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Sources of Sexual Knowledge among Vietnamese High School Students

Advances in Reproductive Sciences 2014年第4期2卷 83-87页

作者： Kaori Watanabe ryoko saruta Naomi Kato Department of Midwifery The Graduate School of Japanese Red Cross Akita College of Nursing Akita Japan

This study determined the sources from which Vietnamese high school students currently acquire sexual knowledge as well as the sources from which they believe they should acquire it. Participants were eleventh-grade students at three public high schools in Hanoi, Vietnam. We conducted a questionnaire-based survey from September to October 2012, with 1672 students participating. Responses were received from all 1672 students, a response rate of 100%. Complete data were received from 1653 respondents (98.9%), including 896 males (54.2%) and 757 females (45.8%). The survey was a self-administrated questionnaire. Although many participants believed that they were knowledgeable about sex, only a small number of them actually possessed accurate sexual knowledge. Few participants in this study, targeted to a specific age (eleventh grade), had used the Internet as a major source for obtaining sexual knowledge, in contrast to results from previous studies which covered a wider age demographic. Future research should include comparative studies between eleventh and twelfth graders as well as between those of the same age who are and who are not enrolled in high school. Additionally, it might be beneficial to consider the relationship between adolescent age and Internet use to study the influence of the Internet on sexual knowledge. Our results suggest that parents and schoolteachers should shoulder more responsibility in providing sexual education, particularly by improving their own knowledge and ability to provide such education, because many participants indicated that sexual knowledge should be acquired from parents and schools.

关键词： High School Students Sexual Knowledge Sources Internet Sex Education

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Effects of denosumab treatment in chronic liver disease patients with osteoporosis

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World Journal of Gastroenterology 2020年第33期26卷 4960-4971页

作者： Chisato Saeki Mitsuru Saito Tsunekazu Oikawa Masanori Nakano Yuichi Torisu Masayuki saruta Akihito Tsubota Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineTokyo 1058461Japan Department of Orthopaedic Surgery The Jikei University School of MedicineTokyo 1058461Japan Core Research Facilities Research Center for Medical ScienceThe Jikei University School of MedicineTokyo 1058461Japan

BACKGROUND Effective treatment of osteoporosis is essential for improving morbidity and health-related quality of life in chronic liver disease(CLD)*** has been shown to increase bone mineral density(BMD)and decrease the risk of osteoporotic fracture in the general ***,there are few reports evaluating the efficacy of denosumab in CLD *** To investigated the effects and safety of denosumab in CLD patients with *** Sixty CLD patients with osteoporosis were subcutaneously administered denosumab once every 6 *** study period for evaluating efficacy and safety was 12 *** from baseline in BMD at the lumbar spine,femoral neck,and total hip were evaluated at 12 mo of denosumab *** turnover and quality were assessed by measuring serum tartrate-resistant acid phosphatase-5b(bone resorption marker),serum total procollagen type I N-terminal propeptide(bone formation maker),and plasma pentosidine(bone quality marker).RESULTS Among the 405 CLD patients,138(34.1%)patients were diagnosed with osteoporosis;among these,78 patients met the exclusion criteria and thus 60 patients were finally included in the present *** median percentage changes from baseline to 12 mo of denosumab treatment in BMD at the lumbar spine,femoral neck,and total hip were+4.44%,+3.71%,and+4.03%,*** significantly improved BMD,regardless of sex,patient age,and presence of liver *** tartrate-resistant acid phosphatase-5b and procollagen type I N-terminal propeptide levels constantly and significantly declined after denosumab treatment(P<0.001).Plasma pentosidine levels were also significantly lower at 12 mo of treatment(P=0.010).No patients experienced fractures and moderate-to-severe adverse events,except for transient *** Denosumab treatment was safe and increased BMD,suppressed bone turnover,and improved bone quality marker levels in CLD patients with osteoporosis,irrespective

关键词： Chronic liver disease Denosumab Osteoporosis Bone mineral density Bone turnover Bone quality

