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船用柴油机NO_x等有害排放气体的评价及处理研究——燃料喷射系统对乳化燃料在船用柴油机上使用的影响及脱硝装置的适用性

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内燃机学报 2000年第4期18卷 380-386页

作者：张洁高杉喜雄菊池正晃桑原孙四郎西尾澄人石村惠以子中岛康晴盐出敬二郎山谷周二西川和美日本国运输省船舶技术研究所机关动力部船舶技术研究所材料加工部

对原试验用柴油机的燃料喷射系统进行了改造。改造后的燃料喷射系统不仅可降低 NOx 的排放 ,而且使高加水率乳化燃料的使用成为可能。但另一方面 ,在低负荷时 ,使用乳化燃料不但不能获得预期的降低 NOx 排放效果 ,反而使其它有害排放增... 详细信息

对原试验用柴油机的燃料喷射系统进行了改造。改造后的燃料喷射系统不仅可降低 NOx 的排放 ,而且使高加水率乳化燃料的使用成为可能。但另一方面 ,在低负荷时 ,使用乳化燃料不但不能获得预期的降低 NOx 排放效果 ,反而使其它有害排放增加。所以 ,也对降低 NOx 排放方法之一的脱硝装置进行了探讨 ,对其在船用柴油机上的适用性进行了试验。

关键词：燃料喷射系统船用柴油机乳化燃料排气污染

Pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis

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World Journal of Meta-Analysis 2019年第5期7卷 249-258页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of MedicineFukushima CityFukushima Prefecture 960-1295Japan Department of Endoscopy Fukushima Medical University HospitalFukushima CityFukushima Prefecture 960-1295Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)plays a major role in the investigation and treatment of pancreaticobiliary ***,post-ERCP pancreatitis(PEP)is a severe adverse *** meta-analyses have shown that prophylactic PS was useful for preventing ***,abstract reports and patients who underwent endoscopic ampullectomy were included in the previous *** addition,two meta-analyses involved non-randomized controlled trials(RCTs).The efficacy of PS for preventing severe PEP was different in each ***,we performed the current metaanalysis,which included only full-text articles,and added new *** To reveal the efficacy of prophylactic pancreatic stent(PS)placement for preventing *** We searched the MEDLINE,Cochrane Library and PubMed databases for related *** the reports retrieved,11 studies were included in this *** full-text articles were published between 1993 and 2016.A total of 1475 patients were enrolled in the included studies;of these patients,734 had a PS inserted,and 741 did not have a PS *** and severe PEP occurrence were evaluated in this *** PEP was observed in all studies and occurred in 39(5.3%)patients who received a *** the other hand,PEP occurred in 141(19%)patients who did not receive a *** occurrence of PEP was significantly lower in the patients who underwent PS placement than in the patients who did not receive a PS(OR=0.32;95%CI:0.23-0.45;P<0.001).In addition,the occurrence of severe PEP was ***,the occurrence of severe PEP was not observed in the stent group;however,the occurrence of severe PEP was observed in 8(1.3%)patients who did not have a PS *** PEP occurred significantly less often in the stent group than in the no stent group(OR=0.24;95%CI:0.06-0.94;P=0.04).CONCLUSION In conclusion,prophylactic PS placement is useful for preventing PEP and severe PEP.

关键词： Endoscopic retrograde cholangiopancreatography Pancreatic stent Postendoscopic retrograde cholangiopancreatography pancreatitis Meta-analysis

Present state of endoscopic ultrasonography-guided fine needle aspiration for the diagnosis of autoimmune pancreatitis type 1

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World Journal of Meta-Analysis 2019年第5期7卷 218-223页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of MedicineFukushima 960-1247Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 960-1247Japan

Autoimmune pancreatitis(AIP)is defined as pancreatitis caused by irregular narrowing of the pancreatic duct accompanied by pancreatic swelling,fibrosis and lymphocyte infiltration,events that are related to autoimmune *** 2010 International Consensus Diagnostic Criteria for AIP defined pancreatitis as“type 1”when increased levels of serum IgG4 were present and other organs were involved;lymphoplasmacytic sclerosing pancreatitis was the main histological *** from surgery,endoscopic ultrasonographyguided fine needle aspiration(EUS-FNA)is the only method for the histological diagnosis of AIP;however,this method is *** use of larger-diameter FNA needles and trucut biopsy did not improve the diagnostic performance of EUS-FNA,but it has improved *** this review,we look back at past efforts to improve the diagnostic performance of EUS-FNA and reveal the present state of EUS-FNA for the histological diagnosis of AIP type 1.

