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Prognostic Factors in Geriatric Patients with Metastatic Colon Cancer

Journal of Cancer Therapy 2019年第10期10卷 779-788页

作者： Kenji Ina Megumi Kabeya Shu Yuasa Yuko Kato Satoshi Kayukawa Takae Kataoka ryuichi furuta Department of Medical Oncology Nagoya Memorial Hospital Nagoya Japan Department of Phamacy Nagoya Memorial Hospital Nagoya Japan Medical Social Work Consultation Room Nagoya Memorial Hospital Nagoya Japan Department of Clinical Oncology Nagoya Memorial Hospital Nagoya Japan.

Backgrounds: Colorectal cancer is an important contributor to cancer morbidity and mortality. Given that many older adult patients often have concomitant diseases and impairments in organ function, they are at increased risk for chemotherapy toxicity. Therefore, it is important to identify prognostic factors in older patients undergoing chemotherapy. Methods: We performed a retrospective chart review of colorectal cancer patients treated at Nagoya Memorial Hospital between 2012 and 2017 and selected those who received chemotherapy for metastatic colon cancer. Overall survival was calculated from the beginning of chemotherapy until death or the most recent follow-up date. We used the Kaplan-Meier method to plot survival curves and performed a statistical comparison using a log-rank test. In addition, multivariate analysis was performed using stepwise Cox proportional hazards models. Finally, a comprehensive geriatric assessment was conducted for older patients. The chart review was approved by the ethics committee of Nagoya Memorial Hospital. Results: The overall survival of metastatic colon cancer patients was not markedly different between patients aged ≥ 65 years of age (N = 37). Neither lesion site nor the RAS status affected survival, whereas the usage of three kinds of cytotoxic agents prolonged longevity. In a multivariate analysis of patients ≥ 65 years of age, the only independent prognostic factor for survival was the functional capacity, as measured by the Tokyo Metropolitan Institute of Gerontology (TMIG) index of competence. Conclusions: A combination of the comprehensive geriatric assessment and TMIG index was useful for predicting the longevity in patients with metastatic colon cancer ≥ 65 years of age.

关键词： Metastatic Colon Cancer Chemotherapy Comprehensive Geriatric Assessment TMIG Index of Competence

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Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy

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World Journal of Clinical Oncology 2011年第10期2卷 339-343页

作者： Kenji Ina ryuichi furuta Takae Kataoka Satoshi Kayukawa Takashi Yoshida Takaya Miwa Yoshitaka Yamamura Yuuki Takeuchi Department of Medical Oncology Nagoya Memorial HospitalNagoya 468-8520Japan Department of Clinical Oncology Nagoya Memorial HospitalNagoya 468-8520Japan Department of Surgery Nagoya Memorial HospitalNagoya 468-8520Japan

AIM:To examine whether administration of lentinan,purifiedβ-1,3-glucan,can prolong survival in advanced gastric cancer patients receiving S-1-based ***:Since 2004,78 patients with metastatic or recurrent gastric cancer have received S-1-based chemotherapy as first-line ***,side effects,and the ratio of granulocytes/lymphocytes(G/L ratio)were compared between 2 groups of patients who received chemo-immunotherapy using lentinan and chemotherapy ***:Median overall survival was significantly longer in the former group than in the latter group[689 d(95%CI:431-2339 d)vs 565 d(95%CI:323-662 d),P=0.0406].In addition,the G/L ratio in patients who received lentinan was maintained around or below 2,which was significantly lower than that in patients who received chemotherapy alone(P<0.001).CONCLUSION:Chemo-immunotherapy with lentinan offers a significant advantage over S-1-based chemotherapy alone in terms of survival in patients with advanced gastric cancer.

关键词： Gastric cancer Lentinan S-1-based chemotherapy

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