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Ergot Alkaloid Effects on Bovine Sperm Motility In Vitro

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Advances in Reproductive Sciences 2019年第1期7卷 7-15页

作者： ryan page Toby Lester Rick Rorie Charles Rosenkrans Jr. Department of Animal Science Division of Agriculture University of Arkansas System Fayetteville Arkansas USA

Cattle in some parts of the world graze pastures that consist of tall fescue that may contain ergot alkaloid contamination. Those ergot alkaloids are associated with reduced reproductive rates in cattle. Our objective was to determine if ergot alkaloids [dihydroergotamine (DHET), ergonovine (EN), and ergotamine (ET)] directly affect bovine sperm characteristics. Spermatozoa were collected from mature Angus (n = 2) and Balancer (n = 4) bulls. Within bull, treatments were structured as a 3 × 5 factorial with three alkaloids (DHET, EN, and ET) and five concentrations of each alkaloid (0, 33, 66, 100, or 200 μM). Spermatozoa (25 × 106) were incubated (39?C) in 1 mL of modified sperm medium. Sperm motility characteristics were evaluated using CASA (Hamiliton Thorne IVOS, Beverly, MA) at 0, 3, and 6 h after initial alkaloid exposure. Initial sperm motility was (69% ± 1.1%) and declined (P = 0.01) to (35% ± 2.6%) at 6 h. Sperm motility decreased (P P < 0.05) both characteristics. Our results demonstrate that ergot alkaloids (ET and DHET) can directly alter bovine sperm motility and morphology, which adds to our understanding of how ergot alkaloids may hinder cattle reproductive rates.

关键词： CASA Bull Spermatozoa Toxins

Diagnostic role of fractional exhaled nitric oxide in pediatric eosinophilic esophagitis, relationship with gastric and duodenal eosinophils

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 407-419页

作者： Panamdeep Kaur Rachel Chevalier Craig Friesen Jamie ryan Ashley Sherman Stephanie page Department of Pediatric Gastroenterology Connecticut Children’s Medical CenterUniversity of Connecticut School of MedicineHartfordConnecticutCT 06106United States Department of Pediatric Gastroenterology Children's Mercy Kansas CityUniversity of Missouri-Kansas City School of MedicineKansas CityMissouriMO 64108United States Department of Pediatrics University of Kansas School of MedicineKansas CityKansasKS 66160United States Department of Biostatistics Children's Mercy Kansas CityKansas CityMissouriMO 64108United States Department of Pediatric Gastroenterology Midwest Pediatric SpecialistsOverland ParkKansasKS 66215United States

BACKGROUND Eosinophilic esophagitis(EoE)is an eosinophilic-predominant inflammation of the esophagus diagnosed by upper endoscopy and biopsies.A non-invasive and cost-effective alternative for management of EoE is being *** studies assessing utility of fractional exhaled nitric oxide(FeNO)in EoE were low *** investigated the contribution of eosinophilic inflammation of the stomach and duodenum to *** To assess the utility of FeNO as a non-invasive biomarker of esophageal eosinophilic inflammation for monitoring disease *** Patients aged 6-21 years undergoing scheduled upper endoscopy with biopsy for suspected EoE were recruited in our observational *** on steroids and with persistent asthma requiring daily controller medication were *** measurements were obtained in duplicate using a chemiluminescence nitric oxide analyzer(NIOX MINO,Aerocrine,Inc.;Stockholm,Sweden)prior to *** on the esophageal peak eosinophil count(PEC)/high power field on biopsy,patients were classified as EoE(PEC≥15)or control(PEC≤14).Mean FeNO levels were correlated with presence or absence of EoE,eosinophil counts on esophageal biopsy,and abnormal downstream eosinophilia in the stomach(PEC≥10)and duodenum(PEC≥20).Wilcoxon rank-sum test,Spearman correlation,and logistic regression were used for analysis.P value<0.05 was considered *** We recruited a total of 134 patients,of which 45 were diagnosed with EoE by *** median interquartile range FeNO level was 17 parts per billion(11-37,range:7-81)in the EoE group and 12 parts per billion(8-19,range:5-71)in the control *** adjusting for atopic diseases,EoE patients had significantly higher FeNO levels as compared to patients without EoE(Z=3.33,P<0.001).A weak yet statistically significant positive association was found between the number of esophageal eosinophils and FeNO levels(r=0.30,P<0.005).On subgroup analysis within the EoE cohort,h

关键词： Nitric oxide Fractional exhaled nitric oxide Eosinophilic esophagitis Esophagus Pediatric Gastroenterology

LOVIN’LIBATION A Review of China-based Artisanal Cocktail Brand Laiba

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城市漫步（上海版、英文） 2021年第3期 22-23页

作者： ryan Gandolfo Phoebe Kut 不详

While premade cocktails may seem like a relatively recent fad,these novelty drinks surprisingly date back to the 1890s in Hartford,*** ready-to-drink(RTD)category has seen success and irrelevance over the past century... 详细信息

关键词： Connect category drink

LOVIN' LIBATION A Review of China-based Artisanal Cocktail Brand Laiba

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城市漫步（GBA版） 2021年第3期 22-23页

作者： ryan Gandolfo Phoebe Kut 不详

关键词： Connect category drink

Synthesis of Gemcitabine-(C4-amide)-[anti-HER2/neu] Utilizing a UV-Photoactivated Gemcitabine Intermediate: Cytotoxic Anti-Neoplastic Activity against Chemotherapeutic-Resistant Mammary Adenocarcinoma SKBr-3

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Journal of Cancer Therapy 2012年第5期3卷 689-711页

