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Immunogenetic biomarkers in inflammatory bowel diseases:Role of the IBD3 region

World Journal of Gastroenterology 2014年第41期20卷 15037-15048页

作者： Manuel Muro ruth López-Hernández Anna Mrowiec Centro de Investigación Biomédica en Red de enfermedades Hepáticas y Digestivas (Ciberehd) Immunology ServiceUniversity Hospital Virgen de la Arrixaca

Many studies have demonstrated the linkage between the IBD3 region (6p21.1-23), an area which encompasses the famous human leukocyte antigen (HLA) complex, and Crohn’s disease (CD) or ulcerative colitis (UC). IBD3 is the only region that meets genome-wide significance, and provides stronger evidence of the linkage than 16p13.1-16q12.2 (IBD1), the locus that contains the susceptibility gene CARD15. However, despite these findings, IBD3 susceptibility genes remain elusive and unclear due to the strong linkage disequilibrium, extensive polymorphism, and high gene density that characterize this area and also due to varying allele frequencies in populations around the world. This area presents an extremely high abundance of genes, including the classical and non-classical major histocompatibility complex (MHC) class I and II genes, and other genes, namely MHC class III genes tumor necrosis factor (TNF)-α and -β, and Hsp, whose proteins play key functions in immunological processes. To date, it is not clear which genes within the MHC family contribute to the IBD pathogenesis, although certain HLA alleles have been associated with IBD. Recent insights into the biological function of other genes encoded within the IBD3 region, such as the MHC class I chain-related (MIC) genes, have led investigators to a more comprehensive exploration of this region. MHC class I chain-related molecule A (MICA) is highly polymorphic and interacts with NKG2D, its receptor on the surface of NK, Tγδ and T CD8+ cells. Increased expression of MICA in intestinal epithelial cells and increased expression of NKG2D in CD4+ T cells (lamina propria) in patients with CD have also been reported. MICA alleles have also been associated with IBD, and a variation at amino acid position 129 of the α2-heavy chain domain seems to categorize MICA alleles into strong and weak binders of NKG2D rece

关键词： IBD3 Tumor necrosis factor MICA HLA Inflammatory bowel disease

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excellent mechanical properties and resistance to cavitation erosion for an ultra-low carbon Cr Mn N stainless steel through quenching and partitioning treatment

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International Journal of Minerals,Metallurgy and Materials 2018年第5期25卷 547-553页

作者： ze-an Zhou Wan-tang Fu Zhe Zhu Bin Li Zhong-ping Shi Shu-hua Sun State Key Laboratory of Metastable Materials Science and Technology Yanshan University

The retained austenite content(RAC),the mechanical properties,and the resistance to cavitation erosion(Ce)of the00Cr13Mn8Mo N steel after quenching and partitioning(Q&P)processing were *** results show that the Q&P process affected the RAC,which reached the maximum value after partitioning at 400°C for 10 *** tensile strength of the steel slightly decreased with increasing partitioning temperature and ***,the elongation and product of strength and elongation first increased and then *** sample partitioned at 400°C for 10 min exhibited the optimal property:a strength-ductility of 23.8 GPa?%.The resistance to Ce for the 00Cr13Mn8Mo N steel treated by the Q&P process was improved due to work hardening,spalling,and cavitation-induced martensitic transformation of the retained austenite.

关键词： CrMnN steel quenching and partitioning process retained austenite mechanical property cavitation erosion

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Understand the Temperature Sensing Behavior of Solid-state Polymerized PeDOT Hybrid Based on X-ray Scattering Studies

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Chinese Journal of Polymer Science 2024年第1期42卷 105-112,I0010页

作者： Zhen-Hang He Guang-Feng Liu ze-Kun Zhou Zhen Liu Yi-Shu zeng Peng Zhang School of Materials Science and engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Shanghai Advanced Research Institute(Zhangjiang Laboratory) Chinese Academy of SciencesShanghai 201204China