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Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

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World Journal of Gastroenterology 2018年第18期24卷 1989-1994页

作者： Kazuki Takakura Tsunekazu Oikawa Yoichi Tomita Yusuke Mizuno Masanori Nakano Chisato Saeki Yuichi Torisu Masayuki saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

As the incidence of hepatocellular carcinoma(HCC) caused by infection with the hepatotropic viruses hepatitis B and hepatitis C decreases, greater attention has become focused on HCC caused by nonalcoholic steatohepatitis(NASH), an advanced form of nonalcoholic fatty liver disease which has shown increasing prevalence in correspondence with the overall increase in metabolic syndrome over the recent decades. Several clinical population studies have shown a positive relationship between NASH and HCC, while also providing initial insights into the underlying mechanisms of HCC development from NASH. Research into the pathological progression of NASH to HCC has advanced by use of several beneficial rodent models. In this review, we summarize the established mouse models for preclinical research of NASH-associated HCC and discuss the underlying hepatic mechanisms of NASH-related tumorigenesis identified to date that could lead to new targets for treatment and prevention.

关键词： Hepatocellular carcinoma Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease

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Snow Cover Detection Based on Visible Red and Blue Channel from MODIS Imagery Data

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International Journal of Geosciences 2015年第1期6卷 51-66页

作者： Paipai Pan Guoyue Chen Kazuki saruta Yuki Terata Graduate School of Systems Science and Technology Integrated Course of Systems Science and Technology Akita Prefectural University Yurihonjo City Japan Department of Electronics and Information Systems Akita Prefectural University Yurihonjo City Japan

In the present work, a new snow cover detection method based on visible red and blue bands from MODIS imagery data is proposed for Akita prefecture under the sunny cloud-free conditions. Before the snow cover detection, the MODIS imagery of the study area is pre-processed by geographic correction, clipping, atmospheric correction and topographic correction. Snow cover detection is carried out by applying the reflectance similarities of snow and other substances in the visible red band 1 and blue band 3. Then, the threshold values are confirmed to distinguish snow pixels from other substances by analyzing the composited true color images and 2-dimensional scatter plots. The MOD10_L2 products and?in-situ?snow depth data from 31 observation stations across the whole study area are chosen to compare and validate the effectivity of proposed method for snow cover detection. We calculate the overall accuracy, over-estimation error and under-estimation error of snow cover detection during the snowy season from May 2012 to April 2014, and the results are compared by classifying all of the observation stations into forest areas, basin areas and plain areas. It proves that the snow cover can be detected effectively in Akita prefecture by the proposed method. And the average overall accuracy of proposed method is higher than MOD10_L2 product, improved by 26.27%. The proposed method is expected to improve the environment management and agricultural development for local residents.

关键词： Akita MODIS Remote Sensing Snow Cover

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Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis

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World Journal of Hepatology 2017年第1期9卷 57-63页

作者： Yuichi Torisu Masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa Ishikawa Masayuki saruta Mikio Zeniya Division of Gastroenterology and Hepatology Department of Internal Medicine the Jikei University School of Medicine Department of Internal Medicine Fuji City General Hospital Department of Internal Medicine Sanno Medical Center

AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA *** In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in pat

关键词： Autoimmune hepatitis Japanese patients Adverse events Corticosteroids Ursodeoxycholic acid

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Pancreatic cancer screening in patients with presumed branch-duct intraductal papillary mucinous neoplasms

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World Journal of Clinical Oncology 2019年第2期10卷 67-74页

作者： Yuichi Torisu Kazuki Takakura Yuji Kinoshita Yoichi Tomita Masanori Nakano Masayuki saruta Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine

