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Enhancing clinical proficiency through laparoscopic training using Japanese origami

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 102-106页

作者： Shunsuke Furukawa Masatsugu Hiraki Naoya Kimura Ryota Sakurai Ryo Kohata Naohiko Kohya Masashi Sakai Akashi Ikubo ryuichiro Samejima Department of Surgery Japanese Red Cross Society Karatsu Red Cross HospitalSaga847-8588Japan Department of Surgery Saga University Faculty of MedicineSaga849-8501Japan

Objective This study aimed to investigate the clinical efficacy of laparoscopic training using origami,a traditional Japanese papercraft,using laparoscopic forceps to create origami *** In this retrospective study,4 surgeons were randomly divided into 2 groups:The training group,consisting of surgeons 1 and 2,and the non-training group,consisting of surgeons 3 and *** the course of a one-year study period,the training group regularly underwent laparoscopic surgery training with a dry box,wherein they folded a total of 1000 origami cranes using laparoscopic *** non-training group periodically underwent common laparoscopic surgery training of techniques such as suturing and *** surgeon regularly performed the transabdominal preperitoneal approach for inguinal *** training was conducted concurrently with the *** procedure time(peritoneum detachment,mesh placement,and closure of the peritoneum),total operation time(time from peritoneum detachment to closure of the peritoneum),and surgical outcomes were *** The training group showed greater improvement in the total operation time and more stable performance than the non-training ***,the time taken for peritoneum detachment was significantly shorter in the training *** Laparoscopic training using origami has the potential to enhance laparoscopic surgical skills and improve surgical outcomes.

关键词： Laparoscopic surgery Training Dry box Origami

Hemi-hepatectomy in pediatric patients using two-surgeon technique and a liver hanging maneuver

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World Journal of Gastroenterology 2011年第10期17卷 1354-1357页

作者： Kyoko Mochizuki Susumu Eguchi ryuichiro Hirose Taiichiro Kosaka Mitsuhisa Takatsuki Takashi Kanematsu Department of Surgery Nagasaki University Graduate School of Biomedical Sciences

AIM： To evaluate the efficacy of the two-surgeon technique with the liver hanging maneuver （LHM） for hepatectomies in pediatric patients with hepatoblastoma. METHODS： Three pediatric patients with hepatoblastoma were enrolled in this study. Two underwent right hemi-hepatectomies and one underwent a left hemihepatectomy using the two-surgeon technique by means of saline-linked electric cautery （SLC） and the Cavitron Ultrasonic Surgical Aspirator （CUSA; Valleylab, Boulder, CO） and the LHM. RESULTS： The mean operative time during the parenchymal transections was 50 rain and the mean blood loss was 235 g. There was no bile leakage from the cut surface after surgery. No macroscopic or microscopic-positive margins were observed in the hepatic transections. CONCLUSION： The two-surgeon technique using SLC and CUSA with the LHM is applicable to even pediatric patients with hepatoblastoma.

关键词： Two-surgeon technique Liver hanging maneuver Hepatoblastoma Hepatectomy Pediatric surgery

Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients

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World Journal of Gastroenterology 2011年第10期17卷 1343-1353页

作者： Masayuki Imamura Izumi Komoto Shuichi Ota Takuya Hiratsuka Shinji Kosugi ryuichiro Doi Masaaki Awane Naoya Inoue Department of Surgery Kansa Electric Power Company Hospital Departments of Surgery and Pathology Saiseikai Noe Hospital Medical Gene Research Center Graduate School of Medicine Kyoto University Department of Surgery Graduate School of MedicineKyoto University

