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Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and factors Affecting Needle Insertion

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Nano-Micro Letters 2021年第6期13卷 190-230页

作者： Pooyan Makvandi Melissa Kirkby Aaron RJHutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli ryan f.donnelly Istituto Italiano Di Tecnologia Centre for Materials InterfaceViale Rinaldo Piaggio 3456025 PontederaPisaItaly School of Pharmacy Queen’s University Belfast97 Lisburn RoadBelfast BT97BLUK The BioRobotics Institute Scuola Superiore Sant’AnnaViale Rinaldo Piaggio 3456025 PontederaPisaItaly Paediatric Dentistry and Orthodontics Faculty of DentistryThe University of Hong KongPrince Philip Dental HospitalHong Kong SARChina Department of Chemical Materials and Industrial Production EngineeringUniversity of Naples FedericoⅡ80125 NaplesItaly Center for Advanced Biomaterials for Health Care(iit@CRIB) Italian Institute of Technology80125 NaplesItaly

Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the *** serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during *** ensures that the cargo is released at the predetermined place and ***,the ability of MN patches to sufficiently pierce the skin is a crucial *** the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and *** is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical *** that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research.

关键词： Insertion responsive Implantable microneedles Skin indentation Transdermal microneedles Pain management

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突破镜头规格极限适马28-45mm f1.8 DG DN|Art镜头体验

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摄影之友 2024年第7期 118-119页

作者： ryan(文/图) 不详

f1.8大光圈与变焦镜头,鱼与熊掌居然可以兼得?适马全新发布的全球第一支f1.8全画幅变焦镜头——适马28-45mm f1.8 DG DN|Art,让我们真正大开眼界。亮点1全焦段实现f1.8恒定光圈。世界上第一支光圈为f1.8的全画幅变焦镜头。对于全画幅镜... 详细信息

f1.8大光圈与变焦镜头,鱼与熊掌居然可以兼得?适马全新发布的全球第一支f1.8全画幅变焦镜头——适马28-45mm f1.8 DG DN|Art,让我们真正大开眼界。亮点1全焦段实现f1.8恒定光圈。世界上第一支光圈为f1.8的全画幅变焦镜头。对于全画幅镜头来说,f1.8的大光圈可以捕捉到充足的光线。

关键词：变焦镜头全画幅大光圈鱼与熊掌 DN

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Optimizing laser coupling,matter heating,and particle acceleration from solids using multiplexed ultraintense lasers

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Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakatsutsumi Sébastien Buffechoux Patrizio Antici Marco Borghesi Andrea Ciardi Sophia N.Chen Emmanuel d’Humières Laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna Mark N.Quinn Lorenzo Romagnani ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-Peter Schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald Willi Julien fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute for Physics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom Department of Physics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and radiation generation will require multi-beam arrangements due to technology ***,we investigate how to optimize their coupling with solid ***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid with a large preplasma can greatly improve the generation of hot electrons at the target front and ion acceleration at the target *** underlying mechanisms are analyzed through multidimensional particle-in-cell simulations,revealing that the self-induced magnetic fields driven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** addition,the resistive magnetic field generated during the transport of the hot electrons in the target bulk tends to improve their *** simulations also indicate that such effects can be further enhanced by overlapping more than two laser beams.

关键词： laser acceleration particle

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Screening antioxidants for the protection of cochlear sensory cells

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Neural Regeneration Research 2018年第1期13卷 62-64页

作者： Dong Gu Hur Arwa Kurabi Allen f.ryan Department of Surgery/Otolaryngology School of Medicine University of CaliforniaSan Diego Department of Otorhinolaryngology Gyeongsang National University Changwon Hospital Research Service Veterans Administration Medical Center

Sensory cell damage is a major cause of hearing loss： Sensorineural hearing loss （SNHL） is a common sensory deficit characterized by tissue damage and/or cell death in the cochlea. Moderate and severe SNHL causes deficits in communication, associated with increased isolation from human relationships, and negativly impacts employabflity. Many etiologies have been associated with SNHL： Noise overexposure, certain drugs, inner or middle ear infection or immune-induced inflammation being common. However, the most prevalent form of SNHL is presbycusis or age-related hearing loss, often aggravated by other factors including a history of noise exposure, diabetes or high blood pressure （Wong and ryan, 2015）. Though systemic steroids are used in the treatment of sudden SNHL, other drugs to prevent or cure hearing loss have not yet been developed. Cochlear sensory cells, known as hair cells （HCs） and neurons have very limited repair capacity. Moreover since these cells do not regenerate, making any loss permanent, prevention of cell damage is critical to protecting hearing.

