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Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions

Translational Neurodegeneration 2020年第1期9卷 66-80页

作者： Seiji Kaji Takakuni Maki Tomoyuki Ishimoto Hodaka Yamakado Ryosuke takahashi Department of Neurology Graduate School of MedicineKyoto University54 Shogoin-Kawahara-choSakyo-kuKyotoJapan

Multiple system atrophy(MSA)is a debilitating and fatal neurodegenerative disorder.The disease severity warrants urgent development of disease-modifying therapy,but the disease pathogenesis is still enigmatic.Neurodegeneration in MSA brains is preceded by the emergence of glial cytoplasmic inclusions(GCIs),which are insoluble α-synuclein accumulations within oligodendrocytes(OLGs).Thus,preventive strategies against GCI formation may suppress disease progression.However,although numerous studies have tried to elucidate the molecular pathogenesis of GCI formation,difficulty remains in understanding the pathological interaction between the two pivotal aspects of GCIs;asynuclein and OLGs.The difficulty originates from several enigmas:1)what triggers the initial generation and possible propagation of pathogenic α-synuclein species?2)what contributes to OLG-specific accumulation of α-synuclein,which is abundantly expressed in neurons but not in OLGs?and 3)how are OLGs and other glial cells affected and contribute to neurodegeneration?The primary pathogenesis of GCIs may involve myelin dysfunaion and dyshomeostasis of the oligodendroglial cellular environment such as autophagy and iron metabolism.We have previously reported that oligodendrocyte precursor cells are more prone to develop intracellular inclusions in the presence of extracellular fibrillary α-synuclein.This finding implies a possibility that the propagation of GCI pathology in MSA brains is mediated through the internalization of pathological α-synuclein into oligodendrocyte precursor cells.In this review,in order to discuss the pathogenesis of GCIs,we will focus on the composition of neuronal and oligodendroglial inclusions in synucleinopathies.Furthermore,we will introduce some hypotheses on how α-synuclein pathology spreads among OLGs in MSA brains,in the light of our data from the experiments with primary oligodendrocyte lineage cell culture.While various reports have focused on the mysterious source of α-synuclein in GCIs,insights into the mechanism wh

关键词： Multiple system atrophy a-synuclein Glial cytoplasmic inclusion Prion Neurodegeneration Oligodendrocyte Microglia Astrocyte Oligodendrocyte precursor cell

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Investigation of Experimental Con6guration for Electron Bernstein Wave Heating on LHD

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Plasma Science and Technology 2009年第4期11卷 430-438页

作者： Hiroe IGAMI ryosuke IKEDA Hiromi takahashi Yasuo YOSHIMURA Takashi SHIMOZUMA Shin KUBO Hitoshi TANAKA Kazunobu NAGASAKI Takashi MUTOH the LHD Experiment Group National Institute for Fusion Science 509-5292 Toki Japan Graduate School of Energy Science Kyoto University 606-8502 Kyoto Japan Institute of Advanced Energy Kyoto University 611-0011 Uji Japan

Investigation of experimental configuration for the electron Bernstein wave （EBW） heating by using the existing electron cyclotron heating （ECH） antennas on LHD was performed. By using an antenna installed in the lower port, direct oblique launching of the extraordinary （X-） mode from the high magnetic field side （HFS） is available. Since the parallel component of the refractive index （NIF） varies during propagation because of the inhomogeneity of the magnetic field, NH can be zero when the launched X-mode crosses the fundamental electron cyclotron resonance （ECR） layer even NⅡ is noonzero initially. In such a condition, if the electron density is above a certain level the obliquely launched X-mode can pass the fundamental ECR layer without being damped out and can be mode-converted to EBW that is absorbed at the Doppler shifted ECR layer. By using an antenna installed in the horizontal port, oblique launching from the lower magnetic field side （LFS） toward the over-dense plasma is available. Excitation of EBW via the mode conversion process of ordinary mode（O）-extraordinary mode（X）-electron Bernstein wave （B） is expected with the O-mode launching toward an appropriate direction. The O-X-B mode conversion rate and the region of power deposition were surveyed by varying the magnetic field strength and the launching direction. The results of the survey suggest that efficient heating in the core region is difficult by using the existing antenna. Rearrangement of the final mirror of the launching antenna may be needed.

