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Awake thoracoscopic surgery under epidural anesthesia: is it really safe?

Chinese Journal of Cancer Research 2014年第4期26卷 368-370页

作者： ryoichi nakanishi Manabu Yasuda Department of Thoracic Surgery Shin-Kokura Hospital Federation of National Public Service Personnel Mutual Aid Associations

Thoracoscopic surgeries usually require single-lung ventilation under general anesthesia because of the need to obtain a sufficient working *** patients with impaired pulmonary function,if the patient can undergo general anesthesia,a more selected collapse of the lung is considered to be beneficial for intraoperative *** selective bronchial blockade of the lobe to be resected has been reported by several investigators （1-3）.Mukaida and coworkers first reported thoracoscopic surgery for pnenmothorax under local and epidural anesthesia in 1998 in high-risk patients contraindicated for general anesthesia （4）.

关键词： is it really safe lung Awake thoracoscopic surgery under epidural anesthesia

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Phase Ⅱ trial of carboplatin/docetaxel in patients with resected NSCLC

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World Journal of Respirology 2014年第1期4卷 1-7页

作者： Hidetaka Uramoto ryoichi nakanishi Akihiko Uchiyama Masaaki Inoue Masakazu Sugaya Teruo Iwata Noriyuki Ebi Takeshi Hanagiri Fumihiro Tanaka Second Department of Surgery School of Medicine University of Occupational and Environmental Health Kitakyushu 807-8555 Japan Department of Thoracic Surgery Shin-Kokura Hospital Federation of National Public Service Personnel Mutual Aid Associations Kokurakita-ku Kitakyushu 803-0816 Japan Department of Surgery Kyushu Kouseinenkin Hospital Kitakyushu 806-8501 Japan Department of Chest Surgery Shimonoseki City Hospital Shimonoseki 750-8520 Japan Department of Chest Surgery Chubu Rosai Hospital Nagoya 455-0018 Japan Department of Thoracic Surgery Niigata Rousai Hospital Niigata 942-0071 Japan Department of Respiratory Medicine Iizuka Hospital Iizuka 820-8505 Japan

AIM: To investigate the development of a safer chemotherapeutic regimen with better compliance, a total of 67 patients were enrolled as a single arm in a twostage multi-center phase Ⅱ ***: The patients received chemotherapy with carboplatin(CBDCA) with an area under the curve(AUC) of 5, and docetaxel(DTX) at 60 mg/m2 tri-weekly for three cycles after surgery. The primary endpoint of this study was compliance, while the secondary endpoints were the adverse events(AE) and recurrencefree survival(RFS).RESULTS: Sixty-one patients were treated in this study arm. The patients were 43 males and 18 females, with a median age of 64.6 years. Fifty-one patients(83.6%)completed all three cycles of therapy. The presence of Grade 3 and 4 neutropenia was noted in 25% and 66%of the patients, respectively. The non-hematological AE were less frequently reported, and no treatmentrelated death was registered. The two-year RFS and OS rates of the 61 patients were 69.8% and 88.3%,***: A tri-weekly schedule of CBDCA and DTX as adjuvant chemotherapy showed a favorable feasibility.

关键词： Non-small cell lung cancer Adjuvant chemotherapy Carboplatin Docetaxel Treatment compliance Surgical resection

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