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Role of sirtuins in esophageal cancer:Current status and future prospects

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 794-807页

作者： ryota Otsuka Koichi Hayano Hisahiro Matsubara Department of Frontier Surgery Graduate School of MedicineChiba UniversityChiba 260-8670Japan

Esophageal cancer(EC)is a malignant cancer that still has a poor prognosis,although its prognosis has been improving with the development of multidisciplinary treatment modalities such as surgery,chemotherapy and ***,identifying specific molecular markers that can be served as biomarkers for the prognosis and treatment response of EC is highly desirable to aid in the personalization and improvement of the precision of medical *** are a family of nicotinamide adenine dinucleotide(NAD+)-dependent proteins consisting of seven members(SIRT1-7).These proteins have been reported to be involved in the regulation of a variety of biological functions including apoptosis,metabolism,stress response,senescence,differentiation and cell cycle *** the variety of functions of sirtuins,they are speculated to be associated in some manner with cancer ***,while the role of sirtuins in cancer progression has been investigated over the past few years,their precise role remains difficult to characterize,as they have both cancer-promoting and cancer-suppressing properties,depending on the type of *** conflicting characteristics make research into the nature of sirtuins all the more ***,the role of sirtuins in EC remains unclear due to the limited number of reports concerning sirtuins in *** herein review the current findings and future prospects of sirtuins in EC.

关键词： Esophageal cancer Sirtuin Esophageal squamous cell carcinoma Esophageal adenocarcinoma Biomarker Treatment

Methane emissions from wetlands on the Qinghai-Tibet Plateau

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Chinese Science Bulletin 1999年第24期44卷 2282-2286页

作者： nakano Tomoko Department of Geography Tokyo Metropolitan University 192-03 Japan

The areal extent of cold freshwater wetlands on the Qinghai-Tibet Plateau (QTP) is estimated at 0.133 × 106 km2, suggesting a significant methane potential. Methane fluxes from wet alpine meadows, peatlands, Hippuris vulgaris mires and secondary marshes were 43.18, 12.96, -0.28 and 45.90 mgf33m-2f33d-1, respectively based on the transect flux studies at the Huashixia Permafrost Station (HPS) from July to August 1996. Average CH4 fluxes in the

关键词： QTP wetland ecosystems CH4 emission spatiality and seasonality fluxes.

Two-dimensional quantum transport of multivalley （111） surface state in topological crystalline insulator SnTe thin films

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Nano Research 2016年第2期9卷 490-498页

作者： ryota Akiyama Kazuki Fujisawa Tomonari Yamaguchi Ryo Ishikawa Shinji Kuroda Institute of Materials Science University of Tsukuba Tsukuba 305-8573 Japan

The magneto-transport properties of （111）-oriented single-crystal thin films of SnTe were investigated. SnTe （111） thin films were epitaxially grown on a BaF2 substrate by molecular beam epitaxy. By optimizing the growth conditions and the thickness of the films, the bulk carrier density could be reduced, making it possible to detect the surface transport. Magneto-conductance （MC） measurements show a cusp-like feature around zero magnetic field, which is attributed to the weak-antilocalization effect of the transport in the topological surface state. Detailed analysis of this negative MC reveals a reduced number of transport channels contributing to the surface transport, suggesting strong coupling between Dirac valleys on the SnTe （111） surface, as a characteristic feature of the transport in the multivalley structure of topological crystalline insulators.

关键词： SnTe (111) films topological crystalline insulators weak antilocalization phase coherence length Dirac valleys

Study on an Undershot Cross-Flow Water Turbine

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Journal of Thermal Science 2014年第3期23卷 239-245页

作者： Yasuyuki Nishi Terumi Inagaki Yanrong Li ryota Omiya Junichiro Fukutomi Department of Mechanical Engineering Ibaraki University 4-12-1 Nakanarusawa-choHitachi-shi Ibaraki 316-8511JAPAN Graduate School of Science and Engineering Ibaraki University 4-12-1 Nakanarusawa-choHitachi-shi Ibaraki316-8511JAPAN Institute of Technology and Science The University of Tokushima 2-1 Minamijosanjima-cho Tokushima-shiTokushima 770-8506 JAPAN

