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Paraneoplastic Syndromes of Hypercalcemia and Leukocytosis Associated with Colonic Metastases from Squamous Cell Carcinoma of the Lung: a Case Report

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Chinese Journal of Clinical Oncology 2006年第1期3卷 66-69页

作者： Xiangtao Ma Xu Wang Liwei Yu Jing Fu Shan Wang ruyu du Zhirong Cui Department of Surgery Beijing Haidian Hospital Beijing 100080 China Department of Neurology Beijing Haidian Hospital Beijing 10080 China Department of Pathology Beijing Haidian Hospital Beijing 100080 China Department of Surgery and Division of Surgical Oncology Peking University People＇s Hospital Beijing 100044 China

Lung cancer is the most common cancer-related death in both men and women in the world. Approximately 25% of all cancer deaths are attributable to lung carcinoma. Moreover, about one-half of patients with lung cancer have metastases at the time of initial diagnosis, most frequently of lymph nodes, adrenals, liver, bone and brain. However metastasis to the colon is very rare. Over the past 25 years about 13 cases of symptomatic colonic metastases from lung malignancies of all types have been reported in the literature. Hypercalcemia and leukocytosis are two of the most common paraneoplastic syndromes associated with various malignancies. However, concomitant manifestation of hypercalcemia and leukocytosis are occasionally observed in the same cancer patients. Here, we present a rare case of colonic metastasis from a squamous cell carcinoma of the lung associated with paraneoplastic syndromes of hypercalcemia and leukocytosis.

关键词： paraneoplastic syndrome lung cancer hypercalcemia leukocytosis prognosis.

有丝分裂蛋白激酶及其上游调节信号在人肝癌组织中的表达(英文)

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中华外科杂志 2002年第1期40卷 1-4页

作者：朱继业冷希圣董南粟光明杜如昱北京大学人民医院肝胆外科中心

目的　探讨有丝分裂原蛋白激酶 (MAPK)通路在调控细胞的增殖和凋亡过程中所起到的作用。方法　手术切除16份肝癌及癌旁组织标本 ,Western印迹检测ERK1、ERK2 、JNK1、p3 8和MEK1、MEK2 的蛋白含量。结果　在本组的 16例患者中 ,每例患... 详细信息

目的　探讨有丝分裂原蛋白激酶 (MAPK)通路在调控细胞的增殖和凋亡过程中所起到的作用。方法　手术切除16份肝癌及癌旁组织标本 ,Western印迹检测ERK1、ERK2 、JNK1、p3 8和MEK1、MEK2 的蛋白含量。结果　在本组的 16例患者中 ,每例患者肝癌组织中的ERK1、ERK2 、JNK1、p3 8蛋白表达显著高于癌旁组织 ,ERK1积分光密度值 (IntegralopticdensityIOD)在肝癌和癌旁组织中分别为 3 0 0± 98和 98± 4 8,差异有显著意义 (P <0 0 1)。ERK2 的IOD值在肝癌和癌旁组织中分别为 5 87± 83和 2 3 2± 96,差异有显著意义 (P <0 0 1) ;p3 8的IOD值在肝癌和癌旁组织中分别为 2 70± 85和 10 7± 88,差异有显著意义 (P <0 0 1) ;肝癌组织中的JNK1蛋白表达显著低于癌旁组织 ;JNK1的IOD值在肝癌和癌旁组织中分别为 111± 93和 2 92± 10 9,差异有显著意义 (P <0 0 1) ;MEK1、MEK2 蛋白表达显著高于癌旁组织 ,MEK1的IOD值在肝癌和癌旁组织中分别为 14 18± 2 4 4和 80 6± 90 ,差异有显著意义 (P <0 0 1) ,MEK2 的IOD值在肝癌和癌旁组织中分别为 10 4 1± 12 2和 4 68± 4 0 ,差异有显著意义 (P <0 0 1)。结论　肝癌组织中细胞分裂增殖的信号传导通路ERK1、ERK2 、MEK1、MEK2 激酶处于高表达。

