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In vitro evaluation of the anti-diabetic potential of soymilk yogurt and identification of inhibitory compounds on the formation of advanced glycation end-products

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Food Bioscience 2022年第6期50卷 668-675页

作者： Yuki Nakashima Naoki Yamamoto ryosuke tsukioka Hikari Sugawa Rina Ohshima Kaede Aoki Tomoyuki Hibi Kotone Onuki Yudai Fukuchi Shin Yasuda Ryoji Nagai Hideki Kinoshita Graduate School of Bioscience Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan School of Agriculture Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan Graduate School of Agriculture Tokai University9-1-1 TorokuHigashi-kuKumamoto-shiKumamotoJapan Probio LLC. 1330-1 FutaNishihara-muraAso-gunKumamotoJapan

In this study, we aimed to identify starter strains of lactic acid bacteria (LAB) to produce soymilk yogurt that can decrease the risk of diabetes mellitus (DM) and its complications. The inhibition assays of the dipeptidyl peptidase IV (DPP- IV) and advanced glycation end products (AGEs) formation were conducted using 70% ethanol (EtOH) extraction of freeze-dried soymilk yogurt. Soymilk yogurt produced using Weissella confusa TOKAI 2 showed the highest inhibition rate in the α-amylase inhibition assay, while soymilk yogurt produced using Lactiplantibacillus plantarum TOKAI 17 showed the highest inhibition rates in the α-glucosidase and DPP-Ⅳ inhibition assays, respectively. Soymilk yogurt produced using Streptococcus macedonicus TOKAI 4 showed the highest inhibitory activities in Nω-(carboxymethyl) arginine (CMA) and Nε-(carboxymethyl) lysine (CML) formation, respectively. Furthermore, soymilk yogurt prepared using Lb. plantarum TOKAI 17 and Lactiplantibacillus pentosus TOKAI 35 exhibited higher proportions of aglycone isoflavones than soymilk and showed a higher fluorescent AGEs inhibitory activity than that of soymilk (p < 0.05). Interestingly, the inhibition assay assessing fluorescent AGEs formation using isoflavones indicated that aglycone-type isoflavones, such as genistein and daidzein, had higher inhibitory activities than that of glycosides (p < 0.05). These results indicate that soymilk yogurt produced using Lb. plantarum TOKAI 17 and Lb. pentosus TOKAI 35 had inhibitory effects on α-glucosidase, DPP-Ⅳ, and AGEs formation in vitro, and that aglycone isoflavones might inhibit the formation of fluorescent AGEs.

关键词： Lactic acid bacteria Soymilk yogurt Diabetes Advanced glycation end products

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Crowd evacuation of pairs of pedestrians

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Communications in Theoretical Physics 2022年第4期74卷 97-112页

作者： ryosuke Yano Tokio Marine d R Co.ltd. 1-5-1OtemachiChiyoda-kuTokyo100-0004Japan

The crowd evacuation of pairs of pedestrians(*** consisting of a parent and a child)is numerically ***,it is assumed that all pedestrians have their own partners,and move randomly inside the bounded domain of the right-hand room as an initial *** pedestrians start their evacuations after they contact their *** evacuations are completed by the transfer of all the pairs from the right-hand room to the left-hand room through an exit.A frozen swarm tends to appear in the right-hand room as the total number of pedestrians *** frozen swarm moves without changing its form,unless it is dissolved by a strong collision with a pair of pedestrians that comes back from the left-hand room by ***,the evacuation speed also depends on the area of the Escape Zone,whereas an obstacle placed in front of an exit also changes the speed of the evacuation in accordance with the type of motion of the children.

关键词： Evacuation of paired pedestrians force chain network escape from crowd

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An integrated model to simulate sown area changes for major crops at a global scale

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Science China Earth Sciences 2008年第3期51卷 370-379页

作者： SHIBASAKI ryosuke Center for Spatial Information Science University of Tokyo

Dynamics of land use systems have attracted much attention from scientists around the world due to their ecological and socio-economic implications. An integrated model to dynamically simulate future changes in sown areas of four major crops (rice, maize, wheat and soybean) on a global scale is pre- sented. To do so, a crop choice model was developed on the basis of Multinomial Logit (Logit) model to model land users' decisions on crop choices among a set of available alternatives with using a crop utility function. A GIS-based Environmental Policy Integrated Climate (EPIC) model was adopted to simulate the crop yields under a given geophysical environment and farming management conditions, while the International Food Policy and Agricultural Simulation (IFPSIM) model was utilized to estimate crop price in the international market. The crop choice model was linked with the GIS-based EPIC model and the IFPSIM model through data exchange. This integrated model was then validated against the FAO statistical data in 2001-2003 and the Moderate Resolution Imaging Spectroradiometer (MODIS) global land cover product in 2001. Both validation approaches indicated reliability of the model for ad- dressing the dynamics in agricultural land use and its capability for long-term scenario analysis. Finally, the model application was designed to run over a time period of 30 a, taking the year 2000 as baseline. The model outcomes can help understand and explain the causes, locations and consequences of land use changes, and provide support for land use planning and policy making.

