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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

Climate change,coastal built heritage,and critical challenges facing the heritage law frameworks of the United States,United Kingdom,and France

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Built Heritage 2022年第1期6卷 42-54页

作者： ryan Rowberry Georgia State University College of Law 85 Park PlaceAtlantaGA 30303USA

Climate change poses a particular threat to the world's unique built heritage-historic buildings,sites monuments,and *** preserving built heritage resources from climate change becomes a global priority,understanding the current inadequacies of legal frameworks designed to protect built heritage in coastal areas is *** by identifying and examining these shortfalls can countries create resilient legal policies and tools that better protect coastal built heritage from the immediate and long-term effects of climate *** on previous comparative cultural heritage law scholarship,this article describes the legal frameworks that the United States,United Kingdom,and France use to protect their respective built heritage in coastal areas and identifies two critical challengesfacing eachcountry.

关键词： Climate change Built heritage law Legal frameworks Challenges United States United Kingdom France

Optical redox imaging of ANT1-de-cient muscles

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 135-140页

作者： He N.Xu ryan M.Morrow Min Feng Huaqing Zhao Douglas Wallace Lin Z.Li Britton Chance Laboratory of Redox Imaging Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA 19104USA Center for Mitochondrial and Epigenomic Medicine Children's Hospital of Philadelphia Research Institute Philadelphia PA 19104USA Center for Biostatistics and Epidemiology Lewis Katz School of Medicine at Temple University Philadelphia PA 19140USA

Adenine nucleotide translocator(ANT)is a mitochondrial protein involved in the exchange of ADP and ATP across the mitochondrial inner *** plays a crucial role in cellular energy metabolism by facilitating the transport of ATP synthesized within the mitochondria to the *** isoform ANT1 predominately expresses in cardiac and skeletal *** or dysregulation in ANT1 have been implicated in various mitochondrial disorders and neuromuscular *** aimed to examine whether ANT1 deletion may affect mitochondrial redox state in our established ANT1-de-cient *** and quadriceps resected from age-matched wild type(WT)and ANT1-de-cient mice were snap-frozen in liquid *** Chance redox scanner was utilized to perform 3D optical redox *** sample underwent scanning across 3–5 *** averaging analysis showed no signi-cant differences in the redox indices(NADH,flavin adenine dinucleotide containing-flavoproteins Fp,and the redox ratio Fp/(NADH+Fp)between WT and ANT1-de-cient ***,quadriceps had higher Fp than hearts in both groups(p¼0:0004 and 0.01,respectively).Furthermore,the quadriceps were also more oxidized(a higher redox ratio)than hearts in WT group(p¼0:004).NADH levels were similar in all *** data suggest that under non-stressful physical condition,the ANT1-de-cient muscle cells were in the same mitochondrial state as WT ones and that the signi-cant difference in the mitochondrial redox state between quadriceps and hearts found in WT might be diminished in ANT1-de-cient *** imaging of muscles under physical stress can be conducted in future.

关键词： ANT1 redox ratio flavoproteins

Capitalizing on Superconvergence for More Accurate Multi‑Resolution Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2022年第2期4卷 417-436页

作者： Jennifer K.ryan Applied Mathematics and Statistics Colorado School of MinesGoldenCO 80401USA

This article focuses on exploiting superconvergence to obtain more accurate multi-resolution analysis. Specifcally, we concentrate on enhancing the quality of passing of information between scales by implementing the Smoothness-Increasing Accuracy-Conserving (SIAC) fltering combined with multi-wavelets. This allows for a more accurate approximation when passing information between meshes of diferent resolutions. Although this article presents the details of the SIAC flter using the standard discontinuous Galerkin method, these techniques are easily extendable to other types of data.

关键词： Multi-resolution analysis Multi-wavelets Discontinuous Galerkin Smoothness-Increasing Accuracy-Conserving(SIAC) Post-processing Superconvergence Accuracy enhancement

Protein-modified SEI formation and evolution in Li metal batteries

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Journal of Energy Chemistry 2022年第10期31卷 248-258,I0006页

作者： Chenxu Wang ryan Odstrcil Jin Liu Wei-Hong Zhong School of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA

Despite numerous reported lithium metal batteries(LMBs) with excellent cycling performance achieved in labs, transferring the high performing LMBs from lab-scale to industrial-production remains challenging. Therefore, via imitating the stand-still process in battery production, a conventional but important procedure, to investigate the formation and evolution of a solid electrolyte interface(SEI) is particularly important for LMBs. Our previous studies indicate that zein(corn protein)-modified carbonate-ester electrolyte(the most commercialized) effectively improves the performance of LMBs through guiding Li-ions and repairing cracked SEI. Herein, we investigate the formation and evolution of the protein-modified SEIs on Li anodes by imitating the stand-still temperature and duration. A simulation study on the protein denaturation in the electrolyte under different temperatures demonstrates a highly unfolded configuration at elevated temperatures. The experiments show that this heat-treated-zein(H-zein) modified SEI forms quickly and becomes stable after a stand-still process of less than 100 min. Moreover, the Hzein SEI exhibits excellent wetting behavior with the electrolyte due to the highly unfolded protein structures with more functional groups exposed. The Li|Li cell with the H-zein SEI achieves prolonged cycling performance(>360 h vs. ~260 h of the cell with the untreated-zein(U-zein) modified SEI). The Li Fe PO_(4)|Li cell with the H-zein SEI shows much stable long-term cycling performance of capacity retention(70% vs.42% of the cell with U-zein SEI) after 200 cycles. This study confirms that the appropriately treated protein is able to effectively improve the performance of LMBs, and will inspire future studies for the production process of LMBs toward their commercialization.

