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T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine:A case report

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世界临床病例杂志 2023年第26期11卷 6200-6205页

作者： Sungwoo Park eun Jeong Jeong Jung Hun Kang Gyeong-Won Lee Se-Il go Dong-Hyun Lee eun-Ha Koh Division of Hematology and Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52727South Korea Department of Internal Medicine Institute of Health SciencesGyeongsang National University Changwon HospitalGyeongsang National University School of MedicineChangwon 52828South Korea Department of Laboratory Medicine Gyeongsang National University HospitalGyeongsang National University School of MedicineGyeongsang National UniversityJinju 52828South Korea

BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid ***,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its *** SUMMARY A 55-year-old male was diagnosed with T/myeloid ***,prednisolone,daunorubicin,and L-asparaginase were administered as induction *** shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory *** and decitabine were administered as chemotherapy-free induction therapy to reduce the infection *** were no serious infections,including febrile neutropenia,at the end of the *** receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to *** CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.

关键词： Mixed-phenotype acute leukemia Venetoclax Decitabine Case report

Is the AIM65 score useful in predicting outcomes in peptic ulcer bleeding?

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World Journal of Gastroenterology 2014年第7期20卷 1846-1851页

作者： Sung Hoon Jung Jung Hwan Oh Hye Yeon Lee Joon Won Jeong Se eun go Chan Ran You eun Jung Jeon Sang Wook Choi Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 130-709South Korea

AIM:To evaluate the applicability of AIMS65 scores in predicting outcomes of peptic ulcer ***:This was a retrospective study in a single center between January 2006 and December *** enrolled 522 patients with upper gastrointestinal haemorrhage who visited the emergency *** patients were regarded as those who had rebleeding within 30 d from the first endoscopy as well as those who died within 30 d of visiting the Emergency room.A total of 149 patients with peptic ulcer bleeding were analysed,and the AIMS65 score was used to retrospectively predict the high-risk ***:A total of 149 patients with peptic ulcer bleeding were *** poor outcome group comprised 28 patients[male:23(82.1%)vs female:5(10.7%)]while the good outcome group included 121patients[male:93(76.9%)vs female:28(23.1%)].The mean age in each group was not significantly *** mean serum albumin levels in the poor outcome group were slightly lower than those in the good outcome group(P=0.072).For the prediction of poor outcome,the AIMS65 score had a sensitivity of35.5%(95%CI:27.0-44.8)and a specificity of 82.1%(95%CI:63.1-93.9)at a score of *** AIMS65 score was insufficient for predicting outcomes in peptic ulcer bleeding(area under curve=0.571;95%CI:0.49-0.65).CONCLUSION:The AIMS65 score may therefore not be suitable for predicting clinical outcomes in peptic ulcer *** albumin levels may be a risk factor associated with high mortality in peptic ulcer bleeding.

关键词： Gastrointestinal haemorrhage Peptic ulcer Mortality Morbidity Prognosis

Effects of aqueous extract from red Liriope platyphylla on phthalic-anhydride-induced atopic dermatitis in Interleukin-4/Luciferase/Consensus non-coding sequence-1 transgenic mice evaluated in terms of luciferase signal and general phenotype biomarkers

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Journal of Traditional Chinese Medicine 2017年第4期37卷 475-485页

作者： Moon Hwa Kwak Ji eun Kim Jun go Hong Joo Son Hee Seob Lee Jin Tae Hong Dae Youn Hwang College of Natural Resources and Life Science/Life and Industry Convergence Research Institute Pusan National UniversityMiryang 627-706South of Korea College of Human Ecology Pusan National UniversityBusan 609-735south of Korea College of Pharmacy and Medical Research Center Chungbuk National UniversityChungju 361-763south of Korea College of Pharmacology Chungbuk National UniversityChungju 361-763south of Korea

OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 ***: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot ***: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated ***: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia.