关键词： HC Screening antioxidants for the protection of cochlear sensory cells

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The role of latitudinal, genetic and temperature variation in the induction of diapause of Papilio glaucus （Lepidoptera： Papilionidae）

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Insect Science 2018年第2期25卷 328-336页

作者： Sean f. ryan Patti Valella Gabrielle Thivierge Matthew L. Aardema J. Mark Scriber Department of Biological Sciences University of Notre Dame Notre Dame Indiana USA USDA-ARS Center for Medical Agricultural and Veterinary Entomology 1600/1700 Southwest 23rd Drive Gainesville Florida USA Department of Entomology Michigan State University East Lansing Michigan USA Life Science Department Long Beach City College Long Beach California USA Sackler Institute for Comparative Genomics American Museum of Natural History New York New York USA McGuire Centerfor Lepidoptera and Diversity University of Florida Gainesville Florida US

A key adaptation in insects for dealing with variable environmental conditions is the ability to diapause. The tiger swallowtail butterflies, Papilio glaucus and P. canadensis are ideal species to explore the genetic causes and population genetic consequences of diapause because divergence in this trait is believed to be a salient factor in maintaining a hybrid zone between these species. Yet little is known about the factors that influence diapause induction in this system. Here we explored how spatial （latitudinal）, environmental （temperature） and genetic （hybridization） factors affect diapause induction in this system. Specifically, a series of growth chamber experiments using wild caught individuals from across the eastern United States were performed to：（1） evaluate how critical photoperiod varies with latitude, （2） isolate the stage in which induction occurs, （3） test whether changes in temperature affected rates of diapause induction, and （4） explore how the incidence of diapause is affected in hybrid offspring. We find that induction occurs in the larval stage, is not sensitive to a relatively broad range of temperatures, appears to have a complex genetic basis （i.e., is not simply a dominant trait following a Mendelian inheritance pattern） and that the critical photoperiod increases by 0.4 h with each increasing degree in latitude. This work deepens our understanding of how spatial, environmental and genetic variation influences a key seasonal adaptation （diapause induction） in a well-developed ecological model system and will make possible future studies that explore how climatic variation affects the population dynamics and genetics of this system.

关键词： adaptation critical photoperiod development diapauses facultative hybridization

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Review of Mercury's dynamic magnetosphere:Post-MESSENGER era and comparative magnetospheres

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Science China Earth Sciences 2022年第1期65卷 25-74页

作者： Weijie SUN ryan MDEWEY Sae AIZAWA Jia HUANG James A.SLAVIN Suiyan fU Yong WEI Charles f.BOWERS Department of Climate and Space Sciences and Engineering University of MichiganAnn ArborMl 48109USA Institut de Recherche en Astrophysique et Planetologie CNRS-UPS-CNESToulouse 31400France Department of Geophysics Graduate School of ScienceTohoku UniversitySendai 980-8578Japan School of Earth and Space Sciences Peking UniversityBeijing 100871China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100864China

This review paper summarizes the research of Mercury’s magnetosphere in the Post-MESSENGER era and compares its dynamics to those in other planetary magnetospheres,especially to those in Earth’s *** review starts by introducing the planet Mercury,including its interplanetary environment,magnetosphere,exosphere,and conducting *** frequent and intense magnetic reconnection on the dayside magnetopause,which is represented by the flux transfer event"shower",is reviewed on how they depend on magnetosheath plasma β and magnetic shear angle across the magnetopause,followed by how it contributes to the flux circulation and magnetosphere-surface-exosphere *** the next,Mercury’s magnetosphere under extreme solar events,including the core induction and the reconnection erosion on the dayside magnetosphere,as well as the responses of the nightside magnetosphere,are ***,the dawn-dusk properties of the plasma sheet,including the features of the ions,the structure of the current sheet,and the dynamics of magnetic reconnection,are *** last topic is devoted to the particle energization in Mercury’s magnetosphere,which includes the energization of the Kelvin-Helmholtz waves on the magnetopause boundaries,reconnection-generated magnetic structures,and the cross-tail electric *** each chapter,the last section discusses the open questions related to each topic,which can be considered by the simulations and the future spacecraft *** end this paper by summarizing the future Bepi Colombo opportunities,which is a joint mission of ESA and JAXA and is en route to Mercury.

