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Colonoscopic evaluation of hematochezia in low and average risk patients for colorectal cancer:A prospective study

World Journal of Gastroenterology 2006年第45期12卷 7304-7308页

作者： Puglisi Carlo russo francesco paolo Barbera Carmelo Incarbone Salvatore Aprile Giuseppe Bonanno Giacomo russo Antonio Cattedra di Gastroenterologia Università di Catania Azienda Ospedaliero Universitaria Policlinico-Catania Italy

AIM: To relate the endoscopic findings in patients with hematochezia with regard to age in “low and average risk” for colorectal cancer (CRC) and to localize signifi cant lesions in order to identify patients who need sigmoidoscopy or total colonoscopy. METHODS: This prospective study was performed in an open access GI endoscopy unit. Out of 4322 consecutive patients undergoing colonoscopy, 918 reported hema- tochezia. The fi nal study group comprized 180 patients aged below 45 and 237 over 45. Main exclusion criteria were a 1st-degree family history of colorectal carcinoma, patients reporting blood mixed with stools and/or pro- gressive colonic symptoms, or patients who had under- gone colon surgery for neoplastic lesions. RESULTS: Total colonoscopy could be performed in 96% of patients. Abnormal findings were observed in 34.3% of the younger and in 65.7% of the older ones. Findings were the presence of polyps in the distal colon (n = 2) and IBD in the proximal colon (n = 29) in the group of the younger patients, and polyps (n = 15), IBD (n = 13), and carcinoma (n = 6, 4 of the lesions were located proximal to the splenic flexure) in the elderly. Our f indings suggest that the diagnostic potential of total colonoscopy in patients younger than 45 referring scant hematochezia, is not mandatory. By exploring only the distal tract of the colon we have misdiagnosed two cases of IBD located in the ascending colon. In this group of patients additional risk factors must be identifi ed before performing a total colonoscopy. Regarding the patients older than 45 yr, the exploration of the distal colon would have led to our overlooking a carcinoma, two neoplastic polyps and one IBD located in the proximal colon. CONCLUSION: Young patients with scant hematochezia but without risk factors for neoplasia do not need a totalcolonoscopy, whereas is mandatory performing a total colonoscopy in older patients even in the presence of anal pathology.

关键词： Hematochezia Colonoscopy Neoplasia Colonic neoplasia

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Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： paolo Abondio francesco Bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

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Groups with Finitely Many Homomorphic Images of Finite Rank

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Algebra Colloquium 2016年第2期23卷 181-187页

作者： francesco de Giovanni Alessio russo Dipartimento di Matematica e Applicazioni Universitg di Napoli Federico II Complesso Universitario Monte S. Angelo Via Cintia 1-80126 Napoli Italy Dipartimento di Matematica e Fisica Seconda Universitg di Napoli Via Lincoln 5 1-81100 Caserta Italy

A group is called a Cernikov group if it is abelian-by-finite and satisfies the minimal condition on subgroups. A new characterization of Cernikov groups is given here, by proving that in a suitable large class of generalised soluble groups they coincide with the groups having only finitely many homomorphic images of finite rank （up to isomorphisms） and admitting an ascending normal series whose factors have finite rank.

关键词： Prufer rank Cernikov group homomorphic image

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On the classification of OADP varieties

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Science China Mathematics 2011年第8期54卷 1561-1575页

作者： CILIBERTO Ciro russo francesco Dipartimento di Matematica Università di Roma Tor VergataVia della Ricerca Scientifica00133 RomaItaly Dipartimento di Matematica Università di CataniaViale A.Doria 695125 CataniaItaly

The main purpose of this paper is to show that OADP varieties stand at an important crossroad of various main streets in different disciplines like projective geometry,birational geometry and *** is a good reason for studying and classifying *** specific results are:(a) the classification of all OADP surfaces (regardless to their smoothness);(b) the classification of a relevant class of normal OADP varieties of any dimension,which includes interesting examples like lagrangian *** Pirio and russo (Comm Math Helv,to appear),the equivalence of the classification in (b) with the one of quadro-quadric Cremona transformations and of complex,unitary,cubic Jordan algebras are explained.

