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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin Fu Xiaoting yang ya Yu Kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang Fan Yuhang Li Yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

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g-C_(3)N_(4)负载双金属Rh@Ru催化氨硼烷析氢反应机理研究

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原子与分子物理学报 2025年第5期42卷 17-21页

作者：郭雅琼武警警官学院成都610213

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、... 详细信息

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、Ⅱ所需活化能较高,反应路径Ⅲ更容易进行,Ⅰ为最优析氢路径.从微观角度揭示双贵金属Rh@Ru负载g-C_(3)N_(4)催化氨硼烷析氢的三条机理,希望为氨硼烷析氢催化剂的优化和设计提供理论信息.

关键词：双金属催化剂 g-C_(3)N_(4) NH_(3)BH_(3) 密度泛函理论反应机理

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A Smart Wellness Service Platform and Its Practical Implementation

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Computers, Materials & Continua 2021年第1期66卷 45-57页

作者： Umar Farooq Intae ryoo Gon Khang Department of Biomedical Engineering Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Korea Department of Computer Engineering Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Korea

Advances in the field of medical sciences and medical technology,and present-day challenges,such as an aging population,rising medical expenses,and lifestyle-related diseases,have collectively catalyzed a research ecosystem termed“smart wellness.”This article describes the establishment of a smart wellness service platform designed to empower individuals to create a sense of balance in their ***-by-step details include service model,design,and architectural *** a proof of concept,implementation details of a Health Improvement and Management Systems(HIMS)Hub,a Smart Wellness Service Platform deployed in six cities in South Korea,are *** on-site survey conducted in Busan Metropolitan City reveals the percentage of satisfied users to be 91.3%.Furthermore,data gathered from 27,236 physical evaluations of users from a Busan city center over the period of April 2013 to May 2018 reveal that males and females in their 50s and 60s account for the highest number of participants,while males in their 70s have a higher rate of participation than females in the same age group.

关键词： Wellness smart wellness smart wellness service platform u-Healthcare sports and exercise medicine

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Deadwood position matters:Diversity and biomass of saproxylic beetles in a temperate beech forest

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Forest Ecosystems 2024年第1期11卷 120-130页

作者： Vaclav Zumr oto Nakladal Josef Gallo JiríRemes Faculty of Forestry and Wood Sciences Czech University of Life Sciences PragueKamýck a 129Praha 6-Suchdol16500Czech Republic

Deadwood plays a key role for biodiversity in forests.A significant number of beetles from this group are currently listed as endangered in the Red *** addition to other management recommendations,there have been recent efforts to enrich stands with dead wood to promote *** important parameter for forestry enterprises is the optimization of these *** study investigated the abundance,species richness,gamma diversity,conservation value and biomass of saproxylic beetles in natural forests using window traps.A total of 89traps were used for saproxylic beetle monitoring,of which 29 were placed on lying logs,30 on snags and 30 as controls in forest stand space.A total of 35,011 beetles were recorded in 564 species(61 families).Notably,20,515 of these belong to saproxylic beetles(59%)in 311 species(55%),with 62 classified as Red-List species(20%).In the group of'all saproxylic beetles',the results indicate that a diversity and y diversity(q=0)remain consistent across various deadwood types,whileβdiversity showed significant *** differences were found in the Red-List species group,where a diversity and y diversity differed,with higher values observed in *** based total species richness of site was estimated to be 391 species,including 74 Red-Listed *** the sample coverage of the studied stand categories showed that all saproxylic species exhibit a pronounced preference for inhabiting areas featuring lying ***,Red-List species mainly inhabit snags,withβdiversity being more similar to snags and forest stand ***,both the conservation value(weighted average by conservation status)and beetle biomass are significantly highest in snags,whereas stand space shows the lowest values across all measured saproxylic beetle ***,the use of traps set on the poles in forest stand space resulted in an underestimation of the actual stand richness by 20%-25%.Our results support th

关键词： Snags Coleoptera Fagus sylvatica Unmanaged forests Red-list Coarse woody debris

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Hydrogen spillover in nonreducible oxides:Mechanism and catalytic utilization