Poly(3,4-ethylenedioxythiophene)(PeDOT) is one of the most successful conductive polymers that recently has been used in wearable sensors for human health monitoring. In this work, we prepared a series of PeDOT hybrids consisting of PeDOT, sodium poly(styrene sulfonate)(PSSNa) and polyethylene oxide(PeO), and their preparation could be scaled-up via an adapted solid-state polymerization process. The resistance of the as-prepared PeDOT:PSS/PeO hybrid shows clear temperature response, i.e., it decreases almost linearly with the temperature increase. To understand this phenomenon, the in situ synchrotron radiation wide-and small-angle X-ray scattering(WAXS/SAXS) characterizations were undertaken to study the temperature-dependent microstructure change of the PeDOT:PSS/PeO hybrid. It demonstrated that PeDOT formed conductive paths in the hybrids, which were not destroyed by the PeO crystallization. As temperature increased, the PeO crystals' melting and the accompanying reorganization of PeDOT chains endowed the hybrid sample temperature responsiveness. Based on these fundamental knowledges, the hybrid materials were used to fabricate flexible wearable sensor that showing temperature sensing performance with an accuracy of 1 ℃. These findings shed lights on the scalable manufacturing of wearable sensors for body temperature monitoring.

关键词： Solid-state polymerization PeDOT hybrid Structure-property correlation X-ray scattering

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Data streams classification with ensemble model based on decision-feedback

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The Journal of China Universities of Posts and Telecommunications 2014年第1期21卷 79-85页

作者： LIU Jing XU Guo-sheng ZHeNG Shi-hui XIAO Da GU Li-ze Information Security Center Beijing University of Posts and Telecommunications National engineering Laboratory for Disaster Backup and Recovery Beijing University of Posts and Telecommunications

The main challenges of data streams classification include infinite length, concept-drifting, arrival of novel classes and lack of labeled instances. Most existing techniques address only some of them and ignore others. So an ensemble classification model based on decision-feedback（eCM-BDF） is presented in this paper to address all these challenges. Firstly, a data stream is divided into sequential chunks and a classification model is trained from each labeled data chunk. To address the infinite length and concept-drifting problem, a fixed number of such models constitute an ensemble model e and subsequent labeled chunks are used to update e. To deal with the appearance of novel classes and limited labeled instances problem, the model incorporates a novel class detection mechanism to detect the arrival of a novel class without training e with labeled instances of that class. Meanwhile, unsupervised models are trained from unlabeled instances to provide useful constraints for e. An extended ensemble model ex can be acquired with the constraints as feedback information, and then unlabeled instances can be classified more accurately by satisfying the maximum consensus of ex. experimental results demonstrate that the proposed eCM-BDF outperforms traditional techniques in classifying data streams with limited labeled data.

关键词： ensemble classification novel class concept drifting decision-feedback

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Aging process design based on the morphological evolution ofγprecipitates in a 4th generation nickel-based single crystal superalloy

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Journal of Materials Science & Technology 2023年第16期147卷 176-188页

作者： Jiachen Xu Xinbao Zhao Weiqi Li Hao Liu Quanzhao Yue Huanchang Duan Yuefeng Gu ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027ZhejiangChina Polytechnic Institute Zhejiang UniversityHangzhou 310027ZhejiangChina

In order to meet the design requirements of the aging treatment process of a 4th generation nickel-based single crystal superalloy(Ni-SX)developed independently,the effects of aging temperatures and aging times on the precipitation and morphological evolution ofγprecipitates are *** morphological evolution behavior ofγprecipitates during the aging process is summarized subsequently and the coarsening behavior ofγprecipitates is discussed by comparing with the Lifshitz-Slyozov-Wagner model(LSW)and the trans-interface diffusion-controlled model(TIDC).It is demonstrated that primary aging temperature and secondary aging time dominate the size and squareness ofγprecipitates respectively,a narrow primary aging temperature range and a suitable secondary aging time are allowed to obtain the optimized morphology ofγ*** optimal aging process of the Ni-SX investigated in the present work is obtained for 1100-1120°C/4 h and 870°C/16 h,confirmed by the corresponding creep *** coarsening growth ofγprecipitates in short-term aging also conforms to the LSW model ***,the aging process design rules of various Ni-SXs of different generations are also summarized.

