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Effects of microalgal polyunsaturated fatty acid oil on body weight and lipid accumulation in the liver of C57BL/6 mice fed a high fat diet

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The Journal of Biomedical Research 2016年第3期30卷 234-242页

作者： ryeo-eun go Kyung-A Hwang Geon-Tae Park Hae-Miru Lee Geum-A Lee Cho-Won Kim So-Ye Jeon Jeong-Woo Seo Won-Kyung Hong Kyung-Chul Choi Laboratory of Biochemistry and Immunology College of Veterinary Medicine Chungbuk National University Cheongju Chungbuk ASI/KR/KS001 Republic of Korea Korea Research Institute of Bioscience & Biotechnology Jeongup Jeonbuk ASI/KR/KS004 Republic of Korea LED Agri-bio Fusion Technology Research Center College of Environmental & Bioresource Science Chonbuk National University Iksan Campus Jeonbuk ASI/KR/KS004 Republic of Korea

Dietary polyunsaturated fatty acids （PUFAs）, which are abundant in marine fish oils, have recently received global attention for their prominent anti-obesogenic effects. Among PUFAs, eicosapentaenoic acid （EPA; 20：5n-3） and docosahexaenoic acid （DHA; 22：6n-3）, which are n-3 long-chain PUFAs widely referred to as omega-3 oils, were reported to prevent the development of obesity in rodents and humans. In the present study, we evaluated the anti-obesity effects of microalgal oil on high-fat induced obese C57BL/6 mice, compared with commercial omega-3 fish oil and vegetable corn oil. Microalgal oil is an inherent mixture of several PUFAs, including EPA, DHA and other fatty acids produced from a marine microalgal strain of Thraustochytriidae sp. derived mutant. It was found to contain more PUFAs （〉80%） and more omega-3 oils than commercial omega-3 fish oil （PUFAs 〉31%） and corn oil （PUFAs 59%）. All three types of oils induced weight loss in high-fat-induced obese mice, with the loss induced by microalgal oil being most significant at 9 weeks （10% reduction）. However, the oils tested did not improve blood lipid levels, although microalgal oil showed an apparent inhibitory effect on lipid accumulation in the liver. These findings may be attributed to the higher PUFA content, including omega-3 oils of microalgal oil than other oils. Collectively, these findings suggest that microalgal oil, derived from Thraustochytriidae sp. derived mutant, is a prominent candidate for replacement of omega-3 fish oils based on its apparent anti-obesity effect in vivo.

关键词： anti-obesity polyunsaturated fatty acid saturated fatty acid omega-3 oil microalgae

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Pulmonary artery diameter ratio as a prognostic indicator of congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第1期7卷 20-25页

作者： Yuichiro Miyake Hiroyuki Koga Shuko Nojiri Shunsuke Yamada Takanori Ochi go Miyano Geoffrey J Lane Atsuyuki Yamataka Tadaharu Okazaki Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Department of Medical Technology Innovation Center Juntendo UniversityBunkyo-ku TokyoJapan Department of Pediatric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Background Following on from an earlier study published in 2008 about left pulmonary artery(LPA)flow measured on serial echocardiography being strongly prognostic in left-sided congenital diaphragmatic hernia(CDH)and the ratio of LPA to right pulmonary artery(RPA)diameters being a simple and reliable indicator for commencing nitric oxide(NO)therapy,the ratio of LPA:RPA diameters(PA ratio orPAR)was hypothesized to possibly reflect cardiopulmonary stresses accompanying CDH *** Subjects with isolated left-sided CDH treated between 2007 and 2020 at a single pediatric surgical center were recruited and classified according to *** obtained retrospectively for subject demographics,clinical course,LPA/RPA diameters,and PAR were compared between survivors and *** value of PAR for optimizing the prognostic value of PA diameter data in CDH were analyzed with receiver operating characteristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)and 11 non-survivors(17.7%);7 of 11 non-survivors died before surgical repair could be *** PAR for survivors(0.851±0.152)was significantly higher than for non-survivors(0.672±0.108)(p=0.0003).Mean PAR for non-survivors was not affected by surgical *** of survivors were:LPA≥2 mm(n=52 of 54;mean PAR=0.866±0.146)and RPA≥3mm(n=46 of 54;mean PAR=0.857±0.152).Non-survivors with similar LPA and RPA diameters to survivors had significantly lower mean *** curve cut-off for PAR was *** with high PAR(≥0.762)required high-frequency oscillatory ventilation/NO less than subjects with low PAR(<0.762)(p=0.0244 and p=0.0485,respectively)and subjects with high PAR stabilized significantly earlier than subjects with low PAR(1.71±0.68 days vs 3.20±0.87 days)(p<0.0001).Conclusions PAR would appear to be strongly correlated with clinical outcome in CDH and be useful for planning management of cardiopulmonary instability in CDH.