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Nano Research 2022年第12期15卷 10357-10365页

作者： Songhyun Lee Hyungjun Kim Ryong ryoo Jeong Young Park Minkee Choi Charles D.Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana47907USA Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and TechnologyDaejeon34141Republic of Korea Department of Chemistry Korea Advanced Institute of Science and TechnologyDaejeon34141Republic of Korea KENTECH Laboratory for Chemical Environmental and Climate TechnologyKorea Institute of Energy Technology(KENTECH)200 Hyeoksin-roNaju58330Republic of Korea Center for Nanomaterials and Chemical Reactions Institute for Basic Science(IBS)Daejeon34141Republic of Korea

Hydrogen(H)spillover in nonreducible oxides such as zeolites and Al2O3 has been a highly controversial phenomenon in heterogeneous *** industrial catalysts are predominantly prepared using these materials as supports,it is important to understand the mechanism and catalytic functions of H spillover on their *** the past decade,fundamental studies on zeolite-encapsulated metal catalysts have revealed that H spillover and reverse spillover can be utilized in the design of hydrogenation and dehydrogenation catalysts with improved *** experimental and theoretical studies have indicated that H spillover can occur in nonreducible oxides when they possess substantial acid sites that aid the surface migration of active *** the present review,we will discuss the possible mechanisms of H spillover in nonreducible oxides and the unique opportunities of using this phenomenon for the design of advanced hydroprocessing catalysts.

关键词： hydrogen spillover nonreducible oxides zeolites hydroprocessing catalysts

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Diversity of click beetles in managed nonnative coniferous and native beech stands: Consequences of changes in the structural and species composition of tree stands in Central Europe

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Forest Ecosystems 2022年第5期9卷 596-605页

作者： Václav Zumr oto Nakladal JiríRemes Tereza Brestovanska Váaclav Zumr Czech University of Life Sciences Prague Faculty of Forestry and Wood SciencesKamýcka 129Praha 6Suchdol16500Czech Republic The Silva Tarouca Research Institute for Landscape and Ornamental Gardening Kvetnove namestí391Průhonice25243Czech Republic SC*** Czech Republic

The natural composition of forests has undergone significant changes over recent centuries.A closer-to-natural tree species composition has long been perceived as key to a high *** investigated the impact on communities of click beetles(Elateridae)caused by changes in the tree species composition of spruce monocultures compared to reference sites of recently unmanaged natural beech *** collect data,passive interception traps were distributed within managed spruce stands of different age classes and natural beech forests of various developmental *** beetle species richness was slightly but not significantly higher in the beech *** saproxylic species group was significantly more common in the spruce stands,whereas the group of nonsaproxylic species was significantly more abundant in the beech *** the commercial stands,the significantly highest species richness was in the clearings(0–10-year-old stands),and at this forest age class,the vast majority of the beetle species occurred in the spruce *** the developmental stages of the natural forest,a slightly higher beetle richness was found at the disintegration *** study results suggested that different tree species compositions and stand structures affect the communities of click beetles and substantially change their species composition and thus their response to external ***,management of stands using diverse silvicultural systems is recommended for creating diverse ecological niches in forests.

关键词： Species richness Forest management Saproxylic beetles Nonsaproxylic beetles Dead wood Elateridae Canopy openness

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Surface and Upper-Level Features Associated with Wintertime Cold Surge Outbreaks in South Korea

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Advances in Atmospheric Sciences 2005年第4期22卷 509-524页

作者： Sang-Boom ryoo Won-Tae KWON Jong-Ghap JHUN Meteorological Research Institute Korea Meteorological Administration Seoul 156-720Meteorological Research Institute Korea Meteorological Administration Seoul 156-720School of Earth and Environment Sciences Seoul National University Seoul 156-720

The surface and upper-level features associated with a sharp drop ofwintertime daily temperature over South Korea is investigated in this study. This sharp drop indaily temperature is called a cold surge and is one of the most hazardous weather phenomena in EastAsian winters. An upper-level baroclinic wave of 60° wavelength propagating eastward at a phasespeed of 12° longitude per day across the continent of northern China from the west of Lake Baikaltoward the eastern coast of China causes the outbreak of cold air over South Korea. The coolingassociated with the upper-level baroclinic jvave is found at all altitudes under the geopotentialheight-fall center near the tropopause. The development in the ridge seems to derive the earlyevolution of the eastward-propagating sinusoidal wave, whereas the trough is connected directly withthe tropospheric temperature-drop. An enhancement of the wintertime East Asian jet stream after theoutbreak of a cold surge is a response to the steep temperature gradient associated with thedeveloping baroclinic wave.

