, 0.758. The DSC differences between LCRF and other techniques were statistically significant (p < 0.05). Tumor segmentation was reliably performed with LCRF.

关键词： Image Segmentation FDG-PET Graph Cut

DEVELOPMENT OF THE 3D UNDERGROUND SPACE INFORMATION MANAGEMENT SYSTEM(USIMS) FOR THE MAINTENACE AND HEALTH ASSESSMENT OF TUNNELS Paper No.191

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DEVELOPMENT OF THE 3D UNDERGROUND SPACE INFORMATION MANAGEME...