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Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy

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World Journal of Gastroenterology 2017年第35期23卷 6437-6447页

作者： Izumi Miki Satoru Murata Fumio Uchiyama Daisuke Yasui Tatsuo Ueda Fumie Sugihara Hidemasa Saito Hidenori Yamaguchi ryusuke murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita Department of Radiology Center of Advanced MedicineNippon Medical School Department of Radiology Ebina-Sogo Hospital Department of Radiology Tamanagayama HospitalNippon Medical School Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical School Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical School

AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B *** The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR *** Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients.

关键词： Hepatocellular carcinoma location Transarterial chemoembolization efficacy Child-Pugh Modified response evaluation criteria in solid tumors Central zone Peripheral zone

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Calcified and Non-Calcified Ductal Carcinoma <i>in Situ</i>: Contrast-Enhanced MRI Features and Pathological Correlation

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Open Journal of Radiology 2017年第3期7卷 151-163页

作者： Hitomi Tani ryusuke murakami Tomoyuki Kuwako Shinichiro Kumita Miyuki Matsubara Department of Radiology Nippon Medical School Tokyo Japan Division of Diagnostic Pathology Nippon Medical School Tokyo Japan

Background: Early detection of ductal carcinoma in situ (DCIS) is essential for improving the prognosis of breast cancer. Among mammographically detected DCIS cases, approximately 10% - 20% of DCIS cases are manifested as non-calcified. Purpose: To evaluate differences in MRI findings and histological features between mammographically evident non-calcified and calcified DCIS. Material and Methods: This study included 84 cases of pathologically proven DCIS in 82 patients who underwent preoperative breast MRI. The lesions were divided into non-calcified and calcified DCIS according to the presence of calcifications on mammography. MRI features were analyzed according to the enhancement pattern. The pathologic features were also reviewed. Results: Among the 84 DCIS cases, 30 (36%) were classified as non-calcified DCIS, and 54 (64%) as calcified DCIS on mammography. On MRI, 27% (8/30) of non-calcified DCIS and 17% (9/54) calcified DCIS presented as mass enhancement, 73% (22/30) non-calcified DCIS and 83% (45/54) calcified DCIS presented as non-mass enhancements. No significant difference in the type of lesion was observed between non-calcified and calcified DCIS (p = 0.274). Histopathologically, high nuclear grade, presence of necrosis, and presence of HER-2 status were more common in calcified DCIS than in non-calcified DCIS (p Conclusion: There were no significant differences in MRI findings between non-calcified and calcified DCIS. However, calcified DCIS had more aggressive histological features than non-calcified DCIS.

关键词： Ductal Carcinoma in Situ Mammography Microcalcification Magnetic Resonance Imaging

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Comparison between Visualization of Microcalcifications by Digital Breast Tomosynthesis and Full-Field Digital Mammography

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Open Journal of Radiology 2020年第2期10卷 90-100页

作者： ryusuke murakami Hitomi Tani Izumi Miki Tamiko Yoshida Shinichiro Kumita Nachiko Uchiyama Department of Radiology Nippon Medical School Hospital Tokyo Japan Department of Radiology National Cancer Center Tokyo Japan

Objective: To date, few studies have compared the diagnostic performance and visibility of microcalcifications obtained using digital breast tomosynthesis (DBT) with those obtained from full-field digital mammography (FFDM). The visualization and characterization of microcalcifications with DBT remain controversial. The purpose of this study was to compare the visibility of microcalcifications and determine whether DBT exhibits a diagnostic advantage for visualizing microcalcifications over FFDM. Methods: We retrospectively reviewed 120 cases including DBT and FFDM imaging (60 histologically verified as breast cancers and 60 as benign microcalcifications or normal). DBT images with a wide scan-angle of 50° and FFDM images were obtained using a flat-panel system (MAMMOMAT Inspiration, Siemens). Images were independently reviewed by four board-certified radiologists and evaluated for the presence of microcalcifications, probability of malignancy (BI-RADS classification), and visibility. Results: In predicting the malignancy of detected microcalcifications, no significant difference was found between readers’ areas under the receiver operating characteristic curve for DBT and FFDM (p = 0.068). The visibility scores of detected microcalcifications were 3.74 ± 1.06 for DBT and 3.46 ± 0.93 for FFDM, respectively. The visibility of microcalcifications when using DBT was found to be significantly superior to that of FFDM (p Conclusion: Our results suggest that the image quality of DBT with a wide scan-angle is comparable or superior to that obtained with FFDM

关键词： Breast Breast Cancer Microcalcifications Digital Mammography Digital Breast Tomosynthesis

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Mucinous Carcinoma of the Breast Accompanied by Coarse Calcification

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Open Journal of Medical Imaging 2012年第4期2卷 125-127页

作者： Hitomi Tani ryusuke murakami Tamiko Yoshida Keiko Yanagihara Shinya Iida Shinichi Tsuchiya Department of Radiology Graduate School of Medicine Nippon Medical School Tokyo Japan Department Surgery for Organ Function and Biological Regulation Graduate School of Medicine Nippon Medical School Tokyo Japan Division of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan

Mucinous carcinoma of the breast has histologically distinct features and constitutes 1-3% of all breast cancers. It produces variable amounts of extracellular epithelial mucin and clinically its prognosis is far better than for other types of invasive carcinoma. On the other hand, coarse calcification is a common mammographic feature of benign tumors. There have been few reported cases of breast cancer containing coarse calcification. We present a unique 40 year-old female case of mucinous carcinoma of the breast accompanied by coarse calcification on mammography, which was mimicking fibroadenoma and an unusual variant of breast cancer. This case illustrates the importance of bearing in mind that mucinous carcinoma may demonstrate coarse calcification.

