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Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy

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World Journal of Cardiovascular Diseases 2012年第4期2卷 305-312页

作者： Hiroki Kasai Yuichiro Kashima Atsushi Izawa Takeshi Tomita Yusuke Miyashita Jun koyama Masafumi Takahashi Taku Yoshio Yoshikazu Yazaki Makoto Higuchi Uichi Ikeda Department of Cardiovascular Medicine Shinshu University School of Medicine Nagano Japan Department of Nephrology Shinshu University School of Medicine Nagano Japan Department of Rheumatology and Clinical Immunology Jichi Medical University Tochigi Japan Division of Bio-Imaging Jichi Medical University Tochigi Japan Division of Cardiology Matsumoto Medical Center Nagano Japan

Several literatures have reported that the elimination of autoantibodies by immunoadsorption (IA) therapy induced short- and long-term improvements in cardiac function of patients with dilated cardiomyopathy (DCM). We assessed whether reduction in oxidative stress was related to the mechanism underlying left ventricular functional benefit from IA. We studied 7 patients with DCM (New York Heart Association (NYHA) functional class III/IV). Autoantibodies were removed with IA by passing patients’ plasma over tryptophan columns. The level of anti-β1-adrenoreceptor (AR) autoantibodies was measured by enzyme- linked immunosorbent assay. The level of diacron- reactive oxygen metabolite (d-ROM) was determined as a marker of oxidative stress. During IA, the anti- β1-AR autoantibodies titers of all the patients decreased significantly from 27.8 ± 5.0 to 18.7 ± 5.5 U/ml (p < 0.01). IA induced the following hemodynamic improvements: cardiac index increased from 1.71 ± 0.40 to 1.97 ± 0.41 l/min/m2 and left ventricular ejection fraction (LVEF) increased from 22.8 ± 6.1 to 29.1±9.1% (p < 0.05). d-ROM level decreased significantly from 392.7 ±17.0 to 314.1 ± 22.0 Carratelli units (p < 0.05), and was negatively correlated with LVEF before and after IA therapy (r = -0.601, p < 0.05). The anti-β1-AR autoantibodies, LVEF and d- ROM returned to the baseline levels at 12 months after IA. In conclusion, oxidative stress reduction may be responsible for the beneficial effect of IA therapy in patients with DCM.

关键词： Autoantibody Immunoglobulin Plasmapheresis

超氧阴离子对牛主动脉平滑肌细胞收缩性的影响

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中国药理学通报 2012年第9期28卷 1215-1217页

作者：承伟小山澈野大池正宏辽宁医学院药学院辽宁锦州121000 九州大学药理学教研室

目的观察超氧阴离子对培养的牛动脉平滑肌细胞内钙及收缩性的影响。方法原代培养牛动脉平滑肌,使用数字荧光显微镜技术测定细胞内钙,采用胶原凝胶收缩方法分析收缩性。结果超氧阴离子对高钾溶液及A-23187诱导的钙内流无明显影响(P>0.05)... 详细信息

目的观察超氧阴离子对培养的牛动脉平滑肌细胞内钙及收缩性的影响。方法原代培养牛动脉平滑肌,使用数字荧光显微镜技术测定细胞内钙,采用胶原凝胶收缩方法分析收缩性。结果超氧阴离子对高钾溶液及A-23187诱导的钙内流无明显影响(P>0.05),但可使凝胶收缩面积减小。超氧阴离子可使高钾诱导的胶原凝胶收缩面积从18.32%±2.11%减小至5.13%±0.45%(P<0.01),使A-23187诱导的胶原凝胶收缩面积从17.16%±1.10%减小至4.31%±0.04%(P<0.01)。结论超氧阴离子可明显抑制牛主动脉平滑肌细胞收缩性,但对电压依赖性钙通道引起的钙内流及A-23187诱导的细胞内钙变化无影响。

关键词：动脉平滑肌细胞收缩性细胞内钙超氧阴离子钙释放激活钙通道电压依赖性钙通道

Antimony and Arsenic Concentration Distribution with Soil Particle Size

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Antimony and Arsenic Concentration Distribution with Soil Pa...

新的血幼素基因突变引发的血红蛋白沉积病:3例中年发病病例

作者： S.Fukutani K.Takamiya Y.Nakano R.Okumura T.Takahashi A.koyama Research Reactor Institute Kyoto University

INTRODUCTION:In this study we attempt to analyze characteristics of antimony contamination in soils around a antimony smelter in contradistinction to arsenic which is the homologous element of antimony. Antimony(Sb) is one of natural occurring trace elements in soil,but it is being identified as a pollutant by increasing its *** retardants,paints and pigments are important industrial products,and 13,279 t of antimony trioxide(SbO) was in demand at 2006 in *** is pointed out that these important products,

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 59-60页

作者： koyama C. HayashiH. WakusawaS. 程欣 Department of Medicine Asanogawa General Hospital Naka 83 Kosaka-cho Kanazawa 920-8621 Japan

Hemochromatosis is a genetically heterogeneous condition. Mutations in the recently described hemojuvelin gene were found in patients with juvenile hemochromatosis, who usually manifest clinical signs of iron overload, including cardiomyopathy and hypogonadism, in their teens and early 20s. In this report, we describe three Japanese patients who showed typical clinical and hepatic histological damage compatible with hemochromatosis at around 50 years of age. Genetic analyses showed that all three patients carried mutations in the hemojuvelin gene. The first patient was homozygous for a novel mutation (745G > C[D249H]), and the second and third patients from the same family were homozygous for another novelmutation (934C > T [Q312X]). No mutations in their HFE, hepcidin, transferrin receptor 2, or ferroportin genes were found. One patient had chronic infection with Helicobacter pylori. The age at initial presentation of hemojuvelin-hemochromatosis occurs over a wider range than previously described.

