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Emergence of a novel reassortant avian influenza virus(H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals

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Science China(Life Sciences) 2022年第5期65卷 1024-1035页

作者： Kaituo Liu Pingyun Ding Yuru Pei ruyi Gao Wenwen Han Huafen Zheng Zhuxing Ji Miao cai Jinyuan Gu Xiuli Li Min Gu Jiao Hu Xiaowen Liu Shunlin Hu Pinghu Zhang Xiaobo Wang Xiaoquan Wang Xiufan Liu College of Veterinary Medicine Yangzhou UniversityYangzhou 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis Yangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Zoonosis Yangzhou 225009China Institute of Translational Medicine Key Laboratory of Geriatric Disease Prevention and Control of Jiangsu ProvinceMedical CollegeYangzhou UniversityYangzhou 225009China

Decades have passed since the first discovery of H10-subtype avian influenza virus(AIV) in chickens in 1949,and it has been detected in many species including mammals such as minks,pigs,seals and *** of human infections with H10N8viruses identified in China in 2013 have raised widespread *** novel reassortant H10N3 viruses were isolated from chickens in December 2019 in eastern China during routine surveillance for *** internal genes of these viruses were derived from genotype S(G57) H9N2 and were consistent with H5N6,H7N9 and H10N8,which cause fatal infections in *** viral pathogenicity and transmissibility were further studied in different animal *** two H10N3 isolates had low pathogenicity in chickens and were transmitted between chickens via direct *** viruses were highly pathogenic in mice and could be transmitted between guinea pigs via direct contact and respiratory *** importantly,these viruses can bind to both human-type SAα-2,6-Gal receptors and avian-type SAα-2,3-Gal *** shedding in chickens and good adaptability to mammals of these H10N3 isolates would make it easier to transmit to humans and pose a threat to public health.

关键词： H10N3 H9N2 receptor binding pathogenicity respiratory droplet transmissibility

基于支持向量机的四自由度船舶操纵运动黑箱建模

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中国造船 2014年第3期55卷 147-155页

作者：王雪刚邹早建任如意蔡韡上海交通大学船舶海洋与建筑工程学院上海200240 上海交通大学海洋工程国家重点实验室上海200240 中国船舶重工集团公司第七〇七研究所(九江) 九江332000

基于整体型船舶操纵运动数学模型,结合船舶操纵运动中横倾运动的特点,建立了应用支持向量机的四自由度船舶操纵运动黑箱预报模型。对某集装箱船进行了10°/10°、15°/15°、20°/20°Z形试验和5°、15°、35°回转试验的数值仿真,获得... 详细信息

基于整体型船舶操纵运动数学模型,结合船舶操纵运动中横倾运动的特点,建立了应用支持向量机的四自由度船舶操纵运动黑箱预报模型。对某集装箱船进行了10°/10°、15°/15°、20°/20°Z形试验和5°、15°、35°回转试验的数值仿真,获得了操纵运动仿真数据;使用1%的15°/15°、20°/20°Z形试验和5°、15°回转试验仿真数据来训练支持向量,并用训练好的支持向量机预报10°/10°、20°/20°Z形试验和35°回转试验;将预报结果与仿真试验数据进行对比,验证了所提出黑箱预报模型的有效性及良好的泛化性能。

关键词：船舶操纵黑箱建模支持向量机四自由度

Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice

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Molecular Plant 2023年第11期16卷 1832-1846页

作者： Ning Xiao Yunyu Wu Xiaoxiang Zhang Zeyun Hao Zichun Chen Zefeng Yang Yue cai ruyi Wang Ling Yu Zhiping Wang Yue Lu Wei Shi Cunhong Pan Yuhong Li Changhai Zhou Jianju Liu Niansheng Huang Guangqing Liu Hongjuan Ji Shuhao Zhu Shuai Fang Yuese Ning Aihong Li Institute of Agricultural Sciences for Lixiahe Region in Jiangsu Yangzhou Rice Experiment Station of the China Agricultural Research SystemJiangsu Key Laboratory of Crop Genomics and Molecular BreedingYangzhou 225009China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Plant Functional Genomics Ministry of EducationJiangsu Key Laboratory of Crop Genomics and Molecular BreedingAgricultural College of Yangzhou UniversityYangzhou 225009China