关键词： land use change crop sown area simulation crop choice global scale

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Fully automatic DOM generation method based on optical flow field dense image matching

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Geo-Spatial Information Science 2023年第2期26卷 242-256页

作者： Wei Yuan Xiuxiao Yuan Yang Cai ryosuke Shibasaki School of Remote Sensing and Information Engineering Wuhan UniversityWuhanChina Center for Spatial Information Science University of TokyoKashiwaJapan

Automatic Digital Orthophoto Map(DOM)generation plays an important role in many downstream works such as land use and cover detection,urban planning,and disaster *** DOM generation methods can generate promising results but always need ground object filtered DEM generation before otho-rectification;this can consume much time and produce building facade contained *** address this problem,a pixel-by-pixel digital differential rectification-based automatic DOM generation method is proposed in this ***,3D point clouds with texture are generated by dense image matching based on an optical flow field for a stereo pair of images,***,the grayscale of the digital differential rectification image is extracted directly from the point clouds element by element according to the nearest neighbor method for matched ***,the elevation is repaired grid-by-grid using the multi-layer Locally Refined B-spline(LR-B)interpolation method with triangular mesh constraint for the point clouds void area,and the grayscale is obtained by the indirect scheme of digital differential rectification to generate the pixel-by-pixel digital differentially rectified image of a single image ***,a seamline network is automatically searched using a disparity map optimization algorithm,and DOM is smartly *** qualitative and quantitative experimental results on three datasets were produced and evaluated,which confirmed the feasibility of the proposed method,and the DOM accuracy can reach 1 Ground Sample Distance(GSD)*** comparison experiment with the state-of-the-art commercial softwares showed that the proposed method generated DOM has a better visual effect on building boundaries and roof completeness with comparable accuracy and computational efficiency.

关键词： Digital Orthophoto Map(DOM) dense image matching based on optical flow field(OFFDIM) 3D point clouds with texture seamline network accuracy

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Study on the transport of suspended sediment in an open channel flow with permeable spur dikes

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International Journal of Sediment Research 2011年第1期26卷 96-111页

作者： ryosuke AKAHORI Syunsuke IKEDA Civil Engineering Research Institute for Cold Region Public Works Research InstituteJapan CTI Engineering Co. Ltd.JapanTokyo Institute of TechnologyJapan

The transport of suspended sediment in rivers with spur dikes is an important issue for bank protection and environmental *** experiments were performed to study the characteristics of the flow and the transport of suspended sediment in an open channel with permeable ***,the essentials of these characteristics were studied by comparing results of flume experiments on permeable and impermeable *** influence of the aspect ratio(d/l) of the interval between dikes(d) to the length of dikes(l) on these characteristics was then *** these experiments,the properties of horizontal eddies,turbulence structures,and suspended sediment concentrations were *** results show that the development of large-scale horizontal eddies requires some distance in a shear layer for permeable dikes,although they are periodically generated from the first dike in the case of impermeable *** basic structures of horizontal eddies are independent of the aspect ratio in the equilibrium region for permeable *** suspended sediment concentrations for cases of permeable dikes gradually decrease between the several upstream dikes and they approach a uniform distribution in the downstream region,although those in the case of the impermeable dikes are relatively uniform in the downstream direction.

关键词： Suspended sediment Permeable spur dike Eddy structure Velocity distribution Power spectrum

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Completing density functional theory by machine learning hidden messages from molecules

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npj Computational Materials 2020年第1期6卷 1306-1313页

作者： Ryo Nagai ryosuke Akashi Osamu Sugino Department of Physics The University of TokyoHongoBunkyo-KuTokyo 113-0033Japan Institute for Solid State Physics The University of TokyoKashiwaChiba 277-8581Japan

Kohn–Sham density functional theory(DFT)is the basis of modern computational approaches to electronic *** accuracy heavily relies on the exchange-correlation energy functional,which encapsulates electron–electron interaction beyond the classical *** its universal form remains undiscovered,approximated functionals constructed with heuristic approaches are used for practical ***,there are problems in their accuracy and transferability,while any systematic approach to improve them is yet *** this study,we demonstrate that the functional can be systematically constructed using accurate density distributions and energies in reference molecules via machine ***,a trial functional machine learned from only a few molecules is already applicable to hundreds of molecules comprising various first-and second-row elements with the same accuracy as the standard *** is achieved by relating density and energy using a flexible feed-forward neural network,which allows us to take a functional derivative via the back-propagation *** addition,simply by introducing a nonlocal density descriptor,the nonlocal effect is included to improve accuracy,which has hitherto been *** approach thus will help enrich the DFT framework by utilizing the rapidly advancing machine-learning technique.

