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Long-Term Prognosis and Predictive Risk Factors for Polyvascular Disease in Patients with Peripheral Arterial Disease

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World Journal of Cardiovascular Diseases 2022年第1期12卷 50-64页

作者： Kuniki Nakashima Hisao Kumakura ryuichi Funada Yae Matsuo Kimimasa Sakata Akiko Ichikawa Toshiya Iwasaki Shuichi Ichikawa Department of Cardiovascular Surgery Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital) Gunma Japan Department of Cardiovascular Medicine Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital) Gunma Japan Department of Nephrology Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular Hospital) Gunma Japan

Background: The aim of the current study was to assess fifteen-year life expectancy, cardiovascular events, fate of the limb, and risk factors with or without polyvascular disease in patients with Peripheral Arterial Disease (PAD). Methods: We conducted a prospective cohort study in 1019 PAD patients. The endpoints were Cardiovascular or Cerebrovascular Death (CCVD), All-Cause Death (ACD), Major Adverse Cardiovascular Events (MACE), and Cardiovascular and/or Limb Events (CVLE). Results: The patients who died were 539 (52.9%) during follow-up periods. The rate of CCVD was 50.5% (n = 272). In multiple regression analysis, the number of affected arteries had correlations with estimated Glomerular Filtration Rate (eGFR), HDL-cholesterol, Ankle Brachial Pressure Index (ABI), and diabetes (p cholesterol, and diabetes (p

Gastrointestinal stromal tumor presenting with prominent calcification

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World Journal of Gastroenterology 2012年第39期18卷 5645-5648页

作者： Naoki Izawa Takeshi Sawada ryuichi Abiko Daisuke Kumon Mami Hirakawa Mika Kobayashi Nobuyuki Obinata Masahito Nomoto Tadateru Maehata Shun-ichi Yamauchi Takefumi Kouro Takashi Tsuda Satoshi Kitajima Hiroshi Yasuda Keiichi Tanaka Ichiro Tanaka Masahiro Hoshikawa Masayuki Takagi Fumio Itoh Division of Gastroenterology and Hepatology St.Marianna University School of MedicineKawasaki 216-8511Japan Division of Gastroenterological and General Surgery St.Marianna University School of MedicineKawasaki 216-8511Japan Department of Pathology St.Marianna University School of MedicineKawasak 216-8511Japan

We present a rare case of a gastrointestinal stromal tumor (GIST) in the stomach with prominent calcifica-tion at presentation. A 61-year-old woman visited our hospital because of epigastric discomfort. A spherical calcified lesion with a diameter of about 30 mm was incidentally shown in the left upper quadrant on an abdominal X-ray. Computed tomography demonstrated that the tumor was growing from the upper gastric body, with calcification in the peripheral ring area. A laparoscopic partial gastrectomy was performed, and the resected specimen revealed a well-circumscribed tumor with exophytic growth from the gastric muscularis propria. Microscopic examination revealed spindle- shaped tumor cells with calcification and hemorrhage. Additionally, positive immunoreactivity of the tumor to KIT and CD34 and a low mitotic index resulted in the diagnosis of very low risk GIST. There are a few case reports of heavily calcified GIST, although solitary or punctate calcification of primary GIST has been reported in several case series. Dystrophic calcification of necrotic or degenerative tissue is the supposed cause of primary calcified GISTs. In contrast, appearance of calcification after administration of imatinib mesylate, which may be one indicator of disease response, is possibly caused by a different mechanism.

关键词： Gastrointestinal stromal tumor Calcifica-tion Stomach Computed tomography Imatinib me-sylate

The Best Choice to Achieve Zero Complications after Pancreatoduodenectomy

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Surgical Science 2011年第2期2卷 45-51页

作者： Shinji Osada Hisashi Imai Yoshiyuki Sasaki Itaru Yasufuku ryuichi Asai Yoshihisa Tokumaru Takuji Sakuratani Kazuhiro Yoshida 不详

Pancreatoduodenectomy (PD) has been performed commonly, but the occurrence of pancreatic fistula (PF) is a critical trigger of complications, which are potentially life threatening, and is also associated with markedly prolonged hospitalization. Many techniques have been proposed for connecting the pancreatic stump with the gastrointestinal tract, stomach vs. jejunum, etc. Among the risk factors for PF, such as general patient factors or disease-related factors, the most important is the texture of the remnant pancreas. Surgical technique might be one improvable aspect that can reduce the pancreatic leakage rate, therefore;various methods of managing the pancreatic remnant have been studied. Methods of reconstruction between the remnant pancreas and the intestine include end-to-side with/without duct-to-mucosa anastomosis or end-to-end invagination styles, has been argued. Here, we review several trials for safety and methods of treating the pancreatic stump after PD, and demonstrate our experiences.

