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Machine learning-guided accelerated discovery of structure-property correlations in lean magnesium alloys for biomedical applications

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Journal of Magnesium and Alloys 2024年第6期12卷 2267-2283页

作者： Sreenivas Raguraman Maitreyee Sharma Priyadarshini Tram Nguyen rya. mcgovern Andrew Kim Adam J.Griebel Paulette Clancy Timothy P.Weihs Department of Materials Science and Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hopkins Extreme Materials Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Department of Chemical and Biomolecular Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Translational Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Department of Biomedical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Research and Development Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Department of Mechanical Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Magnesium alloys are emerging as promising alternatives to traditional orthopedic implant materials thanks to their biodegradability,biocompatibility,and impressive mechanical ***,their rapid in-vivo degradation presents challenges,notably in upholding mechanical integrity over *** study investigates the impact of high-temperature thermal processing on the mechanical and degradation attributes of a lean Mg-Zn-Ca-Mn alloy,*** rapid,cost-efficient characterization methods like X-ray diffraction and optical microscopy,we swiftly examine microstructural changes post-thermal *** Pearson correlation coefficient analysis,we unveil the relationship between microstructural properties and critical targets(properties):hardness and corrosion ***,leveraging the least absolute shrinkage and selection operator(LASSO),we pinpoint the dominant microstructural factors among closely correlated *** findings underscore the significant role of grain size refinement in strengthening and the predominance of the ternary Ca_(2)Mg_(6)Zn_(3)phase in corrosion *** suggests that achieving an optimal blend of strength and corrosion resistance is attainable through fine grains and reduced concentration of ternary *** thorough investigation furnishes valuable insights into the intricate interplay of processing,structure,and properties in magnesium alloys,thereby advancing the development of superior biodegradable implant materials.

关键词： Magnesium alloys Machine learning Corrosion Mechanical properties Rapid characterization

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan Win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB mcgovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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The Practical Historical Approach:A Review of the Principles and Methods of Fact-First History

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World History Studies 2022年第2期9卷 1-14页

作者： Jonathan mcgovern Nanjing University NanjingJiangsu ProvinceP.R.China

This article defines and defends"the practical historical approach",a long-established approach to history which prizes the critical treatment of sources and,above all else,the presentation and assessment of accurate information about the *** approach appreciates the value of historical fact in its own right,not just when it furnishes an opportunity to build theories or to prove *** article does not aim to make a theoretical case for empiricist history,arguing instead that the old philosophy-driven debates about empiricism have little bearing on the practice of historical research and *** prefers to make a practical defence of certain critical methods and habits of thought which are now sometimes dismissed as *** draws on a series of historians'handbooks dating from 1889 to 1980,in which the methods and principles of the practical approach were worked out and refined,and it identifies the main principles and techniques of this approach,many of which derive from the German“scientific"historical tradition,and which furnish historians with a powerful apparatus for critically analyzing *** article also has a polemical angle,arguing that the practical historical approach could profitably be taught more consciously inuniversities.

关键词： Historical Method Scientific History Empiricism Geoffrey Elton

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Hu Shih,China's Sophists,and the Development of Logic in China's Rhetorical Culture

国际修辞学研究

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国际修辞学研究 2012年 240-258页

作者： rya.Butterfield Louisiana State University

Hu Shih is important as both a historical and a philosophical *** is most often referenced for the historical role he played as an advocate of the vernacular language and a leader in the early 20th century reform movement known as the Chinese *** he is important for the theoretical contributions he made to the development of logic in China’s rhetorical *** took a genealogical approach to the study of China’s intellectual legacy and found a lineage of Sophism in ancient China,similar in ways to that of ancient *** essay discusses Hu’s goal to further develop the spirit of doubt,long present in Chinese intellectualism,into a spirit of modern sophistry and the rhetorical contributions Hu attributes to two particular schools of thought,the Mingjia and the Neo-Mohists.

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Measuring Electrospun Nanofibre Diameter： a Novel Approach

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Chinese Physics Letters 2008年第8期25卷 3071-3074页

作者： M. Ziabari V. Mottaghitalab S. T. mcgovern A. K. Haghi Textile Department University of Guilan PO Box 3756 Rasht Iran Intelligent Polymer Research Institute University of Wollongong Wollongong Australia

A new method based on image analysis for electrospun nanofibre diameter measurement is presented. First, the SEM micrograph of the nanofibre web obtained by electrospinning process is converted to binary image using local thresholding method. In the next step, skeleton and distance transformed image are generated. Then, the intersection points which bring about untrue measurements are identified and removed from the skeleton. Finally, the resulting skeleton and distance transformed image are used to determine fibre diameter. The method is evaluated by a simulated image with known characteristics generated by ？-randomness procedure. The results indicate that this approach is successful in making fast, accurate automated measurements of electrospun fibre diameters.

