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Optical redox imaging of ANT1-de-cient muscles

Journal of Innovative Optical Health Sciences 2024年第1期17卷 135-140页

作者： He N.Xu ryan M.Morrow Min Feng Huaqing Zhao Douglas Wallace Lin Z.Li Britton Chance Laboratory of Redox Imaging Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA 19104USA Center for Mitochondrial and Epigenomic Medicine Children's Hospital of Philadelphia Research Institute Philadelphia PA 19104USA Center for Biostatistics and Epidemiology Lewis Katz School of Medicine at Temple University Philadelphia PA 19140USA

Adenine nucleotide translocator(ANT)is a mitochondrial protein involved in the exchange of ADP and ATP across the mitochondrial inner *** plays a crucial role in cellular energy metabolism by facilitating the transport of ATP synthesized within the mitochondria to the *** isoform ANT1 predominately expresses in cardiac and skeletal *** or dysregulation in ANT1 have been implicated in various mitochondrial disorders and neuromuscular *** aimed to examine whether ANT1 deletion may affect mitochondrial redox state in our established ANT1-de-cient *** and quadriceps resected from age-matched wild type(WT)and ANT1-de-cient mice were snap-frozen in liquid *** Chance redox scanner was utilized to perform 3D optical redox *** sample underwent scanning across 3–5 *** averaging analysis showed no signi-cant differences in the redox indices(NADH,flavin adenine dinucleotide containing-flavoproteins Fp,and the redox ratio Fp/(NADH+Fp)between WT and ANT1-de-cient ***,quadriceps had higher Fp than hearts in both groups(p¼0:0004 and 0.01,respectively).Furthermore,the quadriceps were also more oxidized(a higher redox ratio)than hearts in WT group(p¼0:004).NADH levels were similar in all *** data suggest that under non-stressful physical condition,the ANT1-de-cient muscle cells were in the same mitochondrial state as WT ones and that the signi-cant difference in the mitochondrial redox state between quadriceps and hearts found in WT might be diminished in ANT1-de-cient *** imaging of muscles under physical stress can be conducted in future.

关键词： ANT1 redox ratio flavoproteins

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Capitalizing on Superconvergence for More Accurate Multi‑Resolution Discontinuous Galerkin Methods

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Communications on Applied Mathematics and Computation 2022年第2期4卷 417-436页

作者： Jennifer K.ryan Applied Mathematics and Statistics Colorado School of MinesGoldenCO 80401USA

This article focuses on exploiting superconvergence to obtain more accurate multi-resolution analysis. Specifcally, we concentrate on enhancing the quality of passing of information between scales by implementing the Smoothness-Increasing Accuracy-Conserving (SIAC) fltering combined with multi-wavelets. This allows for a more accurate approximation when passing information between meshes of diferent resolutions. Although this article presents the details of the SIAC flter using the standard discontinuous Galerkin method, these techniques are easily extendable to other types of data.

关键词： Multi-resolution analysis Multi-wavelets Discontinuous Galerkin Smoothness-Increasing Accuracy-Conserving(SIAC) Post-processing Superconvergence Accuracy enhancement

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Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan

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Neural Regeneration Research 2018年第8期13卷 1309-1312页

作者： ryan J.Piers Department of Psychological and Brain Sciences Boston University

Apolipoprotein E4（ApoE4） is a prominent genetic risk factor for Alzheimer＇s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan（i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates）. Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer＇s disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.

关键词： MRI healthy aging genetic risk factor biomarker Alzheimer's disease

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SIMULTANEOUS SAXS/WAXS/DSC STUDIES ON MICROSTRUCTURE OF CONVENTIONAL AND METALLOCENE-BASED ETHYLENE-BUTENE COPOLYMERS

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Chinese Journal of Polymer Science 2004年第3期22卷 279-287页

作者：徐君庭 Anthony J. ryan Department of Polymer Science & Engineering Zhejiang University Hangzhou 310027 China Chemistry Department The University of Sheffield Sheffield S3 7HF UK

The fractions of one metallocene-based (mPE) and one conventional (znPE) ethylene-butene copolymer eluted at from temperature rising elution fractionation were selected for DSC and time-resolved small angle X-ray scattering (SAXS) and wide angle X-ray scattering (WAXS) characterization. The DSC and WAXS results show that two crystal structures exist in both mPE and znPE: structure A with higher melting temperature and structure B with lower melting temperature. It was found that original znPE (s-znPE) contains more highly ordered structure A than original mPE (s-mPE) in spite of the higher comonomer content of znPE. Another structure C is also identified because of higher crystallinity measured by WAXS than by DSC and is attributed to the interfacial region. The SAXS data were analyzed with correlation function and two maxima were observed in s-mPE and s-znPE, in agreement with the conclusion of two crystal populations drawn from DSC and WAXS results. These two crystal populations have close long periods in s-mPE, but very different long periods in s-znPE. In contrast, freshly crystallized mPE and znPE (f-mPE and f-znPE) contain only a single crystal population with a broader distribution of long period