This study aims to develop a water turbine suitable for ultra-low heads in open channels, with the end goal being the effective utilization of unutilized hydroelectric energy in agricultural water channels. We performed tests by applying a cross-flow runner to an open channel as an undershot water turbine while attempting to simplify the structure and eliminate the casing. We experimentally investigated the flow fields and performance of water tur- bines in states where the flow rate was constant for the undershot cross-flow water turbine mentioned above. In addition, we compared existing undershot water turbines with our undershot cross-flow water turbine after at- taching a bottom plate to the runner. From the results, we were able to clarify the following. Although the effec- tive head for cross-flow runners with no bottom plate was lower than those found in existing runners equipped with a bottom plate, the power output is greater in the high rotational speed range because of the high turbine ef- ficiency. Also, the runner with no bottom plate differed from rtmners that had a bottom plate in that no water was being wound up by the blades or retained between the blades, and the former received twice the flow due to the flow-through effect. As a result, the turbine efficiency was greater for runners with no bottom plate in the full ro- tational speed range compared with that found in runners that had a bottom plate.

关键词： Water Turbine Cross-Flow Turbine Open Channel Performance Flow Visualization

A New Approach to Graph Recognition and Applications to Distance-Hereditary Graphs

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Journal of Computer Science & Technology 2009年第3期24卷 517-533页

作者： Shin-ichi nakano Ryuhei Uehara Takeaki Uno Department of Computer Science Faculty of EngineeringGunma UniversityGunma 376-8515Japan School of Information Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1292Japan National Institute of Informatics Tokyo 101-8430Japan

Algorithms used in data mining and bioinformatics have to deal with huge amount of data efficiently. In many applications, the data are supposed to have explicit or implicit structures. To develop efficient algorithms for such data, we have to propose possible structure models and test if the models are feasible. Hence, it is important to make a compact model for structured data, and enumerate all instances efficiently. There are few graph classes besides trees that can be used for a model. In this paper, we investigate distance-hereditary graphs. This class of graphs consists of isometric graphs and hence contains trees and cographs. First, a canonical and compact tree representation of the class is proposed. The tree representation can be constructed in linear time by using prefix trees. Usually, prefix trees are used to maintain a set of strings. In our algorithm, the prefix trees are used to maintain the neighborhood of vertices, which is a new approach unlike the lexicographically breadth-first search used in other studies. Based on the canonical tree representation, efficient algorithms for the distance-hereditary graphs are proposed, including linear time algorithms for graph recognition and graph isomorphism and an efficient enumeration algorithm. An efficient coding for the tree representation is also presented; it requires [3.59n] bits for a distance-hereditary graph of n vertices and 3n bits for a cograph. The results of coding improve previously known upper bounds （both are 2^O（nlogn）） of the number of distance-hereditary graphs and cographs to 2^[3.59n] and 2^3n, respectively.

关键词： algorithmic graph theory cograph distance-hereditary graph prefix tree tree representation

CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2

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Science China(Life Sciences) 2008年第3期51卷 191-198页

作者： TOMOMI Takahashi TORU nakano Department of Pathology Medical School and Graduate School of Frontier Biosciences Osaka University Yamada-oka 2-2 Suita Osaka 565-0871 Japan

The GATA family consists of six members, GATA 1-6. In this study, we focused on GATA-2, which is expressed predominantly in hematopoietic progenitor cells and plays the key role in keeping these cells in the undifferentiated status. CREB-binding proteins (CBP) are essential transcriptional coacti- vators for a large number of regulated DNA-binding transcription factors, including GATA-1. But there have been no reports on whether CBP is still a co-activator of GATA-2. Here, we used the immunopre- cipitation and pull-down experiments to show that the GATA-2 and CBP were physically binding to- gether, and clarified the binding sites CH1, CH3 , CH452 and CT1430 in CBP and N-finger, C-finger and N-C-finger in GATA-2. Luciferase assay results in our experiment indicated that CBP could increase GATA-2 transcriptional activity in the dose-dependent manner. GATA-1 is mainly expressed in differen- tiated hematopoietic cells, but still has overlap expression with GATA-2. CBP is a coactivator of GATA-2 and GATA-1. The investigation on the mechanism that could decide whether CBP binds to GATA-2 to keep hematopoietic cells in the progenitor status or to GATA-1 to start differentiation will be a very in- teresting and very meaningful project in the near future.