关键词： apparent double points tangential projective cubic Jordan algebra

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An Ethereum-based solution for energy trading in smart grids

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Digital Communications and Networks 2023年第1期9卷 194-202页

作者： francesco Buccafurri Gianluca Lax Lorenzo Musarella Antonia russo Mediterranea University of Reggio Calabria DIIESReggio CalabriaItaly

The need for a flexible,dynamic,and decentralized energy market has rapidly grown in recent *** a matter of fact,Industry 4.0 and Smart Grids are pursuing a path of automation of operations to insure all the steps among consumers and producers are getting *** leads towards solutions that exploit the paradigm of public blockchain,which represents the best platform to design flat and liquid markets for which providing trust and accountability to mutual interactions becomes *** the other hand,one of the risks arising in this situation is that personal information is exposed to the network,with intolerable threats to *** this paper,we propose a solution for energy trading,based on the blockchain Ethereum and Smart *** solution aims to be a concrete proposal to satisfy the needs of energy trading in smart grids,including the important feature that no information about the identity of the peers of the network is disclosed in advance.

关键词： Blockchain Smart contract Accountability Smart energy Smart grids

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A review of top-down cracking in asphalt pavements:Causes, models, experimental tools and future challenges

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 541-572页

作者： francesco Canestrari Lorenzo paolo Ingrassia Dipartimento di Ingegneria Civile Edile e Architettura(DICEA)Uniuersita Politecnica delle MarcheAncona 60131Italy

In the last decades,a new type of distress has been observed more and more frequently on asphalt *** distress,ascribable to fatigue failure,has been named top-down cracking(TDC) because it consists in longitudinal cracks that initiate on the pavement surface and then propagate downwards.A series of surveys recently carried out on Italian motorways highlighted that TDC can affect up to 20%-30% of the slow traffic ***,in order to achieve a better understanding of such distress,this paper reviews causes,models and experimental tools and highlights future challenges for *** literature review indicates that TDC can evolve on the pavement surface in three stages(i.e.,single crack,sister cracks,alligator cracking) and,below a certain depth,the cracks can form angles of 20°-40° with respect to the vertical *** though multiple factors contribute to TDC development,thick pavements are more likely to fail due to TDC induced by tire-pavement contact stresses,especially in the presence of open-graded friction courses(OGFCs).Moreover,in literature there are several TDC models based on mechanics(e.g.,fracture mechanics or continuum damage mechanics) which allow a rigorous study of crack initiation and *** challenges include the identification of a reliable and feasible test method,among those proposed in literature,to study the TDC performance of asphalt mixtures and the implementation of TDC in pavement management systems(PMSs) through the definition of criteria for TDC recognition in the field as well as for the rehabilitation depth ***,more research is needed for open-graded asphalt mixtures,which present critical drawbacks in terms of TDC.

关键词： Top-down cracking Flexible pavements Fatigue Cracking model Open-graded friction course Pavement management system

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Therapeutic application of stem cells in gastroenterology:An up-date

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World Journal of Gastroenterology 2011年第34期17卷 3870-3880页

作者： Patrizia Burra Debora Bizzaro Rachele Ciccocioppo Fabio Marra Anna Chiara Piscaglia Laura Porretti Antonio Gasbarrini francesco paolo russo Department of Surgical and Gastroenterological Sciences Gastroenterology Section University of Padua First Department of Internal Medicine IRCCS Policlinico San Matteo Foundation University of Pavia Department of Internal Medicine University of Florence Department of Internal Medicine Gemelli Hospital "Gastrointestinal and Liver Stem Cell Research Group" (GILSteR) Catholic University of Rome Center of Transfusion Medicine Cell Therapand Cryobiology IRCCS Fondazione Ospedale Maggiore Poli-clinico Mangiagalli e Regina Elena

Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastro-enterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immunemediated conditions,further studies are needed to fully understand the biology of stem cellsand carefully assess their put ativeonco- ***,there searchonstemcellsarousesferventethical,***llsheldinVeronaduringtheⅩⅥCongressoftheFederationofItalianSocietiesofDigestiveDiseases(March 6-9,2010).Here,we report on the issues discussed,including liver and intestinal diseases that may benefit from stemcell therapy,the biology of hepatic and intestinal tissue repair,and stem cell usage inclinical trials.

