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Phase 1/2 study of concurrent chemoradiotherapy with weekly irinotecan hydrochloride for advanced/recurrence uterine cancer:A multi-institutional study of Kansai Clinical Oncology Group

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Chinese Journal of Cancer Research 2020年第2期32卷 218-227页

作者： Satoshi Takeuchi Haruo Kuroboshi Taisuke Mori Kimihiko Ito Eiji Kondo Tsutomu Tabata Yoshio Itani Ryuji Kawaguchi Kyosuke Takeuchi Toshinori Soejima ryohei sasaki Department of Obstetrics and Gynecology National Hospital Organization Kobe Medical CenterKobe 6540155Japan Division of Gynecologic Oncology Department of GynecologyWomen Health CareKobe Tokushukai HospitalKobe 6500017Japan Department of Obstetrics and Gynecology Kyoto Prefectural University of MedicineKyoto 6028566Japan Department of Obstetrics and Gynecology Kansai Rosai HospitalAmagasaki 6608511Japan Department of Obstetrics and Gynecology Mie University Graduate Medical School Faculty of MedicineTsu5148507Japan Department of Obstetrics and Gynecology Tokyo Women’s Medical UniversityTokyo 1628666Japan Department of Obstetrics and Gynecology Nara Prefectural Nara Hospital(Nara Prefectural General Medical Center)Nara 6308581Japan Department of Palliative Care Palliative Care Center of Yao-city HospitalOsaka 5810069Japan Department of Obstetrics and Gynecology Nara Medical UniversityNara 6348521Japan I0Department of Radiation Oncology Kobe University Graduate School of MedicineKobe 6500017Japan departm ent of Radiation Oncology Hyogo Ion Beam Medical Center Kobe Proton CenterKobe 6500047Japan

Objective:Concurrent chemoradiotherapy using cisplatin was thought to be standard treatment for squamous cell carcinoma of cervix,but it had not been effective for *** chemoradiotherapy using irinotecan hydrochloride(CPT-11)had been effective for colorectal cancer,thus,we chose CPT-11 as a candidate for gynecologic *** evaluate the maximum tolerated dose(MTD)of weekly CPT-11 with external pelvic radiotherapy,a phase 1/2 study was conducted according to modified Fibonacci ***:Eligible patients were advanced uterine cancer with measurable diseases[performance score(PS):0-2].Study period was from August 1 st,2002 to December 31 st,*** starting dose level(DL)of CPT-11 was 30 mg/m2(DL1)given weekly for 4 ***,dose escalation was scheduled in 10 mg/m2 increments to 60 mg/m^2(DL4).The fixed radiotherapy consisted of whole pelvic 1.8 Gy/d,once a day in weekday for five weeks and it amounted to 45 Gy(25 fractions)in ***:Seventeen patients were *** for toxicities,one(1/17:5.9%)grade(G)4 neutropenia lasting 7 days had been seen in DL4.G2 diarrhea was identified in 35.3%(6/17)of the patients,and 11.8%(2/17)G3 diarrhea was observed in DL3 and ***,the MTD of CPT-11 was defined as dose of 60 mg/m^*** recommended dose was decided as 50 mg/m^*** response rate was 88.2%[9 complete response(CR),3 partial response(PR),3 stable disease(SD),2 not evaluable(NE)].Disease control rate at 1 month after treatment completion was 100%but distant metastases were found in 24%(4/17)in longer ***:MTD was 60 mg/m^2 and recommended dose was set as 50 mg/*** concurrent chemoradiation using weekly CPT-11 was feasible at 50 mg/m^2,and it might be effective even in adenocarcinoma of the uterus.