关键词：蛋白沉积基因突变基因分析纯合突变性腺功能减退肝脏组织学心肌病转铁蛋白受体铁超载遗传

Leg Atherosclerosis in Japanese COPD Patients: Prevalence of Undiagnosed Peripheral Artery Disease and Association between Leg Atherosclerosis and Clinical Indices

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Open Journal of Respiratory Diseases 2013年第1期3卷 25-30页

作者： Hirofumi Matsuoka Yusuke Matsumoto Kengo Kimura Midori koyama Towa Uzu Yasuko Koma Kensuke Fukumitsu Yoshitaka Kasai Nariyasu Nakashima Daiki Masuya Harukazu Yoshimatsu Yujiro Suzuki Department of Respiratory Medicine Shinko Hospital Kobe Japan

Introduction: Several studies have suggested that decreased FEV1 is associated with cardiovascular risk in COPD patients. Objective: To identify the prevalence of undiagnosed peripheral artery disease (PAD) and the relationship between leg atherosclerosis and clinical indices, which predict COPD mortality in Japanese COPD patients. Methods: We performed a cross-sectional study in 51 COPD patients and 51 age-matched, healthy control smokers. We measured ankle-brachial index (ABI) as a marker of atherosclerosis of the legs, pulmonary function, body mass index, modified Medical Research Council (MMRC) dyspnea scale, and smoking pack-years. We also calculated the ADO index (Age, Dyspnea, and Obstruction), an established predictor of mortality in COPD patients. Co-morbidities including diabetes mellitus, hypertension, and hypercholesterolemia were identified from blood laboratory tests and medical records. Results: Five subjects (9.8%) had an ABI 0.9. ABI was significantly lower in the COPD patients than in the healthy control smokers (p 0.05). The prevalence of PAD was marginally higher in COPD patients than in control smokers (p = 0.09), with the prevalence of ABI 1.0 being significantly higher in COPD patients than in control smokers (p = 0.04). In the COPD patients, ABI showed significant correlations with age (p = 0.006), FEV1 (p = 0.004), smoking pack-years (p = 0.047), MMRC dyspnea scale (p = 0.0005), SaO2 (p = 0.001), andADOindex (p 0.001). Multiple linear regression modeling showed the factors associated independently with ABI were age, FEV1, smoking pack-years, MMRC dyspnea scale, and SaO2. Conclusion: The risk of leg atherosclerosis in Japanese COPD patients is higher than in smokers without COPD. Leg atherosclerosis in COPD patients is associated with clinical indices that predict COPD mortality.

关键词： COPD Peripheral Artery Disease Leg Atherosclerosis Ankle-Brachial Index

Analysis software for upper atmospheric data developed by the IUGONET project and its application to polar science

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Advances in Polar Science 2013年第4期24卷 231-240页

作者： Yoshimasa Tanaka Atsuki Shinbori Tomoaki Hori Yukinobu koyama Shuji Abe No-rio Umemura Yuka Sato Manabu Yagi Satoru UeNo Akiyo Yatagai Yasunobu Ogawa Yoshizumi Miyoshi National Institute of Polar Research 10-3 Midori-choTachikawaTokyo 190-8518Japan Research Institute for Sustainable Humanosphere GokashoUjiKyoto 611-0011Japan Solar-Terrestrial Environment Laboratory Nagoya UniversityFurou-choChikusaNagoyaAichi 464-8614Japan Data Analysis Center for Geomagnetism and Space Magnetism Graduate School of ScienceKyoto UniversityKi-tashirakawa-Oiwake ChoSakyo-kuKyoto 606-8502Japan International Center for Space Weather Science and Education Kyushu University6-10-1 HakozakiHigashi-kuFukuoka 812-8581Japan Planetary Plasma and Atmospheric Research Center Tohoku UniversityAramaki-aza-aobaAobaSendai 980-8578Japan Kwasan and Hida Observatories Graduate School of ScienceKyoto UniversityKurabashiraKamitakara-choTakayamaGifu 506-1314Japan

To comprehensively understand the Arctic and Antarctic upper atmosphere, it is often crucial to analyze various data that are obtained from many regions. Infrastructure that promotes such interdisciplinary studies on the upper atmosphere has been developed by a Japanese inter-university project called the Inter-university Upper atmosphere Global Observation Network （1UGONET）. The objective of this paper is to describe the infrastructure and tools developed by IUGONET. We focus on the data analysis software. It is written in Interactive Data Language （IDL） and is a plug-in for the THEMIS Data Analysis Software suite （TDAS）, which is a set of IDL libraries used to visualize and analyze satellite- and ground-based data. We present plots of upper atmospheric data provided by IUGONET as examples of applications, and verify the usefulness of the software in the study of polar science. We discuss IUGONET＇s new and unique developments, i.e., an executable file of TDAS that can run on the IDL Virtual Machine, IDL routines to retrieve metadata from the IUGONET database, and an archive of 3-D simulation data that uses the Common Data Format so that it can easily be used with TDAS.

关键词： data analysis software metadata database upper atmosphere ground-based observation polar science,interdisciplinary study IUGONET