关键词： CBP TATA-2 coactivator hematopoietic cells

Enhanced vibrational resonance in a single neuron with chemical autapse for signal detection

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Chinese Physics B 2020年第12期29卷 556-563页

作者： Zhiwei He Chenggui Yao Jianwei Shuai Tadashi nakano Department of Mathematics Shaoxing UniversityShaoxing 312000China College of Mathematics Physics and Information EngineeringJiaxing UniversityJiaxing 314000China Department of Physics State Key Laboratory of Cellular Stress BiologyInnovation Center for Cell Signaling NetworkXiamen UniversityXiamen 361102China Graduate School of Frontier Biosciences Osaka University5408570Japan

Many animals can detect the multi-frequency signals from their external *** understanding for underlying mechanism of signal detection can apply the theory of vibrational resonance,in which the moderate high frequency driving can maximize the nonlinear system's response to the low frequency subthreshold *** this work,we study the roles of chemical autapse on the vibrational resonance in a single neuron for signal *** reveal that the vibrational resonance is strengthened significantly by the inhibitory autapse in the neuron,while it is weakened typically by the excitatory *** is generally believed that the inhibitory synapse has a suppressive effect in neuronal ***,we find that the detection of the neuron to the low frequency subthreshold signal can be improved greatly by the inhibitory *** finding indicates that the inhibitory synapse may act constructively on the detection of weak signal in the brain and neuronal system.

关键词： neuronal dynamics autapse vibrational resonance synchronization time delay

Effect of antioxidant activity of caffeic acid with cyclodextrins using ground mixture method

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 24-33页

作者： ryota Shiozawa Yutaka Inoue Isamu Murata Ikuo Kanamoto Faculty of Pharmacy and Pharmaceutical Sciences Josai University

In the current study, we prepared a ground mixture(GM) of caffeic acid(CA) with α-cyclodextrin(αCD) and with β-cyclodextrin(βCD), and then comparatively assessed the physicochemical properties and antioxidant capacities of these GMs. Phase solubility diagrams indicated that both CA/αCD and CA/βCD formed a complex at a molar ratio of 1/1. In addition, stability constants suggested that CA was more stable inside the cavity of αCD than inside the cavity of βCD. Results of powder X-ray diffraction(PXRD) indicated that the characteristic diffraction peaks of CA and CD disappeared and a halo pattern was produced by the GMs of CA/αCD and CA/βCD(molar ratios = 1/1). Dissolution testing revealed that both GMs had a higher rate of dissolution than CA alone did. Based on the1 H-1 H NOESY NMR spectra for the GM of CA/αCD, the vinylene group of the CA molecule appeared to be included from the wider to the narrower rim of the αCD ring. Based on spectra for the GM of CA/βCD, the aromatic ring of the CA molecule appeared to be included from the wider to the narrower rim of the βCD ring. This suggests that the structures of the CA inclusion complexes differed between those involving αCD rings and those involving βCD rings. Results of a DPPH radical-scavenging activity test indicated that the GM of CA/αCD had a higher antioxidant capacity than that of the GM of CA/βCD. The differences in the antioxidant capacities of the GMs of CA/αCD and CA/βCD are presumably due to differences in stability constants and structures of the inclusion complexes.

关键词： Caffeic acid Cyclodextrins Inclusion Antioxidant activity Solubility Ground mixture

Electroactive species study in the electrochemical reduction of CO_2 in KHCO_3 solution at elevated temperature

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Journal of Energy Chemistry 2016年第3期25卷 517-522页

作者： Heng Zhong Katsushi Fujii Yoshiaki nakano Research Center for Advanced Science and Technology The University of Tokyo Global Solar Plus Initiative The University of Tokyo Department of Electrical Engineering and Information Systems School of Engineering The University of Tokyo

Photoelectrochemical and electrochemical reduction of CO_2 into organic chemicals is promising for directly or indirectly transforming solar energy into chemical energy for further utilization. However,research on the electroactive species in these processes has been rather limited. In this work, we investigated possible electroactive species(CO_2 or HCO_3~– ) involved in the electrochemical reduction of KHCO_3 at elevated temperatures without CO_2 bubbling. The results showed that CO, CH_4, and C_2H_4 were produced after electrochemical reduction of 3.0 mol/L KHCO_3 at elevated temperature on a Cu electrode even without CO_2 bubbling, although their faradaic efficiencies were low(< 6 %). Measurements for CO_2 generation from the decomposition of HCO_3~– showed that elevated temperature and high HCO_3~– concentration strongly promoted this process. These results suggested that the in-situ produced CO_2 from the decomposition of HCO_3~– was probably the electroactive species in the electrochemical reduction of HCO_3~– without CO_2 bubbling. Changes of the Gibbs free energy, rate constant, and activation energy of the decomposition of HCO_3~– into CO_2 were also investigated and calculated from the experimental data.

关键词： CO_2 reduction Electrolytic Electroactive species KHCO_3 electrolyte Bicarbonate ion decomposition Kinetics