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Neural Regeneration Research 2025年第1期20卷 195-196页

作者： hyun Sung Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Medical Research Institute and Department of PharmacologyPusan National University School of MedicineYangsanRepublic of Korea

Neurons are highly polarized,morphologically asymmetric,and functionally compartmentalized cells that contain long axons extending from the cell *** this reason,their maintenance relies on spatiotemporal regulation of organelle distribution between the somatodendritic and axonal *** some organelles,such as mitochondria and smooth endoplasmic reticulum,are widely distributed throughout the neuron,others are segregated to either the somatodendritic or axonal *** example,Golgi outposts and acidified lysosomes are predominantly present in the somatodendritic domain and rarely distributed along the axon,whereas newly formed autophagosomes and synaptic vesicles are mainly distributed in the distal axon(Britt et al.,2016).

关键词： organelle regulation distribution

Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration

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Regenerative Biomaterials 2024年第4期3卷 138-148页

作者： Woo-Jin kim Jeong-hyun ryu Ji Won kim ki-Tae kim Hye-Rim Shin Heein Yoon hyun-Mo Ryoo Young-Dan Cho Department of Molecular Genetics School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul03080Republic of Korea Department of Periodontology School of Dentistry and Dental Research InstituteSeoul National University and Seoul National University Dental HospitalSeoul03080Republic of Korea

Clinical bone-morphogenetic protein 2(BMP2)treatment for bone regeneration,often resulting in complications like soft tissue inflammation and ectopic ossification due to high dosages and non-specific delivery systems,necessitates research into improved biomaterials for better BMP2 stability and *** tackle this challenge,we introduced a groundbreaking bone-targeted,lipoplex-loaded,three-dimensional bioprinted bilayer scaffold,termed the polycaprolactone-bioink-nanoparticle(PBN)scaffold,aimed at boosting bone *** encapsulated BMP2 within the fibroin nanoparticle based lipoplex(Fibroplex)and functionalized it with DSS6 for bone tissue-specific targeting.3D printing technology enables customized,porous PCL scaffolds for bone healing and soft tissue growth,with a two-step bioprinting process creating a cellular lattice structure and a bioink grid using gelatin-alginate hydrogel and DSS6-Fibroplex,shown to support effective nutrient exchange and cell growth at specific pore *** PBN scaffold is predicted through in silico analysis to exhibit biased BMP2 release between bone and soft tissue,a finding validated by in vitro osteogenic differentiation *** PBN scaffold was evaluated for critical calvarial defects,focusing on sustained BMP2 delivery,prevention of soft tissue cell infiltration and controlled fiber membrane pore size in *** PBN scaffold demonstrated a more than eight times longer BMP2 release time than that of the collagen sponge,promoting osteogenic differentiation and bone regeneration in a calvarial defect *** findings suggest that the PBN scaffold enhanced the local concentration of BMP2 in bone defects through sustained release and improved the spatial arrangement of bone formation,thereby reducing the risk of heterotopic ossification.

关键词： 3D bioprinting bone-targeting lipoplex BMP2 bone regeneration

Mo and Ta addition in NbTiZr medium entropy alloy to overcome tensile yield strength-ductility trade-off

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Journal of Materials Science & Technology 2022年第14期109卷 176-185页

作者： Muhammad Akmal hyun Woo Seong Ho Jin ryu Department of Materials Science and Engineering KAISTDaejeonYuseong-gu 34141South Korea Department of Nuclear and Quantum Engineering KAISTDaejeonYuseong-gu 34141South Korea

In this study,single-phase NbTiZr and NbTiZr(MoTa)_(0.1) medium-entropy alloys(MEAs)were investigated for their use in biomedical *** alloys were prepared by arc melting,and were then cold-rolled,annealed,and characterized in terms of phase analysis,mechanical properties,fractography,and wear *** alloys showed a single body-centered cubic phase with superior mechanical,and tribological properties compared to commercially available biomedical *** and Ta-containing MEAs showed higher tensile yield strength(1060±18 MPa)and higher tensile ductility(~20%),thus overcoming the strength-ductility trade-off with no signs of transformation-induced plasticity,twinning,or *** generalized stacking fault energy(GSFE)calculations on the{112}slip system by the first-principles calculations based on density functional theory showed that the addition of less than0.2 molar fraction of Mo and Ta lowers the GSFE *** behavior posits the increase in ductility of the alloy by facilitating slips although strength is also increased by solid solution *** wear resistance of both alloys against hardened steel surfaces was superior to that of commercial biomedical ***,we concluded that NbTiZr(MoTa)_(0.1)MEA with good tensile ductility is a potential candidate for biomedical implants.

