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A pilot randomized control study to evaluate endoscopic resection using a ligation device for rectal carcinoid tumors

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World Journal of Gastroenterology 2006年第25期12卷 4026-4028页

作者： Hiroyuki Sakata ryuichi Iwakiri Akifumi Ootani Seiji Tsunada Shinichi Ogata Hibiki Ootani Ryo Shimoda Kanako Yamaguchi Yasuhisa Sakata Sadahiro Amemori Kotaro Mannen Masanobu Mizuguchi Kazuma Fujimoto Department of Internal Medicine Saga Medical School Saga 849-8501Japan Department of Radiology Saga Medical School Saga 849-8501Japan

AIM： Rectal carcinoid tumors smaller than 10 mm can be resected with local excision using endoscopy. In order to remove rectal carcinoid tumors completely, we evaluated endoscopic mucosal resection with a ligation device in this pilot control randomized study. METHODS： Fifteen patients were diagnosed with rectal carcinoid tumor （less than 10 mm） in our hospital from 1993 to 2002. There were 9 males and 6 females, with a mean age 61.5 years （range, 34-77 years）. The patientshad no complaints of carcinoid syndrome symptoms. Fifteen patients were randomly divided into 2 groups： 7 carcinoid tumors were treated by conventional endoscopic resection, and 8 carcinoid tumors were treated by endoscopic resection using a ligation device. RESULTS： All rectal carcinoid tumors were located at the middle to distal rectum. The size of the tumors varied from 3 mm to 10 mm and background characteristics of the patients were not different in the two groups. The rate of complete removal of carcinoid tumors using a ligation device （100%, 8/8） was significantly higher than that of conventional endoscopic resection （57.1%, 4/7）. The three patients had tumor involvement of deep margin, for which additional treatment was performed. No complications occurred during or after endoscopic resection using a ligation device. All patients in the both groups were alive during the 3-year observation period. CONCLUSION： Endoscopic resection using a ligation device is a useful and safe method for resection of small rectal carcinoid tumors.

关键词： Carcinoid Ligation mucosectomy Endoscopy Rectum Conventional method

Artificial intelligence in gastrointestinal diseases

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Artificial Intelligence in Gastroenterology 2021年第3期2卷 69-76页

作者： Shihori Tanabe Edward J Perkins ryuichi Ono Hiroki Sasaki Division of Risk Assessment Center for Biological Safety and ResearchNational Institute of Health SciencesKawasaki 210-9501Japan Environmental Laboratory US Army Engineer Research and Development CenterVicksburgMS 3180United States Division of Cellular and Molecular Toxicology Center for Biological Safety and ResearchNational Institute of Health SciencesKawasaki 210-9501Japan Department of Clinical Genomics Fundamental Innovative Oncology CoreNational Cancer Center Research InstituteTokyo 104-0045Japan

Artificial intelligence(AI)applications are growing in *** is important to understand the current state of the AI applications prior to utilizing in disease research and *** this review,AI application in the diagnosis and treatment of gastrointestinal diseases are studied and *** most cases,AI studies had large amounts of data,including images,to learn to distinguish disease characteristics according to a human’s *** detailed pros and cons of utilizing AI approaches should be investigated in advance to ensure the safe application of AI in *** suggests that the collaborative usage of AI in both diagnosis and treatment of diseases will increase the precision and effectiveness of *** progress in genome technology such as genome editing provides a specific example where AI has revealed the diagnostic and therapeutic possibilities of RNA detection and targeting.

关键词： Artificial intelligence Gastrointestinal disease RNA Therapeutic application Inflammatory diseases

Container Cargo Simulation Modeling for Measuring Impacts of Infrastructure Investment Projects in Pearl River Delta

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Journal of Marine Science and Application 2010年第1期9卷 54-62页

作者：李家齐 ryuichi Shibasaki 李博威 Graduate School at Shenzhen Tsinghua University National Institute for Land and Infrastructure Management School of Mathematics and Statistics Northeast Normal University

In the Pearl River Delta (PRD), there is severe competition between container ports, particularly those in Hong Kong, Shenzhen, and Guangzhou, for collecting international maritime container cargo. In addition, the second phase of the Nansha terminal in Guangzhou’s port and the first phase of the Da Chang Bay container terminal in Shenzhen opened last year. Under these circumstances, there is an increasing need to quantitatively measure the impact these infrastructure investments have on regional cargo flows. The analysis should include the effects of container terminal construction, berth deepening, and access road construction. The authors have been developing a model for international cargo simulation (MICS) which can simulate the movement of cargo. The volume of origin-destination (OD) container cargo in the East Asian region was used as an input, in order to evaluate the effects of international freight transportation policies. This paper focuses on the PRD area and, by incorporating a more detailed network, evaluates the impact of several infrastructure investment projects on freight movement.