关键词： Concurrent chemoradiotherapy(CCRT) irinotecan hydrochloride(CPT-11) cervical adenocarcinoma endometrial cancer

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Local advanced rectal cancer perforation in the midst of preoperative chemoradiotherapy:A case report and literature review

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World Journal of Clinical Cases 2017年第1期5卷 18-23页

作者： Nobuhisa Takase Kimihiro Yamashita Yasuo Sumi Hiroshi Hasegawa Masashi Yamamoto Shingo Kanaji Yoshiko Matsuda Takeru Matsuda Taro Oshikiri Tetsu Nakamura Satoshi Suzuki Yu-Ichiro Koma Masato Komatsu ryohei sasaki Yoshihiro Kakeji Division of Gastrointestinal Surgery Department of Surgery Kobe University Graduate School of Medicine Division of Pathology Department of Pathology Kobe University Graduate School of Medicine Division of Diagnostic Pathology Department of Pathology Kobe University Graduate School of Medicine Department of Surgery Hyogo Cancer Center Department of Radiation Oncology Kobe University Graduate School of Medicine

Standard chemoradiotherapy(CRT) for local advanced rectal cancer(LARC) rarely induce rectal perforation. Here we report a rare case of rectal perforation in a patient with LARC in the midst of preoperative CRT. A 56-year-old male was conveyed to our hospital exhibiting general malaise. Colonoscopy and imaging tests resulted in a clinical diagnosis of LARC with direct invasion to adjacent organs and regional lymphadenopathy. Preoperative 5-fluorouracil-based CRT was started. At 25 d after the start of CRT, the patient developed a typical fever. Computed tomography revealed rectal perforation, and he underwent emergency sigmoid colostomy. At 12 d after the surgery, the remaining CRT was completed according to the original plan. The histopathological findings after radical operation revealed a wide field of tumor necrosis and fibrosis without lymph node metastasis. We share this case as important evidence for the treatment of LARC perforation in the midst of preoperative CRT.

关键词： Local advanced rectal cancer Preoperative chemoradiotherapy Rectal perforation 5-fluorouracil Tumor necrosis

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Combination of genistein with ionizing radiation on andro-gen-independent prostate cancer cells

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Asian Journal of Andrology 2004年第4期6卷 285-290页

作者： Sen-XiangYan YasuoEjima ryoheisasaki Shu-SenZheng YusukeDemizu ToshinoriSoejima KazuroSugimura DepartmentofRadiology FirstAffiliatedHospitalCollegeofmedicineZhejiangUniversityHangzhou310003China DivisionofRadiology KobeGraduateSchoolofMedicineHyogo6500017Japan

Aim: To study the effect of the combined use of genistein and ionizing radiation (IR) on prostate DU145 cancer cells. Methods: DU145, an androgen-independent human prostate cancer cell line, was used in the experiment. Clonogenic assay was used to compare the survival of DU145 cells after treatments with genistein alone and in combination with graded IR. Apoptosis was assayed by DNA ladder and TUNEL stain. Cell cycle alterations were observed by flow cytometry and related protein expressions by immunoblotting. Results: Clonogenic assay demonstrated that genistein, even at low to medium concentrations, enhanced the radiosensitivity of DU145 cells. Twenty-four hours after treatment with IR and/or genistein, apoptosis was mainly seen with genistein at high concentrations and was minimally related to IR. At 72 h, apoptosis also occurred in treatment with lower concentration of genistein, especially when combined with IR. While both IR and genistein led to G2/M cell cycle arrest, combination of them further increased the DU145 cells at G2/M phase. This Gz/M arrest was largely maintained at 72 h, accompanied by increasing apoptosis and hyperdiploid cell population. Cell-cycle related protein analysis disclosed biphasic changes in cyclin B1 and less dramatically cdc-2, but stably elevated p21cipl levels with increasing genistein concentrations. Conclusion: Genistein enhanced the radiosensitivity of DU145 prostate cancer cells. The mechanisms might be involved in the increased apoptosis, prolonged cell cycle arrest and impaired damage repair.

关键词： prostate cancer genistein ionizing radiation (IR) apoptosis cell cycle

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Acute Hepatic Phenotype of Wilson Disease: Clinical Features of Acute Episodes and Chronic Lesions Remaining in Survivors

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Journal of Clinical and Translational Hepatology 2015年第4期3卷 239-245页

作者： Hisao Hayashi Yasuaki Tatsumi Shinsuke Yahata Hiroki Havashi Kenji Nomose ryohei Isaji Youji sasaki Department of Medicine Aichi-Gakuin University School of PharmacyNagoyaJapan Department of Gastroenterology Hyogo Prefectural Kakogawa Medical CenterKakogawaJapan Department of Gastroenterology Kita-Harima Medical CenterOnoJapan Department of Gastroenterology Kobe University School of MedicineKobeJapan Department of Gastroenterology Konan Kosei HospitalKonanJapan

