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Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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Neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： ruth Hornedo-Ortega Ana m.Espinosa-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biomedicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 *** 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022).

关键词： protective Alzheimer prevalence

Assessing bioactivity of environmental water samples filtered using nanomembrane technology and mammalian cell lines

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Eco-Environment & Health 2024年第3期3卷 347-354页

作者： Sarah E.morgan Lisa A.DeLouise Department of Environmental medicine University of Rochester Medical CenterRochesterNY 14642USA Department of Biomedical Engineering University of RochesterRochesterNY 14627USA Department of Dermatology University of Rochester Medical CenterRochesterNY 14642USA Lake Ontario Center for microplastics and Human Health in a Changing Environment University of Rochester Medical CenterRochesterNY 14642USA

This project reports on the use of a novel nanomembrane filtering technology to isolate and analyze the bioactivity of microplastic(mP)-containing debris from Lake Ontario water *** mPs are a complex mixture of polymers and sorbed chemicals that are persistent and can exhibit a wide range of toxic *** human exposure to mPs is unavoidable,it is necessary to characterize their bioactivity to assess potential health *** work seeks to quantify mP presence in the nearshore waters of Lake Ontario and begin to characterize the bioactivity of the filtrate containing *** utilized silicon nitride(SiN)nanomembrane technology to isolate debris sized between 8 and 20μm from lake water samples collected at various times and *** were identified with Nile red ***-based assays were conducted directly on the filtered debris to test for cell viability,aryl hydrocarbon receptor(AhR)activity,and interleukin 6(IL-6)levels as a measure of proinflammatory *** samples contained *** of the isolated debris impacted cell ***,AhR activity and IL-6 levels varied over ***,no associations were observed between the amount of plastic and *** differences in activity are likely due to variations in the physiochemical properties of debris between *** results highlight the need for increased sampling to fully characterize the bioactivity of mPs in human cells and to elucidate the role that sample physiochemical and spatiotemporal properties play in this activity.

关键词： microplastics SiN nanomembranes Lake Ontario Aryl hydrocarbon receptor(AhR)activity IL-6 levels Bioactivity

Impact of Social Determinants of Health on Self-Perceived Resilience: An Exploratory Study of Two Cohorts of Adults with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 33-48页

作者： Albert Osom Krysta S.Barton Katie Sexton Lyndia Brumback Joyce P.Yi-Frazier Abby R.Rosenberg ruth Engelberg Jill m.Steiner Department of Biostatistics University of WashingtonSeattleWA98195USA Biostatistics Epidemiology and Analytics for Research(BEAR)Core Seattle Children’s Research InstituteSeattleWA98101USA College of medicine University of WashingtonSeattleWA98195USA Center for Clinical and Translational Research Seattle Children’s Research InstituteSeattleWA98101USA Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer InstituteDepartment of MedicineBoston Children’s HospitalBostonMA02215USA Department of Pediatrics Harvard Medical SchoolBostonMA02215USA Division of Pulmonary Critical Care and Sleep MedicineDepartment of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonHarborview Medical CenterSeattleWA98104USA Division of Cardiology Department of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonSeattleWA98195USA

Social determinants of health(SDOH)affect quality of *** investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).Secondary analysis of data from two com-plementary studies:a survey study conducted may 2021–June 2022 and a qualitative study conducted June 2020–August *** was assessed through CD-RISC10 score(range 0–40,higher scores reﬂect greater self-perceived resilience)and interview *** and SDOH(education,employment,living situa-tion,monetary stability,ﬁnancial dependency,area deprivation index)data were collected by healthcare record review and *** used linear regression with robust standard errors to analyze survey data and performed a thematic analysis of interview *** participants(N=127)mean age was 42±14 years;51%were female,87%*** was moderate(75%)or complex(25%);41%functional class C or ***(mean 30±7)varied by monetary stability:compared to people with difﬁculty paying bills,resilience was 15.0 points higher(95%CI:6.9–23.1,pmoney and 14.2 points higher(95%CI:5.9–22.4,p=0.001)for those reporting just enough *** participants’(N=25)mean age was 32 years(range 22–44);52%were female,72%*** was moderate(56%)or complex(44%);76%functional class C or *** discussed factors affecting resilience aligned with each of the major SDOH,prominently,economic stability and healthcare access and *** stability may be important for supporting self-perceived resi-lience in *** knowledge can inform the development of resilience interventions for this population.

关键词： Social determinants of health adult congenital heart disease resilience ﬁnancial stability

THE GREATEST TREASURE A story about happiness

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空中英语教室（初级版．大家说英语） 2024年第11期 21-24,52,53,56页

作者： ruth Devlin 不详

Find It What happened when Li played his flute?ong ago,there was a rich man in *** name was *** day long,he worried about his *** it,and he sorted *** about spending it,and he worried about getting *** had five *** wo... 详细信息

关键词： money happen China.

