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Modern treatment strategies for penile prosthetics in Peyronie’s disease:a contemporary clinical review

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Asian Journal of Andrology 2020年第1期22卷 51-59页

作者： Matthew J Ziegelmann M ryan Farrell Laurence A Levine Division of Urology Rush University Medical CenterChicagoIL 60612USA

Peyronie's disease is a common condition resulting in penile deformity,psychological bother,and sexual *** dysfunction is one common comorbid condition seen in men with Peyronie’s disease,and its presence significantly impacts treatment *** a man with Peyronie's disease and significant erectile dysfunction who desires the most reliable treatment,penile prosthesis placement should be strongly *** some instances,such as those patients with relatively mild curvature,prosthesis placement alone may result in adequate ***,many patients will require additional straightening maneuvers such as manual modeling,penile plication,and tunica albuginea incision with or without *** patients with severe penile shortening,penile length restoration techniques may also be ***,we provide a comprehensive clinical review of penile prosthesis placement in men with Peyronie's ***,we discuss preoperative indications,intraoperative considerations,adjunctive straightening maneuvers,and postoperative outcomes.

关键词： collagenase grafting penile length penile prosthesis Peyronie's

Alzheimer’s disease:a tale of two diseases?

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Neural Regeneration Research 2021年第10期16卷 1958-1964页

作者： Eleonora Nardini ryan Hogan Anthony Flamier Gilbert Bernier Whitehead Institute for Biomedical Research CambridgeMAUSA Stem Cell and Developmental Biology Laboratory Hôpital Maisonneuve-RosemontMontrealQCCanada Department of Neurosciences University of MontrealMontrealQCCanada

Sporadic late-onset Alzheimer’s disease(SLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,are thought to represent a spectrum of the same disorder based on near identical behavioral and histopathological ***,FEOAD transgenic mouse models have been used in past decades as a surrogate to study SLOAD pathogenic mechanisms and as the gold standard to validate drugs used in clinical ***,such research has yielded little output in terms of therapeutics targeting the disease’s development and *** this short review,we interrogate the widely accepted view of one,dimorphic disease through the prism of the Bmi1+/–mouse model and the distinct chromatin signatures observed between SLOAD and FEOAD brains.

关键词： aging Alzheimer’s disease BMI1 epigenetics familial late-onset sporadic

Measuring absolute adsorption in porous rocks using oscillatory motions of a spring-mass system

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Chinese Journal of Chemical Engineering 2022年第4期35卷 131-139页

作者： Younki Cho ryan Lo Keerthana Krishnan Xiaolong Yin Hossein Kazemi Petroleum Engineering Colorado School of MinesGoldenCO 80401USA

We present an oscillation-based method to measure absolute adsorption,or total gas,contained in porous rocks without and with excess *** conducted with a macroporous Berea sandstone sample in nitrogen where excess adsorption is negligible show that absolute adsorption can be obtained after the added mass of co-accelerated gas outside the sample is *** experiments conducted in propane with a crushed Niobrara shale sample with micro-and mesopores,absolute adsorption included significant excess *** subtracting both the added mass outside the sample and the gas that would be in the sample assuming no excess adsorption existed,estimated excess adsorption of propane is in good agreement with that projected based on capillary condensation of propane in the volume of mesopores.

关键词： Adsorption Porous media Shale Capillary condensation Oscillation

A bayesian optimisation methodology for the inverse derivation of viscoplasticity model constants in high strain-rate simulations

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Defence Technology（防务技术） 2022年第9期18卷 1563-1577页

作者： Shannon ryan Julian Berk Santu Rana Brodie McDonald Svetha Venkatesh Applied Artificial Intelligence Institute(A^(2)I^(2)) Deakin University75 Pigdons RdWaurn PondsVIC3216Australia Defence Science and Technology Group 506 Lorimer StreetFishermans BendVIC3207Australia

We present an inverse methodology for deriving viscoplasticity constitutive model parameters for use in explicit finite element simulations of dynamic processes using functional experiments, i.e., those which provide value beyond that of constitutive model development. The developed methodology utilises Bayesian optimisation to minimise the error between experimental measurements and numerical simulations performed in LS-DYNA. We demonstrate the optimisation methodology using high hardness armour steels across three types of experiments that induce a wide range of loading conditions: ballistic penetration, rod-on-anvil, and near-field blast deformation. By utilising such a broad range of conditions for the optimisation, the resulting constitutive model parameters are generalised, i.e., applicable across the range of loading conditions encompassed the by those experiments(e.g., stress states, plastic strain magnitudes, strain rates, etc.). Model constants identified using this methodology are demonstrated to provide a generalisable model with superior predictive accuracy than those derived from conventional mechanical characterisation experiments or optimised from a single experimental condition.

