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A white opaque substance-positive gastric hyperplastic polyp with dysplasia

World Journal of Gastroenterology 2013年第26期19卷 4262-4266页

作者： Hiroya Ueyama Kenshi Matsumoto Akihito Nagahara ryosuke gushima Takuo Hayashi Takashi Yao Sumio Watanabe Department of Gastroenterology Juntendo University School of Medicine Department of Human Pathology Juntendo University School of Medicine

The endoscopic findings of gastric hyperplastic polyps (HPs) with dysplasia have not been well-defined, and the clinical significance of these lesions, including their malignant potential, is unclear. In this report, we describe a case of a white opaque substance (WOS)positive gastric HP with dysplasia. A 76-year-old woman was referred to our hospital for endoscopic resection of a gastric HP. Upper endoscopy revealed a 25-mm whitish and reddish polypoid lesion on the greater curvature in the lower third of the stomach. The whitish part was diagnosed as a WOS using conventional and magnifying endoscopy with narrow band imaging. An examination of the biopsy specimen indicated that the lesion was a typical gastric HP. However, because of its color and the presence of a WOS, we suspected that this lesion was an atypical gastric HP. Therefore, we performed a polypectomy. Histopathologically, diffuse lowto high-grade dysplasia was found on the surface of the polyp. We performed immunohistochemical staining using a monoclonal antibody specific for adipophilin as a marker of lipid droplets (LDs). LDs were detected in approximately all of the neoplastic cells, especially in the surface epithelium of the intervening apical parts and were located in the subnuclear cytoplasm of the neoplastic cells. According to endoscopic and histopathological findings, the WOS-positive epithelium indicated dysplasia of the gastrointestinal phenotype, which could absorb lipids. The presence of a WOS in a gastric HP may be considered an endoscopic finding that is predictive of the neoplastic transformation of a gastric HP. We suggest that a WOS-positive gastric HP should be resected endoscopically to investigate its neoplastic transformation.

关键词： Gastric hyperplastic polyp with dysplasia White opaque substance Adipophilin Lipid droplet Narrow band imaging

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Clinical impact of gastrointestinal endoscopy on the early detection of pharyngeal squamous cell carcinoma: A retrospective cohort study

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World Journal of Gastrointestinal Endoscopy 2021年第10期13卷 491-501页

作者： Hideaki Miyamoto Hideaki Naoe Jun Morinaga Kensuke Sakisaka Sayoko Tayama Kenshi Matsuno ryosuke gushima Masakuni Tateyama Takashi Shono Masanori Imuta Satoru Miyamaru Daizo Murakami Yorihisa Orita Yasuhito Tanaka Department of Gastroenterology and Hepatology Kumamoto University HospitalKumamoto 860-8556Japan Department of Clinical Investigation Kumamoto University HospitalKumamoto 860-8556Japan Department of Gastroenterology Kumamoto Chuo HospitalKumamoto 860-8556Japan Department of Radiology Kumamoto University HospitalKumamoto 860-8556Japan Department of Otolaryngology-Head and Neck Surgery Kumamoto University HospitalKumamoto 860-8556Japan

BACKGROUND In recent years,with the growing availability of image-enhanced gastrointestinal endoscopy,gastroenterologists have contributed to the early detection of pharyngeal squamous cell carcinomas(SCC).AIM To clarify the clinical characteristics of pharyngeal SCCs detected by gastrointestinal *** This is a retrospective cohort study conducted in a single-center,a university hospital in *** retrospectively assessed the clinical records of 522 consecutive patients with oropharyngeal or hypopharyngeal SCC who were examined in our hospital between 2011 and *** lesions were classified into two groups:Group GE(detected by gastrointestinal endoscopy)and Group non-GE(detected by means other than gastrointestinal endoscopy).The clinical characteristics were compared between the two *** data were compared using the Mann–Whitney U ***’sχ2 test or Fisher's exact test was used to analyze the categorical data and compare *** Kaplan–Meier method was used to estimate the cumulative patient survival *** In our study group,the median age was 65 years and 474 patients(90.8%)were *** hundred and ninety-six cases(37.5%)involved the oropharynx and 326 cases(62.5%)involved the *** hundred and ninety-five cases(75.7%)had some symptoms at the time of *** hundred and forty-five(27.8%)cases had concurrent ESCC or a history of *** hundred and sixtyfour(31.4%)cases were detected by gastrointestinal endoscopy and classified as Group *** proportions of asymptomatic cases,cTis-1 cases and cases with no lymph node metastasis were significantly higher in Group GE than Group non-GE(61.6%vs 7.3%,P<0.001,32.9%vs 12.0%,P<0.001 and 69.5%vs 19.0%,P<0.001).Endoscopic laryngo-pharyngeal surgery or endoscopic submucosal dissection were performed in only 0.6%of the lesions in Group non-GE but in 21.3%of the lesions in Group GE(P<0.001).Overall survival was significantly longer in Group GE than in Grou

关键词： Gastrointestinal imaging Head and neck imaging Gastrointestinal endoscope Hypopharyngeal neoplasm Oropharyngeal neoplasm Endoscopic surgery

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