Because delayed diagnosis is one of the causes of poor prognosis in pancreatic ductal adenocarcinoma(PDAC), early detection is a key for overall improvement of prognosis. Towards this end, periodic screening is recommended for individuals considered high-risk for PDAC. Advances in diagnostic imaging modalities have increased the frequency of incidental findings of pancreatic cysts,including the intraductal papillary mucinous neoplasm(IPMN)-a major risk factor of PDAC, having 1% annual prevalence of concomitance with *** retainment of patients with IPMN and regular follow-up by routine imaging examination will likely improve early detection and better prognosis of PDAC. Unfortunately, current guidelines only address management of PDAC derived from IPMN and overlook PDAC concomitant with IPMN. Screening of patients with IPMN, by endoscopic ultrasonography(currently the most reliable modality for detecting small PDAC), may facilitate early detection of both IPMNderived and-concomitant PDAC. Prospective studies to evaluate the usefulness of endoscopic ultrasonography in screening of IPMN-concomitant PDAC will also help in determining the optimal surveillance strategy for more widespread applications.

关键词： Intraductal papillary mucinous neoplasm Pancreatic ductal adenocarcinoma Endoscopic ultrasonography Screening Early diagnosis

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The Efficacy of the Consumption of n-3 Polyunsaturated Fatty Acids for the Maintenance of Remission in Patients with Inflammatory Bowel Disease

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Food and Nutrition Sciences 2018年第2期9卷 105-118页

作者： Kan Uchiyama Hiroko Aiki Aki Matsumura Kanako saruta Ai Yuasa Zensho Ito Shinichiro Takami Keisuke Saito Yuichiro Ohtaki Shizuka Suzuki Susumu Hayashi Shigeo Koido Hiroshi Yoshida Toshifumi Ohkusa Masayuki saruta Department of Internal Medicine Division of Gastroenterology and Hepatology The Jikei University Kashiwa Hospital Kashiwa Japan Department of Nutrition The Jikei University Kashiwa Hospital Kashiwa Japan Department of Laboratory Medicine The Jikei University Kashiwa Hospital Kashiwa Japan Department of Internal Medicine Division of Gastroenterology and Hepatology The Jikei University Hospital Tokyo Japan

The aim of the present study was to investigate the efficacy of the actual consuming n-3 PUFA for remission-maintenance in IBD patients. A questionnaire on the dietary habits of patients one month before hospitalization (Q1) was completed by 24 patients with IBD (10 ulcerative colitis (UC) subjects and 14 Crohn’s disease (CD) subjects) treated at our hospital. We educated the study subjects about an n-3 PUFA diet, and a follow-up survey (Q2) was conducted 6 to 12 months after discharge. Disease activity was evaluated using the International Organization for the Study of Inflammatory Bowel Disease (IOIBD) score and/or the Crohn’s Disease Activity Index (CDAI) score for CD and the partial UCDAI score without endoscopic evaluation for UC. Q1 showed that the average n-3 and n-6 PUFA intakes were 1673 ± 1651 mg and 9146 ± 5217 mg, respectively, and the average n-3/n-6 ratio was 0.27 ± 0.31. In Q2, the intake of n-3 PUFA was significantly higher (3671 ± 1684 mg, p < 0.001), whereas the n-6 PUFA intake decreased significantly (5217 ± 1973 mg, p < 0.001) compared to those in Q1. As a consequence, the dietary n-3/ n-6 ratio was significantly increased (0.87 ± 0.60, p < 0.001). Maintenance of the remission rate was significantly higher in IBD patients who complied with the n-3 diet, and these patients maintained a dietary n-3/n-6 ratio of 0.432 or higher (17 of 23 cases;70.8%, p < 0.03) compared to that observed for IBD patients who did not comply with the diet. These results emphasize the importance of adjusting dietary PUFA and suggest that the n-3 diet may be effective in maintaining the remission of IBD.

