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Coupling of Thermal-Hydraulic-Mechanical Processes for Geothermal Reservoir Modelling

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Journal of Earth Science 2015年第1期26卷 47-52页

作者： Ali Karrechl Oussama Beltaief ruyan Vincec Thomas Poulet Klaus Regenauer-Lieb School of Civil and Resource Engineering The University of Western AustraliaCrawley WA 6009Australia Tunisia Polytechnic School Rue AlkhawarizmiLa MarsaTunisia Earth Science and Resource Engineering CSIROKensington WA 6151Australia School of Petroleum Engineering University of New South WalesSydney NSW 2052Australia School of Earth and Environment The University of Western AustraliaPerth WA 6000Australia

This paper uses a fully coupled framework of thermal-hydraulic-mechanical processes to investigate how the injection and extraction of fluid within a geothermal reservoir impacts on the distributions of temperature, pore pressure, and deformation within the rock formations. Based on this formulation, a numerical model is developed in light of the thermodynamics of porous materials. The proposed procedure relies on the derivation of dissipative flow rules by postulating proper storage and dissipation functions. This approach opens new horizons for several resource engineering applications. Since it allows for full coupling, this formulation can play a key role in predicting risks when used for reservoir simulation. The results indicate that the injection-extraction process and temperature change have a definite impact on altering the in-situ properties of the reservoir.

关键词： poro-mechanics resource engineering fluid injection and extraction temperaturechange pore pressure stress deformation uplift subsidence.

内皮祖细胞外泌体中miRNA-222-3p对糖尿病小鼠皮肤伤口愈合的影响

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安徽医科大学学报 2024年第7期59卷 1195-1200页

作者：王永琪季华唐颖巫婷婷揭茹艳陈明卫安徽医科大学第一附属医院内分泌科合肥230022

目的了解内皮祖细胞外泌体(EPCs-Exo)中的miRNA-222-3p对糖尿病小鼠皮肤伤口愈合的影响。方法采用荧光染色法对C57BL/6小鼠骨髓来源内皮祖细胞(EPCs)进行鉴定。对从EPCs培养基中分离出的EPCs-Exo进行鉴定以及miRNA高通量测序。建立糖尿... 详细信息

目的了解内皮祖细胞外泌体(EPCs-Exo)中的miRNA-222-3p对糖尿病小鼠皮肤伤口愈合的影响。方法采用荧光染色法对C57BL/6小鼠骨髓来源内皮祖细胞(EPCs)进行鉴定。对从EPCs培养基中分离出的EPCs-Exo进行鉴定以及miRNA高通量测序。建立糖尿病小鼠皮肤损伤模型,随机分为5组:PBS组、EPCs-Exo组、空白组、agomiR-222-3p组、antagomiR-222-3p组。根据不同分组,连续处理14 d,观察创面愈合率,免疫荧光方法了解治疗前后创缘组织中活性氧(ROS)、血管内皮生长因子(VEGF)、CD31表达水平变化。结果EPCs-Exo促进糖尿病小鼠皮肤伤口愈合,降低创缘组织中ROS表达水平,增加VEGF、CD31表达水平(P<0.05)。高通量测序提示miRNA-222-3p在EPCs-Exo中高度表达。创缘组织局部皮下注射miRNA-222-3p可显著促进糖尿病小鼠皮肤伤口愈合,降低创缘组织中ROS表达水平,增加VEGF、CD31表达水平(P<0.05)。结论miRNA-222-3p促进糖尿病小鼠伤口愈合,在EPCs-Exo促进创面愈合过程中发挥重要作用。

关键词：内皮祖细胞外泌体糖尿病足 miRNA-222-3p 创面愈合

“双减”背景下中小学教师课后服务参与意愿及影响因素研究

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现代基础教育研究 2024年第3期55卷 43-48页

作者：黄如艳桑国元叶碧欣蔡添北京师范大学教育学部北京100875 珠海市教育局广东珠海519001 清华大学教育研究院北京100084

“双减”背景下,课后服务是推动我国中小学教育走向高质量发展轨道的重要战略。调查发现:(1)当前中小学教师参与课后服务的意愿总体水平一般,行为态度、主观规范、知觉行为控制对中小学教师课后服务参与意愿产生正向影响;(2)行为态度、... 详细信息