AIM： To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. METHODS： Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 （MEN 1） and Zollinger-Ellison syndrome （ZES） underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors （NETs） between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test （SASI test） with secretin or calcium solution was performed as well as somatostatin receptor scintigraphy （SRS） and other imaging methods such as computed tomography （CT） or magnetic resonance imaging （MRI）. The modus of surgery for gastrinoma has been changed over time, searching for the optimal surgery： pancreaticoduodenectomy （PD） was first performed guided by localization with the SAST test, then local resection of duodenal gastrinomas with dissection of regional lymph nodes （LR）, and recently pancreas-preserving total duodenectomy （PPTD） has been performed for multiple duodenal gastrinomas. RESULTS： Among various types of preoperative localizing methods for gastrinoma, the SASI test was the most useful method. Imaging methods such as SRS or CT made it essentially impossible to differentiate functioning gastrinoma among various kinds of NETs. However, recent imaging methods including SRS or CT were useful for detecting both distant metastases and ectopic NETs; therefore they are indispensable for staging of NETs. Biochemical cure of gastrinoma was achieved in 14 of 16 patients （87.5%）; that is, 100% in 3 patients who underwent PD, 100% in 6 patients who underwent LR （although in 2 patients （33.3%） second LR was performed for recurrence of duodenal gastri- noma）, and 71.4% in 7 patients who underwent PPTD. Pancreatic NETs more than 1 cm in diameter were resected either by distal pancreatectomy or enucleations, and no hepatic metastases have developed postoperatively. Pathological study of the

关键词： Gastrinoma Duodenopancreatic neuroendocrine tumors Multiple endocrine neoplasia type 1 Selective arterial secretagogue injection test 5omatostatin receptor scintigraphy Pancreas-preserving total duode- nectomy Pancreaticoduodenectomy

Tween60和SDS强化白腐真菌修复DDT污染土壤

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中国环境科学 2015年第12期35卷 3737-3743页

作者：肖鹏飞李玉文 KONDO ryuichiro 东北林业大学林学院黑龙江哈尔滨150040 Faculty of Agriculture Kyushu University

为了提高DDT污染土壤的修复效果,研究了非离子表面活性剂Tween60及阴离子表面活性剂SDS在单一和组合两种方式对人工污染黑土中白腐真菌Phlebia lindtneri GB1027降解去除DDT的强化作用.结果表明,Tween60和SDS均能不同程度地促进土壤中DD... 详细信息

为了提高DDT污染土壤的修复效果,研究了非离子表面活性剂Tween60及阴离子表面活性剂SDS在单一和组合两种方式对人工污染黑土中白腐真菌Phlebia lindtneri GB1027降解去除DDT的强化作用.结果表明,Tween60和SDS均能不同程度地促进土壤中DDT的生物降解,尤其在两种表面活性剂浓度为***/g干土时,土壤中DDT的降解率分别达到最高的62.9%和53.9%.相同浓度下,Tween60比SDS更有利于提高DDT污染土壤的生物修复效果,去除率提高接近10%将Tween60与SDS以不同质量比例组合处理后的DDT去除率大小为:Tween60-SD S(3:1)>Tween60-SD S(2:1)>Tween60-SD S(1:1),尤其在质量比为3:1和2:1时的DDT去除率甚至高于Tween60单独处理时的去除率,表明将两种类型的表面活性剂组合后对提高DDT的生物可利用性产生了协同效果研究还发现,菌株接种量越高,土壤中DDT的降解去除率越高,当接菌量达到***/g干土时,DDT的30d去除率达到最高的70.9%.在土壤含水率为10%-50%范围内,白腐真菌对DDT的降解去除效果随着土壤含水率的升高而增加,当土壤含水率达到50%时,土壤中有约70%的DDT被降解去除.本研究结果进一步证实了利用表面活性剂强化白腐真菌修复有机污染土壤的可行性.

关键词： DDT 表面活性剂白腐真菌生物降解土壤修复

Extract of Emblica officinalis enhances the growth of human keratinocytes in culture

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Journal of Integrative Medicine 2019年第2期17卷 141-146页

作者： Yoshimi Yamakami Kyoko Morino Yuki Takauji ryuichiro Kasukabe Kensuke Miki Mohammad Nazir Hossain Dai Ayusawa Michihiko Fujii Graduate School of Nanobioscience Yokohama City University Ichiban Life Corporation Department of Biochemistry Primeasia University

