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环境

商业周刊（中文版） 2017年第23期 100-101页

作者： Tim Loh ryan collins 孟洁冰

中国大力开展环境整治行动，正重塑商业环境中国的环境整治行动如火如荼地展开，出乎意料地正改变企业格局。甚至帮助提升全球通胀，而全球供应链可能不久就会感受到这种变化。

关键词：环境整治全球供应链商业环境企业格局中国通胀

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美国页岩油气热潮是否难以为继？

商业周刊（中文版） 2018年第4期 33-34页

作者： Jim Poison Tim Loh ryan collins 永年

美国持续十年的页岩油气热潮可能有点过火了，恐怕会被泼一盆冷水。

关键词：油气页岩美国

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房价波动的金融逻辑

房价波动的金融逻辑

The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia

作者： (英)乔希·瑞安－柯林斯(Josh ryan-collins)，(英)托比·劳埃德(Toby Lloyd)，(英)劳里·麦克法兰(Laurie Macfarlane)

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Bone Research 2016年第2期4卷 85-90页

作者： Qian Zhang Michele Doucet ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T collins Thomas L Clemens Department of Orthopaedic Surgery Johns Hopkins University Baltimore MD USA Department of Medicine University of Tennessee Health Science Center Memphis TN USA Skeletal Clinical Studies Unit craniofacial and Skeletal Diseases Branch National Institutes of HealthBethesda MD USA Baltimore Veterans Administration Medical Center Baltimore MD USA

Tumor-induced osteomalacia （TIO） is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23 （FGF23） by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-la （HIF-la） in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-la mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-la and FGF23 were co-localized in spindle- shaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-la protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-la expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-la inhibitors decreased HIF-la and FGF23 protein accumulation and inhibited HIF-la-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-la consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-la inhibitor. These results show for the first time that HIF-la is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-la activity in TIO contributes to the aberrant FGF23 production in these patients.

关键词： The hypoxia-inducible factor-1 activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia HIF

Headwater regions- Physical, ecological, and social approaches to understand these areas： introduction to the special issue

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Frontiers of Earth Science 2017年第3期11卷 443-446页

作者： Steven R. FASSNACHT ryan W. WEBB William E. SANFORD ESS-Watershed Science Colorado State University Fort Collins CO 80523-1476 USA Geographisches Institut Abt. Kartographie GIS & Femerkundung Georg-August-Universitat Gottingen 37077 Gottingen Germany Cooperative Institute for Research in the Atmosphere Fort Collins CO 80523-1375 USA Geospatial Centroid Colorado State University Fort Collins CO 80523-1101 USA Natural Resources Ecology Laboratory Fort Collins CO 80523-1499 USA Institute of Arctic and Alpine Research University of Colorado Boulder Boulder CO 80309-0450 USA Geosciences Colorado State University Fort Collins CO 80523-1482 USA

Around the world human communities and natural ecosystems both rely on headwater regions for vital resources. Resources provided include groundwater sto- rage （Flint et al., 2008; Clilverd et al., 2011; Cao et al., 2012） in addition to soil moisture and forest ecosystem dynamics （McNamara et al., 2005; Williams et al., 2009; Jencso and McGlynn, 2011; Smith et al., 2011; Harpold et al., 2015; Webb et al., 2015）. Furthermore these regions are ecologically vital zones （Schlosser, 1995; Lowe and Likens, 2005） that impact downstream water quality （Peterson et al., 2001; Alexander et al., 2007）.

关键词： CLIMATE-CHANGE SOIL-MOISTURE SNOWMELT VARIABILITY HYDROLOGY LANDSCAPE SNOWPACK RECHARGE STREAMS STATES

Metabolite profile comparisons between ascending and descending colon tissue in healthy adults

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World Journal of Gastroenterology 2020年第3期26卷 335-352页

作者： Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P ryan Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsFort CollinsCO 80523United States University of Colorado Health Gastroenterology Clinic Fort CollinsCO 80524United States Department of Clinical Sciences Colorado State UniversityFort CollinsCO 80523United States Harmony Surgery Center Fort CollinsCO 80528United States Director of Clinical Operations Harmony Surgery CenterFort CollinsCO 80523United States

BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely *** study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese *** To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer *** Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite *** colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal *** Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass *** acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite *** weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending *** and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese *** There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy *** lipids and other metabolites in

关键词： Colon Ascending Descending Metabolomics Obesity Stool

瓶子、杯子及奶嘴喂养对早产儿母乳喂养的影响:随机对照试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 2-3页

作者： collins C.T ryan P. Crowther C.A 石磊 Dept. Nursing Midwifery Res. P. Women’s and Children’s Hospital 72 King William Road North AdelaideSA 5006 Australia

Objective: To determine the effect of artificial teats (bottle and dummy) and cups on breast feeding in pretern infants. Design: Randomised controlled trial. Setting:Two large tertiary hospitals, 54 peripheral hospitals. Participants:319 preterm infants (born at 23-33 weeks’gestation) randomly assigned to one of four groups:cup/no dummy (n = 89), cup/dummy (n = 72), bottle/no dummy (n = 73), bottle/dummy (n = 85). Women with singleton or twin infants< 34 weeks’gestation who wanted to breastfeed were eligible to participate. Interventions: Cup or bottle feeding occurred when the mother was unable to be present to breast feed. Infants randomised to the dummy groups received a dummy on entry into the *** outcome measures Full breast feeding (compared with partial and none) and any breast feeding (compared with none) on discharge home. Secondary outcomes:prevalence of breast feeding at three and six months after discharge and length of hospital stay. Results: 303 infants(and 278 mothers) were included in the intention to treat analysis. There were no significant differences for any of the study outcomes according to use of a dummy. Infants randomised to cup feeds were more likely to be fully breast fed on discharge home (odds ratio 1.73, 95%confidenceinterval 1.04 to 2.88, P = 0.03), but had a longer length of stay (hazard ratio 0.71, 0.55 to 0.92, P = 0.01). Conclusions:Dummies do not affect breast feeding in preterm infants. Cup feeding significantly increases the likelihood that the baby will be fully breast fed at discharge home,but has no effect on any breast feeding and increases the length of hospital stay.

关键词：母乳喂养随机对照试验三级综合医院随机分配子及无显著性差异