“双减”背景下,课后服务是推动我国中小学教育走向高质量发展轨道的重要战略。调查发现:(1)当前中小学教师参与课后服务的意愿总体水平一般,行为态度、主观规范、知觉行为控制对中小学教师课后服务参与意愿产生正向影响;(2)行为态度、知觉行为控制通过主观规范间接作用于中小学教师课后服务参与意愿。据此提出建议:一是价值引导与激励并重,促成中小学教师形成积极的课后服务参与态度;二是关注人文关怀,增强中小学教师所感知到的课后服务参与主观规范;三是构建专业支持体系,增强中小学教师课后服务参与的知觉行为控制。

关键词： “双减”政策课后服务教师意愿计划行为理论

中美两国宫颈癌发病率与死亡率长期趋势比较分析

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中国预防医学杂志 2024年第6期25卷 782-787页

作者：刘文敏陈茹雁程冬付振明武汉大学人民医院肿瘤中心湖北武汉430060

目的比较中美两国宫颈癌发生率和死亡率的长期趋势,从而评估公共卫生控制政策的效果,以提高中国人群对宫颈癌的认识,降低宫颈癌发病率。方法本研究基于公共数据库,分别收集中国和美国宫颈癌年龄标准化发病率(age-standardized incidence... 详细信息

目的比较中美两国宫颈癌发生率和死亡率的长期趋势,从而评估公共卫生控制政策的效果,以提高中国人群对宫颈癌的认识,降低宫颈癌发病率。方法本研究基于公共数据库,分别收集中国和美国宫颈癌年龄标准化发病率(age-standardized incidence rate,ASIR)和年龄标准化死亡率(age-standardized mortality rate,ASMR)的数据,采用连接点回归模型和年龄-时期-队列(age-period-cohort,APC)模型进行分析。结果美国宫颈癌的ASIR(2000—2018年,APC=-1.21%)呈下降趋势。相反,中国的ASIR(2000—2014年:APC=-5.20%,2004—2018年:APC=0.74%)呈持续上升趋势。中国和美国ASIR均表现出显著的时期效应,与发生率变化趋势一致。美国队列效应显示发病风险随出生队列逐渐降低,中国的队列效应显示发病风险随出生队列位移而逐渐增加。中国和美国ASIR的年龄效应均显示自20岁起宫颈癌发病风险逐渐增高。美国宫颈癌的ASMR(2000—2018年,APC=-1.03%)持续下降,中国死亡率自2004—2009年下降(2004—2009年:APC=-2.15%),而后保持稳定(2009—2018年:APC=0.01%)。中国和美国ASMR年龄效应均显示宫颈癌的死亡风险与年龄呈正比,时期效应和队列效应提示死亡风险分别随着时间和出生队列而逐渐下降。结论中国宫颈癌负担高于美国宫颈癌负担,我国未来要积极推进宫颈癌的预防措施,以降低宫颈癌负担。

关键词：宫颈癌发病率死亡率生存率年龄-时期-队列效应

Multi-agent reinforcement learning for edge information sharing in vehicular networks

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Digital Communications and Networks 2022年第3期8卷 267-277页

作者： ruyan Wang Xue Jiang Yujie Zhou Zhidu Li Dapeng Wu Tong Tang Alexander Fedotov Vladimir Badenko School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China Advanced Network and Intelligent Connection Technology Key Laboratory of Chongqing Education Commission of China Chongqing400065China Key Laboratory of Ubiquitous Sensing and Networking in Chongqing Chongqing400065China Peter the Great St.Petersburg Polytechnic University Polytechnicheskaya29St.Petersburg195251Russia

To guarantee the heterogeneous delay requirements of the diverse vehicular services,it is necessary to design a full cooperative policy for both Vehicle to Infrastructure(V2I)and Vehicle to Vehicle(V2V)*** paper investigates the reduction of the delay in edge information sharing for V2V links while satisfying the delay requirements of the V2I ***,a mean delay minimization problem and a maximum individual delay minimization problem are formulated to improve the global network performance and ensure the fairness of a single user,respectively.A multi-agent reinforcement learning framework is designed to solve these two problems,where a new reward function is proposed to evaluate the utilities of the two optimization objectives in a unified ***,a proximal policy optimization approach is proposed to enable each V2V user to learn its policy using the shared global network *** effectiveness of the proposed approach is finally validated by comparing the obtained results with those of the other baseline approaches through extensive simulation experiments.