Objective: Keratinocytes are the predominant cell type in the epidermis and play key roles in epidermal function. Thus, identification of the compounds that regulate the growth of keratinocytes is of importance. Here we searched for such compounds from the herbs used in traditional medicine ***: Human keratinocytes were cultured in the presence or absence of the herbal extracts for 2 weeks; the effect of the extracts on cell growth was determined by staining the cells with Coomassie brilliant blue. To detect the compounds that regulate the growth of keratinocytes, the herbal extracts were subjected to high-performance liquid chromatography(HPLC).Results: We found that the extract of Emblica officinalis enhanced the growth of keratinocytes in ***, we fractionated the extract of E. officinalis using HPLC and identified the fractions responsible for the enhanced growth of ***: The extract of E. officinalis enhanced the growth of human keratinocytes in culture.E. officinalis contains the compounds that would be beneficial for human skin health because enhanced growth of keratinocytes would promote wound healing.

关键词： Keratinocyte Cell growth Ayurveda Emblica officinalis

Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms： a double-blind, placebo-controlled randomized and dose-ranging study

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Asian Journal of Andrology 2008年第4期10卷 651-658页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Yoshiko Kurita Hiroko Kukihara Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu ryuichiro Kondo Kei Matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To conduct a double-blind, placebo-controlled randomized and dose-ranging study to evaluate the safety and efficacy of the extract of Ganoderma lucidum （G. lucidum） in men with lower urinary tract symptoms （LUTS）. Methods： We enrolled male volunteers （〉 50 years） with an International Prostate Symptom Score （IPSS; questions 1-7）〉 5 and a prostate-specific antigen （PSA） value 〈 4 ng/mL. Volunteers were randomized into groups of placebo （n = 12）, G. lucidum of 0.6 mg （n = 12）, 6 mg （n = 12） or 60 mg （n = 14）, administered once daily. Efficacy was measured as a change from baseline in IPSS and the peak urine flow rate （Qmax）. Prostate volume and residual urine were estimated by ultrasonography, and blood tests, including PSA levels, were measured at baseline and at the end of the treatment. Results： The overall administration was well tolerated, with no major adverse effects. Statistical significances in the magnitude of changes between the experimental groups were observed at weeks 4 and 8. No changes were observed with respect to Qmax, residual urine, prostate volume or PSA levels. Conclusion： The extract of G. lucidum was well tolerated and an improvement in IPSS was observed. The recommended dose of the extract of G. lucidum is 6 mg in men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial

Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms

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Asian Journal of Andrology 2008年第5期10卷 777-785页

作者： Masanori Noguchi Tatsuyuki Kakuma Katsuro Tomiyasu Akira Yamada Kyogo Itoh Fumiko Konishi Shoichiro Kumamoto Kuniyoshi Shimizu ryuichiro Kondo Kei Matsuoka Departments of Urology Kurume University School of Medicine Kurume 830-0011 Japan Departments of Bio-statistics Kurume University School of Medicine Kurume 830-0011 Japan Departments of Immunology Kurume University School of Medicine Kurume 830-0011 Japan Research Laboratories Chlorella Industry Co Ltd Chikugo 833-0056 Japan Department of Forest and Forest Products Science Faculty of Agriculture Kyushu University Fukuoka 812-8582 Japan

Aim： To evaluate the safety and efficacy of an extract of Ganoderma lucidum that shows the strongest 5α-reductase inhibitory activity among the extracts of 19 edible and medicinal mushrooms by a double-blind, placebo-controlled, randomized and dose-ranging study in men with lower urinary tract symptoms （LUTS）. Methods： In this trial, we randomly assigned 88 men over the age of 49 years who had slight-to-moderate LUTS to 12 weeks of treatment with G. lucidum extract （6 mg once a day） or placebo. The primary outcome measures were changes in the International Prostate Symptom Score （IPSS） and variables of uroflowmetry. Secondary outcome measures included changes in prostate size, residual urinary volume after voiding, laboratory values and the reported adverse effects. Results： G. lucidum was effective and significantly superior to placebo for improving total IPSS with 2.1 points decreasing at the end of treatment （mean difference, -1.18 points; 95% confidence interval, -1.74 to -0.62; P 〈 0.0001）. No changes were observed with respect to quality of life scores, peak urinary flow, mean urinary flow, residual urine, prostate volume, serum prostate-specific antigen or testosterone levels. Overall treatment was well tolerated with no severe adverse effects. Conclusion： The extract of G. lucidum was well tolerated and improved IPSS scores. These results encouraged a further, large-scale evaluation of phytotherapy for a long duration using the extract of G. lucidum on men with LUTS.