关键词： Pancreatoduodenectomy Reconstruction Pancreatojejunostomy Pancreatic Fistula Pancreatoenteric Anastomosis

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日本松香松节油工业的状况

国外林业 1990年第3期 45-47页

作者： ryuichi Kohzu 汪宗莲

很久以前,日本没有生产脂松香的松树和生产木浆浮油的针叶树,只能生产少量的香松节油,作为天然树脂或油使用。从第二次世界大战以来,由于经济的高度发展,松香松节油工业也随之发展起来。日本的树脂制造商大约从1950年开始生产地

关键词：松香浮油乳化剂松节油萜类化合物松香树脂日本

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热带西太平洋海表温度的季节内变化

暴雨灾害 1992年第2期24卷 25-28页

作者： ryuichi Kawamura 陈贸

热带西太平洋海表温度(SST)具有明显的季节内(30天-60天)变化,它与热带对流活动有着同一时间尺度的耦合关系,位相相差10天-20天.在向东传播的30天-60天振荡以东地区SST异常偏高,海气反馈系统显示出非常明显的30天-60天振荡.同时,也发现... 详细信息

热带西太平洋海表温度(SST)具有明显的季节内(30天-60天)变化,它与热带对流活动有着同一时间尺度的耦合关系,位相相差10天-20天.在向东传播的30天-60天振荡以东地区SST异常偏高,海气反馈系统显示出非常明显的30天-60天振荡.同时,也发现具有30天-60天时间尺度位相差海气耦合,在1981年北半球夏季期间在热带西太平洋表现较弱,这一年正是1982年-1983年厄尔尼诺南方涛动(ENSO)事件的前一年.

关键词：海表温度热带西太平洋南方涛动 ENSO 海气时间尺度反馈系统热带印度洋距平位相差

Pancreatic volume change using three dimensional-computed tomography volumetry and its relationships with diabetes on longterm follow-up in autoimmune pancreatitis

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World Journal of Radiology 2024年第11期16卷 644-656页

作者： ryuichi Shimada Yasunari Yamada Kazuhisa Okamoto Kazunari Murakami Mitsuteru Motomura Hajime Takaki Kengo Fukuzawa Yoshiki Asayama Department of Radiology Oita University Faculty of MedicineYufu 879-5593OitaJapan Department of Radiology Oita Red Cross HospitalOita 870-0033OitaJapan Department of Gastroenterology Oita University Faculty of MedicineYufu 879-5593OitaJapan Department of Hepato-Biliary-Pancreatic Internal Medicine Oita Red Cross HospitalOita 870-0033OitaJapan Department of Surgery Oita Red Cross HospitalOita 870-0033OitaJapan

BACKGROUND Several studies found that early pancreatic atrophy detected by computed tomo-graphy(CT)within 6 months was associated with a high incidence of diabetes in patients with type-1 autoimmune pancreatitis(AIP)receiving steroid therapy;however,no long-term follow-up studies have been *** To investigate pancreatic volume(PV)changes using three dimensional(3D)-CT volumetry and their relationship with IgG4 and diabetes in patients with *** This retrospective study included 33 patients with type-1 AIP receiving steroid *** were divided into diffuse(D-type)and mass-forming type(M-type)*** was determined by semi-automated 3D-CT volumetry,and changes between initial and follow-up values were *** relationship between PV and serum IgG4 levels was analyzed by Spearman’s rank *** PV atrophy ratio compared with the presumed normal PV at the time of last follow-up CT and its relationship with diabetes were *** There were 16 D-type and 17 M-type patients with long-term follow-up(mean,95.8 months).The regression curve of mean relative PV change reduced exponentially and rapidly during the first 25 months and then more slowly in both *** overall cumulative pancreas re-enlargement rates at 1,3,5,7 and 10 years were 6.1%,12.2%,29.2%,47.5%and 55.0%,*** was a moderate-to-very strong positive correlation(ρ≥0.4)between PV and serum IgG4 levels in nine(9/13,69.2%)*** 33 patients showed pancreatic atrophy(mean 59.3%)after long-term *** with D-type AIP had a significantly higher atrophy rate and higher incidence of diabetes than M-type patients(P<0.05).CONCLUSION PV change initially reduced exponentially and then more slowly and is considered an important factor associated with *** IgG4 levels were positively correlated with PV during follow-up.

