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Characteristics of the Chinese subjects entered the Hypertension in the Very Elderly Trial

Chinese Medical Journal 2008年第16期121卷 1509-1512页

作者： LIU Li-sheng WANG Ji-guang MA Shu-ping WANG Wen LU Fang-hong ZHANG Liang-qing Winston Banya ruth peters Nigel Beckett Astrid Fletcher Christopher J. Bulpitt Beijing Hypertension League Institute Beijing 100039 China Centre for Epidemiological Studies and Clinical Trials Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Cardiology Hebei Provincial Hospital Shijiazhuang Hebei 050051 China National Centre for Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences Beijing 100037 China Shandong Academy of Medical Sciences Jinan Shandong 050051 China Shanxi Cardiovascular Institute Taiyuan Shanxi 030001 China Care of the Elderly Hammersmith Hospital Imperial College London UK

Background The baseline characteristics of patients in a multinational trial are possibly related to cardiovascular outcome. This study compared the baseline characteristics of patients recruited in China with those recruited in other countries. Methods A total of 508 Chinese hypertensive men and 728 women over the age of 80 years who entered the Hypertension in the Very Elderly Trial （HYVET） were compared with those in 860 men and 1348 women who entered the trial in other countries. Results The Chinese subjects were slightly younger, had less previous hypertension but more previous strokes than the subjects from other countries. The Chinese subjects smoked more than those from other countries, but drank less alcohol. They had less previous episodes of myocardial infarction and were, on average, lighter and shorter. The Chinese had lower mean concentrations of blood urea, uric acid and creatinine as well as higher concentrations of high density lipoprotein （HDL） cholesterol. The concentration of total cholesterol was, on average, lower in the Chinese subjects as was blood glucose. The levels of serum sodium and potassium, blood hematocrit and hemoglobin were all, on average, lower in the Chinese subjects. Conclusions Calorie restriction, compared with the rest of the world, may have resulted in lower stature and weight, and recent increases in calorie intake have not changed the metabolic profile of the very elderly hypertensive patients in China. Some of these biochemical differences may reflect different dietary lifestyle in the Chinese.

关键词： elderly epidemiology hypertension China

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