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The Fourth Asia-Pacific Conference on Environmental Electromagnetics

作者： ryuji koga/Cochair Okayama University Japan Professor

＜正＞Electronics is a facet of the modern civilization and the dominant part of it, focused on consumer electronics, is carried in pan-pacific area now centered in far-east districts. Engineers who develop a new product, with better performance, easier to treat and with new function which had never claimed, will inevitably confront to EMC problems when they put their products to the market. They are young and enthusiastic to resolve the difficult subjects. CEEM’06 is the opportunity for the embarrassed engineers to find hints to untie entangled subject or lend other engineers an

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The Prevalence and Characteristics of Thoracic Outlet Syndrome in High School Baseball Players

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Health 2017年第8期9卷 1223-1234页

作者： Kenichi Otoshi Shinichi Kikuchi Kinshi Kato Ryohei Sato Takahiro Igari Takahiro Kaga Hiroaki Shishido Shinichi Konno ryuji koga Kozo Furushima Yoshiyasu Itoh Department of Sports Medicine Fukushima Medical University School of Medicine Fukushima Japan Department of Orthopaedic Surgery Fukushima Medical University School of Medicine Fukushima Japan Keiyu Orthopaedic Hospital Tatebayashi Japan

Thoracic outlet syndrome (TOS) is one of the common neurovascular disorders of the upper extremities, and the compression or traction of the brachial plexus is the main pathology. We hypothesized that baseball players are more likely to be affected by TOS compared with other overhead-throwing athletes because of strenuous use of their throwing arm. The purpose of this study was to investigate the prevalence and clinical characteristics of TOS in high school baseball players. One thousand two hundred eighty-eight high school baseball players were included in this study. The prevalence of symptomatic TOS and its association to disorders of the upper extremities were investigated. The prevalence of symptomatic TOS was 32.8%. Age- and position-adjusted logistic regression analysis revealed that subjects with symptomatic TOS were at significantly higher risk of shoulder and/or elbow pain (odds ratio [OR]: 1.96, 95% confidence interval [CI]: 1.50 - 2.58) and a higher recurrence rate of shoulder and/or elbow pain during the previous season (OR: 2.38, 95% CI: 1.87 - 3.04). As for physical findings, subjects with symptomatic TOS were also at significantly higher risk of MUCL tenderness (OR: 2.53, 95% CI: 1.83 - 3.50), positive milking maneuver, (OR: 2.63, 95% CI: 1.78 - 3.91), positive subacromial impingement sign (OR: 1.92, 95% CI: 1.20 - 3.07), and positive posterior impingement sign (OR: 2.34, 95% CI: 1.67 - 3.28) compared to the subjects without symptomatic TOS. It is necessary to recognize that TOS is not a rare pathology in overhead-throwing athletes, especially baseball players, and that players with symptomatic TOS are at significantly higher risk of shoulder/elbow pain.

关键词： Thoracic Outlet Syndrome Baseball Players Prevalence

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Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel

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World Journal of Gastroenterology 2018年第35期24卷 4036-4053页

作者： Keizo Hiraishi Lin-Hai Kurahara Miho Sumiyoshi Yao-Peng Hu Kaori koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian ryuji Inoue Department of Physiology Graduate School of Medical Sciences Fukuoka University Department of Pathology Faculty of Medicine Fukuoka University Department of Gastroenterological Surgery Faculty of Medicine Fukuoka University Department of Cell Biology University of Connecticut Health Center Department of Gastroenterology and Medicine Faculty of Medicine Fukuoka University College of Letters and Science University of CaliforniaDavis

AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODS Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBS) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting ***^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel *** factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting *** from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. RESULTS Chronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO *** active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,*** counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-SMA) ,which were accompanied by a reduction in the phosphorylation of Smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of ***,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen *** the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly *** The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis

关键词： Intestinal fibrosis Myofibroblast Transient receptor potential ankyrin 1 Crohn’s disease Collagen α-smooth muscle actin

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