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Effects of Eccentric Contractions Induced Electrical Stimulation Training System on Quadriceps Femoris Muscle

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International Journal of Clinical Medicine 2017年第9期8卷 519-533页

作者： Minoru Tanaka ryosuke Nakanishi Noriaki Maeshige Hidemi Fujino Department of Rehabilitation Science Graduate School of Health Sciences Kobe University Kobe Japan Faculty of Health Science Department of Physical Therapy Osaka Yukioka College of Health Science Osaka Japan

We developed an eccentric contraction induced electrical stimulation (ES) training system. The purpose of this study was to investigate whether the eccentric contraction induced ES enhance the knee extension torque compared with typical ES. Twenty-two young untrained men (age: 23 ± 3 years) in the acute response trial (single training) and seven untrained men in the long period training trial (for 6 weeks) were studied. We measured muscle thickness and knee extension torque evoked by ES with eccentric contraction training system (ES + ECC) or ES alone for the quadriceps muscle of men. The levels of pain and discomfort were evaluated using numeric rating scale (NRS) and heart rate variability. The knee extension torque of ES + ECC was higher than that of ES alone in the acute response trial. There were no significant differences in the levels of pain and discomfort between ES and ES + ECC. Additionally, ES + ECC training for 6 weeks was effective on the quadriceps muscle thickness and knee extension torque. In contrast, the ES alone training failed to increase muscle thickness and knee extension torque. These results suggest that eccentric contraction induced ES would have the potential to become an effective intervention to promote muscle strengthening.

关键词： Eccentric Contraction Muscle Strengthening Neuromuscular Electrical Stimulation Middle Frequency

Evaluation of the Distribution and Factors Affecting Blood Pressure Using Medical Checkup Data in Japan

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Health 2017年第1期9卷 124-137页

作者： Kazumitsu Nawata Akikuni Matsumoto ryosuke Kajihara Moriyo Kimura Graduate School of Engineering University of Tokyo Tokyo Japan The Public Health Institute Tokyo Japan

In this paper, we first evaluated the distribution of blood pressure (BP) using a dataset containing 113,979 measurements in 48,022 individuals with the cooperation of one health insurance society in Japan from April, 2013 to March, 2016. The means of the systolic BP (SBP) and diastolic BP (DBP) were 125.4 and 77.6 mmHg with standard deviations of 16.5 and 11.7 mmHg, respectively. Under the 140/90 criterion, 21.6% of the measurements showed hypertension. According to the World Health Organization/International Society of Hypertension criterion, 16.4%, 4.2% and 0.96% were classified as grades 1, 2 and 3, respectively. The factors affecting BP were evaluated by a regression analysis and were found to include age, gender, some eating habits, daily activities, smoking, drinking alcohol, sleeping and wages. Age was a very important factor, and the age cohorts from the previous study might be revised based on these findings. Among factors that individuals can control, the influence of drinking alcohol is very large. Comparing to an individual who does not drink, SBP and DBP of a heavy drinker are more than 5.0 mmHg higher on the average.

关键词： Blood Pressure Hypertension Distributions of SBP and DBP Health Checkups Factors Affecting BP

Fiber Line Optimization in Single Ply for 3D Printed Composites

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Open Journal of Composite Materials 2016年第4期6卷 121-131页

作者： Yusuke Yamanaka Akira Todoroki Masahito Ueda Yoshiyasu Hirano ryosuke Matsuzaki Tokyo Institute of Technology Tokyo Japan Department of Mechanical Engineering Tokyo Institute of Technology Tokyo Japan Department of Mechanical Engineering Nihon University Chiyoda-ku Tokyo Japan Aeronautical Technology Directorate Japan Aerospace Exploration Agency Mitaka-shi Tokyo Japan Department of Mechanical Engineering Tokyo University of Science Noda-shi Japan

In conventional manufacturing processes of composites, Carbon Fibre Reinforced Plastic (CFRP) laminates have been made by stacking unidirectional or woven prepreg sheets. Recently, as a manufacturing process of CFRP, 3D printing of CFRP composites has been developed. The 3D printing process of CFRP composites enables us to fabricate CFRP laminates with arbitrary curvilinear fibre plies. This indicates that the optimization of the in-plane curved carbon fibre placement in a planar ply is strongly required to realize superior 3D printed composites. In the present paper, in-plane curved carbon fibre alignment of a ply with an open hole is optimized in terms of maximization of the fracture strength. For the optimization process, a genetic algorithm is adopted. To describe curved carbon fibre alignments in a planar ply, stream lines of perfect flow is employed. By using the stream lines of the perfect flow, number of optimization parameters is significantly reduced. After the optimization, the fracture strength of CFRP laminate is compared with the results of unidirectional CFRP ply. The curved fibre placement in a planar ply shows superior fracture improvement.