Background and Aims:Wilson disease(WD)is an inherited disorder of copper metabolism,and an international group for the study of WD(IGSW)has proposed three phenotypes for its initial presentation:acute hepatic,chronic hepatic,and neurologic *** of the acute hepatic phenotype may improve our understanding of the ***:Clinical features of 10 WD patients with the acute hepatic phenotype and characteristics of chronic lesions remaining in survivors were assessed by the European Association for the Study of the Liver(EASL)***:All six patients younger than 30 years had survived an acute episode of hemolytic anemia with residual liver disease of cirrhosis or chronic *** acute episode was self-limiting in two of the four patients over the age of 30 years and progressed to acute liver failure in the other two *** of the two survivors had residual liver disease of chronic hepatitis,while the other had chronic hepatitis and neurologic *** disease remained in a patient who successfully received a liver *** acute episodes,serum levels of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)changed rapidly along with ***-specific ALT levels were age-dependently correlated with hemoglobin(Hb)*** reduction was milder for AST than ALT which resulted in a high AST/ALT ratio in the anemic *** anemic stage in two patients transformed to acute liver ***:All survivors of an acute episode of the acute hepatic phenotype had residual liver disease or both liver and neurologic *** rapid changes in liver enzymes during the acute episode and the liver and neurologic diseases remaining in survivors may provide a better understanding of WD.

关键词： Aminotransferase Neurologic disease Liver disease Hemoglobin

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Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： Shinji KATO Shinya sasaki Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

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HYPERGAMES AND BAYESIAN GAMES:A THEORETICAL COMPARISON OF THE MODELS OF GAMES WITH INCOMPLETE INFORMATION

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Journal of Systems Science & Complexity 2012年第4期25卷 720-735页

作者： Yasuo sasaki Kyoichi KIJIMA Graduate School of Decision Science and Technology Tokyo Institute of Technology

The present study discusses the relationships between two independently developed models of games with incomplete information, hypergames （Bennett, 1977） and Bayesian games （Harsanyi, 1967）. The authors first show that any hypergame can naturally be reformulated in terms of Bayesian games in an unified way. The transformation procedure is called Bayesian representation of hypergame. The authors then prove that some equilibrium concepts defined for hypergames are in a sense equivalent to those for Bayesian games. Furthermore, the authors discuss carefully based on the proposed analysis how each model should be used according to the analyzer＇s purpose.

关键词： Bayesian game Bayesian representations of hypergame hypergame incomplete information."

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Hierarchical Hypergames and Bayesian Games:A Generalization of the Theoretical Comparison of Hypergames and Bayesian Games Considering Hierarchy of Perceptions

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Journal of Systems Science & Complexity 2016年第1期29卷 187-201页

作者： sasaki Yasuo KIJIMA Kyoichi School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1AsahidaiNomiIshikawaJapan Department of Value and Decision Science Tokyo Institute of Technology 2-12-1OokayamaMeguro-kuTokyoJapan

This paper discusses the relationship of two independently developed models of games with incomplete information,hierarchical hypergames and Bayesian *** can be considered as a generalization of the previous study on the theoretical comparison of simple hypergames and Bayesian games(sasaki and Kijima,2012) by taking into account hierarchy of perceptions,i.e.,an agent's perception about the other agents' perceptions,and so *** authors first introduce the general way of transformation of any hierarchical hypergames into corresponding Bayesian games,which was called as the Bayesian representation of hierarchical *** authors then show that some equilibrium concepts for hierarchical hypergames can be associated with those for Bayesian games and discuss implications of the results.