关键词： Medium-entropy alloys Wear-resistant Biomedical implants Solid solution hardening Staking fault energy

Heat shock protein family D member 1 in boar spermatozoa is strongly related to the litter size of inseminated sows

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1045-1055页

作者： Won-ki Pang Ji-hyun Son Do-Yeal ryu Md Saidur Rahman Yoo-Jin Park Myung-Geol Pang Department of Animal Science&Technology and BET Research Institute Chung-Ang UniversityAnseongGyeonggi-do 17546Republic of Korea

Background:Sperm quality evaluation is the logical first step in increasing field *** contain cytoplasmic organelles and biomolecules known as sperm-intrinsic factors,which play key roles in sperm maturation,sperm-oocyte fusion,and embryo *** particular,sperm membrane proteins[e.g.,arginine vasopressin receptor 2,beta-actin,prohibitin,and heat shock protein family D member 1(HSPD1)]and RNA could be used as functional indicators of male *** sought to clarify the effects of differential mRNA expression of selected genes on several fertilisation parameters,including sperm motility,motion kinematics,capacitation,and litter size,in a porcine ***:Our results demonstrated that HSPD1 expression was significantly correlated with male fertility,as measured by the litter size of inseminated *** expression of HSPD1 mRNA was linked to sperm motility and other motion kinematic ***,HSPD1 had a 66.7%overall accuracy in detecting male fertility,and the high-litter size group which was selected with the HSPD1 marker had a 1.34 greater litter size than the lowlitter size ***:Our findings indicate that HSPD1 might be a helpful biomarker for superior boar selection for artificial insemination,which could boost field fertility.

关键词： Fertilisation HSPD1 Male fertility Sperm motility Sperm RNA

Simple method for extracting the seasonal signals of photochemical reflectance index and normalized difference vegetation index measured using a spectral reflectance sensor

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Journal of Integrative Agriculture 2021年第7期20卷 1969-1986页

作者： Jae-hyun ryu Dohyeok OH Jaeil CHO Department of Applied Plant Science Chonnam National UniversityGwangju 61186Republic of Korea

A spectral reflectance sensor(SRS)fixed on the near-surface ground was developed to support the continuous monitoring of vegetation indices such as the normalized difference vegetation index(NDVI)and photochemical reflectance index(PRI).NDVI is useful for indicating crop growth/phenology,whereas PRI was developed for observing physiological ***,the seasonal change patterns of NDVI and PRI are two valuable pieces of information in a crop-monitoring ***,capturing the seasonal patterns is considered challenging because the vegetation index values estimated by the reflection from vegetation are often governed by meteorological conditions,such as solar irradiance and ***,unlike growth/phenology,the physiological condition has diurnal changes as well as seasonal *** study proposed a novel filtering method for extracting the seasonal signals of SRS-based NDVI and PRI in paddy rice,barley,and ***,the measurement accuracy of SRSs was compared with handheld spectrometers,and the R^(2)values between the two devices were 0.96 and 0.81 for NDVI and PRI,***,the experimental study of threshold criteria with respect to meteorological variables(i.e.,insolation,cloudiness,sunshine duration,and precipitation)was conducted,and sunshine duration was the most useful one for excluding distorted values of the vegetation *** data processing based on sunshine duration,the R^(2)values between the measured vegetation indices and the extracted seasonal signals of vegetation indices increased by approximately 0.002–0.004(NDVI)and 0.065–0.298(PRI)on the three crops,and the seasonal signals of vegetation indices became noticeably *** method will contribute to an agricultural monitoring system by identifying the seasonal changes in crop growth and physiological conditions.

关键词： photochemical reflectance index normalized difference vegetation index vegetation remote sensing spectral reflectance sensor

Coordination polymers： Challenges and future scenarios for capture and degradation of volatile organic compounds

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Nano Research 2016年第11期9卷 3181-3208页

作者： Kowsalya Vellingiri Pawan Kumar ki-hyun kim Department of Civil and Environmental Engineering Hanyang uniVersity 222 Wangsimni-RoSeoul 04763Republic of Rorea Department of Nano Sciences and Materials Central University of Jammu Jammu 181143 India

Over the past few decades, coordination polymers/metal organic frameworks （CPs/MOFs） have drawn a great deal of attention for diverse applications due to their advantages of intrinsically ttLnable chemical structure, flexible architecture, high pore volume, high surface area, multifunctional properties, etc. To date, numerous CPs/MOFs have been developed and employed for the treatment and control of gaseous pollutants, such as volatile organic compounds （VOCs）, through capture, sorptive removal, and catalytic degradation. Nevertheless, there are also some key drawbacks and challenges for the practical application of these systems （e.g., poor selectivity, high energy （and fiscal） cost, high synthesis cost, low capacity, and difficulties in regeneration and recycling）. In this review, recent developments in CPs/MOFs research are described with their associated mechanisms for capture, sorptive removal, and catalytic degradation of VOCs. To this end, we discuss the key variables and challenges for afforded abatement of VOCs through CPs/MOFs technologies. Hopefully, this review will help the scientific community set future directions for the advancement of CPs/MOFs techniques for the effective management of diverse environmental issues.

