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Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole

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World Journal of Gastroenterology 2008年第15期14卷 2406-2410页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii ryousuke kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences and Department of Pharmaceutical Sciences Tohoku University Hospital Sendai 9808574 Japan

AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ.

关键词： Lafutidine Lansoprazole H2 receptor antagonists Proton pump inhibitors Antisecretory activity

Basic Research on the Burden of Dropping off and Picking up Children: Differences by Employment Type and Gender in the Tokyo Metropolitan Area

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Journal of Transportation Technologies 2024年第3期14卷 445-461页

作者： Jun Morio Koshi Isono Masahiko kikuchi Tetsuo Morita The Institute of Behavioral Sciences (IBS) Tokyo Japan City Bureau Ministry of Land Infrastructure Transport and Tourism Tokyo Japan Maebashi Institute of Technology Maebashi Japan

There is a need to reduce the burden of child drop-off and pick-up for child-rearing generations, but most studies on the actual situation in Japan are based on survey results. In this study, we analyzed differences in child drop-off and pick-up by employment type and gender, utilizing the “Metropolitan Area Person Trip Survey,” which is a statistical data set. The study targeted households in which both spouses were between 30 and 49 years old, had children under the age of 6, and included the following three groups. 1) Dual-income Group 1 (both spouses employed/on contract/temporary);2) Dual-income Group 2 (husband employed/on contract/temporary, wife part-time);3) Full-time housewife group (husband employed, wife unemployed). The analysis revealed that a) wives are almost always responsible for dropping off and picking up their children;b) husbands drop off and pick up their children less frequently in dual-income households;and c) households with children raising within 10 to 30 km of Tokyo Station have longer commuting times and need to reduce the burden of dropping off and picking up their children.

关键词： Drop-Off and Pick-Up Employment Type Gender Dual-Income Households Tokyo Metropolitan Area

Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

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Journal of Transportation Technologies 2024年第3期14卷 372-389页

作者： Ngo Trung Phuong Masahiko kikuchi Aya Kojima Hisashi Kubota Graduate School of Science and Engineering Saitama University Saitama Japan Department of Engineering Affairs City Bureau Ministry of Land Infrastructure Transportation and Tourism Tokyo Japan

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation infrastructure. Despite government efforts, many still prefer motorized transport, citing mobility and safety concerns, exacerbated by insufficient pedestrian infrastructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. Findings reveal safety and convenience as primary factors driving motorized transport use, especially for accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of addressing economic factors and improving access infrastructure to manage motorized vehicle reliance and foster sustainable urban mobility in Hanoi.

关键词： Access Mode Choice Non-Motorized Vehicles Motorized Vehicles Bus User Urban Transport Behavior

AGENT MODEL ANALYSIS TO EXPLORE EFFECTS OF INTERACTION AND ENVIRONMENT ON INDIVIDUAL PERFORMANCE

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Journal of Systems Science & Complexity 2007年第1期20卷 1-17页

作者： Tomoko kikuchi Yoshiteru NAKAMORI School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Nomi Ishikawa 923-1292 Japan

This paper tries to find interaction rules between members and self-reform rules of members in some scientific research laboratories at a graduate school. The candidate of rules are extracted from the personality description sentences about factors： extroversion, agreeableness, conscientiousness, neuroticism and openness in the big five theory of personality psychology. In this paper, interaction and self-reform rules are not described by personalities themselves; instead, they are described by corresponding phenomena： activity, empathy, persistence, autonomy, and analytical ability which appear in the behavior side. Each member＇s initial value is determined from the main 5-factor personality investigation to the member, and the target value is given by the member＇s self-declaration. The rule selection is carried out by the genetic algorithm, where a sigmoid function is introduced in the renewal algorithm of the value, whereby a difficulty of setting the renewal parameters is avoided. An analysis is added about the obtained rules, and the validity of this approach and the subjects for future study are discussed. Finally, consideration is extended to the effect of environment on the behavior of members to reinforce the set of rules.

关键词： Agent model environment interaction performance personality psychology self-reform

Hydrological setting of infertile species-rich wetland——a case study in the warm temperate Japan

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Journal of Environmental Sciences 2003年第2期15卷 279-283页

作者： kikuchi A. Nakagoshi N. Onda Y. Graduate School for International Development and Cooperation Hiroshima UniversityGraduate School for International Development and Cooperation Hiroshima UniversityInstitute of Geoscience University of Tsukuba Higashi-Hiroshima City 739_8529 JapanHigashi-Hiroshima City 739_8529 JapanIbaraki 305_8571 Japan

The detailed groundwater flow and water chemistry to illustrate landscape structure of the infertile peatless mire by using piezometers and groundwater wells were measured. The instruments were installed in lines through a small spring-fed wetland underlying little peat from the hillslope to the valley bottom in southwestern Japan. Flow net and EC data clearly indicated that the wetland was situated in a high-EC groundwater upspring area. The low-productivity graminous vegetation was related with four hydrological factors such as: (1) high water level; (2) low-EC(<25 micro S/cm) groundwater; (3) weakly upward hydraulic gradient; and (4) overflowing of negatively pressured groundwater. In other words, the “old or deep groundwater” constructed the foundation of slope-wetland, and maintained the high groundwater level. In contrast, overflowing “youthful groundwater” is supplied from head of slope-wetland preferentially through the shallow substratum. The plant communities of the peatless mire in southwestern Japan are similar to those of raised bog in northern cool temperate Japan. There have been some reports verifying that the underlying mineral substrata of such wetlands were quartzile rocks such as granite, rhyolite, chart and well-leached sand. Results showed (1) low cation availability affects the water acidity; (2) upward seepage of high-EC groundwater composed the foundation of the investigated peatless mire; and (3) the poor mineral condition seems to play a similar role to northern ombrotrophic(rain-fed) condition.

