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Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature

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Open Journal of Obstetrics and Gynecology 2014年第10期4卷 617-620页

作者： Motoki Matsuura Masato Tamate Masahiro Suzuki Tasuku Mariya Sakura Takada Yuta Tabuchi Mizue Teramoto Seiro Satohisa ryoichi tanaka Masahiro Iwasaki Kaori Fukunaka Noriyoshi Fukunaka Satoshi tanaka Tsuyoshi Saito Department of Obstetrics and Gynecology Hakodate Goryoukaku Hospital Hakodate Japan Department of Obstetrics and Gynecology Sapporo Medical University Sapporo Japan

Primary adenocarcinomas of the uterine cervix account for 5% - 15% of all cervical malignancies, but secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases have been reported in the literature since 1941. We report a 52-year-old Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage Ib2) two years later. A radical hysterectomy was performed and the surgical specimen showed metastatic adenocarcinoma of the uterine cervix from rectal cancer without direct extension. Immunohistochemical staining was positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical staining is important for distinguishing between primary and secondary adenocarcinomas of the cervix, but histologic findings alone are not always adequate to establish the site of the primary lesion. The distinction between primary and secondary adenocarcinomas of the cervix is important for patient management and prognosis. Therefore, the possibility of metastatic adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of the cervix is received.

关键词： Metastatic Adenocarcinoma Cervical Cancer Colorectal Carcinoma

Antithrombin Ⅲ injection via the portal vein suppresses liver damage

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World Journal of Gastroenterology 2012年第16期18卷 1884-1891页

作者： Masayuki Miyazaki Masaki Kato Masatake tanaka Kosuke tanaka Shinichiro Takao Motoyuki Kohjima Tetsuhide Ito Munechika Enjoji Makoto Nakamuta Kazuhiro Kotoh ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-0065Japan Department of Clinical Pharmacology Faculty of Pharmaceutical SciencesFukuoka UniversityFukuoka 814-0180Japan

AIM:To investigate the effects of antithrombin Ⅲ(AT Ⅲ) injection via the portal vein in acute liver ***:Thirty rats were intraperitoneally challenged with lipopolysaccharide(LPS) and D-galactosamine(GalN) and divided into three groups:a control group;a group injected with AT Ⅲ via the tail vein;and a group injected with AT Ⅲ via the portal *** Ⅲ(50 U/kg body weight) was administrated 1 h after challenge with LPS and *** levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were ***:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control *** vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin *** treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme ***:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities.

关键词： Antithrombin Ⅲ Acute liver failure Intravascular coagulation Portal vein

Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia

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World Journal of Gastroenterology 2011年第44期17卷 4928-4931页

作者： Masayuki Miyazaki Masatake tanaka Akihiro Ueda Tsuyoshi Yoshimoto Masaki Kato Makoto Nakamuta Kazuhiro Kotoh ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical ScienceKyushu University Department of Gastroenterology Kyushu Medical CenterNational Hospital Organization

Drug-induced hypersensitivity syndrome(DIHS) is a severe reaction usually characterized by fever,rash,and multiorgan failure,occurring 2-6 wk after drug *** is an immune-mediated reaction involving macrophage and T-lymphocyte activation and cytokine release.A 54-year-old woman was diagnosed with rheumatic arthritis and initiated salazosulfapyridine by *** 10 d later,she had a high fever,skin rash and liver *** was admitted to hospital and diagnosed with a drug *** was treated with oral prednisolone 30 mg/d;however,she developed high fever again and her blood tests showed acute liver failure and cytopenia associated with *** was diagnosed with acute liver failure and hemophagocytosis caused by *** was transferred to the Department of Medicine and Bioregulatory Science,Kyushu University,where she was treated with arterial steroid injection *** this treatment,her liver function improved and serum ferritin immediately *** hypothesized that an immune-mediated reaction in DIHS may have generated over-activation of macrophages and T-lymphocytes,followed by a cytokine storm that affected various *** measurement of serum ferritin might be a useful marker of the severity of DIHS.

关键词： Acute liver failure Drug-induced hypersensitivity syndrome Ferritin Human herpes virus 6 Macrophage

Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

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World Journal of Gastroenterology 2014年第10期20卷 2653-2663页

作者： Kosuke tanaka Yuko Masaki Masatake tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta Masaki Kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan Department of Clinical Pharmacology Faculty of Pharmaceutical Science Fukuoka University Fukuoka 814-0180 Japan Department of Gastroenterology Kyushu Medical Center National Hospital Organization Fukuoka 810-8563 Japan Innovation Center for Medical Redox Navigation Kyushu University Fukuoka 812-8582 Japan

AIM: To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease (NAFLD).

