检索结果-南通市图书馆

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan ryunosuke muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

引用

骨研究:英文版 2023年第3期11卷 607-616页

作者： Minglu Yan Masayuki Tsukasaki ryunosuke muro Yutaro Ando Kazutaka Nakamura Noriko Komatsu Takeshi Nitta Tadashi Okamura Kazuo Okamoto Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Microbiology Tokyo Dental CollegeTokyoJapan Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The bony skeleton is continuously renewed throughout adult life by the bone remodeling process,in which old or damaged bone is removed by osteoclasts via largely unknown *** regulate bone remodeling by producing the osteoclast differentiation factor RANKL(encoded by the TNFSF11 gene).However,the precise mechanisms underlying RANKL expression in osteocytes are still ***,we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene *** analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer ***-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic *** deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage,while RANKL expression was not affected in osteoblasts or *** data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.

关键词： utilize removed linking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Approaches to Stable Operation of Shaftless Centrifugal Pump

引用

Journal of Thermal Science 2009年第1期18卷 48-53页

作者： ryunosuke Kawashima Mitsuo Uno Toshiaki Kanemoto Department of mechanical engineering Kyushu Kyoritsu University 1-8 Jiyugaoka Faculty engineering Kyushu Institute of Technology

The shaft-less impeller of the centrifugal pump, which is driven by the magnetic induction, was developed. Theimpeller rotates under the floating condition without any control device. The floating condition of the impeller isrealized by utilizing the pressure in pump casing. The pump performance and the rotational behavior of the impellerwere investigated experimentally. It has found that the floating position of the impeller become quite unstablein a partial flow rate operation. And the pressure distribution at the casing wall affects the rotational posture ofthe impeller. This paper presents the effect of the casing treatment on the rotational posture of the impeller and thepressure distribution. The reasonable casing treatment is available for the stable rotational posture of the impeller.

关键词：电动机磁感应强度转子数值研究传热学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Joint Angle Correction in Rheumatoid Arthritis and Its Reliability Analysis Based on Phase Dispersion Quantification

引用

Open Journal of Medical Imaging 2022年第4期12卷 171-179页

作者： Yafei Ou Prasoon Ambalathankandy ryunosuke Furuya Tamotsu Kamishima Masayuki Ikebe Research Center for Integrated Quantum Electronics Hokkaido University Sapporo Japan Faculty of Health Sciences Hokkaido University Sapporo Japan

Background: Rheumatoid arthritis is a form of autoimmune disease characterized by synovitis that can ultimately cause joint deformities and impaired functioning. The cartilage destruction is one of the most important indicators for diagnosis and treatment of rheumatoid arthritis, and it is radiographically manifested as joint space narrowing. Issue: In the literature, the joint space narrowing progression between a baseline and its follow-up finger joint images can be quantified by using image registration algorithm. We found that the inconsistencies of joint angles may lead to characteristic mismatches and thus severely affect the accuracy of joint space narrowing quantifications. Methods: In this work, we introduce a rotation invariant phase only correlation in joint space narrowing quantification for the joint angle correction. Further, we propose a confidence index to quantify the quantification reliability of phase only correlation based on phase dispersion in phase difference spectrum. Conclusion: In our clinical experiments, the proposed quantification method can effectively overcome and manage the mismatch due to the inconsistency of joint angles. Additionally, the confidence index shows a high consistency with the joint space narrowing progression examinations manually done by a trained radiologist and one radiological technologist.

关键词： Rheumatoid Arthritis Joint Space Narrowing Frequency Domain Analysis Radiology Computer-Aided Diagnosis Phase Dispersion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Does a combined intervention program of repetitive transcranial magnetic stimulation and intensive occupational therapy affect cognitive function in patients with post-stroke upper limb hemiparesis?

引用

Neural Regeneration Research 2016年第12期11卷 1932-1939页

作者： Takatoshi Hara Masahiro Abo Kiyohito Kakita Takeshi Masuda ryunosuke Yamazaki Department of Rehabilitation Medicine The Jikei University School of Medicine Department of Rehabilitation Medicine Kyoto Ohara Memorial Hospital

Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient＇s Trail-Making Test part B（TMT-B） performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function.

关键词： nerve regeneration stroke repetitive transcranial magnetic stimulation Trail-Making Test cognitive function occupational therapy neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Turbo-pump with Isolated Two Stage Impellers for Future Rocket Engine (Trial to Drive Impellers Independently)

引用

Journal of Thermal Science 2008年第1期17卷 28-34页

作者： Toshiaki Kanemoto Makoto Shimojyo ryunosuke Kawashima Daisuke Tanaka Akira Inagaki Shin Oba Kyushu Institute of Technology:Sensui 1-1 TobataKitakyushu 804-8550Japan Professor Kyushu Institute of Technology:Sensui 1-1 TobataKitakyushu 804-8550Japan DMW Corporation:Miyoshi 3-27 Mishima 411-8560Japan

为了在 impellers 压制成穴并且做涡轮泵，更长生活， inducer 与主要 impeller 被分开，两 impellers 独立地被驾驶。在 impellers 附近的泵和流动条件的表演试验性地被调查，下列结果被获得。(1 ) 主要 impeller 贡献在 inducer 和主... 详细信息