关键词：肝细胞癌有丝分裂蛋白激酶 MAPK 细胞增殖细胞凋亡 JUN 上游调节信号

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农业生产投入要素与农业增长关系研究

地域研究与开发 2019年第3期38卷 160-164页

作者：栗滢超杜如宇李鸣慧李林莉河南农业大学资源与环境学院郑州450002 河南省土地整理中心郑州450016

运用生产函数模型及岭回归分析测度2002—2016年中国内地及其东部、中部、西部和东北地区农业生产投入要素对农业增长的贡献率,为合理配置生产要素从而推进农业供给侧结构性改革、加快农业现代化发展提供依据。结果表明:从长期看,农业... 详细信息

运用生产函数模型及岭回归分析测度2002—2016年中国内地及其东部、中部、西部和东北地区农业生产投入要素对农业增长的贡献率,为合理配置生产要素从而推进农业供给侧结构性改革、加快农业现代化发展提供依据。结果表明:从长期看,农业增长对耕地数量变化的敏感度最高,对劳动力依赖性最小,资本投入在农业生产三大要素中的贡献率最为稳定且相对较高;从短期看,资本对耕地要素具有替代性,其中东部、中部和西部的劳动力要素对农业增长贡献率最高,资本要素次之,而东北地区资本要素贡献率最高。我国农业发展已进入资本驱动的关键阶段,增加农业投资是保障农业增长的重要手段,耕地投入量的减少对农业增长有负向作用,应注重耕地提质增量。

关键词：生产要素农业增长 C-D模型 CES模型

河南省农村劳动力转移、农地规模经营与农业生态环境耦合协调性研究

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河南农业大学学报 2019年第3期53卷 480-487页

作者：杜如宇范莹栗滢超李鸣慧屈梦华河南农业大学资源与环境学院河南郑州450002 河南省土地整治与生态重建工程技术研究中心河南郑州450002 河南省土地整理中心河南郑州450016

本研究通过构建河南省农村劳动力转移、农地规模经营与农业生态环境耦合协调度评价指标体系,采用耦合协调度计量模型对河南省2007—2016年农村劳动力转移、农地规模经营、农村生态环境间耦合协调度进行定量分析。结果表明:2007—2016年... 详细信息

本研究通过构建河南省农村劳动力转移、农地规模经营与农业生态环境耦合协调度评价指标体系,采用耦合协调度计量模型对河南省2007—2016年农村劳动力转移、农地规模经营、农村生态环境间耦合协调度进行定量分析。结果表明:2007—2016年耦合度由低度耦合上升为勉强耦合;耦合协调度在2007—2011年由低度协调上升到勉强协调,2011—2012年由勉强协调转变为低度协调,2012—2016年保持低度协调状态;预测结果显示,2017—2019年耦合协调度由低度协调转变为勉强协调。2007—2016年河南省农村劳动力转移、农地规模经营与农业生态环境耦合协调发展远未达到最优状态,生态环境形势依然严峻,建议从技术、制度、资金等多方面加强对生态环境的保护。

关键词：农村劳动力转移农地规模经营农业生态环境耦合协调

bcl 10 gene mutation in hepatocellular carcinoma

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Chinese Medical Journal 2001年第7期114卷 75-79,109页