关键词： Mercury’s magnetosphere flux transfer event shower Extreme solar events Core induction Reconnection erosion Dawn-dusk asymmetry Substorm current wedge Particle energization Kelvin-Helmholtz wave

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Imidazolium-based ionic liquids as additives to preserve the Enhanced Green fluorescent Protein fluorescent activity

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Green Chemical Engineering 2021年第4期2卷 412-422页

作者： Nathalia V.Veríssimo Carolina f.Saponi Timothy M.ryan Tamar L.Greaves Jorge f.B.Pereira Department of Engineering of Bioprocesses and Biotechnology School of Pharmaceutical SciencesSao Paulo State University(UNESP)Rodovia Araraquara-Jaú/Km 0114800-903AraraquaraSPBrazil School of Science College of ScienceEngineering and HealthRMIT University124 La Trobe StreetMelbourneVIC 3000Australia School of Pharmaceutical Sciences Sao Paulo University(USP)Av.Prof.Lineu Prestesno.580B1605508-000Cidade de UniversitariaSao PauloSPBrazil Australian Synchrotron 800 Blackburn RoadClaytonVIC 3168Australia Univ Coimbra CIEPQPFDepartment of Chemical EngineeringRua Sílvio LimaPolo II–Pinhal de Marrocos3030-790 CoimbraPortugal

fluorescent Proteins(fP)can be applied as biomarkers and biosensors in the industrial and medical fields,but their large-scale use,especially for new industrial applications,is limited due to their low ***,the discovery of additives capable of preserving the activity of fP at room temperature and under stress conditions can help to expand and facilitate their commercial *** this goal,we evaluated the application of 1-alkyl-3-methylimidazolium chloride-based([C_(n)mim]Cl)ionic liquids(ILs)as additives to preserve the activity of Enhanced Green fluorescent Protein(EGfP)at different storage times and under unfavorable ***[C_(n)mim]Cl solutions(at 0.100 mol L^(-1))were able to preserve EGfP fluorescence for longer than the phosphatesaline buffer(PBS)and NaCl solutions,increasing its fluorescence manifestation from 1 to 3 months.[C_(n)mim]Cl with shorter to medium cationic alkyl chains were the most effective in preserving EGfP fluorescence.[C_(n)mim]Cl also protected EGfP activity in the presence of the surfactant SDS,the acid guanidine hydrochloride,and H_(2)O_(2).Therefore,[C_(n)mim]Cl can be added to aqueous solutions to preserve EGfP fluorescence activity at room temperature for longer storage times and to reduce the negative impact of denaturing agents on ***,there is a massive potential for the application of ILs as additives to preserve fP in the long-term without refrigeration and under unfavorable conditions,and this is fundamental to enable expansion of fP in industrial and commercial applications.

关键词： Green fluorescent Protein Protein stability fluorescence Ionic liquids Preservatives

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SIMULTANEOUS SAXS/WAXS/DSC STUDIES ON MICROSTRUCTURE Of CONVENTIONAL AND METALLOCENE-BASED ETHYLENE-BUTENE COPOLYMERS

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Chinese Journal of Polymer Science 2004年第3期22卷 279-287页

作者：徐君庭 Anthony J. ryan Department of Polymer Science & Engineering Zhejiang University Hangzhou 310027 China Chemistry Department The University of Sheffield Sheffield S3 7HF UK

The fractions of one metallocene-based (mPE) and one conventional (znPE) ethylene-butene copolymer eluted at from temperature rising elution fractionation were selected for DSC and time-resolved small angle X-ray scattering (SAXS) and wide angle X-ray scattering (WAXS) characterization. The DSC and WAXS results show that two crystal structures exist in both mPE and znPE: structure A with higher melting temperature and structure B with lower melting temperature. It was found that original znPE (s-znPE) contains more highly ordered structure A than original mPE (s-mPE) in spite of the higher comonomer content of znPE. Another structure C is also identified because of higher crystallinity measured by WAXS than by DSC and is attributed to the interfacial region. The SAXS data were analyzed with correlation function and two maxima were observed in s-mPE and s-znPE, in agreement with the conclusion of two crystal populations drawn from DSC and WAXS results. These two crystal populations have close long periods in s-mPE, but very different long periods in s-znPE. In contrast, freshly crystallized mPE and znPE (f-mPE and f-znPE) contain only a single crystal population with a broader distribution of long period