为了在 impellers 压制成穴并且做涡轮泵，更长生活， inducer 与主要 impeller 被分开，两 impellers 独立地被驾驶。在 impellers 附近的泵和流动条件的表演试验性地被调查，下列结果被获得。(1 ) 主要 impeller 贡献在 inducer 和主要 impeller 之间的流动相互作用。(2 ) 两 impellers 的旋转速度能独立地被控制以便同时总体上压制成穴不仅 impeller，而且在 inducer。

关键词：离心式水泵诱导物涡轮机火箭发动机 NPSH

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrochemical Oscillation Model in Electrohydrodynamic Fluid

引用

Open Journal of Physical Chemistry 2013年第1期3卷 14-19页

作者： Hiroshi Abe Yusuke Imai ryunosuke Goto Department of Materials Science and Engineering National Defense Academy Yokosuka Japan

In electrohydrodynamic phenomena, rhythmic oscillations of current under ac electric fields were observed in dielectric liquid, C4F9OCH3 (Abe et al., Jpn. J. Appl. Phys. (2010)). The oscillations of current and static pressure depended extensively on surface conditions of the electrodes, where an electric double layer on the surface of electrodes is sensitive to its smoothness. The characteristic frequency of current was defined by a crossover point on the power spectrum. This is based on non-synchronization with external ac fields above the critical frequency of current. Simulations are carried out using feedback loop including two-dimensional diffusion process. The observed crossover point on the power spectrum is reproducible qualitatively in the simulations.

关键词： Electric Double Layer Feedback Loop Simulation Rhythmic Current Oscillation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dominant Factors of the Nature Regulating CO2 Release from Boreal Forest Land

引用

International Journal of Geosciences 2012年第2期3卷 333-338页

作者： ryunosuke Kikuchi Tamara T. Gorbacheva Faculty of Science and Technology Ryukoku University Otsu Japan Institute of the North Industrial Ecology Problems Kola Science Center Apatity Murmansk Russia

Temperature is often considered as a primary factor for microbial decomposition of soil organic carbon. Boreal forests are the large terrestrial carbon pool: if carbon stored in this region is transferred to the atmosphere as CO2 by a warming-induced acceleration of its decomposition, there will be positive feedback to global warming. It is reported that real issue regarding the release of carbon from soils to the atmosphere is how natural factors interact to influence decomposition of soil organic matter, so we observed mass losses (indicating decomposition rates) from litter and litterfall in a Northern Fennoscandia forest over 3 years under natural conditions. Our field survey has demonstrated that mass losses from most kinds of sample had moderate correlation with the temperature. Of the various samples, the canopy-gap litter alone had a greater rate (~70%) of mass loss. It is at least necessary to make a clear distinction of monitoring sites (under the canopy and in the canopy gap) when discussing the effect of climate on soil CO2 release from high-latitude forests. Though temperature, soil moisture and soil properties are prioritized in the issue of soil CO2 release, our results suggest that the fungi/bacteria rate and the wind-related mix/fragmentation are also important factors to be considered;however, this speculation is just tentative, and more detail research is called for.

关键词： Fragmentation Global Warming High-Latitude Forest Microbial Decomposition Wind

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Hub Profiles on Efficiency and Flow of Jet Fan with Single Stage Impeller

引用

Open Journal of Fluid Dynamics 2013年第2期3卷 141-146页

作者： Shinpei Kametaka Daichi Deki Toshiaki Kanemoto ryunosuke Kawashima Faculty of Engineering Kyushu Institute of Technology Kitakyushu Japan

The traditional jet fans have equipped with the tandem impellers and the exclusive motors, and such designs are associated with the expensive initial cost. This serial research proposes how to simplify the fan profile for reducing the initial cost without the performance deteriorations. The paper discusses the effects of the hub profiles installed in the traditional/commercial jet fan, on the performances in the several type single-stage work. The hub with the long tail corn gives the best efficiency, and not only the stay vanes but also the cooling fins deteriorate more or less the performances, accompanying the impeller works as follows. The efficiency at the reverse rotation of the original impeller, namely at the flow condition running from the outlet to the inlet, is doubtlessly lower than one at the original rotation. The unique cascade, where the leading and the trailing edges of the blade are alternated in the tangential direction, was prepared in anticipation of improving the performances. These results advise the desirable profile of the jet fan equipped with the single-stage impeller, and the numerical simulation provides the optimum blade profile for the bidirectional flow.

关键词： Jet Fan Bidirectional Flow Impeller Initial Cost Performance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

“时尚”呼吁“和平”,从未止步

引用

艺术与设计 2022年第4期11卷 82-87页

作者：张倩倩 Balenciaga(图) Maison Margieia(图) COMME des GARÇONS(图) ryunosuke Okazaki(图) 不详

艺术界对于“和平”的探讨与追求从未止步。时装,也从未停歇地以其为灵感,向人们传递着和平的愿望。德姆纳•格瓦萨里亚(Demna Gvasalia)通过“末日景象”营造一种坚忍的优雅传递希望,约翰加利亚诺(John Galliano)用颓废美学讲述着战争... 详细信息

艺术界对于“和平”的探讨与追求从未止步。时装,也从未停歇地以其为灵感,向人们传递着和平的愿望。德姆纳•格瓦萨里亚(Demna Gvasalia)通过“末日景象”营造一种坚忍的优雅传递希望,约翰加利亚诺(John Galliano)用颓废美学讲述着战争中的凄凉故事。

关键词：瓦萨里和平止步

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：