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Localization of ATP-sensitive K^+ channel subunits in rat liver

World Journal of Experimental Medicine 2019年第2期9卷 14-31页

作者： Ming Zhou Kiwamu Yoshikawa Hideo Akashi Mitsutaka Miura ryoji Suzuki Tao-Sheng Li Hiroshi Abe Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Cell Biology and Morphology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan TRUST A Long-Term Care Health FacilitySendai 980-0011Japan

BACKGROUND ATP-sensitive K^+(KATP)channels were originally found in cardiac myocytes by Noma in *** channels were formed by potassium ion-passing poreforming subunits(Kir6.1,Kir6.2)and regulatory subunits SUR1,SU2A and SUR2B.A number of cells and tissues have been revealed to contain these channels including hepatocytes,but detailed localization of these subunits in different types of liver cells was still *** To investigate the expression of KATP channel subunits in rat liver and their localization in different cells of the *** Rabbit anti-rat SUR1 peptide antibody was raised and purified by antigen immunoaffinity column *** of Sprague-Dawley rats were used for liver protein extraction for immunoblot analysis,seven of them were used for immunohistochemistry both for the ABC method and immunofluorescence *** of Wistar rats were used for the isolation of hepatic stellate cells(HSCs)and Kupffer cells for both primary culture and *** Immunoblot analysis showed that the five kinds of KATP channel subunits,***6.1,Kir6.2,SUR1,SUR2A,and SUR2B,were detected in *** staining showed that Kir6.1 and Kir6.2 were weakly to moderately expressed in parenchymal cells and sinusoidal lining cells,while SUR1,SUR2A,and SUR2B were mainly localized to sinusoidal lining cells,such as HSCs,Kupffer cells,and sinusoidal endothelial *** for SUR2A and SUR2B was expressed in the hepatocyte *** immunofluorescence staining further showed that the pore-forming subunits Kir6.1 and/or Kir6.2 colocalized with GFAP in rat liver sections and primary cultured *** KATP channel subunits also colocalized with CD68 in liver sections and primary cultured Kupffer *** SUR subunits colocalized with GFAP in liver sections and colocalized with CD68 both in liver sections and primary cultured Kupffer *** addition,five KATP channel subunits colocalized with SE-1 in si

关键词： ATP-sensitive K^+channel Liver Hepatic stellate cells Kupffer cells Sinusoidal endothelial cells Rat

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Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第29期18卷 3883-3888页

作者： Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka Department of Gastroenterology Nagoya University Graduate School of Medicine65 Tsuruma-choShowa-kuNagoya 466-8550Japan Department of Endoscopy Nagoya University Hospital65 Tsuruma-choShowa-kuNagoya 466-8550Japan

AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic *** 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for ***:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent ***-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic *** of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of *** one met level 1 findings of IDCP,but 3 patients met level 2 findings of *** 10 seronegative cases,2 cases were diagnosed with "definitive type 1 AIP",and 3 cases were diagnosed with "probable type 2 AIP" when considering both the level 2 histological findings and response to ***:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases.

关键词： Autoimmune pancreatitis Endoscopic ultrasound-guided fine needle aspiration Idiopathic duct centric pancreatitis Lymphoplasmacytic sclerosing pancreatitis Pancreatic cancer

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Dynamic Contact Problem for Slide Hinge

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Open Journal of Applied Sciences 2012年第4期2卷 82-86页

作者： Kazunori Shinohara ryoji Takaki Takeshi Akita Faculty of Engineering Chiba Institute of Technology Chiba Japan Institute of Space and Astronautical Science (ISAS) Japan Aerospace Exploration Agency (JAXA) Sagamihara Japan JAXA's Engineering Digital Innovation Center (JEDI) Japan Aerospace Exploration Agency (JAXA) Sagamihara Japan

Contact analysis can be either static or dynamic. In static contact analysis, the position on the contact surface is constant. In dynamic contact analysis, the position on the contact surface changes at every time step. In static contact analysis, the computing results (stress, strain, etc.) of contact states have been verified through the Hertz contact problem in literature. On the other hand, there has been insufficient research into dynamic contact analysis. The contact algorithm is insufficiently constructed in finite element model (FEM) discretization. The gap between two objects cannot be calculated accurately. A contact method is demanded for artificial parameters. Inappropriate setting of artificial parameters causes artificial numerical oscillations on the contact surface between objects. To develop a high-reliability satellite, we started the development of FEM contact-friction modeling techniques in this study. A dynamic contact method was realized by using the appropriate parameters required in the contact analysis. We verified the reproducibility of the physical behavior of the contact friction via numerical simulation techniques by using a computational model of the hinge joints.

