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SOFT FULLERENE mATERIALS: CLICK CHEmISTRY AND SUPRAmOLECULAR ASSEmBLIES

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SOFT FULLERENE MATERIALS: CLICK CHEMISTRY AND SUPRAMOLECULAR...

Regulation ofβ2-adrenoceptors in brain glia:implications for neuroinflammatory and degenerative disorders

第四届国际高分子化学学术讨论会

作者： Wen-Bin Zhang Xuehui Dong ryan m.van horn Roderic P.Quirk Stephen Z.D.Cheng. Institute and Department of Polymer Science Department of ChemistryThe University of Akron

＜正＞Fullerenes are carbon nanostructures with excellent electronic properties which rely critically on their ordered spatial arrangements.1 However,they are very difficult to control due to their *** research topic is to develop‘soft fullerene materials’which uses the self-assembly of polymers as templates to manipulate C60’s ordered *** prepare fullerene polymers with

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Neural Regeneration Research 2020年第11期15卷 2035-2036页

作者： Karen m.ryan Andrew Harkin Trinity College Institute of Neuroscience Trinity College Dublin Neuropsychopharmacology Research Group School of Pharmacy and Pharmaceutical Sciences&Trinity College Institute of NeuroscienceTrinity College DublinDublinIreland

Noradrenaline:Within the central nervous system(CNS),the primary source of the catecholamine neurotransmitter noradrenaline is the locus coeruleus(LC)in the pontine tegmentum,with LC neurons projecting to almost all regions of the brain and spinal *** its release from LC neurons,noradrenaline has wide ranging *** example,noradrenaline is the endogenous agonist for G-coupledα-andβ-adrenoceptors that are expressed on many cell types,including neurons and glia,in both the peripheral nervous system and *** is via these receptors that noradrenaline exerts its anti-inflammatory and neurotrophic effects in the *** additionally has adrenoceptor-independent neuroprotective actions,and as such plays a role in free radical scavenging and reducing oxidative stress(Feinstein et al.,2016).

关键词： adrenoceptor protective endogenous

Dissecting genetic diversity and genomic background of Petunia cultivars with contrasting growth habits

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Horticulture Research 2020年第1期7卷 634-648页

作者： Yufang Guo ryan m.Warner Department of Horticulture Michigan State UniversityEast LansingMI 48824USA

The cultivated petunia(Petunia×hybrida)is derived from the progenitor species *** and *** hybridization dates back only to the 1830s,though intensive breeding efforts have yielded cultivars exhibiting incredible diversity for many traits,including growth habit,flower color,and flower *** now,little is known about the genetic diversity and genomic background of modern *** we selected a panel of 13 cultivars with contrasting growth habits and three wild species(the progenitors and ***)to estimate the genomic contribution from the ancestral species and to study whether the variation of the genetic origin could be associated with different breeding programs or morphological *** sequencing identified 1,164,566 SNPs representing 98.4%(32,451)of the transcripts that cover 99.2%(of 52,697,361 bp)of the *** *** with an upright growth habit had more homozygous alleles and more ***-derived alleles than trailing cultivars,while mounded cultivars had intermediate *** previous studies,we found the proportions of alleles derived from each progenitor species varied across cultivars but overall were not biased toward one progenitor species,suggesting diverse selection during cultivar *** trailing cultivars,alleles potentially introgressed from other wild species(“out”alleles)were ***“out”alleles were clustered in particular regions of chromosomes,suggesting that these regions may be hotspots of *** in these regions were enriched with gene ontology terms associated with growth *** study provides novel insight into the contributions of progenitor species to the genomic background of modern petunia cultivars and identifies genome regions that may harbor genes conferring the trailing growth habit for further exploration.