关键词： technique functional theory

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Development of thermodynamic and kinetic databases in micro-soldering alloy systems and their applications

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Progress in Natural Science:Materials International 2011年第2期21卷 97-110页

作者： Ikuo OHNUMA ryosuke KAINUMA Kiyohito ISHIDA Department of Materials Science Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan

Recent progress in the development of thermodynamic and kinetic databases of micro-soldering alloys,which were constructed within the framework of the Thermo-Calc and DICTRA software,was ***,a thermodynamic tool, ADAMIS(alloy database for micro-solders) was developed by combining the thermodynamic databases of micro-solders with Pandat,a multi-component phase diagram calculation software *** contains 11 elements,namely,Ag,Al,Au,Bi,Cu, In,Ni,Sb,Sn,Zn and Pb,and can handle all combinations of these elements in the whole composition *** obtained thermodynamic and kinetic databases can not only provide much valuable thermodynamic information such as phase equilibria and phase fraction,but also shows the kinetics and the evolution of microstructures when they are combined with some appropriate software programs and models,such as the phase field method and ADSTEFAN *** the viewpoints of computational thermodynamics and kinetics,some technical examples were given to demonstrate the great utility of these databases for the applications in the development of micro-soldering *** databases are expected to be powerful tools for the development of micro-solders and Cu substrate materials,as well as for promoting the understanding of interfacial phenomena and microstructure evolution between solders and substrates in electronic packaging technology.

关键词： micro-soldering alloys thermodynamics kinetics

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On the Effects of Central Japan Expressway’s Commuter Toll Discount Policy in Nagoya Area

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Tsinghua Science and Technology 2007年第2期12卷 151-157页

作者：应江黔 ryosuke Ando Faculty of Regional Studies Gifu University 1-1 Yanagido Gifu 501-1193 Japan Toyota Transportation Research Institute Wakamiya-cho 1-1 Toyota Aichi 471-0026 Japan

Road pricing policies have two equally important objectives that have to be considered： the optimal use of the road network and the fiscal sustainability for the management of the network. The aim of this work is to examine the effects on these two objectives of a recent pricing policy implemented in Japan＇s expressway networks. Recently the Nippon （Japan） Expressway Companies （NEXCO, operators of Japan＇s nation wide expressway network） have implemented several toll discount policies for users equipped with electronic toll collectors （ETCs）. One of the policies is the commuter discount policy that discounts 50% for a journey on the NEXCO expressway no longer than 100 km during the commuting peak hours. This paper examines its effect on congestion reduction in the road network of Nagoya area and its influence on the use of expressways operated by another major local public expressway company in Nagoya. The congestion easing effect of this policy is compared with a potential marginal cost pricing scheme. These observations suggest that policy coordination regarding toll levels is needed for expressway corporations and transportation authorities for improving transportation efficiency of utilization of the whole network.

关键词： electronic toll collector (ETC) expressway toll discount user equilibrium marginal cost pricing revenue

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Calculation of the self-formation driving force for composite microstructure in liquid immiscible alloy system

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Progress in Natural Science:Materials International 2005年第2期15卷 74-78页

作者： Ikuo OHNUMA,ryosuke KAINUMA,Kiyohito ISHIDA Tohoku University Sendai 980-8579 Japan Department of Materials Science Tohoku University Sendai 980-8579 Japan Department of Materials Science Tohoku University Sendai 980-8579 Japan Department of Materials Science

Using Becker's method, we calculate the interfacial energy between two liquid phases in an immiscible system. Based on the Gibbs-Thomson equation, the force acting on the droplet towards the thermal center can be obtained by integrating the interfacial energy between the droplet and matrix liquid phase, which is related to both the radius of a droplet and the temperature gradient. In addition, the forces of gravitation and buoyancy also act on the droplet. The calculated results indicate that the resultant for these forces together mainly decides the microstructure morphology of the solidified alloy. The calculated results are in good agreement with the corresponding experimental results.

关键词： liquid immiscible alloy system interfacial energy composite materials phase diagram

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New primitive ichthyosaurian (Reptilia,Diapsida) from the Middle Triassic of Panxian,Guizhou,southwestern China and its position in the Triassic biotic recovery

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Progress in Natural Science:Materials International 2008年第10期18卷 1315-1319页

作者： ryosuke Motani Lars Schmitz Olivier Rieppel Department of Geology University of CaliforniaDavisCA 95616-8605USA Department of Geology The Field MuseumChicagoIL 60605-2496USA

A new primitive ichthyopterygian Xinminosaurus catactes *** erected based on a complete skeleton from the Middle Triassic Upper Member of the Guanling Formation at Panxian,Guizhou,southwestern *** has a suite of uniquely derived char- acters in its dentition,ulna,carpals and *** is similar to primitive ichthyopterygians in retaining elongated limb *** new taxon and a diversity of marine reptiles in Panxian Fauna are the physical markers of the Middle Triassic Biotic *** stud- ies of this fauna will supply essential knowledge on the diversity,migration and paleobiogeographic affinity of Middle Triassic ichthyopterygians.

关键词： Ichthyosauria Ichthyopterygia Middle Triassic Panxian Guizhou

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