关键词： LHD electron cyclotron heating （ECH） electron Bernstein wave （EBW）,high density plasma

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Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report

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World Journal of Hepatology 2021年第3期13卷 384-392页

作者： Kazuhiro takahashi Jaejeong Kim Amane takahashi Shinji Hashimoto Manami Doi Kinji Furuya ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda Department of Gastrointestinal and Hepatobiliary Pancreatic Surgery University of TsukubaTsukuba 3058575IbarakiJapan Department of Gastroenterological Surgery Saitama Cancer CenterSaitama 3620806SaitamaJapan Department of Diagnostic Pathology University of TsukubaTsukuba 3058575IbarakiJapan

BACKGROUND Hepatocellular carcinoma(HCC)accompanied by portal vein tumour thrombus(PVTT)presents an aggressive disease course,worsening liver function reserve,and a high recurrence rate.Clinical practice guidelines recommend systemic therapy as the first-line option for HCC with portal invasion.However,to achieve longer survival in these patients,the treatment strategy should be concluded with removal of the tumour by locoregional therapy.We experienced a case of initially unresectable HCC with main PVTT converted to radical hepatectomy after lenvatinib treatment.CASE SUMMARY A 59-year-old male with chronic hepatitis C infection visited our clinic as a regular post-surgery follow-up.Contrast-enhanced abdominal computed tomography revealed a liver mass diffusely located at the lateral segment with a massive PVTT extending from the umbilical portion to the main and contralateral third-order portal branches.With the diagnosis of unresectable HCC with Vp4(main trunk/contralateral branch)PVTT,lenvatinib was started at 12 mg/d.The computed tomography taken 3 mo after starting lenvatinib showed regression of the PVTT,which had retreated to the contralateral first-order portal branch.He tolerated the full dose without major adverse effects.With cessation of lenvatinib for 7 d,radical left lobectomy and PVTT thrombectomy were conducted.The patient’s postoperative course was uneventful.Microscopically,the primary lesion showed fibrotic changes,with moderately to poorly differentiated tumour cells surrounded by granulation tissues in some areas.The majority of the PVTT showed necrosis.He was alive without recurrence for 8 mo.CONCLUSION This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein tumour thrombus Conversion hepatectomy Case report

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Frequency Control of Power System with Renewable Power Sources by HVDC Interconnection Line and Battery Considering Energy Balancing

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Journal of Power and Energy Engineering 2020年第4期8卷 11-24页

作者： Shoyu Onuka Atsushi Umemura Rion takahashi Junji Tamura Atsushi Sakahara Fumihito Tosaka ryosuke Nakamoto Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami Japan Hokkaido Electric Power Co. Inc. Sapporo Japan

Recently, introduction of renewable energy sources like wind power generation and photovoltaic power generation has been increasing from the viewpoint of environmental problems. However, renewable energy power supplies have unstable output due to the influence of weather conditions such as wind speed variations, which may cause fluctuations of voltage and frequency in the power system. This paper proposes fuzzy PD based virtual inertia control system to decrease frequency fluctuations in power system caused by fluctuating output of renewable energy sources. The proposed new method is based on the coordinated control of HVDC interconnection line and battery, and energy balancing control is also incorporated in it. Finally, it is concluded that the proposed system is very effective for suppressing the frequency fluctuations of the power system due to the large-scale wind power generation and solar power generation and also for keeping the energy balancing in the HVDC transmission line.

关键词： High Voltage Direct Current (HVDC) Transmission Power System Frequency Control Coordinated Control Battery Renewable Power Energy Balancing

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