关键词： FEM Contact Friction Stress Joints Structural Analysis Advance/FrontSTR Dynamic Contact Analysis Static Contact Analysis

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Lightning Induced Surge on the Distribution Lines in the House near by the Lightning Point

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Journal of Energy and Power Engineering 2012年第5期6卷 840-844页

作者： Aiko Takahara ryoji Oshiro Eiji Kaneko Graduate School of Electrical and Electronic Engineering University of the Ryukyus Okinawa 903-0213 Japan Toshiba Corporation Hamakawasaki Works Kawasaki 210-0862 Japan

Recently, a lightning surge is recognized as one of the biggest risks to the society. If the surges induced by lightning invade into low voltage distribution lines, there might be a possibility of giving some severe damages to the systems. Therefore, it is necessary to examine these induced phenomena. FDTD （finite difference time domain） method which treats objects as three-dimensional solid circuits is applied to analyze these induced phenomena. VSTL （Virtual Surge Test Lab.） is the surge analysis simulation program using FDTD method. In this paper, the lightning induced phenomena on the low voltage distribution line in the house are analyzed by using VSTL. In this paper, investigation results about induced surge when a lightning struck the point nearby the house, and about a suppressing effect of surges by comparing the results of analysis with and without SPD （surge protective device） are shown. As a result, it is confirmed that SPD is effective for suppressing lightning surge.

关键词： Lightning surge induced phenomena FDTD method distribution line VSTL.

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Intramedullary Spinal Cord Metastases in Breast Cancer: Report a Case

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Journal of Cancer Therapy 2016年第13期7卷 1034-1038页

作者： Masahiro kitada Nana Takahashi Shunsuke Yasuda Satoshi Okazaki Kei Ishibashi Satoshi Hayashi Department of Breast Disease Center Asahikawa Medical University Asahikawa Japan

Background: Intramedullary spinal cord metastasis (ISCM) from breast cancer is a relatively rare disease. We present this disease. Case presentation: The patient was a 67-year-old woman with lung metastasis appearing 3 years after breast cancer surgery. Complete remission was achieved for the metastatic lesion with chemotherapy, but multiple cerebellar metastases were found 3 months after the completion of chemotherapy. Whole-brain irradiation was administered, resulting in symptomatic improvement. Approximately 6 months later, the patient experienced weakness in the lower extremities and difficulty walking. Magnetic resonance imaging detected a well-defined intraspinal tumor measuring 13 × 13 × 30 mm at the level of Th12-L1. After 20-Gy irradiation to the tumor, oral steroid administration, and rehabilitation, the patient regained the ability to walk. Eight months have passed, to date, since these interventions and the patient is currently receiving treatment for metastases to bones, including the spine, but is still capable of walking without difficulty. We herein report this case with a review of the relevant literature. Conclusion: ISCM in the breast cancer is relatively rare. But, it is the clinical condition which it should always place in the mind.

关键词： Breast Cancer Intramedullary Spinal Cord Metastasis (Iscm) Brain Metastasis

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Clinicopathological Study of Epithelial Metaplastic Breast Cancer

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Journal of Cancer Therapy 2016年第13期7卷 1039-1044页

作者： Masahiro kitada Shunsuke Yasuda Nana Takahashi Satoshi Okazaki Kei Ishibashi Satoshi Hayashi Department of Breast Disease Center Asahikawa Medical University Asahikawa Japan

Introduction: Metaplastic breast cancer (MBC) is a rare pathological type with an incidence rate of not more than 1%, and has been reported to be often detected after its progression and highly malignant with a high proportion of triple negative type tumors, with poor outcomes as compared to IDC [1] [2] [3]. We analyzed clinicopathological characteristics of patients who underwent surgery for epithelial MBC at our department. Patients and Methods: From January 2000 to March 2014, a total of 2120 patients underwent surgery for breast cancer, and MBC was diagnosed in 15 of these patients. Fourteen of the 15 had epithelial MBC and were included in this study. The present study compared clinopathological characteristics of MBC with those of IDC of triple negative type (TN type group) and IDC of non-triple negative type (IDC group). Results: Breast conserving surgery was performed in 7 patients with MBC (50%), a proportion clearly lower than the 64.3% in the IDC group. The mean tumor size was 3.8 cm, which was greater than the 2.13 cm in the TN type group and the 1.7 cm in the IDC group. About nuclear grade, the proportion of grade III was 57.1%, markedly higher than the 38.6% in the TN type group and the 12.6% in the IDC group. All patients were estrogen receptor (ER) and progesterone receptor (PgR) negative;11 patients were TN type tumors and 3 were HER2 type. Conclusion: We studied patients who underwent surgery for epithelial MBC. The examined cases showed clinopathological characteristics of the disease, including large tumors with a highly malignant nature at the initial detection, higher Ki-67 levels, ER and PgR negativity (all cases), mostly TN type, and a high recurrence rate.