Impact on Soil Organic C and Total Soil N from Cool- and Warm-Season Legumes Used in a Green manure-Forage Cropping System

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Agricultural Sciences 2024年第3期15卷 333-357页

作者： Clark B. Neely Francis m. Rouquette Jr. Cristine L.S. morgan Frank m. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&m AgriLife Research Overton TX USA Chief Scientific Officer Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Annual forage legumes are important components of livestock production systems in East Texas and the southeastern US. Forage legumes contribute nitrogen (N) to cropping systems through biological N fixation, and their seasonal biomass production can be managed to complement forage grasses. Our research objectives were to evaluate both warm- and cool-season annual forage legumes as green manure for biomass, N content, ability to enhance soil organic carbon (SOC) and soil N, and impact on post season forage grass crops. Nine warm-season forage legumes (WSL) were spring planted and incorporated as green manure in the fall. Forage rye (Secale cereale L.) was planted following the incorporation of WSL treatments. Eight cool-season forage legumes (CSL) were fall planted in previously fallow plots and incorporated as green manure in late spring. Sorghum-sudangrass (Sorghum bicolor x Sorghum bicolor var. sudanense) was planted over all treatments in early summer after forage rye harvest and incorporation of CSL treatments. Sorghum-sudangrass was harvested in June, August and September, and treatments were evaluated for dry matter and N concentration. Soil cores were taken from each plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 cm, and soil C and N were measured using combustion analysis. Nylon mesh bags containing plant samples were buried at 15 cm and used to evaluate decomposition rate of above ground legume biomass, including change in C and N concentrations. mungbean (Vigna radiata L. [Wilczek]) had the highest shoot biomass yield (6.24 t Dm ha-1) and contributed the most total N (167 kg∙ha-1) and total C (3043 kg∙ha-1) of the WSL tested. Decomposition rate of WSL biomass was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum sativum L. spp. sativum), arrow leaf clover (Trifolium vesiculosum Savi.), and crimson clover (Trifolium incarnatum L.) were the most productive CSL in this trial. Austrian winter pea

关键词： Annual Legumes Soil N Soil Organic C Green manure Deer Browse Forage Cropping Systems

Legume Green manure and Intercropping for High Biomass Sorghum Production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely Francis m. Rouquette Jr. Cristine L. S. morgan Frank m. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&m AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor L.) production systems on a Lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [Cynodon dactylon (L.) Pers.] pasture. In this split-split plot design, ‘Dixie’ crimson clover (Trifolium incarnatum L.) and ‘Iron and Clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, C concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOC). main plots were split into crimson clover green manure (CLGm) and winter fallow (FALL) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (CPGm), cowpea-sorghum intercrop (CPSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The CLGm increased (P sorghum biomass yield (16.5 t Dm∙ha−1) 28% in year three but had no effect in the first two years. The CPSR treatment reduced sorghum yield up to 62% compared to SORG;whereas CPGm increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. Decrease in SOC and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. Cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-Biomass Sorghum Legumes Green manure Intercrop Cowpea Crimson Clover Soil Organic Carbon Soil Nitrogen

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迷人的巴黎

空中英语教室（初级版．大家说英语） 2024年第7期 29-31,54页

作者： ruth Devlin 不详

每年都有数百万人游览巴黎这座美妙的城市很多人会去参观著名的埃菲尔铁塔,那是巴黎的象征。你可以坐电梯到铁塔的顶层,将迷人的景色尽收眼底!晚上11点,铁塔上的彩灯会变幻出绚丽的灯光秀!《蒙娜丽莎》是世界上最著名的画作,就展示在巴... 详细信息

每年都有数百万人游览巴黎这座美妙的城市很多人会去参观著名的埃菲尔铁塔,那是巴黎的象征。你可以坐电梯到铁塔的顶层,将迷人的景色尽收眼底!晚上11点,铁塔上的彩灯会变幻出绚丽的灯光秀!《蒙娜丽莎》是世界上最著名的画作,就展示在巴黎的卢浮宫。你还可以在那里欣赏到数千件美丽的艺术品。

关键词：《蒙娜丽莎》埃菲尔铁塔卢浮宫艺术品巴黎

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我非常抱歉

空中英语教室（初级版．大家说英语） 2024年第5期 30-32,54页

作者： ruth Devlin 不详

当你说错话或做错事时,你可以说:“我很抱歉。”道歉并化解嫌隙是很重要的事,你不想让人感到失望难过。当你迟到、举止粗鲁或是打破东西时,你可以说“对不起”。说抱歉,就是承认你的错误,然后说:“我很抱歉。”那是表现你关心别人的一... 详细信息

当你说错话或做错事时,你可以说:“我很抱歉。”道歉并化解嫌隙是很重要的事,你不想让人感到失望难过。当你迟到、举止粗鲁或是打破东西时,你可以说“对不起”。说抱歉,就是承认你的错误,然后说:“我很抱歉。”那是表现你关心别人的一种简单方式。当你说了对不起,别人通常会原谅你。

关键词：道歉举止对不起

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Take的各种用法

空中英语教室（初级版．大家说英语） 2024年第2期 28-29,53页

作者： ruth Devlin 不详

英文中take这个动词有许多和其他词语结合的用法。如果是时候要离开一个地方,你可以takeoff(离开)到别的地方去;如果你同意做更多工作,可以说你takeon(接下)那件工作;如果你做别人的工作,就是takeover(接手)那件工作;如果你退还一件商品... 详细信息

英文中take这个动词有许多和其他词语结合的用法。如果是时候要离开一个地方,你可以takeoff(离开)到别的地方去;如果你同意做更多工作,可以说你takeon(接下)那件工作;如果你做别人的工作,就是takeover(接手)那件工作;如果你退还一件商品,可以说takeback(退货);要是邀请某个人和你一起到某个地方去,就是takeout(带出去);或者你要是在一家餐厅购买食物带回家吃,就是买了takeout(外带餐点)。

关键词： take 用法地方