Rice blast,caused by the fungal pathogen Magnaporthe oryzae,is one of the most important diseases of *** of blast-resistance genes is the most economical,effective,and environmentally friendly way to control the ***,genetic resources with broad-spectrum resistance(BSR)that is effective throughout the rice growth period are *** this work,using a genome-wide association study,we identify a new blast-resistance gene,Pijx,which encodes a typical CC-NBS-LRR *** is derived from a wild rice species and confers BSR to *** at both the seedling and panicle *** functions of the resistant haplotypes of Pijx are confirmed by gene knockout and overexpression ***,the LRR domain in Pijx interacts with and promotes the degradation of the ATP synthase β subunit(ATPb)via the 26S proteasome *** acts as a negative regulator of Pijx-mediated panicle blast resistance,and interacts with OsRbohC to promote its ***,loss of ATPb function causes an increase in NAPDH content and ROS ***,when Pijx is introgressed into two japonica rice varieties,the introgression lines show BSR and increased yields that are approximately 51.59%and 79.31%higher compared with those of their parents in a natural blast disease *** addition,we generate PPL^(Pijx Pigm) and PPL^(Pijx Piz-t) pyramided lines and these lines also have higher BSR to panicle blast compared with Pigm-or Piz-t-containing rice ***,this study demonstrates that Pijx not only confers BSR to *** but also maintains high and stable rice yield,providing new genetic resources and molecular targets for breeding rice varieties with broad-spectrum blast resistance.

关键词： panicle blast broad-spectrum resistance Pijx ATPb ROS burst

Hyperuricemia and the metabolic syndrome in Chinese type 2 diabetes mellitus patients with overweight or obesity

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Hyperuricemia and the metabolic syndrome in Chinese type 2 d...

Effects of Twin-Screw Extrusion on Physicochemical Properties and Functional Properties of Bamboo Shoots Dietary Fiber

中华医学会第十二次全国内分泌学学术会议

作者： ruyi Zhang Jiao Wang Rongping Chen Rui Yang Jia Sun Qing-Qing Song De-Hong cai Department of Endocrinology Zhujiang HospitalSouthern Medical University

Objective To determine the prevalence and clinical correlates of hyperuricaemia and also to evaluate associations with the metabolic syndrome(MS) in Chinese type 2 diabetes mellitus (T2DM) patients with overweight or obesity Methods A multicentric hospital-based cross-sectional study was carried out inGuangdongProvmcebetween August 2011 and March *** each hospital,Chinese T2DM patients with central obesity,whose age over 20 years,whose blood

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Effects of Twin-Screw Extrusion on Physicochemical Propertie...

生物强化自发电化学氧化含硫废水及关键功能微生物研究

中国生物工程学会第十一届学术年会暨2017年全国生物技术大会

作者： Qing Ge Jian-Wei Mao Chenggang cai Jun Huang Yifeng Zhou Jilei Fang Yuxin Sun ruyi Sha Zhejiang Provincial Collaborative Innovation Center of Agricultural Biological Resources Biochemical Manufacturing Key Laboratory of Chemical and Biological Processing Technology for Farm Products of Zhejiang Province School of Biological and Chemical EngineeringZhejiang University of Science and Technology

A co-rotating twin-screw extruder was used to study the effect of extrusion processing on nutritional and textural properties of extruded bamboo shoots. The soluble dietary fiber(SDF), insoluble dietary fiber(IDF), total dietary fiber(TDF), swelling capacity, water holding capacity, oil holding capacity,cholesterol absorption capacity, and fat absorption capacity were determined. The results showed that the content of SDF increased, but IDF and TDF decreased upon extrusion cooking. In addition,the dietary fiber in extruded bamboo shoots had higher swelling capacity, water holding capacity,fat absorption the capacity and cholesterol absorption capacity than those of unextruded ones. The results showed that twin-screw extrusion technology has the potential to increase the levels of SDF in bamboo shoots and improve the efficiency of extrusion.

关键词： Bamboo Shoots Twin-Screw Extrusion Soluble Dietary Fiber Physicochemical Properties

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环境科学学报 2021年第5期41卷 1840-1846页

作者：蔡靖王凯权孙月楼菊青王如意李强标浙江工商大学环境科学与工程学院杭州310018

构建了以高锰酸钾溶液为阴极电子受体,石墨棒为电极的硫化物自发电化学氧化系统.该系统可自发电化学氧化硫化物,去除率为68.15%~89.30%,其主要氧化产物为单质硫(68.10%~86.63%),且最大氧化速率可达34.76 mg·L^(-1)·h^(-1),最大稳定电... 详细信息

构建了以高锰酸钾溶液为阴极电子受体,石墨棒为电极的硫化物自发电化学氧化系统.该系统可自发电化学氧化硫化物,去除率为68.15%~89.30%,其主要氧化产物为单质硫(68.10%~86.63%),且最大氧化速率可达34.76 mg·L^(-1)·h^(-1),最大稳定电流密度为37.38 mA·m^(-2).经生物强化后,该系统的硫化物去除率高于99.80%,其主要氧化产物为硫酸盐(21.98%~74.43%)和单质硫(25.43%~78.02%),其最大氧化速率可达45.90 mg·L^(-1)·h^(-1),最大稳定电流密度为36.61 mA·m^(-2).并通过高通量测序分别从门和属分类水平对生物强化系统阳极室内污泥细菌群落进行分析,相对丰度较高的是具有硫化物氧化功能的变形菌门和具有胞外电子传递能力的拟杆菌门.