关键词： Constitutive modelling Finite element Bayesian optimisation Finite element model updating

Numerical Diffusion Control of a Space-Time Discontinuous Galerkin Method

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Communications in Computational Physics 2009年第2期5卷 469-483页

作者： Michel Borrel Juliette ryan ONERA BP72-29 Avenue de la Division Leclerc92322Chatillon CedexFrance

Variations on space-time Discontinuous Galerkin(STDG)discretization associated to Runge-Kutta schemes are *** new schemes while keeping the original scheme order can improve accuracy and *** analysis is made on academ... 详细信息

关键词： Gas dynamics aeroacoustics discontinuous Galerkin discretization Runge-Kutta schemes numerical diffusion control

A Multi-Flow Information Flow Tracking Approach for Proving Quantitative Hardware Security Properties

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Tsinghua Science and Technology 2021年第1期26卷 62-71页

作者： Yu Tai Wei Hu Lu Zhang Dejun Mu ryan Kastner the School of Cybersecurity Northwestern Polytechnical UniversityXi'an 710072China the School of Automation Northwestern Polytechnical UniversityXi'an 710072China the Department of Computer Science and Engineering University of CaliforniaSan DiegoCA 92093USA

Information Flow Tracking(IFT)is an established formal method for proving security properties related to confidentiality,integrity,and *** has seen promise in identifying security vulnerabilities resulting from design flaws,timing channels,and hardware Trojans for secure hardware ***,existing IFT methods tend to take a qualitative approach and only enforce binary security properties,requiring strict non-interference for the properties to hold while real systems usually allow a small amount of information flows to enable desirable ***,existing methods are inadequate for reasoning about quantitative security properties or measuring the security of a design in order to assess the severity of a security *** this work,we propose two multi-flow solutions—multiple verifications for replicating existing IFT model and multi-flow IFT *** proposed multi-flow IFT method provides more insight into simultaneous information flow behaviors and allows for proof of quantitative information flow security properties,such as diffusion,randomization,and boundaries on the amount of simultaneous information *** results show that our method can be used to prove a new type of information flow security property with verification performance benefits.

关键词： hardware security Information Flow Tracking(IFT) multi-flow IFT security property

Epidemiology of diabetic retinopathy,diabetic macular edema and related vision loss

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Eye and Vision 2015年第1期2卷 137-161页

作者： ryan Lee Tien YWong Charumathi Sabanayagam Singapore Eye Research Institute Singapore National Eye CentreSingaporeSingapore Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Graduate Medical SchoolSingaporeSingapore

Diabetic retinopathy(DR)is a leading cause of vision-loss *** an estimated 285 million people with diabetes mellitus worldwide,approximately one third have signs of DR and of these,a further one third of DR is vision-threatening DR,including diabetic macular edema(DME).The identification of established modifiable risk factors for DR such as hyperglycemia and hypertension has provided the basis for risk factor control in preventing onset and progression of *** research investigating novel risk factors has improved our understanding of multiple biological pathways involved in the pathogenesis of DR and DME,especially those involved in inflammation and oxidative *** in DR prevalence between populations have also sparked interest in genetic studies to identify loci associated with disease *** this review,major trends in the prevalence,incidence,progression and regression of DR and DME are explored,and gaps in literature *** and novel risk factors are also extensively reviewed with a focus on landmark studies and updates from the recent literature.

关键词： Diabetic retinopathy Diabetic macular edema Epidemiology Risk factors

Constraints on treeline advance in a warming climate:a test of the reproduction limitation hypothesis

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Journal of Plant Ecology 2018年第3期11卷 411-422页

作者： Dasvinder Kambo ryan K.Danby Department of Geography Queen’s University99 University AvenueKingstonOntario K7L 3N6Canada School of Environmental Studies Queen’s University99 University AvenueKingstonOntario K7L 3N6Canada

Aims Several mechanistic hypotheses have been developed to explain the existence of alpine treelines *** reproduction limita-tion hypothesis(RLH)postulates that reproductive processes such as seed production and dispersal are restricted in treeline envi-ronments,thereby limiting the establishment of new individuals in advance of extant *** its popularity,no study has tested this hypothesis in a comprehensive *** this experi-ment,we attempted to answer whether there are enough viable seeds being dispersed beyond treeline for sexually mediated tree-line advance,and what the implications of climate change might be on these *** We established 30 plots across two aspects(north ***)and three elevational habitats(forest,treeline and tundra)in a white spruce(Picea glauca)boreal forest-alpine tundra ecotone in south-west Yukon,*** each plot,tree characteristics,seed produc-tion and predispersal damage were ***,eight dispersal trays were positioned in each plot to measure seed rain,and germination trials with and without predation exclosures were constructed in a subset of plots to quantify dispersal and germina-tion *** Findings Results were highly variable both temporally and *** 2014,a mast year,69%of adult trees produced cones compared to 0.4%in the following *** density of trees in forest plots compared to treeline and tundra resulted in greater seed production at lower *** all plots,88%of seeds were damaged before dispersal or were not *** plots had significantly greater predispersal *** rain was greater in south-facing plots than north-facing *** than 2%of seeds produced on the landscape were dispersed into Tundra plots,located 50 m above *** was a net movement of seeds from the north-facing slope to the south at our study site,likely due to prevailing winds during the dispersal *** counts were more

关键词： altitudinal gradients treeline dynamics predispersal seed damage seed predation seed masts ecotones

The Role of the p38 Pathway in Adaptive Immunity

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Cellular & Molecular Immunology 2007年第4期4卷 253-259页

作者： ryan Cook Chia-Cheng Wu Young Jun Kang Department of Immunology The Scripps Research Institute10550 North Torrey Pines RoadLa JollaCA 92037USA

Since its discovery in 1993, the mitogen-activated protein （MAP） kinase p38 has attracted much attention for its role in a wide range of cellular processes, many of which involve the immune system. Although p38 has been heavily implicated in the function of all type immune cells, research has tended focus on its role in innate immunity. In this review we attempt to highlight some of the major discoveries that have been made regarding p38＇s role in adaptive immunity, and also to discuss the possible future implications of these discoveries.

关键词： p38 MAPK adaptive immunity T cell B cell