关键词： Breast Cancer Metaplastic Breast Cancer Triple Negative Type Epithelial-Mesenchymal Transition

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HER2 Type Male Breast Cancer Successfully Treated with Pertuzumab, Trastuzumab, and Eribulin Therapy: A Case Report

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Journal of Cancer Therapy 2020年第3期11卷 154-159页

作者： Masahiro kitada Shunsuke Yasuda Masahiro Abe Nana Yoshida Satoshi Okazaki Kei Ishibashi Department of Breast Disease Center Asahikawa Medical University Asahikawa Japan

Background:?Male breast cancer is rare, accounting for approximately 0.5% - 1.0% of all breast cancer cases;hormone-dependent luminal type male breast cancer is the most common. The proportion of hormone receptor-negative and human epithelial growth factor Receptor type 2-positive breast cancer is?extremely low among male breast cancer.?A patient with advanced HER2 type breast cancer, a rare male breast cancer, was successfully treated with pertuzumab, trastuzumab, and eribulin therapy. Case Presentation:?A 75-?year-old man presented to our hospital with induration of the right anterior chest and lymphoedema of the right upper limb. Based on the results of core needle biopsy, he was diagnosed with HER2 type invasive ductal carcinoma associated with bone metastasis (stage IV). Chemotherapy with pertuzumab, trastuzumab, and eribulin was started. The drugs were remarkably effective, and his lymphoedema tended to improve.?Conclusion:?We reported a successful case of chemotherapy and targeted therapy for a rare male breast cancer of HER2 positive and hormone negative type.

关键词： Male Breast Cancer HER2 Type

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Improvement of Water and Wastewater Treatment Process Using Various Sound Waves—A Consideration from the Viewpoint of Frequency

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Journal of Water Resource and Protection 2014年第15期6卷 1464-1474页

作者： Akira Hiratsuka Yugo Tomonaga Yoshiro Yasuda ryoji Tsujino Department of Civil Engineering Osaka Sangyo University Osaka Japan National Museum of Ethnology Osaka Japan University of Hyogo Kobe Japan SetsunanUniversity Osaka Japan

Application of sound waves is one of the novel techniques for the improvement of water treatment process. In this study, various sound waves such as 1) ultrasonic wave, 2) music box, and 3) windbell were irradiated to water and wastewater for removing contaminants such as nitrate, phosphorus and BOD/COD. As a result, a possibility of improvement of water and wastewater treatment process using sound waves with various frequencies was proposed.

关键词： Sound Waves (Frequency) Total Hardness (Ca2+ Mg2+) Nitrogen (N) Phosphorus (P) Water Treatment

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<i>In-Situ</i>Measurements of the Photoconductivity of Multi-Layered Organic Photovoltaic Devices Using Impedance Spectroscopy

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Advances in Materials Physics and Chemistry 2015年第2期5卷 47-52页

作者： ryoji Maeda Hiroshi Tokairin Jun-Ichi Takahashi Yuji Yoshida Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Yokohama Japan Advanced Technology Research Laboratories Idemitsu Kosan Co. Ltd. Sodegaura Japan Research Center for Photovoltaic Technologies AIST Tsukuba Japan

In-situ impedance spectroscopy (IS) observations of the photoconductivity of the carriers induced by photo-irradiation in organic hetero-junction structured photovoltaic devices are presented. In the IS measurements, the externally applied voltage and the dependence of the light intensity applied to the device were investigated. Analysis of the frequency characteristics which was measured by changing the light intensity shows there is a proportional relationship between the changes in the conductivities of the two components. The mobilities of the CuPc and C60 layers were calculated from the conductivities and were in the orders of 10﹣4 and 10﹣3 cm2/Vs, respectively.

关键词： Organic Photovoltaic Cells Impedance Spectroscopy Modulus Analysis Photoconductivity

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Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux

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World Journal of Gastroenterology 2013年第31期19卷 5118-5124页

作者： ryoji Tokashiki Isaku Okamoto Nobutoshi Funato Mamoru Suzuki Department of Otolaryngology Tokyo Medical University Tokyo 160-0023 Japan

AIM: To investigate the effect of rikkunshito on laryngopharyngeal reflux(LPR) symptoms and gastric emptying in patients with proton-pump inhibitor(PPI)refractory ***: In total,22 patients with LPR were *** a 2-wk treatment with PPI monotherapy,PPI-refractory LPR patients were randomly divided into two treatment groups(rikkunshito alone or rikkunshito plus the PPI,lansoprazole).LPR symptoms were assessed using a visual analog scale(VAS) score,gastrointestinal symptoms were assessed using the gastrointestinal symptom rating scale(GSRS),and gastric emptying was assessed using the radio-opaque marker method prior to and 4 wk following ***: The 4-wk treatment with rikkunshito alone and with rikkunshito plus the PPI significantly decreased the globus sensation VAS *** VAS score for sore throat was significantly decreased following treatment with rikkunshito plus PPI but not by rik kunshito *** treatment significantly changed the GSRS *** improved delayed gastric *** found a significant positive correlation between improvements in globus sensation and in gastric emptying(r2= 0.4582,P < 0.05).CONCLUSION: Rikkunshito improved globus sensation in patients with PPI-refractory LPR,in part,because of stimulation of gastric ***,rikkunshito is an effective treatment for PPI-refractory LPR.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux disease Globus sensation Gastric emptying Rikkunshito

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