关键词： logistics simulation modeling cargo container infrastructure investment

Emulsion Graft Polymerization of Methyl Methacrylate onto Cellulose Nanofibers

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Green and Sustainable Chemistry 2021年第1期11卷 9-22页

作者： Hiromu Okada Chao Zhao Yusuke Mizuta Katsumi Yoshino ryuichi Sugimoto School of Environmental Science and Engineering Kochi University of Technology Kochi Japan Shimane Institute for Industrial Technology Matsue Japan

Methyl methacrylate (MMA) was successfully grafted onto cellulose nanofibers (CNFs) at room temperature in an emulsion system using a diethyl(1,10-phenanthroline N1,N10)zinc(II) complex (Phen-DEZ) with oxygen as the radical initiator. The effects of reaction temperature, initiator concentration, and monomer content on the grafting reaction were investigated. The molecular weight of the non-grafted PMMA, which was produced during graft polymerization, was more than 1 million, as determined by size exclusion chromatography. The PMMA-grafted CNFs were analyzed by Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy, which confirmed the grafting of PMMA on the nanofiber surface. The study presents a strategy for the grafting of high-molecular weight PMMA onto CNFs in an emulsion system using Phen-DEZ and O2.

关键词： Cellulose Nanofibers Graft Polymerization Methyl Methacrylate Emulsion Diethylzinc

CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy

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World Journal of Hepatology 2013年第4期5卷 189-195页

作者： Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara Department of Gastroenterological Surgery Transplantand Surgical OncologyOkayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan

AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after *** tomography(CT)images were evaluated every 6 mo after PD for *** steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield *** biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo *** compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver ***-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy ***:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after *** patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin *** biopsy was performed in four patients with NAFLD after *** four patients showed moderate-to-severe steatosis and NASH was diagnosed in *** of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy *** number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with meta

关键词： Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells

EFFECTS OF SPUR DIKE DIRECTIONS ON RIVER BED FORMS AND FLOW STRUCTURES

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EFFECTS OF SPUR DIKE DIRECTIONS ON RIVER BED FORMS AND FLOW ...

Safety assessment of dextrin hydrogel adhesion barrier (AdSpray®) for elective laparoscopic cholecystectomy

16th IAHR-APD Congress and 3rd Symposium of IAHR-ISHS

作者： Terunori Ohmoto ryuichi Hirakawa Kunitoshi Watanabe Kumamoto University 39-1 Kurokami 2-chome Kumamoto Japan Saga University 1 Honjo-machi Saga-city Saga Japan

Resent studies have shown that group of non-submerged spur dikes can provide a valuable habitat for fishes and macro invertebrates in addition to the function to established a more desirable river for a flood, navigation and bank erosion. The study on the effects of non-submerged spur dikes on bed deformation, water surface oscillations and mean flow characteristics by changing the spur dikes facing upstream, downstream and normal to the main flow respectively. The results showed that the spur dikes facing downstream led to the maximum scour at the tip of the dikes, the maximum one in the main channel bed. In addition, it was found that in the case with a facing downstream, resistance is largest.

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第2期5卷 61-65页

作者： Toshiro Masuda Hiroshi Takamori Moeko Kato Chisho Mitsuura Yuta Shiraishi Rumi Itoyama Kenji Shimizu ryuichi Karashima Hidetoshi Nitta Hideo Baba Department of Surgery Saiseikai Kumamoto HospitalKumamoto861-4193Japan Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto860-0811Japan