关键词： lower urinary tract symptoms phytotherapy outcome randomized trial Ganoderma lucidum

Patterns of Recurrence and Their Significance in Patients with Endometrial Carcinoma<br>—For Improved Follow-Up after Initial Treatment<br>

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Surgical Science 2013年第2期4卷 154-159页

作者： Fumi Utsumi Hiroaki Kajiyama Kiyosumi shibata Hiroko Mitsui ryuichiro Sekiya Mika Mizuno Shiro Suzuki Tomokazu Umezu Eiko Yamamoto Fumitaka Kikkawa Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya Japan

Objectives: The aim of this study was to identify the patterns of recurrence and their significance in patients with endometrial carcinoma (EMCA). Patients and Methods: After a search of the medical records from single institutions, a total of 49 patients with relapsed endometrial carcinoma were retrospectively evaluated. Various clinical information was examined, including the site of recurrence, detection procedure, and presence or absence of any symptom at the time of recurrence. Furthermore, the postrecurrence survival analysis was based on the Kaplan-Meier method. Results: The median follow-up period of all patients was 39.4 months (5.8 - 293.1). In all, twenty-five (51.0%) patients experienced recurrence within 12 months after the final treatment. At the time of recurrence, 15 (30.6%) and 34 (69.4%) patients were symptomatic and asymptomatic, respectively. Among the 34 asymptomatic patients, recurrence was detected by CT scan in 14 (28.6%), tumor markers alone in 14 (28.6%), and pelvic examination/ultrasound scan in 5 (10.2%). There was no relapsed case detected by vaginal vault cytology alone. The 5-year postrecurrence survival rates in symptomatic and asymptomatic patients were 57.5 and 36.6 months, respectively (P = 0.2973). After recurrence, 12 patients underwent debulking surgery, and 37 received salvage chemotherapy or radiotherapy. The postrecurrence survival of patients receiving surgery did not differ from that of those with chemotherapy/radiotherapy (P = 0.9198). Conclusion: Although imaging studies and tumor marker measurement contributed to the early detection of recurrence, they did not necessarily improve the prognosis postrecurrence.

关键词： Endometrial Carcinoma Recurrence Site Postrecurrence Survival Symptomatic Vaginal Vault Cytology

用于AR显示技术的亚波长Al光栅的ICP刻蚀工艺研究

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微纳电子与智能制造 2024年第1期6卷 59-64页

作者：吴必昇周燕萍上村隆一郎左超杨秉君爱发科(苏州)技术研究开发有限公司苏州215147 日本真空技术股份有限公司AEED部茅崎253-0071

铝材料因其良好的光反射率和低热线性膨胀系数,被广泛应用在增强现实设备的光栅光波导中。采用ULVAC公司生产的电感耦合等离子体(ICP)刻蚀设备NE-550对Al材料进行了干法刻蚀工艺的研究。实验中采用SiO_(2)作为刻蚀掩膜,Cl_(2)/BCl_(3)... 详细信息

铝材料因其良好的光反射率和低热线性膨胀系数,被广泛应用在增强现实设备的光栅光波导中。采用ULVAC公司生产的电感耦合等离子体(ICP)刻蚀设备NE-550对Al材料进行了干法刻蚀工艺的研究。实验中采用SiO_(2)作为刻蚀掩膜,Cl_(2)/BCl_(3)气体作为工艺气体,通过对实验工艺参数的调整,探究了ICP源功率、射频偏压功率、腔体压强以及气体流量对Al的刻蚀速率、与上层掩膜的选择比的影响。最后通过优化工艺参数,得到了底部平整、侧壁垂直的栅槽结构。此研究为亚波长尺度的光栅刻蚀工艺的优化和技术突破提供了参考。

关键词：电感耦合等离子体刻蚀亚波长光栅金属铝硅基液晶增强现实