SUMMARY A married mother in her 50s acutely developed vomiting,diarrhoea and severe epigastric pain 2 weeks following discharge from an acute psychiatric inpatient *** presented to the emergency department complaining...
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SUMMARY A married mother in her 50s acutely developed vomiting,diarrhoea and severe epigastric pain 2 weeks following discharge from an acute psychiatric inpatient *** presented to the emergency department complaining of a 2-day history of the above *** tests revealed neutrophilia,grossly raised inflammatory markers and amylase levels triple the normal *** on radiological investigations,she was treated for necrotising pancreatitis that quickly escalated to multi-system organ failure and a lengthy intensive care unit *** causes of pancreatitis,including cholelithiasis,alcohol and other drugs,were ruled *** this,she suffered recurrent episodes of pancreatitis with significant ***,started during her psychiatric admission,was determined to be the offending *** years following the discontinuation of olanzapine,the patient has had no further episodes of acute pancreatitis.
Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also *** recent years,a series of animal models ha...
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Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also *** recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory *** note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of *** wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic *** on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage ***:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult *** HFS Weanling and HFS Adult animals had a significant increase in body mass and pe
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