关键词： cultivar breeding trail

Is clinically measured knee range of motion after total knee arthroplasty‘good enough?’:A feasibility study using wearable inertial measurement units to compare knee range of motion captured during physical therapy versus at home

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medicine in Novel Technology and Devices 2021年第3期11卷 195-204页

作者： ryan m.Chapman Wayne E.moschetti Douglas W.van Citters Dartmouth College Thayer School of Engineering14 Engineering DriveHanoverNH03755USA Dartmouth Hitchcock medical Center Department of Orthopaedics1 Medical Center DriveLebanonNH03766USA University of Rhode Island Department of Kinesiology25 W Indendence WayKingstonRI02881USA

Total knee arthroplasty is highly successful,in part due to range of motion(Rom)*** is typically estimated goniometrically/visually by physical therapists(PTs)in the clinic,which is ***,a validated inertial measurement unit(ImU)method for capturing knee Rom was deployed assessing postoperative Rom both in and outside of the clinical *** study's objectives were to evaluate the feasibility of continuously capturing knee Rom pre-/post-op via ImUs,dividing data into PT/non-PT portions of each day,and comparing PT/non-PT *** hypothesized ImU-based clinical knee Rom would differ from ImU-based knee Rom captured outside clinical settings.10 patients(3 m,69±13 years)completed informed consent documents following ethics board approval.A validated ImU method captured long duration(8–12 h/day,~50 days)knee Rom pre-/***-op metrics were subdivided(PT versus non-PT).Clinical Rom and patient reported outcome measures were also *** and clinical disruption were *** compared post-op PT and non-PT means and change *** flexion during PT was less than outside *** stance/swing Rom and activity level were greater than outside *** temporal variable differences were found PT versus *** Rom measurements capture richer information than clinical *** PT flexion was likely less than non-PT due to the exercises completed(*** passive Rom *** Rom gait).PT gait flexion likely exceed non-PT because of‘white coat effects’wherein patients are closely monitored *** implies data captured clinically represents optimum performance whereas data captured non-clinically represents realistic performance.

关键词： Knee replacement Postoperative rehabilitation Wearable Inertial measurement unit Total joint arthroplasty Range of motion

modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review

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Asian Journal of Andrology 2020年第1期22卷 51-59页

作者： matthew J Ziegelmann m ryan Farrell Laurence A Levine Division of Urology Rush University Medical CenterChicagoIL 60612USA

Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual *** dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment *** a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly *** some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate ***,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without *** patients with severe penile shortening,penile length restoration techniques may also be ***,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's ***,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes.

关键词： collagenase grafting penile length penile prosthesis Peyronie's

High energy neutron and pion-decay gamma-ray emissions from solar flares

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Chinese Journal of Astronomy and Astrophysics 2009年第1期9卷 11-40页

作者： Edward L.Chupp James m.ryan Physics Department and Space Science Center in the Institute for the Study of Earth Oceans and Space University of New Hampshire

Solar flare gamma-ray emissions from energetic ions and electrons have been detected and measured to GeV energies since 1980. In addition, neutrons produced in solar flares with 100 meV to GeV energies have been observed at the Earth. These emissions are produced by the highest energy ions and electrons accelerated at the Sun and they provide our only direct （albeit secondary） knowledge about the properties of the accelerator（s） acting in a solar flare. The solar flares, which have direct evidence for pion-decay gamma-rays, are unique and are the focus of this paper. We review our current knowledge of the highest energy solar emissions, and how the characteristics of the acceleration process are deduced from the observations. Results from the RHESSI, INTEGRAL and CORONAS missions will also be covered. The review will also cover the solar flare capabilities of the new mission, FERmI GAmmA RAY SPACE TELESCOPE, launched on 2008 June II. Finally, we discuss the requirements for future missions to advance this vital area of solar flare physics.

关键词： Sun -- Flares -- Particle Acceleration-meson Production

Seasonal Development of microbial Activity in Soils of Northern Norway

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Pedosphere 2005年第6期15卷 716-727页

作者： m. BLTER N. SOETHE R. horn C. UHLIG Institut für Polarkologie Christian-Albrechts-Universitt zu Kiel Wischhofstr. 1-3 D-24148 Kiel (Germany). de Institut für Pflanzenernhrung und Bodenkunde Christian-Albrechts-Universitt zu Kiel Olshausenstr. 40 D-24098 Kiel (Germany) Holt Research Centre The Norwegian Crop Research Institute N-9292 Tromsφ(Norway)