关键词： Protein Zein Lithium metal Stand-still Battery SEI

A WEPp-Water Quality model for simulating nonpoint source pollutants in nonuniform agricultural hillslopes:Model development and sensitivity

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International Soil and Water Conservation Research 2023年第3期11卷 455-469页

作者： ryan PMcGehee Dennis CFlanagan Bernard AEngel Department of Agricultural and Biological Engineering Purdue University225 South University StreetWest LafayetteIN47907USA DA-Agricultural Research Service National SoilErosion Research Laboratory275 South Russell StreetWest LafayetteIN4797USA

The Water Erosion Prediction Project(WEPP)model code was modified extensively to support the simulation of nonpoint source(NPS)pollutant sourcing and transport in nonuniform hillslopes based on NPS science from the Soil and Water Assessment Tool(SWAT).This was accomplished utilizing WEPP's overland flow element(OFE)in place of SWAT's hydrologic response unit(HRU)construct which enabled more physically plausible routing within a *** addition,several improvements to the NPS code base were *** include:free-source format,modern-Fortran conventions,minor enhancements to NPS model science,and code *** manuscript documents all model development activities,presents a comparison of relevant WEPP and WEPP-WQ code bases,and performs a local sensitivity analysis of the final model code for the most important input parameters and *** results indicated that the model performed as expected according to its design and provided important insights for potential subsequent validation studies.

关键词： WEPP SWAT WEPP-WQ Water quality Nonpoint Sensitivity

A bayesian optimisation methodology for the inverse derivation of viscoplasticity model constants in high strain-rate simulations

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Defence Technology（防务技术） 2022年第9期18卷 1563-1577页

作者： Shannon ryan Julian Berk Santu Rana Brodie McDonald Svetha Venkatesh Applied Artificial Intelligence Institute(A^(2)I^(2)) Deakin University75 Pigdons RdWaurn PondsVIC3216Australia Defence Science and Technology Group 506 Lorimer StreetFishermans BendVIC3207Australia

We present an inverse methodology for deriving viscoplasticity constitutive model parameters for use in explicit finite element simulations of dynamic processes using functional experiments, i.e., those which provide value beyond that of constitutive model development. The developed methodology utilises Bayesian optimisation to minimise the error between experimental measurements and numerical simulations performed in LS-DYNA. We demonstrate the optimisation methodology using high hardness armour steels across three types of experiments that induce a wide range of loading conditions: ballistic penetration, rod-on-anvil, and near-field blast deformation. By utilising such a broad range of conditions for the optimisation, the resulting constitutive model parameters are generalised, i.e., applicable across the range of loading conditions encompassed the by those experiments(e.g., stress states, plastic strain magnitudes, strain rates, etc.). Model constants identified using this methodology are demonstrated to provide a generalisable model with superior predictive accuracy than those derived from conventional mechanical characterisation experiments or optimised from a single experimental condition.

关键词： Constitutive modelling Finite element Bayesian optimisation Finite element model updating

Measuring absolute adsorption in porous rocks using oscillatory motions of a spring-mass system

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Chinese Journal of Chemical Engineering 2022年第4期35卷 131-139页

作者： Younki Cho ryan Lo Keerthana Krishnan Xiaolong Yin Hossein Kazemi Petroleum Engineering Colorado School of MinesGoldenCO 80401USA

We present an oscillation-based method to measure absolute adsorption,or total gas,contained in porous rocks without and with excess *** conducted with a macroporous Berea sandstone sample in nitrogen where excess adsorption is negligible show that absolute adsorption can be obtained after the added mass of co-accelerated gas outside the sample is *** experiments conducted in propane with a crushed Niobrara shale sample with micro-and mesopores,absolute adsorption included significant excess *** subtracting both the added mass outside the sample and the gas that would be in the sample assuming no excess adsorption existed,estimated excess adsorption of propane is in good agreement with that projected based on capillary condensation of propane in the volume of mesopores.

关键词： Adsorption Porous media Shale Capillary condensation Oscillation

Vibrating Particles System Algorithm for Solving Classification Problems

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Computer Systems Science & Engineering 2022年第12期43卷 1189-1206页

作者： Mohammad Wedyan Omar Elshaweesh Enas Ramadan ryan Alturki Department of Autonomous Systems Faculty of Artificial IntelligenceAl-Balqa Applied UniversityAl-Salt19117Jordan Department of Software Engineering Information Technology CollegeAL-Hussein bin Talal UniversityMa’an71111Jordan Department of Computer Science Prince Abdullah Bin Ghazi Faculty of Communication and Information TechnologyAl-Balqa Applied UniversityAl-Salt19117Jordan Department of Information Science College of Computer and Information SystemsUmm Al-Qura UniversityMakkah21961Saudi Arabia

Big data is a term that refers to a set of data that,due to its largeness or complexity,cannot be stored or processed with one of the usual tools or applications for data management,and it has become a prominent word in recent years for the massive development of *** immediately thereafter,the term“big data mining”emerged,i.e.,mining from big data even as an emerging and interconnected field of *** is an important stage in data mining since it helps people make better decisions in a variety of situations,including scientific endeavors,biomedical research,and industrial *** probabilistic neural network(PNN)is a commonly used and successful method for handling classification and pattern recognition *** this study,the authors proposed to combine the probabilistic neural network(PPN),which is one of the data mining techniques,with the vibrating particles system(VPS),which is one of the metaheuristic algorithms named“VPS-PNN”,to solve classi-fication problems more *** data set is eleven common benchmark medical datasets from the machine-learning library,the suggested method was *** suggested VPS-PNN mechanism outperforms the PNN,biogeography-based optimization,enhanced-water cycle algorithm(E-WCA)and the firefly algorithm(FA)in terms of convergence speed and classification accuracy.

关键词： Vibrating particles system(VPS) probabilistic neural network(PNN) classification problem data mining