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Primary hepatic choriocarcinoma in a 49-year-old man:Report of a case

World Journal of Gastroenterology 2013年第48期19卷 9485-9489页

作者： ryosuke sekine Masanobu Hyodo Masayuki Kojima Yoshiyuki Meguro Akifumi Suzuki Taku Yokoyama Alan T Lefor Norio Hirota Department of Emergency Medicine Ibaraki Prefectural Central Hospital Ibaraki 309-1793 Japan Department of Surgery Hitachiomiya Saiseikai Hospital Ibaraki 319-2256 Japan Department of Surgery Jichi Medical University Tochigi 329-0498 Japan Department of Pathology Hirota Institute for Surgical Pathology Tochigi 329-0403 Japan

We report a case of hepatic choriocarcinoma in a man diagnosed at autopsy after a rapid downhill clinical course.The patient was a 49-year-old man who presented with acute right-sided abdominal pain.There were no masses palpable on physical examination.Radiographic findings showed large multi-nodular tumors mainly in the right lobe of the liver.Fludeoxyglucosepositron emission tomography scan showed uptake only in the liver,and no uptake in the testes.We initially planned to perform a liver resection for the presumed diagnosis of intra-hepatic cholangiocarcinoma.However,the tumors grew rapidly and ruptured.Multiple lung metastases rapidly developed resulting in respiratory failure,preventing liver resection or even biopsy.He died 60 d after initial presentation with no pathological diagnosis.Postmortem studies included histopathological and immunohistological examinations which diagnosed a primary choriocarcinoma of the liver.Primary hepatic choriocarcinoma is very rare but should be considered in the differential diagnosis of a liver tumor in a middle aged man.Establishing this diagnosis may enable treatment of the choriocarcinoma.Liver biopsy and evaluation of serum human chorionic gonadotropin are recommended in these patients.

关键词： Hepatic choriocarcinoma Male Human chorionic gonadotropin Liver biopsy Fludeoxyglucosepositron emission tomography

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