关键词： Dermatitis, Atopic Liriope plant Interleukin-4 Luciferases Mice, transgenic Phthalic anhydrides Immunoglobulin E

A qualitative approach to aberrations of optical elements

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Chinese Optics Letters 2010年第11期8卷 1022-1023页

作者： Jerry Barretto Clark Kendrick go Department of Physics School of Science and EngineeringAteneo de Manila University Department of Mathematics School of Science and EngineeringAteneo de Manila University

A qualitative method to analyze wavefront aberrations is *** of the primary type,expressed in their matrix forms,are used to write the generalized ray transfer matrix of an optical *** aberrations were treated collectively by examining the pseudospectra of an augmented matrix constructed from the aberration *** show that aberrations can be distinguished and relative strengths pronounced using this qualitative method.

关键词： A qualitative approach to aberrations of optical elements

多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值

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临床医学工程 2024年第7期31卷 771-772页

作者：齐玉晓郭广春河南省新野县中医院影像科河南南阳473500 南阳市中心医院影像科河南南阳473000

目的探讨多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值。方法选择2019年10月至2023年10月我院收治的疑似腰椎压缩性骨折患者124例,均予以多序列MRI、CT多平面重组,以患者临床综合诊断结果为依据进行一致性分析,比较多序列MRI、C... 详细信息

目的探讨多序列MRI联合CT多平面重组诊断腰椎压缩性骨折的价值。方法选择2019年10月至2023年10月我院收治的疑似腰椎压缩性骨折患者124例,均予以多序列MRI、CT多平面重组,以患者临床综合诊断结果为依据进行一致性分析,比较多序列MRI、CT多平面重组及联合检测诊断腰椎压缩性骨折的灵敏度、特异度、准确率。结果124例患者经临床综合诊断确定为腰椎压缩性骨折阳性99例,阴性25例;多序列MRI及CT多平面重组诊断结果与临床综合诊断结果一致性均较高(κ=0.847、0.826,P<0.001),多序列MRI联合CT多平面重组诊断结果与临床综合诊断结果几乎完全一致(κ=0.977,P<0.001);多序列MRI联合CT多平面重组灵敏度、特异度、准确率均显著高于单一多序列MRI、CT多平面重组(P<0.05)。结论多序列MRI联合CT多平面重组诊断腰椎压缩性骨折较单一诊断效果更好,应用价值高。

关键词：多序列核磁共振成像 CT多平面重组腰椎压缩性骨折

Metal chalcogenide-based photoelectrodes for photoelectrochemical water splitting

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Journal of Energy Chemistry 2022年第10期31卷 189-213,I0005页

作者： Marwa Mohamed Abouelela go Kawamura Atsunori Matsuda Department of Electrical and Electronic Information Engineering Toyohashi University of TechnologyToyohashi 441-8580AichiJapan Petrochemical Department Egyptian Petroleum Research InstituteCairo 11727Egypt

Photoelectrochemical water splitting(PEC-WS)is a promising technique for transforming solar energy into storable and environmentally friendly chemical *** semiconductor photoelectrodes with high light absorption capability,rapid e-/h+separation and transfer,and sufficient chemical stability is vital for developing an efficient PEC-WS *** chalcogenides(MCs)have emerged as promising candidates for light absorbers because of their unique electrical and optical *** this review,we present recent developments in hydrogen generation via PEC-WS using MC-based ***,we present a simple illustration of PEC-WS ***,the current performance of various metal(mono-,di-,and tri-)chalcogenide/semiconductor photoelectrodes in PEC-WS is ***,the charge transfer mechanism at the MC/semiconductor interface and the PEC-WS mechanism is thoroughly ***,we discuss future research perspectives toward developing efficient and stable MC/semiconductor photoelectrodes.