Seasonal development of soil microbial activity and bacterial biomass in sub-polar regions was investigated to determine the impacts of biotic and abiotic factors, such as organic matter content, temperature and moisture. The study was performed during spring thaw from three cultivated meadows and two non-cultivated forest sites near Alta, in northern Norway. Samples from all five sites showed increasing respiration rates directly after the spring thaw with soil respiration activity best related to soil organic matter content. However, distributions of bacterial biomass showed fewer similarities to these two parameters. This could be explained by variations of litter exploitation through the biomass. microbial activity started immediately after the thaw while root growth had a longer time lag. An influence of root development on soil microbes was proposed for sites where microorganisms and roots had a tight relationship caused by a more intensive root structure. Also a reduction of microbial activity due to soil compaction in the samples from a wheel track could not be observed under laboratory conditions. New methodological approaches of differential staining for live and dead organisms were applied in order to follow changes within the microbial community. Under laboratory conditions freeze and thaw cycles showed a damaging influence on parts of the soil bacteria. Additionally, different patterns for active vs. non-active bacteria were noticeable after freeze-thaw cycles.

关键词： bacterial biomass freezing microbial activity soil compaction thawing

Demonstration of tantalum as a structural material for mEmS thermal actuators

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microsystems & Nanoengineering 2021年第1期7卷 85-97页

作者： Longchang Ni ryan m.Pocratsky maarten P.de Boer CmU mechanical Engineering Dept. 5000 Forbes Ave.PittsburghPA 15213USA Present address:Fischione Instruments 9003 Corporate CirExportPA 15632USA

This work demonstrates the processing,modeling,and characterization of nanocrystalline refractory metal tantalum(Ta)as a new structural material for microelectromechanical system(mEmS)thermal actuators(TAs).Nanocrystalline Ta films have a coefficient of thermal expansion(CTE)and Young’s modulus comparable to bulk Ta but an approximately ten times greater yield *** mechanical properties and grain size remain stable after annealing at temperatures as high as 1000°*** has a high melting temperature(Tm=3017℃)and a low resistivity(ρ=20µΩcm).Compared to TAs made from the dominant mEmS material,polycrystalline silicon(polysilicon,Tm=1414℃,ρ=2000µΩcm),Ta TAs theoretically require less than half the power input for the same force and displacement,and their temperature change is half that of *** TAs operate at a voltage 16 times lower than that of other TAs,making them compatible with complementary metal oxide semiconductors(CmOS).We selectα-phase Ta and etch 2.5-μm-thick sputterdeposited films with a 1μm width while maintaining a vertical sidewall profile to ensure in-plane movement of TA *** is 25 times thicker than the thickest reactive-ion-etchedα-Ta reported in the technical *** stress sensitivities to sputter parameters and to hydrogen incorporation are investigated and ***,a V-shaped TA is fabricated and tested in *** conventional actuation by Joule heating and passive self-actuation are as predicted by models.

关键词： thermal structural thick

What Do Students Know about University Rankings?Testing Familiarity and Knowledge of Global and Domestic University League Tables in China

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Frontiers of Education in China 2019年第1期14卷 59-89页

作者： ryan m.ALLEN Attallah College of Educational Studies Chapman UniversityOrangeCA 92866USA

While academics and university administrators often criticize rankings,league tables have become important tools for student decision-making,especially in the Chinese ***,research has not fully explored how students in China have engaged with both global and local rankings,as most studies have focused on one setting or the ***,researchers have not tested students’knowledge of rankings,despite the intense focus on these actors by *** a survey of over 900 students from Chinese universities,the author explored how knowledge of rankings varies in different student *** multivariate analysis,it is found that students from elite institutions and those with educated parents were more attuned to university rankings in ***,when testing students’knowledge of rankings,elite university students performed better in knowing their domestic ranking,but worse when guessing their global ranking,while associations to parental education *** study,the first of its kind in terms of testing student knowledge,illustrates that the impact from university rankings are mitigated by local and individual characteristics.

关键词： China university rankings student perspective internationalization higher education metrics league tables