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建筑模拟(英文) 2023年第9期16卷 1645-1658页

作者： Manan Singh ryan Sharston Florida Institute for Built Environment Resilience(FIBER) College of DesignConstruction and PlanningUniversity of FloridaGainesvilleFL 32601USA

Despite known effects of urban heat island(UHI)on building energy consumption such as increased cooling energy demand,typical building energy simulation(BES)practices lack a standardized approach to incorporate UHI into building energy *** seasonal and diurnal variation of UHI makes the task of incorporating UHI into BES an especially challenging task,often limited by the availability of detailed hourly temperature data at building *** paper addresses the temporal variation of UHI by deriving four normalized UHI indicators that can successfully capture the seasonal and diurnal variation of *** accuracy of these indicators was established across four climate types including hot and humid(Miami,FL),hot and dry(Los Angeles,CA),cold and dry(Denver,CO),and cold and humid(Chicago,IL),and three building types including office,hospital,and *** four indicators are mean summer daytime UHI,mean summer nighttime UHI,mean winter daytime UHI,and mean winter nighttime UHI,which can accurately predict cooling,heating,and annual energy consumption with mean relative error of less than 1%.Not only do these indicators simplify the application of UHI to BES but also,they provide a new paradigm for UHI data collection,storage,and usage,specifically for the purpose of BES.

关键词： building energy simulation(BES) UHI indicators UHI temporal variation urban temperature variation

Inter-signal interaction and uncertain information in anuran multimodal signals

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Current Zoology 2011年第2期57卷 153-161页

作者： ryan C. TAYLOR Barrett A. KLEIN Michael J. ryan Department of Biological Sciences Salisbury University Salisbury MD 21801 USA Section of Integrative Biology University of Texas at Austin Austin TX 78712 USA Smithsonian Tropical Research Institute P.O. Box 0843-03092 Balboa Ancon Republic of Panama

Disentangling the influence of multiple signal components on receivers and elucidating general processes influencing complex signal evolution are difficult tasks. In this study we test mate preferences of female squirrel treefrogs Hyla squirella and female tungara frogs Physalaemus pustulosus for similar combinations of acoustic and visual components of their multimodal courtship signals. In a two-choice playback experiment with squirrel treefrogs, the visual stimulus of a male model significantly increased the attractivness of a relatively unattractive slow call rate. A previous study demonstrated that faster call rates are more attractive to female squirrel treefrogs, and all else being equal, models of male frogs with large body stripes are more attractive. In a similar experiment with female tungara frogs, the visual stimulus of a robotic frog failed to increase the attractiveness of a relatively unattractive call. Females also showed no preference for the distinct stripe on the robot that males commonly bear on their throat. Thus, features of conspicuous signal components such as body stripes are not universally important and signal function is likely to differ even among species with similar ecologies and communication systems. Finally, we discuss the putative information content of anuran signals and suggest that the categorization of redundant versus multiple messages may not be sufficient as a general explanation for the evolution of multimodal signaling. Instead of relying on untested assumptions concerning the information content of signals, we discuss the value of initially collecting comparative empirical data sets related to receiver responses.

关键词： Inter-signal interaction Multimodal signaling Signal detection Signal weighting Squirrel treefrog Hyla squirella Tfingara frog Physalaemus pustulosus Vocal sac

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冰岛东部最美小镇白日梦想家们的隐世仙境

环球人文地理 2024年第13期 144-153页

作者：邓文倩 Vladimir marieagns Nataliya Fotokon Sen Isabel Baldovi Marc Jedamus Kristina ryan Unsplash 摄图网

冰岛东部峡湾，有一个小镇被群山、瀑布环绕，远离城市喧嚣，宛如被时间遗忘的世外桃源。在电影《白日梦想家》中，男主角沃尔特为了找到杂志新刊的底片，踏上了一段奇幻冒险旅程。他在影片里看似穿越了格陵兰岛、冰岛、尼泊尔、喜马拉...

冰岛东部峡湾，有一个小镇被群山、瀑布环绕，远离城市喧嚣，宛如被时间遗忘的世外桃源。在电影《白日梦想家》中，男主角沃尔特为了找到杂志新刊的底片，踏上了一段奇幻冒险旅程。他在影片里看似穿越了格陵兰岛、冰岛、尼泊尔、喜马拉雅山脉……但实际上整部电影的取景地全都在冰岛。影片最令人印象深刻的部分，大概是沃尔特用公仔和小孩子交换滑板后，在一条盘山公路上急速滑行。公路的尽头就是被LonelyPlanet评为“冰岛东部最美小镇”的塞济斯菲厄泽。

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Protein-mediated interactions in the dynamic regulation of acute inflammation

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BIOCELL 2023年第6期47卷 1191-1198页

作者： ryan STARK Department of Pediatric Critical Care Medicine Vanderbilt University Medical CenterNashvilleTN37232-9075USA

Protein-mediated interactions are the fundamental mechanism through which cells regulate health and *** interactions require physical contact between proteins and their respective targets of *** targets include not only other proteins but also nucleic acids and other important molecules as *** proteins are often involved in multibody complexes that work dynamically to regulate cellular health and *** techniques have been adapted to study these important interactions,such as affinity-based assays,mass spectrometry,and fluorescent *** application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory *** pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation.