关键词： hernia congenital diameters

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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

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Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu Congnuan Liu Song Hao Lee Lewis Sze Chun Choi Michael T.Wilson Dirk U.Pfeiffer Yun Young go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina Center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina College of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Mid-infrared computational temporal ghost imaging

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Light(Science & Applications) 2024年第6期13卷 1088-1097页

作者： Han Wu Bo Hu Lu Chen Fei Peng Zinan Wang goery Genty Houkun Liang College of Electronics and Information Engineering Sichuan UniversityChengduSichuan610064China College of Electrical Engineering Sichuan UniversityChengduSichuan610064China Key Lab of Optical Fiber Sensing&Communications University of Electronic Science&Technology of ChinaChengduSichuan611731China Laboratory of Photonics Tampere UniversityFI-33014TampereFinland

Ghost imaging in the time domain allows for reconstructing fast temporal objects using a slow *** technique involves correlating random or pre-programmed probing temporal intensity patterns with the integrated signal measured after modulation by the temporal ***,the implementation of temporal ghost imaging necessitates ultrafast detectors or modulators for measuring or pre-programming the probing intensity patterns,which are not available in all spectral regions especially in the mid-infrared ***,we demonstrate a frequency downconversion temporal ghost imaging scheme that enables to extend the operation regime to arbitrary wavelengths regions where fast modulators and detectors are not *** approach modulates a signal with temporal intensity patterns in the near-infrared and transfers the patterns to an idler via difference-frequency generation in a nonlinear crystal at a wavelength where the temporal object can be *** a proof-of-concept,we demonstrate computational temporal ghost imaging in the mid-infrared with operating wavelength that can be tuned from 3.2 to 4.3μ*** scheme is flexible and can be extended to other *** results introduce new possibilities for scan-free pump-probe imaging and the study of ultrafast dynamics in spectral regions where ultrafast modulation or detection is challenging such as the mid-infrared and THz regions.

关键词： ghost Ghost scheme

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乡村教师使用数字化教学资源的责任伦理及风险应对

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中国电化教育 2024年第8期 102-109页

作者：龚洪陈恩伦唐旭西南大学教师教育学院重庆北碚400715 武昌理工学院文法学院湖北武汉430223 西南大学继续教育学院重庆北碚400715

教育数字化转型进程里,确保乡村教师坚守数字与信息责任伦理,已成为合理运用数字资源提升高质量教学的职业操守。当乡村教师在使用数字化教学资源中失去责任伦理的规约与限制,易造成数字化信息茧房行为蔓延,致使数字化教学资源偏离乡土... 详细信息

教育数字化转型进程里,确保乡村教师坚守数字与信息责任伦理,已成为合理运用数字资源提升高质量教学的职业操守。当乡村教师在使用数字化教学资源中失去责任伦理的规约与限制,易造成数字化信息茧房行为蔓延,致使数字化教学资源偏离乡土教情,损害数字化教学资源应用可信生态链。为提升乡村教师合理开发使用数字化教学资源,需要明确数字责任伦理的特定取旨,从强化主体责任伦理意识、紧扣乡村教学实际、恪守求真务实底线向度,纾解“信息茧房”行为泛化隐忧,提升“数实融合”尽责能力水平,夯实“可信尚善”责任行为规范。

关键词：乡村教师数字化教学资源高质量教学数字责任

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Taxonomic Study of Five Parasitic Polypores of the Hymenochaetaceae Family of TIN Vegetation in Western Burkina Faso

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American Journal of Plant Sciences 2024年第6期15卷 441-454页

作者： Kusiélé Somda Andjièrèyir Nankoné Samson Nana R. Sylvie Bakiono Benovana Sédégo K. Jean Edouard Dabiré Kounbo Sanon Elise Department of Plant Biology and Physiology Joseph Ki-Zerbo University Ouagadougou Burkina Faso Life and Earth Sciences Laboratory Science and Technology Training and Research Unit Norbert Zongo University Koudougou Burkina Faso Tenkodogo University Center Ouagadougou Burkina Faso