关键词： Breast Cancer Calcification Mucinous Carcinoma Mammography

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Contrast-Induced Nephropathy in Patients with Hepatocellular Carcinoma Undergoing Transcatheter Arterial Chemoembolization

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Open Journal of Radiology 2016年第3期6卷 243-249页

作者： ryusuke murakami Hidemasa Saito Izumi Miki Daisuke Yasui Fumie Sugihara Tatsuo Ueda Satoru Murata Hiromitsu Hayashi Shinichiro Kumita Department of Radiology Nippon Medical School Tokyo Japan

Purpose: The purpose of this retrospective study was to assess the incidence and the risk factors of contrast-induced nephropathy (CIN) following transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Materials and Methods: We performed a retrospective review of 186 sessions of TACE in 122 patients with HCC. We examined the incidence and factors associated with risk of CIN, defined as an increase of at least 0.5 mg/dl (44.2 μmol/l) or 25% of the baseline serum creatinine level between 48 and 72 hours after TACE. Results: CIN developed in 14 (7.5%) of the 186 sessions after TACE. A univariate analysis showed that the Child-Pugh class B or C [10/14 (71%) vs. 70/172 (41%), P = 0.046], a low albumin level (3.0 ± 0.5 vs. 3.4 ± 0.6, P = 0.018), and a low hemoglobin level (10.6 ± 2.0 vs. 11.8 ± 2.0, P = 0.035) were significantly associated with the development of CIN. Multivariate analysis revealed that the hemoglobin value was associated with CIN [odds ratio (OR) 1.6;P = 0.038]. Conclusions: CIN after TACE is closely associated with the severity of liver cirrhosis, and with low levels of albumin and hemoglobin. Effective preventive methods remain to be considered in patients with HCC and advanced LC who are undergoing TACE.

关键词： Contrast Induced Nephropathy Hepatocellular Carcinoma Transcatheter Arterial Chemoembolization Contrast Media

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Prognostic Value of SUVmax of <sup>18</sup>F-FDG PET/CT in Early Stage Breast Cancer with No LN Metastasis

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Open Journal of Medical Imaging 2017年第3期7卷 112-123页

作者： ryusuke murakami Yoshimitsu Fukushima Hitomi Tani Kotomi Iwata Shinichiro Kumita Maki Nakai Tomoko Kurita Keiko Yanagihara Hiroyuki Takei Miyuki Matsubara Department of Radiology Nippon Medical School Hospital Tokyo Japan Department of Breast Surgery Nippon Medical School Hospital Tokyo Japan Division of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan

Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials and Methods: This retrospective study investigated 75 patients (mean age 58.9 years;age range 30 - 82 years) with invasive breast cancer who underwent FDG-PET/CT for preoperative staging. All patients underwent subsequent surgery without prior neoadjuvant chemotherapy or endocrine therapy, and those who were confirmed to have T1- or T2-stage by histopathology with no LN metastasis were included. Two patients who had no perceptible FDG accumulation on PET/CT scans were excluded. The correlations between the SUVmax of the tumor and the pathological and immunohistochemical data were evaluated. Results: The mean SUVmax for the total 73 tumors was 5.46 ± 4.05. The mean SUVmax was 3.95 ± 3.28 for the T1 stage group (n = 36) and 7.23 ± 4.10 (p p p p = 0.008), and high Ki-67 status (p < 0.001), respectively. Conclusion: In T1-T2 breast cancer with no LN metastasis, the SUVmax of FDG-PET/CT had significant positive relationships with several prognostic parameters of pathological status. Even in early-stage breast cancer patients, pretreatment FDG-PET/CT is useful for predicting malignant behavior and prognosis).