作者：程继华冷希圣蔡胜利曹宗献曹广彭吉润王申五杜如昱北京大学附属人民医院外科北京100044 首都医科大学附属安贞医院普外科北京100029

Abstract:Objective To detect the mutation frequency of the bcl 10 gene in the early and advanced stages of hepatocellular carcinoma (HCC).Methods Genome DNA samples were extracted from 46 cases of fresh HCC tumor tissues and their non-tumor adjacent tissues. Polymerase chain reaction-single strand conformation polymorphism method was used to detect point mutations of the three exons of the bcl 10 gene. For each individual exon, six random samples from those showing abnormal DNA bands were sequenced to verify those mutations. The relationship between serum alpha-fetoprotein (AFP) level and bcl 10 mutation, between the tumor size and bcl 10 mutation was also *** Among the 46 samples, 26 cases (56.5%) were found to have mutations in exon 1, 5 out of the 6 cases were shown to have 5744 C→G mutation by sequencing; 25 cases (54.3%) were found to have mutations in exon 2, 4 out of the 6 cases were shown to have 11?311 T deletion mutation by sequencing. Twenty-one cases (45.7%) were found to have mutations in exon 3, all of the 6 cases selected for sequencing were shown to have 14?116 C→T mutation. Statistical analysis showed that neither serum alpha-fetoprotein level nor the size of hepatocellular carcinoma has a significant relationship with bcl 10 *** The bcl 10 gene has a high mutation frequency in liver cancer.

关键词： bcl 10 gene · liver cancer · mutation

“互联网+”背景下农科院校人才培养现状调查与分析

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科教文汇 2019年第27期 16-17,26页

作者：栗滢超屈梦华杜如宇河南农业大学资源与环境学院

互联网对大学教育的冲击倒逼着教育方法、人才培养模式的不断创新。农业发展正处于从传统农业向现代农业、智慧农业转型跨越的新阶段。本文在对农业院校人才培养现状调查的基础上,提出从打造多渠道学习平台、革新教学方法手段、建立立... 详细信息

互联网对大学教育的冲击倒逼着教育方法、人才培养模式的不断创新。农业发展正处于从传统农业向现代农业、智慧农业转型跨越的新阶段。本文在对农业院校人才培养现状调查的基础上,提出从打造多渠道学习平台、革新教学方法手段、建立立体化实践教学体系、构建创新教育模块和完善教育考评机制等方面探索创新应用型人才培养的新途径,逐步建立以能力提升为导向的人才培养机制。

关键词： “互联网+” 农科院校人才培养

The genome of okra (Abelmoschus esculentus) provides insights into its genome evolution and high nutrient content

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Horticulture Research 2023年第8期10卷 29-43页

作者： ruyu Wang Wei Li Qiang He Hongyu Zhang Meijia Wang Xinyuan Zheng Ze Liu Yu Wang Cailian du Huilong du Longsheng Xing College of Life Sciences Institute of Life Sciences and Green DevelopmentHebei UniversityBaoding 071000China Hebei Basic Science Center for Biotic Interaction Institute of Life Sciences and Green DevelopmentHebei UniversityBaoding 071000China

Okra(Abelmoschus esculentus)is an important vegetable crop with high nutritional ***,the mechanism underlying its high nutrient content remains poorly ***,we present a chromosome-scale genome of okra with a size of 1.19 *** genomics analysis revealed the phylogenetic status of ***,as well as whole-genome duplication(WGD)events that have occurred widely across the Malvaceae *** found that okra has experienced three additional WGDs compared with the diploid cotton Gossypium raimondii,resulting in a large chromosome number(2n=130).After three WGDs,okra has undergone extensive genomic deletions and retained substantial numbers of genes related to secondary metabolite biosynthesis and environmental adaptation,resulting in significant differences between okra and *** in the gene families related to cellulose *** transcriptomic and metabolomic analysis,we revealed the relationship between gene expression and metabolite content change across different okra developmental ***,the sinapic acid/S-lignin biosynthesis-related gene families have experienced remarkable expansion in okra,and the expression of key enzymes involved in the sinapic acid/S-lignin biosynthesis pathway vary greatly across developmental periods,which partially explains the differences in metabolite content across the different *** study gains insights into the comprehensive evolutionary history of Malvaceae species and the genetic basis that underlies the nutrient content changes in okra,which will facilitate the functional study and genetic improvement of okra varieties.