关键词： SAXS WAXS Microstructure Metallocene Ethylene-butene copolymer

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《再论语言学习者心理》述评

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外语教学与研究 2018年第1期50卷 152-155页

作者：林敦来 Zoltán D?rnyei Stephen ryan 北京师范大学

1.引言2005年英国诺丁汉大学Zoltan Domyei教授撰写了《语言学习者心理》。时隔十年，原书作者联合日本专修大学的Stephenryan教授再论语言学习者心理。从Skehan（1989）起，学习者个体差异因其影响二语习得速度和最终水平而备受研究者... 详细信息

1.引言2005年英国诺丁汉大学Zoltan Domyei教授撰写了《语言学习者心理》。时隔十年，原书作者联合日本专修大学的Stephenryan教授再论语言学习者心理。从Skehan（1989）起，学习者个体差异因其影响二语习得速度和最终水平而备受研究者关注，但由独立作者整本论述学习者个体差异的著作不多，本书便是其中之一。D6myei教授长期致力于个体差异研究，特别在动机研究方面有突出贡献。本书作为D6myei（2005）的续篇，读来可以很清楚地了解过去十年学习者个体差异研究的进展。

关键词：学习者心理语言个体差异研究英国诺丁汉大学述评二语习得教授研究者

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Vasectomy reversal： a clinical update

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Asian Journal of Andrology 2016年第3期18卷 365-371,I0007页

作者： Abhishek P Patel ryan P Smith Department of Urology University of Virginia Charlottesville VA 22908-0422 USA.

Vasectomy is a safe and effective method of contraception used by 42-60 million men worldwide. Approximately 3%-6% of men opt for a vasectomy reversal due to the death of a child or divorce and remarriage, change in financial situation, desire for more children within the same marriage, or to alleviate the dreaded postvasectomy pain syndrome. Unlike vasectomy, vasectomy reversal is a much more technically challenging procedure that is performed only by a minority of urologists and places a larger financial strain on the patient since it is usually not covered by insurance. Interest in this procedure has increased since the operating microscope became available in the 1970s, which consequently led to improved patency and pregnancy rates following the procedure. In this clinical update, we discuss patient evaluation, variables that may influence reversal success rates, factors to consider in choosing to perform vasovasostomy versus vasoepididymostomy, and the usefulness of vasectomy reversal to alleviate postvasectomy pain syndrome. We also review the use of robotics for vasectomy reversal and other novel techniques and instrumentation that have emerged in recent years to aid in the success of this surgery.

关键词： epididymovasostomy microsurgery postvasectomy orchialgia postvasectomy pain syndrome vas deferens vasectomy vasectomy reversal vasoepididymostomy vasovasostomy

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A new framework for reverse cholesterol transport: Non-biliary contributions to reverse cholesterol transport

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World Journal of Gastroenterology 2010年第47期16卷 5946-5952页

作者： ryan E Temel J Mark Brown Department of Pathology Section on Lipid SciencesWake Forest University School of Medicine

Reduction of low-density lipoprotein-cholesterol through statin therapy has only modestly decreased coronary heart disease (CHD)-associated mortality in developed countries, which has prompted the search for alternative therapeutic strategies for CHD. Major efforts are now focused on therapies that augment high-density lipoprotein (HDL)-mediated reverse cholesterol transport (RCT), and ultimately increase the fecal disposal of cholesterol. The process of RCT has long been thought to simply involve HDL-mediated delivery of peripheral cholesterol to the liver for biliary excretion out of the body. However, recent studies have revealed a novel pathway for RCT that does not rely on biliary secretion. This nonbiliary pathway rather involves the direct excretion of cholesterol by the proximal small intestine. Compared to RCT therapies that augment biliary sterol loss, modulation of non-biliary fecal sterol loss through the intestine is a much more attractive therapeutic strategy, given that excessive biliary cholesterol secretion can promote gallstone formation. However, we are at an early stage in understanding the molecular mechanisms regulating the non-biliary pathway for RCT, and much additional work is required in order to effectively target this pathway for CHD prevention. The purpose of this review is to discuss our current understanding of biliary and nonbiliary contributions to RCT with particular emphasis on the possibility of targeting the intestine as an inducible cholesterol secretory organ.