关键词： Autoimmune pancreatitis type 1 Endoscopic ultrasonography-guided fine needle aspiration IgG4-related disease Lymphoplasmacytic sclerosing pancreatitis

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis using pancreatic stents: A review of efficacy, diameter and length

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World Journal of Meta-Analysis 2019年第6期7卷 259-268页

作者： Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi kikuchi Mika Takasumi Minami Hashimoto Takuto Hikichi Hiromasa Ohira Department of Gastroenterology Fukushima Medical UniversitySchool of Medicine Fukushima 9601247Japan Department of Endoscopy Fukushima Medical University HospitalFukushima 9601295Japan

Although endoscopic retrograde cholangiopancreatography (ERCP) is an important procedure for the diagnosis and treatment of pancreaticobiliary diseases, post-ERCP pancreatitis (PEP) is the most frequent adverse event that can sometimes be fatal. However, prophylactic pancreatic stent (PS) insertion has been performed to prevent PEP in high-risk patients. In some randomized controlled trials (RCTs) and meta-analyses, the efficacy of prophylactic PS insertion has been shown to prevent PEP. In addition, several types of stents have been used to decrease PEP. In this review, we introduce the details of these RCTs and meta-analyses and reveal the specifications for stent placement, for example, the stent diameter and length and the pancreatic region into which the stent should be inserted.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Prophylactic pancreatic stent

日本血吸虫虫卵毛蚴中带信号序列基因的全长cDNA序列分析

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中国血吸虫病防治杂志 2006年第1期18卷 10-14页

作者：余传信殷旭仁菊池三惠子平山谦二朱荫昌江苏省血吸虫病防治研究所无锡214064 日本长崎大学热带医学研究所分子与免疫遗传室

目的对带有信号序列的日本血吸虫虫卵毛蚴基因的全长cDNA序列进行分析。方法根据日本血吸虫虫卵毛蚴中带信号序列的cDNA片段序列设计合成基因特异性引物。以虫卵的第一链全长cDNA为模板,采用套式PCR,快速扩增带信号序列的虫卵毛蚴cDNA的... 详细信息

目的对带有信号序列的日本血吸虫虫卵毛蚴基因的全长cDNA序列进行分析。方法根据日本血吸虫虫卵毛蚴中带信号序列的cDNA片段序列设计合成基因特异性引物。以虫卵的第一链全长cDNA为模板,采用套式PCR,快速扩增带信号序列的虫卵毛蚴cDNA的5′、3′末端片段,将特异性扩增片段进行TA克隆与序列分析。将每个带信号序列的虫卵毛蚴cDNA片段序列与其5′、3′末端片段序列进行比对和拼接,构建每个带信号序列的虫卵毛蚴基因的完整全长cDNA序列,对部分带信号序列虫卵毛蚴基因的信号序列所对应的基因组序列结构进行分析。结果本研究分析了30个带有信号序列的cDNA片段,其中16个片段的5′、3′末端cDNA序列被成功扩增,并测定了它们的DNA序列,通过序列比对和拼接,获得了该16个虫卵毛蚴基因的全长cDNA序列。对开放阅读框演绎的氨基酸序列进行分析,发现基因SjP4001与SjP1531的信号肽序列完全相同,而基因SjP3742和SjP1183的信号肽氨基酸序列甚为相似,从而进一步证明不同的基因可拥有相同或相似的信号肽。基因组序列分析表明,基因SjP1183的信号肽基因序列与成熟肽基因序列通过交替拼接(alternativesplicing)方式进行拼接;而基因SjP4001、SjP1531、SjP3742的信号肽基因序列与成熟肽基因序列之间可能是通过转移拼接的方式进行拼接。结论确定了16个带有信号序列的虫卵毛蚴基因的全长cDNA序列,虫卵毛蚴基因可通过交替拼接方式或转移拼接方式获得信号肽序列。

关键词：日本血吸虫基因克隆全长cDNA序列拼接模式

糖尿病患者角质层的功能特征:与老年性干燥病相似

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 30-30页

作者： Sakai S. kikuchi K. Satoh J. S. Inoue 惠海英 Basic Research Laboratory Kanebo Ltd. 5-3-28 Kotobuki-cho Odawarashi Kanagawa 250-0002 Japan

Background: Although diabetes mellitus is known to induce many pathophysiological changes in the skin, none of the earlier studies has focused on the state of the stratum corneum (SC) in patients with diabetes. In our previous report on a diabetic mouse model, we described a decreased SC hydration state and abnormalities in the function of the sebaceous gland together with a normally retained barrier function of the SC. Objectives: To examine the functional changes of the SC in patients with diabetes. Methods: The following values were measured in 49 patients with diabetes: fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c); skin surface lipid level on the forehead; and high-frequency conductance (HFC) and transepidermal water loss (TEWL) of the SC of the volar forearm and extensor surface of the lower leg. These functions of the SC were compared in two pairs of patient groups, i.e. between groups with high and low FPG, and between groups with high and low HbA1c. Results: The HFC levels on the extensor leg and volar forearm were significantly lower in the group with high FPG (FPG > 110 mg dL-1) than in the group with low FPG (FPG 5.8%) and the group with low HbA1c (HbA1c<5.8%), whereas the TEWL of the volar forearm was slightly lower in the former than in the latter. Conclusions: These new results as well as our earlier results with diabetic mice suggest that patients with diabetes mellitus tend to show a reduced hydration state of the SC together with decreased sebaceous gland activity, without any impairment of the SC barrier function.