关键词： eco-hydrology electrical conductivity groundwater flow plant community wetland

Effect of a Curved Duct Upstream on Performance of Small Centrifugal Compressors for Automobile Turbochargers

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Journal of Thermal Science 2013年第1期22卷 92-96页

作者： Shigeta kikuchi Nobuhiko Yamasaki Akihiro Yamagata Department of Aeronautics and Astronautics Kyushu University Products Development Center IHI Corporation

Since the automobile turbochargers are installed in an engine compartment with limited space, the ducts upstream of the turbocharger compressor may be curved in a complex manner. In the present paper, the effect of a curved duct upstream on performance of small centrifugal compressors for automobile turbochargers is discussed. The computational fluid dynamics (CFD) analysis of a turbocharger compressor validated for the compressor model with the straight pipe applied to the compressor with the curved pipe are executed, and the deterioration of the performance for the curved pipe is confirmed. It is also found that the deterioration of compressor performance is caused by the interaction of the secondary flow and the impeller.

关键词： Cartesian grid cylindrical grid validation calculation

High-accuracy same-beam VLBI observations using Shanghai and Urumqi telescopes

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Science China(Physics,Mechanics & Astronomy) 2009年第10期52卷 1858-1866页

作者： kikuchi Fuyuhiko KAMATA Shun'ichi MATSUMOTO Koji HANADA Hideo National Astronomical Observatory of Japan Tokyo University

The same-beam VLBI observations of Rstar and Vstar,which were two small satellites of Japanese lunar mission,SELENE,were successfully performed by using Shanghai and Urumqi 25-m telescopes. When the separation angle between Rstar and Vstar was less than 0.1 deg,the differential phase delay of the X-band signals between Rstar and Vstar on Shanghai-Urumqi baseline was obtained with a very small error of 0.15 mm rms,which was reduced by 1-2 order compared with the former VLBI results. When the separation angle was less than 0.56 deg,the differential phase delay of the S-band signals was also obtained with a very small error of several mm rms. The orbit determination for Rstar and Vstar was performed,and the accuracy was improved to a level of several meters by using VLBI and Doppler data. The high-accuracy same-beam differential VLBI technique is very useful in orbit determination for a spacecraft,and will be used in orbit determination for Mars missions of China Yinghuo-1 and Russia Phobos-grunt.

关键词： same-beam differential VLBI phase delay precise orbit determination

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Generalized 3D Scattering Channel Model with MIMO Antenna Systems

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China Communications 2016年第5期13卷 66-81页

作者： Jie Zhou Hao Jiang Hisakazu kikuchi Department of Jiangsu Key Laboratory of Meteorological Observation and Information Processing Nanjing University of Information Science and Technology Department of Electrical and Electronic Engineering Niigata University

In this paper, a generalized three-dimensional(3D) scattering channel model for macrocellular land mobile environments is considered. This model simultaneously describes angular arrival of multi-path signals in the azimuth and elevation planes in an environment where uniformly distributed scatterers are assumed to be present in hemispheroids around the base station(BS) and mobile station(MS). Using this channel model, we first derive the closed-form expression for the joint and marginal probability density functions of the angle-of-arrival and time-of-arrival measured at the BS and the MS corresponding to the azimuth and elevation angles. Next, we derive an expression for the Doppler spectral distribution caused by motion of the MSs. Furthermore, we analyze the performance of multiple-input multiple-output antenna systems numerically. The results show that the proposed 3D scattering channel model performs better than previously proposed two-dimensional(2D) models for indoor and outdoor environments. We compare the results with previous scattering channel models and measurement results to validate the generalizability of our model.

关键词： 3D scattering channel model angle of arrival Doppler spectra multiple-input multiple-output

Analysis of MIMO antenna array based on 3D Von Mises Fisher distribution

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The Journal of China Universities of Posts and Telecommunications 2015年第2期22卷 15-23页

作者： Zhou Jie Cao Zhigang Hisakazu kikuchi Jiangsu Key Laboratory of Meteorological Observation and Information Processing Department of Electrical and Electronic Engineering

A three-dimensional （3D） Von Mises Fisher （VMF） distribution model was derived in multiple-input and multiple-output （MIMO） antenna communication environment. The azimuth of arrival and elevation of arrival are distributed for VMF distribution instead of the uniform or other traditional distributions. In particular the MIMO uniform Y-shaped array （UYA） and the uniform circular array （UCA） antenna topology are considered at mobile station and base station. The developed spatial fading correlation of the VMF model is determined by parameters of the concentration parameter, antenna spacing, mean azimuth of arrival, mean elevation of arrival. Using the channel model, the effects of the concentration parameter and the mean elevation angle on the capacity of MIMO antenna systems was analyzed. It is shown that the mean elevation of arrival must be taken into account in 3D MIMO communication environment.

关键词： MIMO antenna array VMF distribution spatial fading correlation channel capacity