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Machine learning-guided accelerated discovery of structure-property correlations in lean magnesium alloys for biomedical applications

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Journal of Magnesium and Alloys 2024年第6期12卷 2267-2283页

作者： Sreenivas Raguraman Maitreyee Sharma Priyadarshini Tram Nguyen ryan mcgovern Andrew Kim Adam J.Griebel Paulette Clancy Timothy P.Weihs Department of Materials Science and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins Extreme Materials Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Translational Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Research and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnesium alloys are emerging as promising alternatives to traditional orthopedic implant materials thanks to their biodegradability,biocompatibility,and impressive mechanical ***,their rapid in-vivo degradation presents challenges,notably in upholding mechanical integrity over *** study investigates the impact of high-temperature thermal processing on the mechanical and degradation attributes of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cost-efficient characterization methods like X-ray diffraction and optical microscopy,we swiftly examine microstructural changes post-thermal *** Pearson correlation coefficient analysis,we unveil the relationship between microstructural properties and critical targets(properties):hardness and corrosion ***,leveraging the least absolute shrinkage and selection operator(LASSO),we pinpoint the dominant microstructural factors among closely correlated *** findings underscore the significant role of grain size refinement in strengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phase in corrosion *** suggests that achieving an optimal blend of strength and corrosion resistance is attainable through fine grains and reduced concentration of ternary *** thorough investigation furnishes valuable insights into the intricate interplay of processing,structure,and properties in magnesium alloys,thereby advancing the development of superior biodegradable implant materials.

关键词： Magnesium alloys Machine learning Corrosion Mechanical properties Rapid characterization

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Understanding the management of brachial plexus birth palsy and the roles of nerve transfers

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Plastic and Aesthetic Research 2023年第1期10卷 451-462页

作者： Wendy Chen ryan Keyho Idris Gharboui Department of Plastic and Reconstructive Surgery UT Houston McGovern Medical SchoolHoustonTX 77030USA

Early recognition and management of neonatal brachial plexus injury(NBPP)is key to optimizing outcomes and surgical *** up to a third of patients with birth palsy may require surgical intervention,the multidisciplinary team must follow up on the function and recovery of the entire upper extremity,from shoulder to fingertips,within the first few months of *** include neuroma resection and primary nerve grafting and/or nerve transfers,which can be intra-or extra-plexal,as adjunctive or standalone *** limited proximal nerve roots are available for nerve grafting,or when too many nerve roots are involved,exceeding the supply of nerve graft,extra-plexal nerve transfers are then *** early intervention is preferred(between 3 and 6 months for most authors),older children presenting late(>1 year since birth)with partial nerve recovery may still potentially benefit from nerve transfers,which can be offered to late-presenting *** we discuss the anatomy,indications,work-up,options,complications,and outcomes for such nerve transfers for upper,lower,and global plexus palsy in *** transfers are a common procedure done for the treatment of various types of birth plexus ***,while there is an abundance of clinical reports and evidence,there is still a lack of clarity regarding best practices or in terms of the type of procedure and technique for the treatment of birth plexus *** hope is that this chapter provides a concise source after an extensive cumulative review of the evidence of best practices for nerve transfers in the case of birth plexus palsy.

关键词： Neonatal birth plexus palsy brachial plexus nerve transfer birth palsy

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