关键词： Composites Carbon Fibre Reinforced Plastic Optimization 3D Print Genetic Algorithm Curvilinear Fibre

Acceleration of <i>Hericium erinaceum</i>mycelial growth in submerged culture using yogurt whey as an alternative nitrogen source

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Advances in Bioscience and Biotechnology 2012年第7期3卷 828-832页

作者： Chikako Asada ryosuke Okumura Chizuru Sasaki Yoshitoshi Nakamura Department of Life System Institute of Technology and Science The University of Tokushima Tokushima Japan

The effects of various carbon sources and their initial concentrations on mycelia production by Hericium erinaceum were investigated by determining the dry cell weight (DCW) and β-glucan content of mycelia in submerged culture. Glucose and xylose were superior carbon sources for promoting mycelial growth resulting in mycelial concentrations of 3.99 g/L and 4.01 g/L, respectively;glucose was the best carbon source in terms of productivity (0.44 g/L/day). Experiments were also performed using yogurt whey as an alternative nitrogen source for submerged cultivation of H. erinaceum mycelia, and DCW and β-glucan content were compared with those with chemical nutrient medium. When whey was used as a nitrogen source, DCW and total amount of β-glucan were 2.3- and 2.8-fold higher, respectively, than that with chemical nutrient medium. Thus, whey appears to be an alternative nitrogen source for promoting H. erinaceum mycelial growth.

关键词： Hericium Erinaceum Mycelia Submerged Culture Yogurt Whey

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湖北省南漳/远安动物群特征及其意义初探

中国地质 2015年第2期42卷 676-684页

作者：程龙阎春波陈孝红曾雄伟 ryosuke Motani 武汉地质矿产研究所湖北武汉430223 Department of Geology University of California

通过资料整理和野外调查,本文认为南漳/远安动物群是产自于嘉陵江组三段顶部纹层状灰岩、微晶灰岩中,以海生爬行动物为特色,伴有大量菌藻类和软体动物的早三叠世奥伦尼克期Spathian晚期的动物群落。该动物群中的海生爬行动物为幻龙类-... 详细信息

通过资料整理和野外调查,本文认为南漳/远安动物群是产自于嘉陵江组三段顶部纹层状灰岩、微晶灰岩中,以海生爬行动物为特色,伴有大量菌藻类和软体动物的早三叠世奥伦尼克期Spathian晚期的动物群落。该动物群中的海生爬行动物为幻龙类-鱼龙类-汉江蜥-贵州龙-湖北鳄类的组合特征。湖北鳄类相对其他海生爬行动物类型,数量最多,多样性最为丰富。独特的骨骼特征暗示其位于脊椎动物食物链的最低层。大量分异度较高的海生爬行动物在同一群落中出现,暗示在Spathian晚期,海洋生态系统可能已经开始恢复。

关键词：三叠纪海生爬行动物嘉陵江组南漳/远安动物群湖北

Involvement of Circadian Clock Gene BMAL1 in Doxorubicin-Induced Inflammation in Vascular Smooth Muscle Cells

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Pharmacology & Pharmacy 2021年第11期12卷 255-268页

作者： Akira Takaguri Makina Moriwaki ryosuke Tatsunami Keisuke Sato Kumi Satoh Department of Pharmacology Hokkaido University of Science Hokkaido Japan Department of Pharmacy Hokkaido University of Science Hokkaido Japan

The molecular clock component Brain and Muscle Arnt-Like protein-1 (BMAL-1) affects various biologic processes, including cell survival, in numerous cell types. We previously demonstrated that BMAL1 positively regulates cell proliferation in Vascular Smooth Muscle Cells (VSMCs). However, its role in VSMC inflammation remains unelucidated. Because doxorubicin causes phlebitis associated with vascular inflammation, the present study used cultured VSMCs to investigate whether BMAL1 affected doxorubicin-induced vascular inflammation. Doxorubicin treatment led to Increased Interleukin (IL)-6 mRNA expression with an increase in BMAL1 expression in VSMCs. BMAL1 knockdown significantly increased IL-6 mRNA and further enhanced doxorubicin-induced IL-6 mRNA expression in VSMCs. BMAL1 knockdown also significantly decreased cell viability and affected the expression of other clock genes, including Per1 and Clock. Furthermore, the levels of nuclear factor erythroid 2-related factor 2, which has anti-inflammatory effects, increased in VSMCs with BMAL1 knockdown. Finally, BMAL1 knockdown increased NADPH oxidase 4 mRNA, p38α mRNA, and p38β mRNA levels, leading to increased total p38 Mitogen-Activated Protein Kinase (MAPK) and phosphorylated p38 MAPK. IL-6 mRNA induction caused by BMAL1 knockdown was significantly inhibited in

Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma

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World Journal of Virology 2023年第3期12卷 209-220页

作者： Ryuta Kojima Shingo Nakamoto Tadayoshi Kogure Yaojia Ma Keita Ogawa Terunao Iwanaga Na Qiang Junjie Ao Ryo Nakagawa ryosuke Muroyama Masato Nakamura Tetsuhiro Chiba Jun Kato Naoya Kato Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8670Japan

BACKGROUND Hepatitis B virus(HBV)is a major cause of hepatocellular carcinoma(HCC).HBV DNA can get integrated into the hepatocyte genome to promote ***,the precise mechanism by which the integrated HBV genome promotes HCC has not been *** To analyze the features of HBV integration in HCC using a new reference database and integration detection *** Published data,consisting of 426 Liver tumor samples and 426 paired adjacent non-tumor samples,were re-analyzed to identify the integration *** Reference Consortium Human Build 38(GRCh38)and Telomere-to-Telomere Consortium CHM13(T2T-CHM13(v2.0))were used as the human reference *** contrast,human genome 19(hg19)was used in the original *** addition,GRIDSS VIRUSBreakend was used to detect HBV integration sites,whereas high-throughput viral integration detection(HIVID)was applied in the original study(HIVID-hg19).RESULTS A total of 5361 integration sites were detected using *** the tumor samples,integration hotspots in the cancer driver genes,such as TERT and KMT2B,were consistent with those in the original *** VIRUSBreakend detected integrations in more samples than by *** of integration was observed at chromosome 11q13.3,including the CCND1 pro-moter,in tumor *** integration sites were observed in mitochondrial *** GRIDSS VIRUSBreakend using T2T-CHM13 is accurate and sensitive in detecting HBV ***-analysis provides new insights into the regions of HBV integration and their potential roles in HCC development.

关键词： Carcinoma Hepatocellular Hepatitis B virus Virus integration

Investigation of Relation between Solar Activity and Earthquakes with Deep Learning Method

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International Journal of Geosciences 2021年第8期12卷 704-713页

作者： Leilei Li Hong Gu ryosuke Kikuyama Ryuei Nishii Pan Qin Faculty of Electronic Information and Electrical Engineering Dalian University of Technology Dalian China Mazda Motor Company Hiroshima Japan School of Information and Data Sciences Nagasaki University Nagasaki Japan

Solar activity (SA) has been hypothesized to be a trigger of earthquakes, although it is not as intuitively associated as other potential triggers such as tidal stress, rainfall, and the building of artificial water reservoirs. Here, we investigate the relation between SA and global earthquake numbers (GEN) by using a deep learning method to test the hypothesis. We use the daily data of GEN and SA (1996/01/01-2019/12/31) to construct a temporal convolution network (TCN). From the computational results, we confirm that the TCN captures the relation between SA and earthquakes with magnitudes from 4.0 to 4.9. We also find that the TCN achieves better fitting and prediction performance compared with previous work.

关键词： Deep Learning Earthquakes Prediction Solar Activities Temporal Convolution Network

Effects of Denture Removal on Expiratory Upper Airway Patency during Mask Ventilation in Complete Denture Wearers under General Anesthesia

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Open Journal of Anesthesiology 2021年第2期11卷 39-48页

作者： Takashi Imaizumi Toshiyuki Yano Chiho Uneda Kazuhiko Kawamoto ryosuke Nakayama Division of Anesthesia Kumamoto Kinoh Hospital Kumamoto Japan

Background: Some anesthetized patients present with expiratory airway obstruction (EAO) during mask ventilation (MV). EAO may occur more frequently among edentulous patients for whom a firmer grip of the mask and the mandible is needed to avoid gas leakage. We compared EAO grades before and after denture removal and identified predictors of EAO during MV in edentulous patients. Methods: One hundred and eight denture-wearing edentulous patients were anesthetized, their mouths were wrapped with film, their nasal masks and mandibles were held with two hands, and their lungs were ventilated in a pressure-controlled mode. Their dentures were subsequently removed, mouths were re-wrapped, and nasal MV was reapplied. EAO was graded based on capnography waveforms as follows: Grade I, normal waveform (no obstruction);II, loss of the alveolar plateau of the waveform (partial obstruction);and III, no waveform (total obstruction). EAO grades were compared before and after denture removal. Predictive demographic variables for occurrence of total EAO were identified using a multivariate analysis. Results: The proportions of Grades I, II, and III were 43.5%, 26.9%, and 29.6% when dentures were worn and 35.2%, 15.7%, and 49.1%, respectively, when dentures were removed. A significant difference was observed in EAO grades before and after denture removal (P = 0.000034). Age ≥ 75 years (adjusted odds ratio 3.41;95% confidence int

关键词： Airway Obstruction Edentulous Jaw Expiration Nasopharynx Soft Palate