关键词： Cholesterol Intestine Bile Lipoprotein Reverse cholesterol transport

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A central role for mitochondrial-derived vesicles in the innate immune response: implications for Parkinson's disease

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Neural Regeneration Research 2021年第9期16卷 1779-1780页

作者： Thomas A.ryan David A.Tumbarello Institute of Systems Molecular&Integrative BiologyFaculty of Health&Life SciencesNuffield WingSherrington BuildingUniversity of LiverpoolLiverpoolUK Biological Sciences Life Science Building 85University of SouthamptonHighfield CampusSouthamptonUK

Mitochondria are well known for their function in energy production;however they also play a crucial role in phospholipid transfer, inflammation, calcium balance and cell death, positioning them as a central regulator of cellular homeostasis. The cell therefore relies on quality control mechanisms to limit mitochondrial damage and the production of harmful reactive oxygen species(ROS).

关键词： homeostasis damage limit

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Protein-modified SEI formation and evolution in Li metal batteries

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Journal of Energy Chemistry 2022年第10期31卷 248-258,I0006页

作者： Chenxu Wang ryan Odstrcil Jin Liu Wei-Hong Zhong School of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA

Despite numerous reported lithium metal batteries(LMBs) with excellent cycling performance achieved in labs, transferring the high performing LMBs from lab-scale to industrial-production remains challenging. Therefore, via imitating the stand-still process in battery production, a conventional but important procedure, to investigate the formation and evolution of a solid electrolyte interface(SEI) is particularly important for LMBs. Our previous studies indicate that zein(corn protein)-modified carbonate-ester electrolyte(the most commercialized) effectively improves the performance of LMBs through guiding Li-ions and repairing cracked SEI. Herein, we investigate the formation and evolution of the protein-modified SEIs on Li anodes by imitating the stand-still temperature and duration. A simulation study on the protein denaturation in the electrolyte under different temperatures demonstrates a highly unfolded configuration at elevated temperatures. The experiments show that this heat-treated-zein(H-zein) modified SEI forms quickly and becomes stable after a stand-still process of less than 100 min. Moreover, the Hzein SEI exhibits excellent wetting behavior with the electrolyte due to the highly unfolded protein structures with more functional groups exposed. The Li|Li cell with the H-zein SEI achieves prolonged cycling performance(>360 h vs. ~260 h of the cell with the untreated-zein(U-zein) modified SEI). The Li Fe PO_(4)|Li cell with the H-zein SEI shows much stable long-term cycling performance of capacity retention(70% vs.42% of the cell with U-zein SEI) after 200 cycles. This study confirms that the appropriately treated protein is able to effectively improve the performance of LMBs, and will inspire future studies for the production process of LMBs toward their commercialization.

关键词： Protein Zein Lithium metal Stand-still Battery SEI

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Development of a brownfield inventory for prioritizing funding outreach in Tucson,Arizona

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Geo-Spatial Information Science 2021年第4期24卷 742-754页

作者： Theresa Foley Ann Marie Wolf Chloe Jackson ryan Stephenson Sonora Environmental Research Institute Inc.(SERI)TucsonAZUSA Pima County ITD/GIS TucsonAZUSA Pima County Community Development&Neighborhood Conservation TucsonAZUS

Fear of liability from the 1980 Comprehensive Environmental Response,Compensation,and Liability Act(CERCLA or Superfund)has prompted developers to build preferentially upon undeveloped green space rather than potentially contaminated former industrial sites,leading to urban sprawl in the suburban areas while blighted properties in the urban core remain vacant.A brownfield is defined as a property in which the presence or potential presence of a hazardous substance or contaminant poses a barrier to *** often create brownfield inventories by performing a site suitability analysis,using distinguishing features such as ecolo-gically and culturally significant areas or neighborhoods that need *** County,Arizona and the Sonora Environmental Research Institute,Inc.(SERI)developed a brownfield inventory of the large,industrial area directly to the west of Davis-Monthan Air Force *** the brownfield target area has few residential neighborhoods and lacks the distinguish-ing features usually used in a brownfield site suitability analysis,the county and SERI used the official tax assessor database and 11 federal,state and county environmental databases to develop a brownfield *** goal of the project was to prioritize properties that stood to benefit from the grant *** final brownfield inventory contained 531 parcels.

关键词： GIS site suitability analysis brownfield urban planning brownfield inventory

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