关键词：空腹血糖额部皮肤病理生理水合作用传导率

Progress in Physics and Technology Developments for the Modification of JT-60

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Plasma Science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tamai M.Matsukawa G.Kurita N.Hayashi K.Urata Y.M.Miura K.Kizu K.Tsuchiya A.Morioka Y.Kudo S.Sakurai K.Masaki T.Suzuki M.Takechi Y.Kamada A.Sakasai S.Ishida K.Abe A.Ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatayama T.Hino H.Horiike N.Hosogane M.Ichimura Tsuji-Iio S.Itoh M.Katsurai M.kikuchi A.Kohyama H.Kubo M.Kuriyama M.Matsuoka Y.Miura N.Miya T.Mizuuchi K.Nagasaki H.Ninomiya N.Nishino Y.Ogawa K.Okano T.Ozeki M.Saigusa M.Sakamoto M.Satoh M.Shimada R.Shimada M.Shimizu T.Takagi Y.Takase T.Tanabe K.Toi Y.Ueda Y.Uesugi K.Ushigusa Y.Yagi T.Yamamoto K.Yatsu K.Yoshikawa Japan Atomic Energy Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University of Tsukuba Osaka University Kyushu University Keio University Hokkaido University Tokyo Institute of Technology the University of Tokyo Kyoto University Mie University Hiroshima University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoya University National Institute for Fusion Science Kanazawa University National Institute of Advanced Industrial Science and Technology

Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the MHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.

关键词： modification of JT-60 physics design technology developments

Effective Skin Care Guidance for Patients with Acne Vulgaris after Standard Treatment

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Hematogenous umbilical metastasis from colon cancer treated by palliative single-incision laparoscopic surgery

Journal of Cosmetics, Dermatological Sciences and Applications（化妆品、皮肤病及应用期刊） 2023年第4期

作者： Katsuko kikuchi Yumi Murakami Haruna Sato Ryoko Yamashita Yumiko Saya Ichiko Morino Rikako Uchino Hiroshi Matsunaka

来源：博看期刊评论

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World Journal of Gastrointestinal Surgery 2013年第10期5卷 272-277页

作者： Tomohide Hori Noriyuki Okada Masaya Nakauchi Shuji Hiramoto Ayako kikuchi-Mizota Masahisa Kyogoku Fumitaka Oike Hidemitsu Sugimoto Junya Tanaka Yoshiki Morikami Kaori Shigemoto Toyotsugu Ota Masanobu Kaneko Masato Nakatsuji Shunji Okae Takahiro Tanaka Daigo Gunji Akira Yoshioka Department of Surgery Mitsubishi Kyoto Hospital Department of Medical Oncology Mitsubishi Kyoto Hospital Department of Histopathology Mitsubishi Kyoto Hospital Department of Gastroenterology Mitsubishi Kyoto Hospital Department of Radiology Mitsubishi Kyoto Hospital Department of Internal Medicine Mitsubishi Kyoto Hospital

Sister Mary Joseph’s nodule(SMJN)is a rare umbilical nodule that develops secondary to metastatic *** malignancies are located in the abdomen or *** with SMJN have a poor *** 83-year-old woman presented to our hospital with a1-month history of a rapidly enlarging umbilical *** findings revealed advanced transverse colon *** tomography and fluorodeoxyglucose-positron emission tomography revealed tumors of the transverse colon,umbilicus,right inguinal lymph nodes,and left *** feeding arteries and drainage veins for the SMJN were the inferior epigastric *** findings of the left lung tumor allowed for identification of the primary lung cancer,and a diagnosis of advanced transverse colon cancer with SMJN and primary lung cancer was *** patient underwent local resection of the SMNJ and subsequent single-site laparoscopic surgery involving right hemicolectomy and paracolic lymph node ***-abdominal dissemination to the mesocolon was confirmed during ***,the transverse colon cancer was confirmed to be moderately differentiated tubular *** suspect that SMJN may occur via a hematogenous *** chemotherapy for colon cancer and thoracoscopic surgery for the primary lung cancer were scheduled,the patient and her family desired home *** months after surgery,she died of rapidly growing lung cancer.

关键词： Umbilicus Sister Mary Joseph Singleincision laparoscopic surgery Palliative operation Hematogenous metastasis