关键词： Protein interactions Inflammation Sepsis RNA DNA Therapeutics

Advances in the hyperlens

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Chinese Science Bulletin 2010年第24期55卷 2618-2624页

作者： AGUINALDO ryan Department of Electrical and Computer Engineering University of CaliforniaSan DiegoCalifornia 92093-0407 USA

As a superlens to overcome the well-known diffraction limit,the hyperlens has received much attention due to its super resolving power and magnifying *** this article,we review the recent developments,including theore... 详细信息

关键词：双曲衍射极限放大功能分辨能力镜片

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空客时刻

商业周刊（中文版） 2024年第4期 10-14页

作者： Siddharth Philip Anthony Palazzo Julie Johnsson Charlotte ryan Danny Lee Mary Schlangenstein 晴川(译) 不详

●对手波音正因737Max的质量问题而深陷泥沼,借此时机,空客已开始规划全新机型,以期在未来数十年里称霸业内1987年初,法国南部某机场内上演了不同寻常的一幕。当时还是王储的查尔斯王子站在一个登机扶梯上,轻轻地将一个超大瓶内的香槟... 详细信息

●对手波音正因737Max的质量问题而深陷泥沼,借此时机,空客已开始规划全新机型,以期在未来数十年里称霸业内1987年初,法国南部某机场内上演了不同寻常的一幕。当时还是王储的查尔斯王子站在一个登机扶梯上,轻轻地将一个超大瓶内的香槟洒在空客SE A320喷气机的机头上,他的妻子戴安娜王妃看着这一切,脸上带着她标志性的似显困惑的微笑。随后,现场激光华彩、干冰升腾,为1400名到场嘉宾开启了一场奢华庆典——毕竟,那是在80年代。

关键词：法国南部 A320 空客

The polyadenylation code:a unified model for the regulation of mRNA alternative polyadenylation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第5期15卷 429-437页

作者： ryan DAVIS Yongsheng SHI Department of Microbiology and Molecular Genetics School of Medicine University of CaliforniaIrvineIrvineCA 92697USA

The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3＇ ends through a process called mRNA alternative polyadenylation （APA）. Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation.

关键词： mRNA Alternative polyadenylation (APA) Polyadenylation site (PAS)

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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

Using ground penetrating radar to assess the variability of snow water equivalent and melt in a mixed canopy forest, Northern Colorado

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Frontiers of Earth Science 2017年第3期11卷 482-495页

作者： ryan W. WEBB Institute of Arctic and Alpine Research University of Colorado Boulder Boulder CO 80309-0450 USA

Snow is an important environmental variable in headwater systems that controls hydrological processes such as streamflow, groundwater recharge, and evapotran- spiration. These processes will be affected by both the amount of snow available for melt and the rate at which it melts. Snow water equivalent （SWE） and snowmelt are known to vary within complex subalpine terrain due to terrain and canopy influences. This study assesses this variability during the melt season using ground penetrating radar to survey multiple plots in northwestern Colorado near a snow telemetry （SNOTEL） station. The plots include south aspect and flat aspect slopes with open, coniferous （subalpine fir, Abies lasiocarpa and engelman spruce, Picea engelmanii）, and deciduous （aspen, popu- lous tremuooides） canopy cover. Results show the high variability for both SWE and loss of SWE during spring snowmelt in 2014. The coefficient of variation for SWE tended to increase with time during snowmelt whereas loss of SWE remained similar. Correlation lengths for SWE were between two and five meters with melt having correlation lengths between two and four meters. The SNOTEL station regularly measured higher SWE values relative to the survey plots but was able to reasonably capture the overall mean loss of SWE during melt. Ground Penetrating Radar methods can improve future investiga- tions with the advantage of non-destructive sampling and the ability to estimate depth, density, and SWE.

关键词： headwaters snowmelt snow water equiva-lent ground penetrating rdar SNOTEL

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重新审视美国国债市场的容量和弹性

金融市场研究 2024年第8期 48-57页

作者：彼得·瑞恩徐恒革(编译) 证券行业和金融市场协会不详

近年来,市场更为频繁出现严重的干扰事件和波动性加剧现象,美国国债市场的容量和弹性受到质疑。这凸显了两个结构性问题:国债发行量快速增长和银行资本金要求限制了交易商提供流动性的能力。近期,关于银行机构实施《巴塞尔协议Ⅲ》最终... 详细信息

近年来,市场更为频繁出现严重的干扰事件和波动性加剧现象,美国国债市场的容量和弹性受到质疑。这凸显了两个结构性问题:国债发行量快速增长和银行资本金要求限制了交易商提供流动性的能力。近期,关于银行机构实施《巴塞尔协议Ⅲ》最终资本改革要求的提案中的交易账簿基本审查(FRTB)和证券融资交易担保品最低折扣率框架,将进一步束缚交易商资产负债表,并严重扰乱国债回购市场的运作。而且结合修订全球系统重要性银行资本附加费计算方式的提案,将极大限制交易商在美国国债现货或期货期权市场的做市能力。此外,在美国国债市场扩大中央清算适用范围等市场结构改革举措将放大上述审慎规则对市场的负面作用。建议监管机构全面评估提案措施的成本和收益,根据需要进行实质性修订,促进而不是破坏美国国债市场的弹性,这对于维持美国政府低融资成本、全球金融稳定和美国经济增长至关重要。

关键词：巴塞尔协议Ⅲ 美国国债市场 FRTB 市场容量市场弹性

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