关键词： Breast Cancer Molecular Subtype Prognosis PET/CT SUVmax

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Effects of wing deformation on aerodynamic performance of a revolving insect wing

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Acta Mechanica Sinica 2014年第6期30卷 819-827页

作者： ryusuke Noda Toshiyuki Nakata Hao Liu Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-ku Chiba Japan Shanghai Jiao Tong University and Chiba University International Cooperative Research Center (SJTU-CUICRC) Structure and Motion Laboratory The Royal Veterinary CollegeUniversity of London Hawkshead LaneNorth Mymms Hatfield AL9 7TA United Kingdom

Flexible wings of insects and bio-inspired micro air vehicles generally deform remarkably during flapping flight owing to aerodynamic and inertial forces,which is of highly nonlinear fluid-structure interaction（FSI）*** elucidate the novel mechanisms associated with flexible wing aerodynamics in the low Reynolds number regime,we have built up a FSI model of a hawkmoth wing undergoing revolving and made an investigation on the effects of flexible wing deformation on aerodynamic performance of the revolving wing *** take into account the characteristics of flapping wing kinematics we designed a kinematic model for the revolving wing in two-fold：acceleration and steady rotation,which are based on hovering wing kinematics of hawkmoth,Manduca *** results show that both aerodynamic and inertial forces demonstrate a pronounced increase during acceleration phase,which results in a significant wing *** the aerodynamic force turns to reduce after the wing acceleration terminates due to the burst and detachment of leading-edge vortices（LEVs）,the dynamic wing deformation seem to delay the burst of LEVs and hence to augment the aerodynamic force during and even after the *** the phase of steady rotation,the flexible wing model generates more ver-tical force at higher angles of attack（40°–60°）but less horizontal force than those of a rigid wing *** is because the wing twist in spanwise owing to aerodynamic forces results in a reduction in the effective angle of attack at wing tip,which leads to enhancing the aerodynamics performance by increasing the vertical force while reducing the horizontal ***,our results point out the importance of the fluid-structure interaction in evaluating flexible wing aerodynamics：the wing deformation does play a significant role in enhancing the aerodynamic performances but works differently during acceleration and steady rotation,which is mainly induced by inertial force in accelerati

关键词： Insect flight Flexible wing Revolving wing Fluid-structure interaction

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Nitrous oxide fluxes from upland soils in central Hokkaido,Japan

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Journal of Environmental Sciences 2008年第11期20卷 1312-1322页

作者： Sonoko D.KIMURA Yo TOMA ryusuke HATANO Graduate School of Agriculture Tokyo University of Agriculture and TechnologyTokyo 183-8509Japan Graduate School of Agriculture Hokkaido UniversitySapporo 060-8589Japan

Nitrous oxide (N2O) fluxes from soils were measured using the closed chamber method during the snow-free seasons (middle April to early November),for three years,in a total of 11 upland crop fields in central Hokkaido,*** annual mean N2O fluxes ranged from 2.95 to 164.17 μgN/(m2·h),with the lowest observed in a grassland and the highest in an onion *** instantaneous N2O fluxes showed a large temporal variation with peak emissions generally occurring following fertilization and heavy rainfall eve...

关键词： mineral N pool N2O flux soil upland cropping system

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A simulation-based study on longitudinal gust response of flexible flapping wings

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Acta Mechanica Sinica 2018年第6期34卷 1048-1060页

作者： Toshiyuki Nakata ryusuke Noda Shinobu Kumagai Hao Liu Graduate School of Engineering Chiba UniversityChiba 263-8522Japan Department of Mechanical Engineering Kanto Gakuin UniversityKanagawa 263-8501Japan

Winged animals such as insects are capable of flying and surviving in an unsteady and unpredictable aerial *** generate and control aerodynamic forces by flapping their flexible *** the dynamic shape changes of their flapping wings are known to enhance the efficiency of their flight,they can also affect the stability of a flapping wing flyer under unpredictable disturbances by responding to the sudden changes of aerodynamic forces on the *** order to test the hypothesis,the gust response of flexible flapping wings is investigated numerically with a specific focus on the passive maintenance of aerodynamic forces by the wing *** computational model is based on a dynamic flight simulator that can incorporate the realistic morphology,the kinematics,the structural dynamics,the aerodynamics and the fluid-structure interactions of a hovering *** longitudinal gusts are imposed against the tethered model of a hovering hawkmoth with flexible flapping *** is found that the aerodynamic forces on the flapping wings are affected by the gust,because of the increase or decrease in relative wingtip velocity or kinematic angle of *** passive shape change of flexible wings can,however,reduce the changes in the magnitude and direction of aerodynamic forces by the gusts from various directions,except for the downward *** adaptive response of the flexible structure to stabilise the attitude can be classified into the mechanical feedback,which works passively with minimal delay,and is of great importance to the design of bio-inspired flapping wings for micro-air vehicles.

关键词： Insect flight Flapping wing Flexible wing Gust response Fluid-structure interaction Mechanical feedback

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Advanced diffusion-weighted magnetic resonance imaging in the evaluation of white matter axons in patients with idiopathic normal pressure hydrocephalus

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Neural Regeneration Research 2017年第12期12卷 1974-1975页

作者： Masaaki Hori Kouhei Kamiya ryusuke Irie Department of Radiology Juntendo University School of MedicineTokyo Japan Department of Radiology The University of Tokyo Tokyo Japan

With the increasing application of regenerative medicine in vivo,non-invasive and accurate methods for estimating the white matter axons in neuronal tissue have become increasingly *** a non-invasive method for patients,magnetic resonance（MR）imaging has demonstrated potential as a promising tool for evaluating axons in *** particular,diffusion-weighted MR imaging（d MRI）and its applications,

关键词： Advanced diffusion-weighted magnetic white matter pressure hydrocephalus

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