Objective:Adhesion barriers have not traditionally been used during laparoscopic cholecystectomy(lapchole),and so there are no data confirming the safety of the dextrin hydrogel adhesion barrier(AdSpray®)for the use during *** aim of this prospective study is to investigate the safety of AdSpray®for elective ***:Between July 2019 and March 2021,we conducted a prospective study at Saiseikai Kumamoto Hospital to assess the safety of applying AdSpray®around the hepatoduodenal ligament,liver surface,and port area after extraction of the gallbladder during elective *** assessed patient morbidity,mortality,and laboratory data on postoperative day 1 and at the outpatient follow-up ***:A total of 100 patients(43 men,57 women)received AdSpray®application during elective lapchole at our *** mean patient age was 56.5±14.8 y,and the mean body mass index was 25.1±4.8 kg/*** gallbladder drainage was performed in 3(3.0%)patients as conservative treatment for acute *** mean operative time was 91.7±35.1 min,and the median blood loss was 5 mL(range,5e120 mL).Intraoperative gallbladder perforation was observed in 4.0%of patients(n=4).There was no intraoperative bile duct ***(1.0%)patient had a postoperative subhepatic fluid collection without bacterial *** mean white blood cell count and C-reactive protein level was significantly elevated on postoperative day 1 but returned to preoperative levels by the time of the follow-up *** patients were successfully discharged after surgery,and the median postoperative hospital stay was 2 d(range,2e9 d).Conclusion:Applying AdSpray®during elective lap-chole is safe,with an acceptable rate of postoperative complications.

关键词： Adhesion barrier Dextrin hydrogel Laparoscopic cholecystectomy

The Usefulness of Ryusei<sup>®</sup>Perfusion Balloon for Treating Acute Coronary Syndrome with Vulnerable Plaque

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World Journal of Cardiovascular Diseases 2019年第2期9卷 69-80页

作者： Fumitsugu Yoshikawa Tetsu Nakajima Masaharu Hanada Kazuo Hirata ryuichi Aikawa Kuwana City Medical Center Mie Prefecture Japan JCHO Sakuragaoka Hospital Shizuoka Japan

Background: Intracoronary thrombus followed by a rupture of unstable vulnerable plaque is a well-known cause of acute coronary syndrome (ACS). The no reflow/slow flow phenomenon is sometimes observed during a primary percutaneous coronary intervention (PCI) against ACS. It has already been shown that long inflation using a perfusion balloon (PB) is useful to remediate a coronary perforation. Thus, we investigated the usefulness of a PB for treating ACS. Methods: This study was a retrospective, single-center, observational study. One hundred-seven patients with ACS underwent PCI from January 2015 to December 2017 in our hospital. Fifty patients were treated by PB directly (PB group) and the remaining 57 patients were treated by another conventional balloon (C group). We used the Ryuseiò balloon (Kaneka, Japan) as a PB. The clinical outcome was the incidence of the no reflow or slow flow phenomenon, the incidence of using IABP. Results: One patient in the PB group demonstrated slow flow phenomenon temporarily, and the coronary flow was quickly restored by thromboaspiration. In contrast, nine patients in the C group had occurrences of no reflow/slow flow phenomenon. Although all patients in the C group required stenting, some patients (24%) of the PB group did not require stenting. Conclusion: We found that the use of PB had a favorable effect on the treatment of ACS. Some patients completed PCI without a need for stenting.

关键词： A Perfusion Balloon Vulnerable Plaque Acute Coronary Syndrome

A histologically proven case of progressive liver sarcoidosis with variceal rupture

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World Journal of Hepatology 2011年第10期3卷 271-274页

作者： Hitoshi Yoshiji Kou Kitagawa ryuichi Noguchi Masahito Uemura Yasuhide Ikenaka Yosuke Aihara Keisuke Na-kanishi Yusaku Shirai Chie Morioka Hiroshi Fukui Third Department of Internal Medicine Nara Medical University

Sarcoidosis is a chronic multi-systemic granulomatous disease,and liver involvement frequently *** most cases,no evidence of liver dysfunction is ob-served,and portal hypertension due to sarcoid liver diseases is a ***,no case of liver sarcoidosis has ever been reported with confirma-tion of the disease *** we describe a patient having hepatic sarcoidosis with severe portal hypertension and liver *** diagnosis was histologically confirmed from granulomatous status to established liver cirrhosis over 10 years.A 46-year-old woman developed massive hematemesis due to the rupture of gastric cardial *** underwent emer-gency endoscopic injection sclerotherapy,and clear evi-dence of chronic hepatic *** years ago,she was diagnosed as having sarcoidosis with *** biopsy revealed asymptomatic incidental granulomas without fibrosis *** a couple of years,features of liver dysfunction were manifest and *** years after the first biopsy,a second liver biopsy was performed,and well established dense fibrosis was *** significant liver dysfunction with portal hypertension is rarely seen in sarcoidosis,this case indicates that we have to consider the possibility that sarcoidosis may cause end-stage liver cirrhosis.

关键词： Liver sarcoidosis Portal hypertension He-patic failure Liver cirrhosis