关键词： Nickel-based single crystal superalloy Aging temperature Aging time γprecipitates Creep

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A New Grasping Mode Based on a Sucked-type Underactuated Hand

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Chinese Journal of Mechanical engineering 2018年第6期31卷 25-33页

作者： Pei-Chen Wu Nan Lin Ting Lei Qian Cheng Jin-ze Wu Xiao-Ping Chen School of Computer Science and Technology University of Science and Technology of China Hefei 230000 China

Robot hands have been developing during the last few decades. There are many mechanical structures and analyti?cal methods for di erent hands. But many tough problems still limit robot hands to apply in homelike environment. The ability of grasping objects covering a large range of sizes and various shapes is fundamental for a home service robot to serve people better. In this paper, a new grasping mode based on a novel sucked?type underactuated(STU) hand is proposed. By combining the flexibility of soft material and the e ect of suction cups, the STU hand can grasp objects with a wide range of sizes, shapes and materials. Moreover, the new grasping mode is suitable for some situations where the force closure is failure. In this paper, we deduce the e ective range of sizes of objects which our hand using the new grasping mode can grasp. Thanks to the new grasping mode, the ratio of grasping size between the biggest object and the smallest is beyond 40, which makes it possible for our robot hand to grasp diverse objects in our daily life. For example, the STU hand can grasp a soccer(220 mm diameter, 420 g) and a fountain pen(9 mm diameter, 9 g). What’s more, we use the rigid body equilibrium conditions to analysis the force condition. experiment evaluates the high load capacity, stability of the new grasping mode and displays the versatility of the STU hand. The STU hand has a wide range of applications especially in unstructured environment.

关键词： Grasping mode Underactuated hand Sucked?type Stability of new mode Grasping diverse objects

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Inconsistent creep between dendrite core and interdendritic region under different degrees of elemental inhomogeneity in nickel-based single crystal superalloys

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Journal of Materials Science & Technology 2021年第33期92卷 88-97页

作者： Wanshun Xia Xinbao Zhao Liang Yue Quanzhao Yue Jiangwei Wang Qingqing Ding Hongbin Bei ze Zhang Institute of Superalloys Science and Technology School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Univ Ctr Electron MicroscopyHangzhou 310027China

The creep inconsistency between dendrite core and interdendritic region is investigated in a nickel-based single crystal superalloy under 1373 K and 137 *** specimens with higher and lower degree of elemental inhomogeneity on dendritic structures are *** specimen with higher inhomogeneity,stronger segregation of refractory elements reinforces the local strength in dendrite core,but damages the strength in interdendritic *** strain is accumulated faster in interdendritic region giving rise to promoted dislocation shearing inγphase,faster degradation of dislocation networks and facilitated topological inversion of rated *** the segregation of refractory elements produces a high density of topologically close-packed(TCP)phase in dendrite core,faster accumulation of creep strain forms microcracks prior in interdendritic region that gives rise to final rupture of the *** another specimen,increased solid solution time gives rise to overall reduced *** inconsistency is relieved to show more uniform evolution of dislocation substructures and rafting between dendrite core and interdendritic *** second specimen is ruptured by formation and extension of microcracks along TCP phase although the precipitation of TCP phase is relatively restricted under reduced ***,the balance of local strength between dendrite core and interdendritic region results in over 40%increase of creep rupture life of the second specimen.