关键词： Vehicular networks Edge information sharing Delay guarantee Multi-agent reinforcement learning Proximal policy optimization

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输电线路架设用导线提升装置设计分析

电力设备管理 2024年第12期 274-276页

作者：李青竹樊汝岩马亚南国网山东省电力公司冠县供电公司

随着我国社会经济的不断发展,我国国民的经济水平有了显著的提高。人们逐渐追求更高品质的生活,导致其对用电的需求呈现多元化趋势。电网也因此发挥出了越来越重要的作用,通过输电线路架设用导线提升装置设计,能够将更多的新技术与新工... 详细信息

随着我国社会经济的不断发展,我国国民的经济水平有了显著的提高。人们逐渐追求更高品质的生活,导致其对用电的需求呈现多元化趋势。电网也因此发挥出了越来越重要的作用,通过输电线路架设用导线提升装置设计,能够将更多的新技术与新工艺应用到线路的结构设计当中,从而进一步增强输电线路的稳定性与经济性。本文概括了输电线路架设的步骤和输电线路架设用导线提升装置设计的必要性,并从多方面阐述了相应的有效策略,供同行参考。

关键词：输电线路架设导线装置设计

Dendritic cells maturation facilitated by group-adjustable lipopolysaccharide analogues synthesized via RAFT polymerization

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Chinese Chemical Letters 2022年第9期33卷 4331-4334页

作者： Xingyu Heng ruyan Feng Lijuan Zhu Liyin Yu Gaojian Chen Hong Chen College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Center for Soft Condensed Matter Physics and Interdisciplinary Research Soochow UniversitySuzhou 215006China

Transforming immature DCs into mature state to activate cellular immunity is a critical step in initiating immunoprophylaxis and ***(LPS)can promote DCs maturation by binding receptor on DCs surface,but their clinical application is limited due to biological *** many LPS analogues have been developed,complex synthesis and purification hinder their practical ***,we propose a novel and simple strategy to synthesize LPS analogues with adjustable structural *** monomer units similar to the key functional groups of LPS,we synthesize LPS analogues with different group ratios by RAFT *** obtained analogues have little negative effect on cell *** with LPS,the analogues show greater promoting effect on DCs *** the analogues can be applied to different scenarios since the degrees of promoting DCs maturation by LPS analogues with different group ratios are *** strategy provides a new direction for synthesizing LPS analogues,and it has the potential to produce LPS analogues on a large scale with tunable promoting DCs maturation effect.

关键词： LPS analogues Glycopolymer RAFT polymerization Dendritic cells(DCs) Immune enhancement

Ethnobotanical survey of plants traditionally used against hematophagous invertebrates by ethnic groups in the mountainous area of Xishuangbanna, Southwest China

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Plant Diversity 2020年第6期42卷 415-426页

作者： Yi Gou Zhennan Li ruyan Fan Zuchuan Qiu Lu Wang Chen Wang Yuhua Wang Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming650201China University of Chinese Academy of Sciences Beijing100049China

Hematophagous invertebrates such as mosquitoes,leeches,mites,ticks,lice and bugs cause various problems for *** reports on insecticide resistance and requirements for improved environmental and toxicological profiles,there is a continuing need to discover and develop new insecticides and *** surveys of traditional plant-based repellents provide a direct method of identifying plants for potential *** five field surveys in Bulang,Jinuo and Lahu villages between August 2018 and July 2019,semi-structured interviews were conducted with 237 informants(151 male,86 female;mean age 63).Frequency of citation,use value,informant consensus factor and Jaccard index were employed to statistically analyze the collected data.A total of 709 use reports relating to 32 plant species and 71 remedies were *** and differences between the three groups,as well as the Dai and Hani of Xishuangbanna,who were studied earlier,were shown through network *** five ethnic groups living in the same area have a common understanding of traditional botanical knowledge against hematophagous invertebrates,but each group also possesses unique *** and protecting this traditional knowledge is potentially useful for protecting this cultural diversity and related biodiversity and can also have important practical *** this study,traditional knowledge provided us with many new potential plants for follow-up research for the development of new insecticides and repellents,among which Artemisia indica,Nicotiana tabacum and Clausena excavata are the most promising.

关键词： Ethnobotanical survey Insecticide Repellent Traditional knowledge

Advances in research on chemical constituents and pharmacological effects of Paecilomyces hepiali

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Food Science and Human Wellness 2021年第4期10卷 401-407页

作者： Akang Dan Yujia Hu ruyan Chen Xiangyang Lin Yongqi Tian Shaoyun Wang School of Biological Science and Technology Fuzhou UniversityFuzhou 350108China

Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps *** main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and *** to the huge development potential of *** in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the *** this paper,the chemical constituents and their pharmacological effects of *** are reviewed,which can provide reference for the development and application of ***.

关键词： Paecilomyces hepiali Chemical constituents Pharmacological effects