关键词： content insight evolution

Molecular events in the jaw vascular unit:A traditional review of the mechanisms involved in inflammatory jaw bone diseases

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The Journal of Biomedical Research 2023年第5期37卷 313-325页

作者： ruyu Wang Haoran Wang Junyu Mu Hua Yuan Yongchu Pang Yuli Wang Yifei du Feng Han Department of Oral and Maxillofacial Surgery the Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210029China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine NanjingJiangsu 210029China International Joint Laboratory for Drug Target of Critical Illnesses Key Laboratory of Cardiovascular and Cerebrovascular MedicineSchool of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Orthodontics the Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China.

Inflammatory jaw bone diseases are common in stomatology,including periodontitis,peri-implantitis,medication-related osteonecrosis of the jaw,radiation osteomyelitis of the jaw,age-related osteoporosis,and other specific *** diseases may lead to tooth loss and maxillofacial deformities,severely affecting patients'quality of *** the years,the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic ***,exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial for improving prognosis and developing new targeted *** evidence indicates that the integrated bone formation and dysfunction arise from complex interactions among a network of multiple cell types,including osteoblast-associated cells,immune cells,blood vessels,and lymphatic ***,the role of these different cells in the inflammatory process and the'rules'with which they interact are still not fully *** many investigations have focused on specific pathological processes and molecular events in inflammatory jaw diseases,few articles offer a perspective of ***,we review the changes and mechanisms of various cell types in inflammatory jaw diseases,with the hope of providing insights to drive future research in this field.

关键词： inflammatory diseases osteogenesis-related cells immune cells blood vessels lymphatic vessels jaw vascular unit

Enhanced antibiotic degradation performance of Cd_(0.5)Zn_(0.5)S/Bi_(2)MoO_(6) S-scheme photocatalyst by carbon dot modification

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Journal of Materials Science & Technology 2023年第33期164卷 59-67页

作者： Shijie Li ruyu Yan Mingjie Cai Wei Jiang Mingyi Zhang Xin Li Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province National Engineering Research Center for Marine AquacultureCollege of Marine Science and TechnologyZhejiang Ocean UniversityZhoushan 316022China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China

S-scheme heterojunction engineering is an effective strategy to attain distinctive ***,a carbon dots modulated S-scheme hetero-structured photocatalyst of Cd_(0.5)Zn_(0.5)S nanoparticles/Bi_(2)MoO_(6) microspheres/carbon dots (CZCBM),aiming to conquer the photo-corrosion and strengthen the photocatalytic property of Cd_(0.5)Zn_(0.5)S,was developed via a facile solvothermal *** visible light,the optimal CZCBM-2 affords a 1.8-,1.5-,or 0.6-time reinforcement in the oxytetracycline degradation rate constant compared to Bi_(2)MoO_(6),Cd_(0.5)Zn_(0.5)S or Cd_(0.5)Zn_(0.5)S/Bi_(2)MoO_(6),which is credited to the strengthened visible-light response,increased reactive sites,and efficient dissolution of photo-carriers with optimal redox capacity because of the co-effect of carbon dots and S-scheme ***,the photo-corrosion of Cd_(0.5)Zn_(0.5)S is significantly suppressed and CZCBM-2 affords superior stability and reusability during cycling ***,CZCBM-2 can be well adapted to various *** toxicology appraisement unravels the decreased eco-toxicity of most intermediates compared to ***,an S-scheme charge transfer mechanism with carbon dots as electron reservoir in CZCBM is deduced,which uncloses that •O_(2)− and h+ dominantly account for oxytetracycline eradication and *** study demonstrates the design of unique carbon dots favored S-scheme heterostructures as an effective “Two Birds with One Stone” strategy to achieve high anti-photo-corrosion performance and reinforced photocatalytic performance of sulfides.

关键词： Carbon dots S-scheme heterojunction Synergistic effect Pharmaceuticals and personal care products(PPCPs) Toxicity analysis Anti-photocorrosion