关键词：硫化物自发电化学氧化生物强化微生物群落

基于超声视频的深度学习在乳腺结节良恶性鉴别诊断中的价值

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中国医学计算机成像杂志 2023年第5期29卷 590-593页

作者：杨茹怡陈宏蔡叶华李梅上海市静安区中心医院(复旦大学附属华山医院静安分院)超声科上海200040 上海市静安区中心医院(复旦大学附属华山医院静安分院)普外科复旦大学附属华山医院超声医学科

目的:探讨基于U-net和PyRadiomics的一种深度学习与影像组学相结合的方法在乳腺结节良恶性鉴别诊断中的应用价值。方法:纳入上海市静安区中心医院285例乳腺结节患者超声影像视频资料,其中乳腺良性结节216例,乳腺恶性结节69例。经图像预... 详细信息

目的:探讨基于U-net和PyRadiomics的一种深度学习与影像组学相结合的方法在乳腺结节良恶性鉴别诊断中的应用价值。方法:纳入上海市静安区中心医院285例乳腺结节患者超声影像视频资料,其中乳腺良性结节216例,乳腺恶性结节69例。经图像预处理和U-net图像分割后,通过PyRadiomics提取图像病灶特征,经过特征选择降维得到17种特征,使用逻辑回归算法对乳腺结节良恶性进行分类,绘制受试者工作特征曲线和混淆矩阵分析深度学习后模型对乳腺良恶性结节的诊断效能。结果:基于超声视频的深度神经网络模型对乳腺良恶性诊断的准确度、灵敏度、特异度、曲线下面积分别为86.0%、85.7%、86.0%、0.890。结论:基于超声视频的深度神经网络模型在乳腺结节良恶性鉴别诊断中具有较高的应用价值。

关键词：乳腺结节超声视频深度学习人工智能

烟草野火病菌的基因组学分析及其致病性分化研究进展

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中国烟草学报 2018年第6期24卷 123-129页

作者：蔡训辉王如意范彦君陈焘周玮湖南农业大学植物保护学院植物病虫害生物学与防控湖南省重点实验室长沙410128 湖南省农业大数据分析与决策工程技术研究中心长沙410128 湖南农业大学湖南省生物农药与制剂加工工程技术研究中心长沙410128 湖南农业大学农学院长沙410128

烟草野火病是世界普遍发生的一种细菌性病害。本文从野火病菌基因组学和致病性两方面归纳了烟草野火病的研究现状,总结了5个已完成测序的丁香假单胞菌属的基因组特征、致病岛、T3SS及其毒力研究、基因水平转移与病原菌寄主适应性进化,... 详细信息

烟草野火病是世界普遍发生的一种细菌性病害。本文从野火病菌基因组学和致病性两方面归纳了烟草野火病的研究现状,总结了5个已完成测序的丁香假单胞菌属的基因组特征、致病岛、T3SS及其毒力研究、基因水平转移与病原菌寄主适应性进化,分析了野火病菌株的致病机理和生理小种,并对烟草野火病的深入研究方向进行了展望。

关键词：烟草野火病基因组致病机理生理小种

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下胫腓联合损伤的弹性固定治疗进展

医学综述 2018年第24期24卷 4899-4902,4907页

作者：张如意云才首都医科大学石景山教学医院北京市石景山医院骨科北京100043

下胫腓联合是维持踝关节稳定的重要结构,踝关节损伤常伴有下胫腓联合损伤,越来越多的骨科医师开始在治疗踝关节损伤时重视下胫腓联合的诊疗。随着生物学固定理念逐渐普及,既往作为治疗金标准的下胫腓联合螺钉固定技术因存在相关并发症... 详细信息

下胫腓联合是维持踝关节稳定的重要结构,踝关节损伤常伴有下胫腓联合损伤,越来越多的骨科医师开始在治疗踝关节损伤时重视下胫腓联合的诊疗。随着生物学固定理念逐渐普及,既往作为治疗金标准的下胫腓联合螺钉固定技术因存在相关并发症而逐渐受到质疑。弹性固定符合下胫腓联合的解剖及生物力学特点,逐渐被认可并推广。目前,弹性固定的方法主要有韧带重建(自体和异体)、锚钉缝合重建、Endobutton系统、Suture button系统和胫腓钩等固定装置。各种方法均有各自的临床适应证及优缺点。

关键词：下胫腓联合损伤弹性固定