关键词： NANOFIBERS SIMULATION NONWOVENS

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Comparison of Chick Quality, Health, and Inflammation from Two Hatchery Environments

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Food and Nutrition Sciences 2023年第9期14卷 824-842页

作者： Kaylin M. Chasser Audrey F. Duff Kate mcgovern Mike Trombetta Lisa R. Bielke Department of Animal Sciences The Ohio State University Columbus USA Prestage Department of Poultry Science North Carolina State University Raleigh USA

Hatchery contamination can result in ingested or inhaled microbes that may modify colonization of the intestinal and respiratory tract, with potential to influence early growth, inflammation, and overall health. Six experiments were completed to compare chick quality, inflammation, and health between two hatcheries (H1 and H2). On embryonic d0, 45 eggs from the same breeder flock were set at each hatchery. On d0, length, abdominal height, navel and leg abnormalities, and self-righting were measured for 36 chicks/hatchery, yolk sacs were weighed, and crop/cloaca swabs were cultured from 12 chicks/hatchery. On d7, mid-ileum and ceca were cultured from 12 chicks/hatchery. On d0 and d7, body weight (BW) and intestinal weight were measured, lung/air sac swabs and liver were cultured, and liver and air sacs were scored for health. Blood was collected on d0 and d7 for serum alpha-1-acid glycoprotein concentrations in Exp 1 and 2. Data was analyzed using Student’s t-test or χ2, significance p < 0.05. On d0, BW, length, yolk free BW, and intestinal weight were greater for H2 chicks (p < 0.05). Liver bacterial recovery was decreased in H2 on d0 (p < 0.05) and there were fewer average leg and righting abnormalities in H2 (p < 0.05). Decreased lactase positive Enterobacteriaceae were noted in H2 in crop/cloaca and lung/air sac swabs (p < 0.05), and of alpha and beta hemolysis in crop/cloaca swabs, and alpha and gamma hemolysis in lung/air sac swabs (p < 0.05) on d0. By d7, only alpha hemolytic bacteria were increased in lung/air sac swabs of H2. Based on factors measured, chicks from H2 showed favorable microbial colonization, starting quality, and improved health on d0. While not sustained through d7, differences in d0 microbial recovery may have shifted microbial development and potentially influenced immune response development. These experiments elucidated the importance of hatchery environment on early chick quality, microbial colonization, overall inflammation,

关键词： Chick Quality Hatchery Environment Enterobacteriaceae Hemolysis

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BEAUTY AND THE BEAST THE OPEN-ENDED WORLD OF BHARTI KHER

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城市漫步（上海版、英文） 2014年第2期 48-49页

作者： JESSICA mcgovern 不详

In acclaimed Delhi-based artist Bharti Kher's inaugural Mainland solo exhibition,Misdemeanours,the Rockbund Art Museums past as a former museum of natural history in colonial Shanghai is explored.

关键词： OPEN claimed exhibition

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Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

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World Journal of Gastroenterology 2017年第40期23卷 7265-7273页

作者： Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB mcgovern Department of Medicine Cedars-Sinai Medical Center F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute Cedars-Sinai Medical Center Department of Gastroenterology Cedars-Sinai Medical Center

AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic *** This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population *** Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an

关键词： Genetic associations Inflammatory bowel disease Anti-tumor necrosis factor Adverse events

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香书宝鉴

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游艇业 2006年第5期 124-125页

作者：陈建钊 rya.图）小刚（图）

rya.Royal Yachting Association）是英国休闲游艇主和船员的会员制组织，同时也是欧洲知名的游艇培训机构，目前该机构在世界各地20个国家设有2220家培训中心，每年有18．5万名学员学成结业。此外他们还是专业游艇书籍出版机构，每年... 详细信息

rya.Royal Yachting Association）是英国休闲游艇主和船员的会员制组织，同时也是欧洲知名的游艇培训机构，目前该机构在世界各地20个国家设有2220家培训中心，每年有18．5万名学员学成结业。此外他们还是专业游艇书籍出版机构，每年销量为50万册。以下我们简要介绍几本该培训机构所用的基础教材供广大航海及游艇爱好者们参考。

关键词：培训机构培训中心游艇会员制休闲

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机械合金化93W—5.6Ni—1.4Fe高比重钨合金

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国外金属加工 1998年第4期19卷 27-33页

作者： rya.HJ 李金平五二研究所宁波分所

通过研究Ｗ，Ｎｉ，Ｆｅ元素的混合粉在氩气中高能球磨，且机械合金化９３Ｗ－５．６Ｎｉ－１．４Ｆｅ高比重钨合金的过程，改变机械合金化工艺参数，诸如球磨速度，球磨时间，球料比和磨球充填率等，以研究这些因素对粉末机械合金化过... 详细信息

通过研究Ｗ，Ｎｉ，Ｆｅ元素的混合粉在氩气中高能球磨，且机械合金化９３Ｗ－５．６Ｎｉ－１．４Ｆｅ高比重钨合金的过程，改变机械合金化工艺参数，诸如球磨速度，球磨时间，球料比和磨球充填率等，以研究这些因素对粉末机械合金化过程中显微结构的变化的影响。机械合金化过程随球磨时间延长按以下五个分明的阶段进行；变平阶段，焊合主导阶段，各方等大颗粒形成阶段，随机层状形成阶段和稳定阶段。在球磨速度为７５ｒｐｍ。

关键词：钨合金粉末冶金机械合金化

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