关键词： Crohn’s Disease Inflammatory Bowel Disease N-3 Diet Polyunsaturated Fatty Acid Ulcerative Colitis

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Liver injury after aluminum potassium sulfate and tannic acid treatment of hemorrhoids

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World Journal of Gastroenterology 2017年第27期23卷 5034-5040页

作者： Kenichi Yoshikawa Reimi Kawashima Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Akiyoshi Kinoshita Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Masayuki saruta Division of Gastroenterology and Hepatology Internal Medicinethe Jikei University Daisan Hospital Division of Gastroenterology and Hepatology Internal Medicinethe Jikei University School of Medicine

We are reporting a rare case of acute liver injury that developed after an internal hemorrhoid treatment with the aluminum potassium sulfate and tannic acid(ALTA) regimen. A 41-year-old man developed a fever and liver injury after undergoing internal hemorrhoid treatment with a submucosal injection of ALTA with lidocaine. The acute liver injury was classified clinically as hepatocellular and pathologically as cholestastic. We could not classify the mechanism of injury. High eosinophil and immunoglobulin E levels characterized the injury,and a drug lymphocyte stimulation test was negative on postoperative day 25. Fluid replacement for two weeks after hospitalization improved the liver injury. ALTA therapy involves injecting chemicals into the submucosa,from the rectum to the anus,and this is the first description of a case that developed a severe liver disorder after this treatment; hence,an analysis of future cases as they accumulate is desirable.

关键词： Aluminum potassium sulfate and tannic acid injection Aluminum potassium sulfate and tannic acid therapy Rectal submucosal injection Drug-induced lymphocyte stimulation test Drug-induced liver injury

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Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma

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World Journal of Gastroenterology 2017年第45期23卷 8097-8103页

作者： Kenichi Yoshikawa Akiyoshi Kinoshita Yuki Hirose Keiko Shibata Takafumi Akasu Noriko Hagiwara Takeharu Yokota Nami Imai Akira Iwaku Go Kobayashi Hirohiko Kobayashi Nao Fushiya Hiroyuki Kijima Kazuhiko Koike Haruka Kaneyama Keiichi Ikeda Masayuki saruta Division of Gastroenterology and Hepatology Internal MedicineJikei University Daisan Hospital Department of Endoscopy Jikei University Daisan Hospital Division of Gastroenterology and Hepatology Internal MedicineJikei University School of Medicine

We report the first use of endoscopic submucosal dissection(ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus(EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus. The lesion partially stained with Lugol's solution,and narrow band imaging with magnification showed intrapapillary capillary loops with mild dilatation and a divergence of caliber in the center of the lesion. Endoscopic ultrasound imaging revealed a solid 8 mm × 4.2 mm tumor,primarily involving the second and third layers of the esophagus. A preoperative biopsy was non-diagnostic. ESD was performed to resect the lesion,an 8 mm submucosal tumor. Immunohistologically,tumor cells differentiating into ductal epithelium and myoepithelium were observed,and the tissue type was adenoid cystic carcinoma. There was no evidence of esophageal wall,vertical stump or horizontal margin invasion with p T1 b-SM2 staining(1800 μm from the muscularis mucosa). Further studies are needed to assess the use of ESD for the treatment of patients with EACC.

关键词： Adenoid cystic carcinoma of esophagus Endoscope Ultrasound Esophageal Tumor Endoscopic submucosal dissection

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云峰山温泉度假村

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城市环境设计 2024年第1期147卷 70-75页

作者：横尾实秋山弘明猿田晓生神田刚隈研吾建筑都市设计事务所

这座温泉度假村坐落在中国云南省腾冲市的山区中。项目用地西面有一座山，名叫云峰山，被誉为道教圣地。于是，我们把这些建筑物布置得像是顺着道教“精神”从山上下来的水流。我们还利用了附近采石场的不同种类的石头，把各种石头像马...

这座温泉度假村坐落在中国云南省腾冲市的山区中。项目用地西面有一座山，名叫云峰山，被誉为道教圣地。于是，我们把这些建筑物布置得像是顺着道教“精神”从山上下来的水流。我们还利用了附近采石场的不同种类的石头，把各种石头像马赛克一样拼在一起。通过使用当地的石头，我们试图在我们设计的建筑中表达“大地的力量”。

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