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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang wu Yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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智能精密播种机的优化设计

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农机化研究 2025年第1期47卷 114-119页

作者：吴政内蒙古机电职业技术学院呼和浩特010070

智能精密播种机是一种自动化的农业设备,可大幅提高种植效率、减少种植成本。但是,目前智能精密播种机依赖高精度的传感器、控制系统和算法来实现准确的种子投放和深度控制,需要较高的技术要求和技术支持,且对于一些不规则形状的种子或... 详细信息

智能精密播种机是一种自动化的农业设备,可大幅提高种植效率、减少种植成本。但是,目前智能精密播种机依赖高精度的传感器、控制系统和算法来实现准确的种子投放和深度控制,需要较高的技术要求和技术支持,且对于一些不规则形状的种子或大粒小种的种子,适应性较差。为此,提出了一种智能精密播种机优化方案,并使用高精度传感器和控制系统实现多功能播种,控制种子的投放量和调整播种深度,使用节能设备模块化设计和使用易于更换的部件、数据分析功能和简单易用的用户界面。最后,通过田间试验进行功能性试验,结果表明:经过优化后的智能精密播种机播种变异系数≤5%,满足播种农艺要求,可以实现准确的种子投放和深度控制,避免种植密度不均匀和深度不一致等问题,从而提高种植效率和作物品质。

关键词：智能精密播种机优化设计精度多功能性种植效率

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小世界、结构洞与城市创新的网络机制:来自长三角城市群的证据

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管理工程学报 2025年第2期39卷 14-26页

作者：袁燕吴妍杨大鹏浙江科技大学经济与管理学院浙江金融职业学院电子商务与新消费研究院中共浙江省委党校工商管理教研部

近年来,创新网络作为区域和城市创新驱动力的重要性得到了广泛关注。一些研究将网络关系视为知识在城市内和城市间传播的渠道,并通过网络分析视角洞察城市创新的结构和动态。然而,城市创新的网络机制,特别是数字经济发展背景下的数字赋... 详细信息

近年来,创新网络作为区域和城市创新驱动力的重要性得到了广泛关注。一些研究将网络关系视为知识在城市内和城市间传播的渠道,并通过网络分析视角洞察城市创新的结构和动态。然而,城市创新的网络机制,特别是数字经济发展背景下的数字赋能城市创新能力提升机制还有待进一步研究。本文利用长三角城市群26个城市2009年—2018年联合申请专利数据构建了城市创新网络,探讨了网络结构属性——小世界和结构洞对城市创新能力的影响。结果表明,小世界与城市创新能力呈“倒U型”关系,数字经济发展水平正向调节了二者之间的“倒U型”关系,结构洞对城市创新能力具有正向影响。本文厘清了创新网络结构对城市创新能力的影响,回应了以往研究关于小世界和结构洞对创新影响的理论争议,为区域创新的理论研究提供了新颖性观点,深化了对城市群创新发展规律的认识,对推进中国城市群协同创新具有重要意义。

关键词：创新网络城市创新能力专利合作数字经济

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Comparative analysis of empirical and deep learning models for ionospheric sporadic E layer prediction

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Earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue Christopher JScott HaiLun Ye JianFei wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic E(Es)layers in the ionosphere are characterized by intense plasma irregularities in the E region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of Es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present Es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting Es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic E layer radio occultation ionosondes numerical model deep learning model artificial intelligence

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Investigation on the interaction of dispersed and elongated bubbles based on laser-induced fluorescence

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Optoelectronics Letters 2025年

作者： XUE Ting SHI Ruini LIU Jinshun WANG Haixia wu Yan School of Electrical and Information Engineering， Tianjin University

The purpose of this paper is to investigate the interaction between dispersed and elongated bubbles in horizontal slug flow utilizing the laser-induced fluorescence method. A Segmentation method based on the fuzzy C-mean (FCM) algorithm is proposed to effectively separate elongated bubbles from the liquid phase， and an extreme value extraction method is developed to calculate the number of dispersed bubbles in front of the nose of elongated bubbles. Moreover， the velocity offsets of elongated bubbles with and without dispersed bubbles are calculated separately based on contour extraction. In addition， the effect of dispersed bubbles on the fluctuating offsets of the nose tip position and velocity of elongated bubbles are statistically investigated under different flow velocities. The experimental results show that the increase of the gas-liquid flow velocity exacerbates the radial deviation of the nose tip and the fluctuation of axial velocity.