关键词： coordination polymers/metal organic frameworks(CPs/MOFs) volatile organic compounds sorptive removalcatalytic degradation

Practical considerations of Si-based anodes for lithiumion battery applications

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Nano Research 2017年第12期10卷 3970-4002页

作者： Jaegeon ryu Dongki Hong hyun-Wook Lee Soojin Park Department of Energy Engineering School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea

Using Si-based anodes in Li-ion batteries is one of the most feasible approaches to achieve high energy densities despite their disadvantages, such as low conductivity and massive volume expansion, which cause unstable solid electrolyte interphase layers with mechanical failure. The forefront in research and development to address the above challenges suggests the possibility of fully commercially viable cells using various structural and interfacial modifications. In particular, we present a discussion of each dimension of Si-based anodes in multiple controlled systems, including plain, hollow, porous, and uniquely engineered structures, which are further evaluated based on their anode performances, such as initial reversibility, capacity retention for extended cycles with its efficiency, degree of volume expansion tolerance, and rate capabilities, by several practical standards in half cells. With these practical considerations, multi-dimensional structures with uniform size distributions （micrometers, on average） are strongly desired to satisfy the rigorous requirements for widespread applications. Furthermore, we closely examined several full cells composed of Si-based multicomponent anodes coupled with suitable cathodes based on practical standards to propose future research directions for Si-based anodes to keep pace with the rapidly changing market demands for diverse energy storage systems.

关键词： silicon anode dimensional control full celllithium-ion batteries practicality

Counter-balancing effects of Si on C partitioning and stacking fault energy of austenite in 10Mn quenching and partitioning steel

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Journal of Materials Science & Technology 2022年第3期98卷 248-257页

作者： Dong Hwi kim Jee-hyun Kang Hojun Gwon Joo hyun ryu Sung-Joon kim Graduate Institute for Ferrous Technology Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Materials Science and Engineering Institute of Materials TechnologyYeungnam UniversityGyeongsan 38541Republic of Korea POSCO Technical Research Laboratories POSCOGwangyang 57807Republic of Korea

Silicon is an essential alloying element in quenching and partitioning(Q&P)steels,because it is known to suppress carbide precipitation during partitioning step and promote carbon partitioning to stabilize *** 2 wt%Si was added to 10Mn-2Al-0.2C steel,the size and fraction of the carbides formed during partitioning became smaller than in the Si-free ***,the suppression of carbide formation promoted C partitioning into austenite as ***,austenite stability was always lower with Si under the equivalent partitioning condition because Si effectively decreased the stacking fault energy of *** partitioning progressed,the both yield and tensile strengths of the Si-added steel exceeded that of the Si-free steel with the similar ductility *** was because Si was an effective solid solution strengthener,and the austenite in the Si-added steel exhibited the appropriate stability to gradually transform into martensite throughout the *** resulting strengthening effect compensated for the softening caused by martensite ***,strain hardening rate decreased continuously throughout deformation,which resulted in high tensile strength and ductility.

关键词： Steels Q&P steel Silicon Austenite stability Tensile deformation Stacking fault energy Medium Mn steel

Airborne bioaerosols and their impact on human health

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Journal of Environmental Sciences 2018年第5期30卷 23-35页

作者： ki-hyun kim Ehsanul Kabir Shamin Ara Jahan Department of Civil and Environmental Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Farm Power&MachineryBangladesh Agricultural UniversityMymensinghBangladesh BRAC Clinic DhakaBangladesh

Bioaerosols consist of aerosols originated biologically such as metabolites, toxins, or fragments of microorganisms that are present ubiquitously in the environment. International interests in bioaerosols have increased rapidly to broaden the pool of knowledge on their identification,quantification, distribution, and health impacts（e.g., infectious and respiratory diseases,allergies, and cancer）. However, risk assessment of bioaerosols based on conventional culture methods has been hampered further by several factors such as：（1） the complexity of microorganisms or derivatives to be investigated;（2） the purpose, techniques, and locations of sampling; and（3） the lack of valid quantitative criteria（e.g., exposure standards and dose/effect relationships）. Although exposure to some microbes is considered to be beneficial for health,more research is needed to properly assess their potential health hazards including inter-individual susceptibility, interactions with non-biological agents, and many proven/unproven health effects（e.g., atopy and atopic diseases）.

关键词： Health effect Exposure Infectious diseases Respiratory diseases Cancer Guideline