关键词： Adipose tissue Energy expenditure Exenatide Glucagon-like peptide-1 Hepatic steatosis Lipolysis Nonalcoholic fatty liver disease

Phase Ⅱ trial of carboplatin/docetaxel in patients with resected NSCLC

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World Journal of Respirology 2014年第1期4卷 1-7页

作者： Hidetaka Uramoto ryoichi Nakanishi Akihiko Uchiyama Masaaki Inoue Masakazu Sugaya Teruo Iwata Noriyuki Ebi Takeshi Hanagiri Fumihiro tanaka Second Department of Surgery School of Medicine University of Occupational and Environmental Health Kitakyushu 807-8555 Japan Department of Thoracic Surgery Shin-Kokura Hospital Federation of National Public Service Personnel Mutual Aid Associations Kokurakita-ku Kitakyushu 803-0816 Japan Department of Surgery Kyushu Kouseinenkin Hospital Kitakyushu 806-8501 Japan Department of Chest Surgery Shimonoseki City Hospital Shimonoseki 750-8520 Japan Department of Chest Surgery Chubu Rosai Hospital Nagoya 455-0018 Japan Department of Thoracic Surgery Niigata Rousai Hospital Niigata 942-0071 Japan Department of Respiratory Medicine Iizuka Hospital Iizuka 820-8505 Japan

AIM: To investigate the development of a safer chemotherapeutic regimen with better compliance, a total of 67 patients were enrolled as a single arm in a twostage multi-center phase Ⅱ ***: The patients received chemotherapy with carboplatin(CBDCA) with an area under the curve(AUC) of 5, and docetaxel(DTX) at 60 mg/m2 tri-weekly for three cycles after surgery. The primary endpoint of this study was compliance, while the secondary endpoints were the adverse events(AE) and recurrencefree survival(RFS).RESULTS: Sixty-one patients were treated in this study arm. The patients were 43 males and 18 females, with a median age of 64.6 years. Fifty-one patients(83.6%)completed all three cycles of therapy. The presence of Grade 3 and 4 neutropenia was noted in 25% and 66%of the patients, respectively. The non-hematological AE were less frequently reported, and no treatmentrelated death was registered. The two-year RFS and OS rates of the 61 patients were 69.8% and 88.3%,***: A tri-weekly schedule of CBDCA and DTX as adjuvant chemotherapy showed a favorable feasibility.

关键词： Non-small cell lung cancer Adjuvant chemotherapy Carboplatin Docetaxel Treatment compliance Surgical resection

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神经源性骨盆脏器综合征537例分析

中华胃肠外科杂志 2010年第12期13卷 921-923页

作者：高野正博緒方俊二野崎良一久野三朗佐伯泰愼福永光子高野正太田中正文眞方紳一郎中村寧坂田玄太郎山田一隆高野医院大肠肛门病中心日本雄本8620924

目的总结神经源性骨盆脏器综合征的症状并推测其可能的发生机制.方法对2001-2005年日本高野医院大肠肛门病中心收治的537例神经源性骨盆脏器综合征的临床资料进行回顾性分析.结果本组患者男205例,女332例,平均年龄58.5岁.单一症状者8... 详细信息

目的总结神经源性骨盆脏器综合征的症状并推测其可能的发生机制.方法对2001-2005年日本高野医院大肠肛门病中心收治的537例神经源性骨盆脏器综合征的临床资料进行回顾性分析.结果本组患者男205例,女332例,平均年龄58.5岁.单一症状者80例（14.9%）,以肛门直肠痛最为常见（43.8%,35/80）;两个症状者156例（29.1%）,以肛门直肠痛加排粪障碍最为多见（26.3%,41/156）;3个症状者144例（26.8%）,以肛门直肠痛、排粪障碍加腹部症状多见（30.0%,43/144）;4个症状者105例（19.6%）,以肛门直肠痛、肛门失禁、腹部症状加腰椎症状多见（65.7%,69/105）;5个症状者52例（9.7%）.各症状出现频率分别为肛门直肠痛73.6%、肛门失禁27.9%、排粪障碍69.6%、腹部症状55.3%和腰椎症状53.6%.结论神经源性骨盆脏器综合征的症状复杂多样,其发生很可能与骶骨神经和骨盆内脏神经同时发生障碍有关.

关键词：神经源性骨盆脏器综合征症状肛门疼痛