关键词： cold surge south korea baroclinic wave east asian jet stream

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gscaLCA in R: Fitting Fuzzy Clustering Analysis Incorporated with Generalized Structured Component Analysis

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Computer Modeling in Engineering & Sciences 2022年第9期132卷 801-822页

作者： Ji Hoon ryoo Seohee Park Seongeun Kim Heungsun Hwang Department of Education College of Educational SciencesYonsei UniversitySeoul03722South Korea Psychometrics Department American Board of Internal MedicinePhiladelphia19016USA Department of Educational Research Methodology School of EducationUniversity of North Carolina at GreensboroGreensboro27412USA Department of Psychology McGill UniversityMontrealH3A 0G4Canada

Clustering analysis identifying unknown heterogenous subgroups of a population(or a sample)has become increasingly popular along with the popularity of machine learning *** there are many software packages running clustering analysis,there is a lack of packages conducting clustering analysis within a structural equation modeling *** package,gscaLCA which is implemented in the R statistical computing environment,was developed for conducting clustering analysis and has been extended to a latent variable *** specifically,by applying both fuzzy clustering(FC)algorithm and generalized structured component analysis(GSCA),the package gscaLCA computes membership prevalence and item response probabilities as posterior probabilities,which is applicable in mixture modeling such as latent class analysis in *** a hybrid model between data clustering in classifications and model-based mixture modeling approach,fuzzy clusterwise GSCA,denoted as gscaLCA,encompasses many advantages from both methods:(1)soft partitioning from FC and(2)efficiency in estimating model parameters with bootstrap method via resolution of global optimization problem from *** main function,gscaLCA,works for both binary and ordered categorical *** addition,gscaLCA can be used for latent class regression as *** of profiles of latent classes based on the posterior probabilities is also available in the package *** paper contributes to providing a methodological tool,gscaLCA that applied researchers such as social scientists and medical researchers can apply clustering analysis in their research.

关键词： Fuzzy clustering generalized structured component analysis gscaLCA latent class analysis

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The diameter of beech snags is an important factor for saproxylic beetle richness: Implications for forest management and conservation

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Forest Ecosystems 2023年第5期10卷 635-645页

作者： Václav Zumr oto Nakládal Lukás Bílek JiríRemes Czech University of Life Sciences Prague Faculty of Forestry and Wood SciencesKamýcka 129Praha 6–Suchdol16500Czech Republic

Snags are an important component of beech forests that promote ***,their occurrence is completely marginal in managed *** snags in these stands would greatly enhance *** investigated whether snag dimensions were important for saproxylic beetle richness since they were easily transferable parameters to forest management and assessed the presence of other snag microhabitats affecting beetle *** collection was performed using passive flight traps placed on thirty snags in a recent beech reserve.A total of 6706 adults belonging to 231 saproxylic species(53 Red List species,23%)were *** results showed that the most important snag parameters were the diameter(thickness)and canopy openness of the surrounding *** occurrence of Fomes fomentarius,the volume of snag and decay class 3 were marginally significant in terms of the preference of all saproxylic *** diversity was reduced by an advanced degree of decay and a surprisingly deep stem *** dividing snag thickness into categories(70 cm DBH),we found that categories with snag diameter greater than 35 cm showed little differences in all saproxylic and Red List species richness and diversity indices and exhibited the highest similarity in beetle *** recommendations to forest managers in terms of optimization and simplification of practical procedures,we suggest actively creating high stumps to act as snags greater than 35 cm in DBH diameter to promote biodiversity in beech management stands.

关键词： Deadwood Coleoptera Biodiversity Active management Endangered beetles

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