The aim of this work is to inventory and study the lignicolous parasitic macrofungi of the Tin plant formation. The mycological outings from July to September 2018 and 2019, collected forty-four (44) basidiomes through a random sampling device over an area of 40,000 m2 including 1000 m long by 40 m2 wide. The standard methods and techniques used in mycology for taxonomic studies were used to describe and classify the carpophores collected in three families: Hymenochaetaceae, Ganodermataceae and Polyporaceae, into eight genera: Onnia (4.55%), Amauroderma (4.55%), Ganoderma (20.45%), Phellinus (52.27%), Inonotus (4.55%), Phellinopsis (6.82%), Grammothele (2.27%) and Trametes (4.55%). The genera Phellinus and Ganoderma were the most abundant. Finally, eight species were identified: Inonotus cf. ochroporus, Inonotus cf. pachyphloeus, Phellinus cf. cryptarum, Phellinus cf. hartigii, Phellinus cf. hippophaecola;Phellinus cf. robustus, Phellinus cf. igniarius, et Amauroderma cf. fasciculatum. Seven fungal species belong to the family Hymenochaetaceae and only the species Amauroderma cf. fasciculatum is a Ganodermataceae. However, all these fungal species are shown to be parasites of trunks and/or branches of the following woody: Parkia biglobosa (50%), Anogeissus leiocarpus (25%), Annona senegalensis (12.5%) and Mangifera indica (12.5%). Authors attest that the presence of phytoparasitic polypores in a plant formation is an indicator of aging hence the urgency to put in place the appropriate measures to safeguard and restore Tin’s plant formation.

关键词： Identification Macrofungi Lignicolous Parasites Vegetation Tin Burkina Faso

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T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine:A case report

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世界临床病例杂志 2023年第26期11卷 6200-6205页

作者： Sungwoo Park eun Jeong Jeong Jung Hun Kang Gyeong-Won Lee Se-Il go Dong-Hyun Lee eun-Ha Koh Division of Hematology and Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52727South Korea Department of Internal Medicine Institute of Health SciencesGyeongsang National University Changwon HospitalGyeongsang National University School of MedicineChangwon 52828South Korea Department of Laboratory Medicine Gyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52828South Korea

BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid ***,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its *** SUMMARY A 55-year-old male was diagnosed with T/myeloid ***,prednisolone,daunorubicin,and L-asparaginase were administered as induction *** shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory *** and decitabine were administered as chemotherapy-free induction therapy to reduce the infection *** were no serious infections,including febrile neutropenia,at the end of the *** receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to *** CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.

关键词： Mixed-phenotype acute leukemia Venetoclax Decitabine Case report

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多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值

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临床医学工程 2024年第7期31卷 771-772页

作者：齐玉晓郭广春河南省新野县中医院影像科河南南阳473500 南阳市中心医院影像科河南南阳473000

目的探讨多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值。方法选择2019年10月至2023年10月我院收治的疑似腰椎压缩性骨折患者124例,均予以多序列MRI、CT多平面重组,以患者临床综合诊断结果为依据进行一致性分析,比较多序列MRI、C... 详细信息

目的探讨多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值。方法选择2019年10月至2023年10月我院收治的疑似腰椎压缩性骨折患者124例,均予以多序列MRI、CT多平面重组,以患者临床综合诊断结果为依据进行一致性分析,比较多序列MRI、CT多平面重组及联合检测诊断腰椎压缩性骨折的灵敏度、特异度、准确率。结果124例患者经临床综合诊断确定为腰椎压缩性骨折阳性99例,阴性25例;多序列MRI及CT多平面重组诊断结果与临床综合诊断结果一致性均较高(κ=0.847、0.826,P<0.001),多序列MRI联合CT多平面重组诊断结果与临床综合诊断结果几乎完全一致(κ=0.977,P<0.001);多序列MRI联合CT多平面重组灵敏度、特异度、准确率均显著高于单一多序列MRI、CT多平面重组(P<0.05)。结论多序列MRI联合CT多平面重组诊断腰椎压缩性骨折较单一诊断效果更好,应用价值高。

关键词：多序列核磁共振成像 CT多平面重组腰椎压缩性骨折

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Metal chalcogenide-based photoelectrodes for photoelectrochemical water splitting

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Journal of Energy Chemistry 2022年第10期31卷 189-213,I0005页

作者： Marwa Mohamed Abouelela go Kawamura Atsunori Matsuda Department of Electrical and Electronic Information Engineering Toyohashi University of TechnologyToyohashi 441-8580AichiJapan Petrochemical Department Egyptian Petroleum Research InstituteCairo 11727Egypt

Photoelectrochemical water splitting(PEC-WS)is a promising technique for transforming solar energy into storable and environmentally friendly chemical *** semiconductor photoelectrodes with high light absorption capability,rapid e-/h+separation and transfer,and sufficient chemical stability is vital for developing an efficient PEC-WS *** chalcogenides(MCs)have emerged as promising candidates for light absorbers because of their unique electrical and optical *** this review,we present recent developments in hydrogen generation via PEC-WS using MC-based ***,we present a simple illustration of PEC-WS ***,the current performance of various metal(mono-,di-,and tri-)chalcogenide/semiconductor photoelectrodes in PEC-WS is ***,the charge transfer mechanism at the MC/semiconductor interface and the PEC-WS mechanism is thoroughly ***,we discuss future research perspectives toward developing efficient and stable MC/semiconductor photoelectrodes.

关键词： Photoelectrochemical water splitting Metal chalcogenides Photoelectrode Energy conversion

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