关键词： SAXS WAXS Microstructure Metallocene Ethylene-butene copolymer

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Like mother, like daughter： heritability of female Richardson＇s ground squirrel Urocitellus richardsonii cortisol stress responses

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Current Zoology 2018年第2期64卷 153-163页

作者： Kevin R. BAIROS-NOVAK Calen R ryan Angela R. fREEMAN W. Gary ANDERSON James f, HARE Department of Biological Sciences University of Manitoba Winnipeg Manitoba R3T 2N2 Canada Departmentof Biology University of Saskatchewan Saskatoon S7N 5E2 Saskatchewan Canada Department ofAnthropology Northwestern University Evanston 60208 Illinois USA Department of Biological Sciences Kent State University Kent 44242 Ohio USA

Activation of the hypothalamic-pituitary-adrenal （HPA） axis liberates glucocorticoids, which provides an acute indication of an individual＇s response to stressors. The heritability of the stress response in wild mammals, however, remains poorly documented. We quantified the cortisol stress response of female Richardson＇s ground squirrels （RGSs） to handling and physical restraint, testing for：（1） the effects of individual age, time of day, and sample latency; （2） repeatability within individuals; （3） narrow-sense heritability; and （4） differences among individuals owing to potential genetic and/or environmental effects. We detected a positive linear relationship between baseline plasma cortisol （BL-cortisol） concentration and stress-induced plasma cortisol （Sl-cortisol） concentration that defined each individual＇s cortisol stress response. BL-cortisol, SI-cortisol, and stress response did not differ according to the time the sample was taken, or by subject age. Cortisol stress response was highly repeatable within individuals, had a mother-offspring heritability of h2 =0.40 ± 0.24 （mean ±SE）, full-sibling heritability of h2s = 0.37 ± 0.71, and half-sibling heritabil- ity of hHS^2 = 0.75 ± 1.41. Stress responses of sibling groups, immediate-family groups, and squir- rels within a given area did not differ, whereas those of individuals from more distantly related matrilines did. Our results highlight the natural variability in HPA axis reactivity among individuals by quantifying both BL- and SI-cortisol levels, demonstrate partial heritability of the stress response that is not attributable to environmental variation, and suggest that at least part of an indi- vidual＇s stress response can be accounted for by differences in matrilineal history.

关键词： glucocorticoids ground squirrel heritability hypothalamic-pituitary-adrenal axis reactivity stress response.

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Assessment of Weight and Health in the Emergency Department: A Cross-Sectional Study

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Open Journal of Emergency Medicine 2022年第2期10卷 138-147页

作者： Matthew f. ryan Department of Emergency Medicine University of Florida Gainesville USA

Introduction: The prevalence of obesity and obesity-related diseases continues to rise. A key aspect of prevention and treatment of these disorders requires clear communication about weight and health between patients and healthcare providers. Objective: We sought to examine the prevalence rate of obesity and associated comorbid illnesses in an emergency department (ED) population. A second aim was to assess patients’ perceptions of their weight and their overall health. Methods: This is a cross-sectional study performed in an academic tertiary-care center using a representative sample of patients (≥18 yr) who presented to the ED. Pregnant patients, patients who were medically unstable, cognitively impaired or who were unable or unwilling to provide informed consent were excluded. Anthropometric measurements were taken which include BMI (the ratio of a patient’s weight and height expressed as kg/m2) and waist circumference. In addition, the prevalence rates of all enrolled patients who 1) feel their health is affecting their weight and 2) who have had or recall discussions about their health and weight with their provider were examined by using a two-question validated survey. Results: The overall prevalence rate of obesity in this study was 38.6%. Only 71.8% (95% CI, 63.2% - 80.6%) of overweight patients (BMI = 25.0 - 29.9) and 28.4% (95% CI, 21.6% - 35.2%) of obese patients (BMI ≥ 30.0) believe their present weight is damaging to their health. further, only 15.5% (95% CI, 8.5% - 22.6%) and 59.4% (95% CI, 53% - 67%) of those overweight and obese, respectively, recall being informed by their healthcare provider they are overweight. for morbidly obese patients (BMI ≥ 40.0), 79.6% (95% CI, 12.2 - 28.6) feel their weight is damaging their health and 83.7% (95% CI, 9.4 - 23.2) recall having a conversation about weight with their healthcare provider. Conclusion: Many obese and overweight patients believe their weight does not impact their health and have not h

关键词： Obesity Comorbid Conditions Health and Weight Patient Perceptions Emergency Medicine Patient-Provider Communication

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