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Bringing epigenetics into the diagnostics of the andrology laboratory： challenges and perspectives

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Asian Journal of Andrology 2014年第5期16卷 669-674,I0006页

作者： ruth Klaver Jorg Gromoll Centre of Reproductive Medicine and Andrology University Clinics of MOnster MOnster Germany

Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspective article discusses the current state and value of DNA methylation analysis in the diagnostic setup of infertile men and outlines challenges and perspectives. It highlights the potential of DNA methylation in andrological diagnostics and its putative benefit in the examination of hitherto idiopathic infertile patients is described.

关键词： DNA methylation male infertility spermatogenesis

Nashville Qi?Chinese Medicine in an American Heartland

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Chinese Medicine and Culture 2023年第3期6卷 224-232页

作者： ruth Rogaski Department of History and Asian Studies Vanderbilt UniversityNashville 37235USA

This article shares preliminary results from current research on Chinese medicine in Nashville,Tennessee,a city in the American South known both as“Music City,USA”and“The Buckle of the Bible Belt.”The author has interviewed dozens of patients and practitioners in Nashville to understand how Chinese medicine came to the city,what styles of practice are present,and whether or not new understandings of Chinese medicine’s fundamental concept of qi might emerge from the unique cultural setting of the American *** Chinese medicine is flourishing in the city,because of complexities at the intersection of religion,science,and the experience of healing,the clinical encounter between patients and practitioners is not typically characterized by a mutual embrace of a language of qi.

关键词： Chinese medicine Nashville Qi United States

Exorcising memories of internalised stigma: The demons of lived experience

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World Journal of Psychiatry 2021年第3期11卷 63-72页

作者： Joanna ruth Fox School of Education and Social Care Anglia Ruskin UniversityCambridge CB11PTUnited Kingdom

Public stigma and self-stigma impact negatively on the lives of people with mental health *** people in society stereotype and discriminate against people with mental ill-health,and often this negative process of marginalisation is internalised by people with lived ***,this negative internalisation leads to the development of *** this article,I reflect on my own experiences of shame and self-stigma as a person with mental ill-health socially bullied by peers from my community and social groups.I present a personal narrative of both public and self-stigmatisation which I hope will enable me to exorcise memories of internalised stigma,which are encountered as my demons of lived *** reflexivity,a process used widely in health and social care fields,I consider how social bullying shattered my fragile confidence,selfesteem,and self-efficacy in the early days of my recovery;the impact of associative stigma on family members is also *** this,the potential to empower people who experience shame and stigma is explored alongside effective anti-stigma processes which challenge discrimination.I connect the concept of recovery with the notion of empowerment,both of which emphasise the importance of agency and self-efficacy for people with mental ***,I consider how the concepts of empowerment and recovery can challenge both the public stigma held by peers in the community and the selfstigma of those with lived experiences.

关键词： Stigma User-led narrative Reflexivity Empowerment Recovery Mental health

Sliding wear behavior of fully nanotwinned Cu alloys

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Friction 2019年第3期7卷 260-267页

作者： Jianfeng YAN Andrew LINDO ruth SCHWAIGER Andrea MHODGE Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA90089USA Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Institute for Applied Materials Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen76344Germany

Highly nanotwinned(NT) metals have advantages such as high strength,good ductility,favorable corrosion resistance,and thermal *** has been demonstrated that the introduction of high density NT microstructures can enhance the tribological properties of ***,the influence of the microstructure and the composition of NT alloys on the tribological behavior are not *** this work,the sliding wear behavior of fully NT materials,specifically Cu-Al and Cu-Ni alloys,are studied by a nanoscratch technique using a *** effects of microstructure and chemical composition on the wear properties are also *** results show that the chemical composition has an obvious influence on the wear resistance and microstructural *** NT Cu-Al alloys,the hardness and sliding wear resistance improve with increased Al content from Cu-2 wt.%Al to Cu-6 wt.%*** Cu-10 wt.%Ni alloy shows even better wear resistance than Cu-6 wt.%*** microstructural analysis shows that NT Cu alloys with higher wear resistance correspond to a smaller deformation-affected *** improvement of sliding wear properties of Cu-Al alloys with higher Al content may be ascribed to their decreased stacking fault *** Cu-Ni alloy shows better wear resistance than Cu-Al alloy,this may be related to the formation of intermetallic compounds in Cu-Al *** study broadens the knowledge about tribological properties of NT materials and provides a potential method to optimize their sliding wear resistance by altering the chemical composition of NT Cu alloys.

关键词： nanotwinned alloys thin film stacking fault energy tribology

China in the Center:What Will It Mean for Global Education?