关键词： Bayesian games game theory hierarchy of perceptions hypergames incomplete information

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Population synthesis of planet formation using a torque formula with dynamic effects

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Geoscience Frontiers 2017年第2期8卷 215-222页

作者： Takanori sasaki Toshikazu Ebisuzaki Department of Astronomy Kyoto University RIKEN

Population synthesis studies into planet formation have suggested that distributions consistent with observations can only be reproduced if the actual Type Ⅰ migration timescale is at least an order of magnitude longer than that deduced from linear *** past studies considered the effect of the Type I migration of protoplanetary embryos,in most cases they used a conventional formula based on static torques in isothermal disks,and employed a reduction factor to account for uncertainty in the mechanism ***,in addition to static torques,a migrating planet experiences dynamic torques that are proportional to the migration *** dynamic torques can impact on planet migration and predicted planetary *** this study,we derived a new torque formula for Type Ⅰ migration by taking into account dynamic *** formula was used to perform population synthesis simulations with and without the effect of dynamic *** many cases,inward migration was slowed significantly by the dynamic *** the static torque case,gas giant formation was effectively suppressed by Type I migration;however,when dynamic effects were considered,a substantial fraction of cores survived and grew into gas giants.

关键词： Planetary formation Population synthesis Type Ⅰ migration

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Highly active and stable supported Pd catalysts on ionic liquidfunctionalized SBA-15 for Suzuki–Miyaura cross-coupling and transfer hydrogenation reactions

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Green Energy & Environment 2019年第2期4卷 180-189页

作者： Etty N.Kusumawati Takehiko sasaki Department of Chemistry Graduate School of Science The University of Tokyo Institute for Catalysis Hokkaido University Department of Complexity Science and Engineering Graduate School of Frontier Sciences The University of Tokyo

Highly dispersed palladium nanoparticles were synthesized in the presence of immobilized ionic liquid on mesoporous silica ***(2.4 nm)_me-Im@SBA-15 catalyst was prepared by the reduction using NaBH_4 as the reducing agent with controlled feed rate and has been investigated as ligand-free catalyst for Suzuki–Miyaura cross-coupling reaction at room temperature in aqueous solution under *** catalyst was also prepared in situ from PdCl4_me-Im@SBA-15 during the reaction and demonstrated high activity and stability towards nitrobenzene hydrogenation at high temperature. Both catalysts were reusable at least for four recycle processes without significant loss in activity with simple procedure. The catalysts were characterized by TEM, EXAFS, FTIR and XPS.

关键词： Palladium nanoparticle Ionic liquid SBA-15 Suzuki–Miyaura cross-coupling Hydrogenation

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Reconstruction of Chest Wall after Extensive Chest Wall Necrosis Caused by Transcatheter Arterial Embolization of Bilateral Internal Mammary Arteries Injured by Cardiopulmonary Resuscitation—A Case Report

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Modern Plastic Surgery 2019年第2期9卷 33-43页

作者： Ayako Kamitomo Minoru Hayashi ryohei Tokunaka Yuki Yoshida Sayo Tatsuta Yoshie sasaki Department of Plastic Reconstructive and Aesthetic Surgery Japan Red Cross Maebashi Hospital Maebashi-shi Japan

Transcatheter Arterial Embolization (TAE) is known to be effective for controlling severe hemorrhage caused by iatrogenic or blunt trauma. Out of more than 100 cases of TAE performed in our hospital, we have treated some cases of skin or muscle necrosis that resulted from embolization of the main arteries. In this study, we report the case of a patient with significant chest wall necrosis after TAE of the bilateral internal mammary arteries (IMAs). A 66-year-old male was transported to our hospital for loss of consciousness while playing golf. Cardiopulmonary resuscitation (CPR) was performed for cardiac arrest, which resulted in several rib fractures and mediastinal hematoma due to bilateral mammary artery injuries. Immediate TAE embolization was performed because of continuous hemorrhage. He was referred to our department 16 days after embolization due to the presentation of chest wall necrosis. Heart, lungs and diaphragm were exposed after surgical debridement under systemic anesthesia. We performed several operations to reconstruct the anterior chest wall. His spontaneous respiration returned, and is now controlled with a tracheostomy tube. Complete epithelialization was achieved, and he was transferred to another hospital for further rehabilitation. To the best of our knowledge, this is the first report of chest wall necrosis resulting from TAE of IMAs. Arterial embolization can cause widespread necrosis of bone, muscle and skin. Although treatment required an extended period, we managed to reconstruct the chest wall with multidisciplinary strategies.

关键词： Transcatheter Arterial Embolization Chest Wall Reconstruction Internal Mammary Arteries Negative Pressure Wound Therapy Cardiopulmonary Resuscitation

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