作者： Cody P. Coyne Toni Jones ryan Bear Department of Basic Sciences College of Veterinary Medicine Mississippi State University Oktibbeha County USA Wise Center Mississippi State University Oktibbeha County USA

Gemcitabine is a pyrimidine nucleoside analog that becomes triphosphorylated intracellularly where it competitively inhibits cytidine incorporation into DNA strands. Another mechanism-of-action of gemcitabine (diphosphorylated form) involves irreversible inhibition of the enzyme ribonucleotide reductase thereby preventing deoxyribonucleotide synthesis. Functioning as a potent chemotherapeutic gemcitabine promote decreases in neoplastic cell proliferation and apoptosis which is frequently found to be effective for the treatment of several leukemias and a wide spectrum of carcinomas. A brief plasma half-life in part due to rapid deamination and chemotherapeutic-resistance restricts the utility of gemcitabine in clinical oncology. Selective “targeted” delivery of gemcitabine represents a potential molecular strategy for simultaneously prolonging its plasma half-life and minimizing innocient tissues and organ systems exposure to chemotherapy. The molecular design and an organic chemistry based synthesis reaction is described that initially generates a UV-photoactivated gemcitabine intermediate. In a subsequent phase of the synthesis method the UV-photoactivated gemcitabine intermediate is covalently bonded to a monoclonal immunoglobulin yielding an end-product in the form of gemcitabine-(C4-amide)-[anti-HER2/neu]. Analysis by SDS-page/chemiluminescent auto-radiography did not detect evidence of gemcitabine-(C4-amide)-[anti-HER2/neu] polymerization or degradative fragmentation while cell-ELISA demonstrated retained binding-avidity for HER2/neu trophic membrane receptor complexes highly over-expressed by chemotherapeutic-resistant mammary adenocarcinoma (SKBr-3). Compared to chemotherapeutic-resistant mammary adenocarcinoma (SKBr-3), the covalent immunochemotherapeutic, gemcitabine-(C4-amide)-[anti-HER2/neu] is anticipated to exert greater levels of cytotoxic anti-neoplastic potency against other neoplastic cell types like pancreatic carcinoma, small-cell lung carcinoma,

关键词： Gemcitabine HER2/neu UV-Photoactivated Gemcitabine-(C4-amide) Intermediate Organic Chemistry Reaction Gemcitabine-(C4-amide)-[anti-HER2/neu] Covalent Bond Synthesis Gemcitabine (C5- methylcarbamate)-[anti-HER2/neu] Cytotoxic Anti-Neoplastic Potency Chemotherapeutic-Resistant Mammary Adenocarcinoma Cell-ELISA SDS-page Immunodetection Chemiluminescent Autoradiography

Improved Behavioural Engagement of Students through Low-stakes Online Tests and Immediate Dialogic Feedback

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Journal of International Education and Practice 2023年第1期6卷 10-20页

作者： Glen Currie Tracii ryan Faculty of Engineering and Information Technology The University of MelbourneAustralia

The engagement of students is a recognised challenge for *** offers some practical student engagement tools,and this paper examines the use of low-stakes online tests and immediate dialogic feedback to improve behavioural *** academic exploration of low-stakes tests and dialogic feedback has been extensive,and they are credible teaching *** this study,we explore the learning benefit of their *** engineering students’self-reported and learning analytics data shows conclusive evidence of improved behavioural *** measured a 500%increase in the Learning Management System(LMS)page views on the days when we ran the low-stakes tests(each worth 2%of the marks for the subject)and engaged in immediate dialogic *** interpret these results,we draw on theories of behavioural engagement,low-stakes tests,and *** conclude that the combination of low-stakes tests and immediate feedback improves student behavioural engagement.

关键词： Behavioural engagement Immediate dialogic feedback Low-stakes tests Mixed-methods Online learning Quantitative Survey

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万事通奥利佛之修车篇

空中英语教室（初级版．大家说英语） 2020年第10期 17-19,51页

作者： John ryan 不详

One Saturday,Oliver page's friend Katie called *** sounded unhappy. "Oliver", she said."I need *** you help me?"" I hope so," replied Oliver."What's the problem?"

关键词： she need hope

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万事通奥利佛之钻石大考验

空中英语教室（初级版．大家说英语） 2020年第8期 14-16,51页

作者： John ryan page DESIGN BY MICHELLE TI ILLUSTRATED BY ARNOLD L EE

奥利佛·沛吉在一家图书馆工作。他非常喜欢在书堆当中工作,他的许多朋友也都爱书,他的同事杰洛德就是一个例子。有一天,杰洛德来到奥利佛的办公桌前,很兴奋地说。“奥利佛,我需要告诉你一件事,”杰洛德兴奋地说,“我要结婚了!”

关键词：爱书图书馆洛德办公桌兴奋

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万事通奥利佛之寻狗记

空中英语教室（初级版．大家说英语） 2020年第9期 21-23,52页

作者： John ryan 不详

奥利佛•沛吉敲了敲他朋友乔安娜所住公寓的门,乔安娜打开门。“谢谢你这么快就赶过来,”她说。奥利佛踏进门,环顾四周“你的小毛球不见了?”他问。“是啊,”乔安娜说,“有人趁我去转角商店的时候抓走了我的小狗。我只去了20分钟,当时小... 详细信息

奥利佛•沛吉敲了敲他朋友乔安娜所住公寓的门,乔安娜打开门。“谢谢你这么快就赶过来,”她说。奥利佛踏进门,环顾四周“你的小毛球不见了?”他问。“是啊,”乔安娜说,“有人趁我去转角商店的时候抓走了我的小狗。我只去了20分钟,当时小毛球在外面的阳台上。唉,我为什么没有锁门呢?”乔安娜指向桌上的一张纸。

关键词：乔安娜公寓阳台