关键词： Photoelectrochemical water splitting Metal chalcogenides Photoelectrode Energy conversion

Characteristics of Nb/Al superconducting tunnel junctions fabricated using ozone gas

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Chinese Physics B 2015年第9期24卷 182-186页

作者： Masahiro Ukibe go Fujii Masataka Ohkubo Nanoelectronics Research Institute (nano) National Institute of Advanced Industrial Science and Technology (AIST)

To improve the energy resolution（？E） of Nb/Al superconducting tunnel junctions（STJs）, an ozone（O3） oxidation process has been developed to fabricate a thin defect-free tunnel barrier that simultaneously shows high critical current JC〉 1000 A/cm^2 and high normalized dynamic resistance RDA 〉 100 MΩ·μm^2, where A is the size of the STJ. The 50-μm^2 STJs produced by O3 exposure of 0.26 Pa·min with an indirect spray of O3 gas, which is a much lower level of exposure than the O2 exposure used in a conventional O2 oxidation process, exhibit a maximum JC= 800 A/cm^2 and a high RDA = 372 MΩ ·μm^2. The 100-pixel array of the 100-μm^2STJs produced using the same O3 oxidation conditions exhibits a constant leak current I leak= 14.9 ± 3.2 n A at a bias point around △ /e（where e is half the energy gap of an STJ）,and a high fabrication yield of 87%. Although the I leak values are slightly larger than those of STJs produced using the conventional O2 oxidation process, the STJ produced using O3 oxidation shows a ？E = 10 eV for the C-Kα line, which is the best value of our Nb/Al STJ x-ray detectors.

关键词： Nb/Al superconducting tunnel junctions high critical current density high energy resolution ozone

First quarter century of laparoscopic liver resection

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World Journal of Gastroenterology 2017年第20期23卷 3581-3588页

作者： Zenichi Morise go Wakabayashi Department of Surgery Fujita Health University School of Medicine Department of Surgery Center for Advanced Treatment of HBP DiseasesAgeo Central General Hospital

The beginnings of laparoscopic liver resection(LLR)were at the start of the 1990s,with the initial reports being published in 1991 and *** were followed by reports of left lateral sectionectomy in *** the years following,the procedures of LLR were expanded to hemi-hepatectomy,sectionectomy,segmentectomy and partial resection of posterosuperior segments,as well as the parenchymal preserving limited anatomical resection and modified anatomical(extended and/or combining limited)resection *** expanded range of LLR procedures,mimicking the expansion of open liver resection in the past,was related to advances in both technology(instrumentation)and technical skill with conceptual *** this period of remarkable development,two international consensus conferences were held(2008 in Louisville,KY,United States,and 2014 in Morioka,Japan),providing up-to-date summarizations of the status and perspective of *** advantages of LLR have become clear,and include reduced intraoperative bleeding,shorter hospital stay,and-especially for cirrhotic patients-lower incidence of complications(e.g.,postoperative ascites and liver failure).In this paper,we review and discuss the developments of LLR in operative procedures(extent and style of liver resections)during the first quarter century since its inception,from the aspect of relationships with technological/technical developments with conceptual changes.

关键词： Hepatectomy Laparoscopic surgery Liver cancer History Technology Technique Concept Approach Posture Simulation

Investigation of newly developed added damping and stiffness device with low yield strength steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2004年第3期5卷 77-85页

作者： SHIH Ming-hsiang go Cheer-germ Department of Construction Engineering National Kaoshiang First University of Science and TechnologyDepartment of Civil Engineering National Chung Hsing University Taiwan 824 ChinaTaiwan 40227 China

Energy dissipators, isolated-resistant and specific structural forms for earthquake resistance are popular topics in the research to improve shock-resistance. In this work, experimental methods were used to investigate the property of low yield strength steel. Carbon content in LYS material is lower than that in other steels; the ultimate stress is three times the yield stress. The ultimate elongation rate is about 62% and the ductility is 23 times that of A36 steel. In order to overcome some defects of ordinary use metallic dampers, the mechanical characteristic of low yield strength steel is used to develop added damping and stiffness for rhombic steel plate absorber. Test of the energy dissipation behavior for this newly de-veloped device indicated that LYS could stably dissipate or absorb the input energy of earthquake. Then, the analytical model for the hysteretic behavior of this new device is proposed. Comparison of experimental data and numerical simulation results showed that this analytical model is suitable for simulating the hysteretic energy behavior of this new device.

关键词： Seismic shock absorbance elements Capability of seismic resistance Hysteretic behavior of rhombic steel plate Nonlinear analytical model