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Frontiers of Education in China 2017年第1期12卷 3-28页

作者： ruth HAYHOE O.I.S.E. University of TorontoToronto M5S1V6Canada

This paper begins by reflecting on the significance of the 16th World Congress of Comparative Education Societies which was held at Beijing Normal University(BNU)in August *** I focuses on China’s experience in educational development since the late 1970s,and the support provided by organizations such as the Canadian International Development Agency(CIDA)and the World Bank,which facilitated the rapid restoration of China’s universities after the Cultural Revolution and supported a dramatic social and economic *** II goes on to profile China’s rich educational civilization and suggests that the normal university is uniquely suited to bringing that to a wider *** III overviews China’s programs of support for educational development in Africa and Southeast Asia,and suggests that these embody forms of dialogue and reciprocity that have the potential to open up refreshingly new approaches to educational thought and practice in the global arena.

关键词： Confucian thought mutuality normal university transformation

Evidences of hydroxytyrosol as an anti-inflammatory agent in Parkinson’s disease:insights into the mechanisms of action

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Neural Regeneration Research 2021年第5期16卷 992-993页

作者： ruth Hornedo-Ortega Ana María Espinosa-Oliva Axe Molécules d’Intérêt Biologique(MIB) Unitéde Recherche OenologieEA4577USC 1366 INRAISVVUniversitéde BordeauxBordeauxFrance Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de Sevillaand Instituto de Biomedicina de Sevilla(IBiS)Hospital Universitario Virgen del Rocío/CSICSevilleSpain

Neuroinflammation in neurodegenerative diseases:Inflammatory processes play a critical role in neurodegenerative diseases,such as Parkinson’s disease(PD).Thus,neuroinflammation is involved in the progression and development of these diseases,becoming an important pathological *** cells,the“macrophages”from central nervous system,are the initiating cells of the innate immune response against different stimuli in the brain.

关键词： inflammation diseases insight

Direct Determination of Trace Impurities in High Purity Neodymium after In-Situ Analyte-Matrix Separation by Fluorination Assisted ETV-ICP-AES

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Journal of Rare Earths 2004年第3期22卷 319-322页

作者： ruth Wanjau 胡斌何蔓江祖成吴英亮 Kenyatta University Kenya Department of Chemistry Wuhan University Wuhan 430072 China

Using PTFE as a chemical modifier, a method for the determination of trace impurities in high purity Nd_2O_3 by in-situ separation and electrothermal vaporization-inductively coupled plasma-atomic emission spectrometry (ETV-ICP-AES) was developed. The analyte-matrix separation and the temperature program of graphite furnace were investigated and optimized. The solid samples were directly introduced into graphite furnace in the form of slurry, where selective volatilization between the matrix and the analytes took place. The Nd matrix was retained in the graphite furnace during the evaporation step, while the trace analyte impurities were vaporized and removed. As a result, the matrix interference that is serious without the modifier is suppressed effectively. The achievable detection limits are (μg·g^(-1)): Ti 0.15, Mn 0.15, Ni 0.20, Co 0.54, respectively. The proposed method was applied to direct determination of trace impurities in high purity Nd_2O_3 with satisfactory results.

关键词： chemical analysis fluorination ETV-ICP-AES in-situ separation rare earths

Noise-induced hippocampal damage:potential mechanisms

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Neural Regeneration Research 2022年第3期17卷 563-564页

作者： Sonia Jazmín Molina Laura ruth Guelman Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasCentro de Estudios Farmacológicos y Botánicos(CEFyBOUBA-CONICET)Facultad de MedicinaBuenos AiresArgentina Universidad de Buenos Aires Facultad de Medicina1^(a) Cátedra de FarmacologíaBuenos AiresArgentina

Exposure to noise of high intensities(> 80 dB) is considered a stressful event and might produce both auditory and extra-auditory damage,including different central nervous system(CNS) *** the CNS,the hippocampus(HC),a structure related to several cognitive functions,has shown to be particularly susceptible to the effects of noise.

关键词： damage auditory injuries

The evolution of a geoscience standard:An instructive tale of science keyword development and adoption

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Geoscience Frontiers 2023年第5期14卷 396-401页

作者： Mark A.Parsons ruth Duerr Øystein Godøy University of Alabama in Huntsville AlabamaUSA Ronin Institute BroomfieldCOUSA Norwegian Meteorological Institute OsloNorway

In 1987,NASA sponsored an international workshop that inspired the Directory Interchange Format or DIF–a metadata format to enable“catalog interoperability”.The DIF formed the basis of the International Directory Network(IDN)and the Global Change Master Directory(GCMD)and included a set of science *** primary intent was to catalog NASA Earth science and related data,but the keywords have been implemented in many different systems and adopted in varying ways by many different organizations around the *** review provides an ethnographic examination of how the keywords have evolved and been managed and how they have been adopted over the last 35 *** illustrates how semantic approaches have evolved over time and provides insights on how standards and associated processes can be sustained and *** institutional commitment is essential,but so is transparency and technical *** and empowering the different roles involved in standards creation,maintenance,and use of standards as well as the services that standards enable is also *** is apparent that semantic representations need to be mindful of different contexts and carefully define verbs as well as nouns and *** and representing relationships is central to interdisciplinary interoperability.

关键词： Data management Standards Digital earth Semantic web Information science