关键词： Autoimmune pancreatitis Computerized tomography volumetry Follow-up study IgG4 Diabetes

Arbuscular Mycorrhizal Fungal Community Structure in Soybean Roots: Comparison between Kanagawa and Hokkaido, Japan

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Advances in Microbiology 2011年第1期1卷 13-22页

作者： Katsunori Isobe Kohei Maruyama Singo Nagai Masao Higo Tomiya Maekawa Gaku Mizonobe Rhae A. Drijber ryuichi Ishii 不详

The objectives of this study were to determine arbuscular mycorrhizal fungi (AMF) community structure in colonized roots of soybean cultivated from Kanagawa and Hokkaido in Japan and to relate the community structure to environmental conditions, which included soil type, preceding crops, and soil chemical properties. The average number of AMF OTU (operational taxonomic unit) colonizing soybean roots collected from Kanagawa and Hokkaido was 11.2 and 5.8, respectively, a significant difference. Moreover, AMF from the family Gigasporasera was not identified in soybean roots collected from Hokkaido, suggesting that AMF in the family Gigasporasea is absent or rare in the soybean fields of sampled in Hokkaido. We postulate that the soil type, preceding crops or soil chemical properties are not the underlying factor differentiating AMF community structure colonizing in soybean roots between Kanagawa and Hokkaido. Instead we conclude that temperature and phosphate absorption coefficient are the determining factors of AMF OTU in this study.

关键词： AM Fungi Colonization Community Structure Soybean

Cryoablation-Induced Anti-Cancer Immune Reaction—Immune Reaction Induced By Cryoablation

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Journal of Cancer Therapy 2011年第2期2卷 135-139页

作者： Shinji Osada Hisashi Imai Yoshiyuki Sasaki Itaru Yasufuku ryuichi Asai Yoshihisa Tokumaru Takuji Sakuratani Kazuhiro Yoshida Surgical Oncology Gifu University School of Medicine Yanagido Gifu City JAPAN.

Among the ablation procedures used against advanced liver cancer, thermal ablation therapy is widely applied, and the safety and efficacy of this technique have been well characterized. In contrast, the principle of cryosurgery is not only to control local recurrence, but also to stimulate the immune system into initiating an anti-tumor response. In recent years, we have developed a treatment method for patients with advanced liver tumors. From these experiences, repeated treatment was demonstrated to induce anti-cancer immune reaction-related factors. In the present review, mechanisms for anti-tumor immune reaction will be argued with introducing a novel strategy of a cryoablation.

关键词： Cryoablation Helper T cell Immune reaction Hepatoma Ablation therapy

Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy

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World Journal of Clinical Oncology 2011年第10期2卷 339-343页

作者： Kenji Ina ryuichi Furuta Takae Kataoka Satoshi Kayukawa Takashi Yoshida Takaya Miwa Yoshitaka Yamamura Yuuki Takeuchi Department of Medical Oncology Nagoya Memorial HospitalNagoya 468-8520Japan Department of Clinical Oncology Nagoya Memorial HospitalNagoya 468-8520Japan Department of Surgery Nagoya Memorial HospitalNagoya 468-8520Japan

AIM:To examine whether administration of lentinan,purifiedβ-1,3-glucan,can prolong survival in advanced gastric cancer patients receiving S-1-based ***:Since 2004,78 patients with metastatic or recurrent gastric cancer have received S-1-based chemotherapy as first-line ***,side effects,and the ratio of granulocytes/lymphocytes(G/L ratio)were compared between 2 groups of patients who received chemo-immunotherapy using lentinan and chemotherapy ***:Median overall survival was significantly longer in the former group than in the latter group[689 d(95%CI:431-2339 d)vs 565 d(95%CI:323-662 d),P=0.0406].In addition,the G/L ratio in patients who received lentinan was maintained around or below 2,which was significantly lower than that in patients who received chemotherapy alone(P<0.001).CONCLUSION:Chemo-immunotherapy with lentinan offers a significant advantage over S-1-based chemotherapy alone in terms of survival in patients with advanced gastric cancer.

关键词： Gastric cancer Lentinan S-1-based chemotherapy