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2D free-standing ultra-large ferromagnetic nanosheets via a topotactic transformation strategy

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Science China Chemistry 2025年

作者： Haofeng Sun Minghao Wang Wenjie Li Yang Liu Xinyu Sun Wenjie Wang Yuqiao Guo Yi Xie Changzheng wu Key Laboratory of Precision and Intelligent Chemistry University of Science&Technology of China National Synchrotron Radiation Laboratory University of Science and Technology of China

Considerable progress has been made in synthesizing two-dimensional （2D） materials by exfoliating layered ***,for tremendous non-layered inorganic materials,especially magnet solids,usually with closely packed bulk phases by strong chemical bonds,it is challenging to obtain their high-quality 2D ***,we highlighted a new structure of free-standing ferromagnetic nanosheets featuring （111） *** magnet,Fe3O4,its inversed spinel crystalline has limited abilities to exfoliate into 2D forms and rarely exists as free-standing nanosheets owing to aggregation induced by magnetic *** realized a breakthrough in achieving free-standing ferromagnetic nanosheets with dramatically surpassing size limitations via topotactic conversion from layered *** Fe3O4nanosheets exhibited a maximum width of 60μm while only～4 nm thick,prominently exposing （111） facets.2D Fe3O4behaved anisotropic magnetism,which displayed a 4.6 emu g-1moment（H=500 Oe） in the （111） plane but 2.1 emu g-1out of the （111） plane,indicating a （111） in-plane easy *** anticipated our topotactic conversion strategy would inspire the creation of 2D non-layered materials and enrich the 2D materials family.

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The low-latitude sodium layer:comparative data from lidar observations at Hainan,China and São Paulo,Brazil

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Earth and Planetary Physics 2025年第1期9卷 39-53页

作者： Fang wu Jing Jiao GuoTao Yang LiFang Du ZhengKuan Liu HaoRan Zheng JiXin Guo ShaoHua Gong YaJun Zhu State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Hainan National Field Science Observation and Research Observatory for Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China China-Brazil Joint Laboratory for Space Weather NSSC/INPESão Josédos Campos 12227-010Brazil School of Physics and Electronics Engineering Hainan Normal UniversityHaikou 571158China

Physical and chemical processes observed in the mesosphere and thermosphere above the Earth’s low latitudes are complex and highly interrelated to activity in the low-latitude *** sodium detected by lidar can yield clues to dynamic and chemical processes in these spatial layers above the Earth’s *** paper is based on sodium layer data collected at two low-latitude stations,one in the northern hemisphere and one in the *** low-latitude sodium layer exhibits conspicuous seasonal variations in shape,density,and altitude;these variations are similar between Earth’s hemispheres:sodium layer density at both stations reaches its seasonal maximum in autumn and minimum in ***,maximal Na density over Brazil is greater than that over *** variations of Na density above the two low-latitude stations are also similar;at both,maxima are observed before *** variations of the Na layer over Brazil that differ from those observed in the northern hemisphere may be related to the South Atlantic Magnetic Anomaly(SAMA)or fountain *** suggest that low-latitude Na layer data may provide useful additional evidence that could significantly improve the low-latitude part of the WACCM-Na model.

关键词： metallic sodium layer seasonal variation nocturnal variation lidar

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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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PVIIAD: industrial visual anomaly detection method based on partially visible image inpainting

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Optoelectronics Letters 2025年

作者： wu Qiliang FEI Dongce YAO Minghui NIU Yan WANG Cong School of Aeronautics and Astronautics， Tiangong University School of Artificial Intelligence， Tiangong University

Industrial anomaly detection is dedicated to identifying and locating regions that deviate from the standard appearance. The prevailing approach achieves unsupervised anomaly detection through the reconstruction of images using autoencoders. Due to the simplistic structure of some abnormal regions， the autoencoder can effectively reconstruct these areas， consequently diminishing the model's anomaly detection capabilities. To address this issue， this paper transforms the reconstruction task into the inpainting-filling-reconstruction task to increase the reconstruction error between abnormal samples and normal samples. In PVIIAD， the masked regions inpainted by the filling network are used to fill in the input image， thereby achieving an effect similar to masking. Unlike typical masking processes， this approach retains partial authentic information in the input image， rendering it partially visible. This is beneficial for the reconstruction network to repair the masked areas. Due to the consistent structure between the masked region inpainted by the filling network and the normal region， the filled abnormal regions display a complex structure that has not been learned， making it difficult for the reconstruction network to reconstruct the abnormal regions. Experimental results indicate that PVIIAD performs better than other methods on both the MVTec AD dataset and the MVTec LOCO AD dataset.

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