关键词： Nickel-based single crystal superalloys Dendritic structure Inhomogeneity Creep Rafting Dislocation networks

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effect and Mechanism of Solvent Properties on Solution Behavior and Films Condensed State Structure for the Semi-rigid Conjugated Polymers

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Chinese Journal of Polymer Science 2021年第7期39卷 796-814页

作者： Hao Zhang Tao Li Bin Liu Teng-Ning Ma Long Huang ze-Ming Bai Dan Lu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

Solvents have an essential association with polymer solution ***,few researches have been deeply done on this *** recent years,our research group focus on the study on effect of solvent properties on solution behavior and film condensed state structure for semi-rigid conjugated polymer up till to apply for optoelectronic ***,influence of solvent properties including solubility of solvent,aromaticity,polarity and hydrogen bonds on semi-rigid polymer chain solution behavior,i.e.,single chain conformation,chain shape,size and chains aggregated density were studied by means of static/dynamic laser light scattering(DLS/SLS)and exponential law *** of solvent properties on condensed state structure of the semi-rigid conjugated polymer film was studied by UV absorption spectroscopy,PL spectroscopy and electron microscopy *** essential reasons for the influence were discovered and the mechanism was *** was found that solution behavior with different solvent properties had an essential physical relationship with chains condensed state structure of the semi-rigid conjugated *** importantly,there was a quantitative structure-activity relationship between solution and *** key to this relationship depended on the interaction between solvent molecules and the semi-rigid conjugated polymer *** interaction could also affect optoelectronic devices *** study is of great significance to effectively control the condensed state structure of the semirigid conjugated polymers in the process of dynamic evolution from solutions to *** not only enriches the knowledge and understanding of both semi-rigid conjugated polymer solution behaviors and film condensed state physics based on polymer physics,but also is meaningful to practical application for conjugated polymer and other traditional polymer systems.

关键词： Semi-rigid conjugated polymer Solution behavior Solvents Condensed state structure Optoelectronic performance

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NUMeRICAL STUDY ON AIR FLOW AROUND AN OPeNING WITH LARGe eDDY SIMULATION

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Journal of Hydrodynamics 2003年第6期15卷 45-48页

作者： Fan Hong-ming, Ren Hong-ze, Li Xian-ting, Yi JiangDepartment of Building Science, Tsinghua University, Beijing 100084, China, e-mail:xting li @ *** Department of Building Science Tsinghua University Beijing 100084 China

Jet characteristics of air supply opening in a ventilating or anair-conditioning system is primarily decided by the folw state in the duct connected to the *** is valuable to study the opening jet characteristics and the flow state in a duct. In thisstudy, the Large eddy Simulation (LeS) technique combined with the Tarlor-Galerkin Finite elementMethod (FeM) in Computational Fluid Dynamics (CFD) was applied to the problem. The 3-D flow fieldsin ducts around air supply opening under typical conditions were investigated by numericalsimulation as well as experimental measurements. Numerical results agree well with the availableexperimental data. It indicates that the LeS method is available under the conditions withcomplicated boundaries and inner accompanied by anisotropic large-scale eddies, and it is credibleto predict the jet deflection characteristics around an opening.

关键词： computational fluid dynamics (CFD) finite element method (FeM) large eddysimulation (LeS)

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15%efficiency All-Polymer Solar Cells Based on a Polymer Acceptor Containing B←N Unit

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Chinese Journal of Polymer Science 2022年第8期40卷 989-995,I0011页

作者： Ying-ze Zhang Ning Wang Ying-Hui Wang Jun-Hui Miao Jun Liu Li-Xiang Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and engineering University of Science and Technology of ChinaHefei230026China

The development of new polymer acceptors strongly paves the power conversion efficiency(PCe)improvement of all polymer solar cells(all-PSCs).Herein,we develop a new polymer acceptor PBN26,which is the alternating copolymer of 2,2′-((2Z,2′Z)-((12,13-bis(2-octyldodecyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,3″:4′,5′]thieno[2′,3′:4,5]pyrrolo[3,2-g]thieno[2′,3′:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1 H-indene-2,1-diylidene))dimalononitrile and B←N bridged thienylthiazole(BNTT).The optimized all-PSCs device based on PBN26 exhibits a PCe of 15.09%,which is the highest value of the all-PSCs based on B←N-based polymer acceptors at ***,we also fabricate an all-PSC module with active area of 10 cm2 by blade coating,which exhibits a PCe of 8.78%.These results prove that polymer acceptors containing B←N units are promising for all-PSC device applications.

关键词： Organic photovoltaic All-polymer solar cells Polymer acceptors Boron-nitrogen coordination bond

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