关键词： Stem cells Cell therapy Regenerative medicine Liver disease Inflammatory bowel disease

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Mortality from chronic liver disease:Recent trends and impact of the COVID-19 pandemic

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World Journal of Gastroenterology 2023年第26期29卷 4166-4173页

作者： Ugo Fedeli Claudio Barbiellini Amidei Veronica Casotto Enrico Grande Mario Saia Alberto Zanetto francesco paolo russo Epidemiological Department Azienda ZeroVeneto RegionPadova 35132Italy Integrated System for Health Social Assistance and WelfareNational Institute of StatisticsRome 00184Italy Clinical Governance Azienda ZeroVeneto RegionPadova 35132Italy Department of Surgery Oncology and Gastroenterology University of PaduaPadova 35128Italy Gastroenterology and Multivisceral Transplant Unit Azienda Ospedale-Universitàdi PadovaPadova 25128Italy

Prepandemic time trends in mortality from chronic liver disease(CLD)differed according to specific cause of death(decreasing for liver cirrhosis,stable or increasing for liver cancer),etiology(increasing for nonalcoholic fatty liver disease,generally decreasing for other etiologies),and world region(decreasing in areas with the highest burden of hepatitis B virus,increasing in Eastern Europe and other countries).The coronavirus disease 2019(COVID-19)pandemic affected mortality of patients with CLD both directly,with a higher risk for severe illness and death depending on age,stage and etiology of the disease,and indirectly,through social isolation and loss of support,harmful drinking,and difficulties in access to ***,only sparse data are available on variations in CLD as a cause of death during the *** the USA,in 2020-2021 a growth in mortality was registered for all liver diseases,more marked for alcoholic liver disease,especially among young people aged 25-44 years and in selected ethnic ***-19 related deaths accounted only for a minor part of the *** data from mortality registers of other countries are warranted,preferably adopting the so-called multiple cause-of-death approach,and extended to deaths attributed to viral hepatitis and liver cancer.

关键词： Mortality Multiple causes of death COVID-19 Chronic liver disease Liver cirrhosis Liver cancer

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Markers of acute rejection and graft acceptance in liver transplantation

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World Journal of Gastroenterology 2015年第4期21卷 1061-1068页

作者： Giacomo Germani Kryssia Rodriguez-Castro francesco paolo russo Marco Senzolo Alberto Zanetto Alberto Ferrarese Patrizia Burra Multivisceral Transplant Unit Department of SurgeryOncology and GastroenterologyPaduaUniversity Hospital35128 PaduaItaly

The evaluation of the immunosuppression state in liver transplanted patients is crucial for a correct posttransplant management and a major step towards the personalisation of the immunosuppressive therapy. However, current immunological monitoring after liver transplantation relies mainly on clinical judgment and on immunosuppressive drug levels, without a proper assessment of the real suppression of theimmunological system. Various markers have been studied in an attempt to identify a specific indicator of graft rejection and graft acceptance after liver transplantation. Considering acute rejection, the most studied markers are pro-inflammatory and immunoregulatory cytokines and other proteins related to inflammation. However there is considerable overlap with other conditions, and only few of them have been validated. Standard liver tests cannot be used as markers of graft rejection due to their low sensitivity and specificity and the weak correlation with the severity of histopathological findings. Several studies have been performed to identify biomarkers of tolerance in liver transplanted patients. Most of them are based on the analysis of peripheral blood samples and on the use of transcriptional profiling techniques. Amongst these, NK cell-related molecules seem to be the most valid marker of graft acceptance, whereas the role CD4+CD25+Foxp3+ T cells has still to be properly defined.

关键词： Liver transplantation Acute cellular rejection Tol

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Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors

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World Journal of Gastroenterology 2017年第12期23卷 2095-2105页

作者： Roberto Ballarin Alessandro Cucchetti francesco paolo russo paolo Magistri Matteo Cescon Umberto Cillo Patrizia Burra Antonio Daniele Pinna Fabrizio Di Benedetto Hepatopancreatobiliary Surgery and Liver Transplant Unit University Hospital "Policlinico" University of Modena and Reggio Emilia Department of Medical and Surgical Sciences DIMEC S. Orsola-Malpighi Hospital Alma Mater Studiorum University of Bologna Gastroenterology/Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital Department of Medical and Surgical Sciences and Translational Medicine Sapienza University of Rome

Liver transplant for hepatitis B virus(HBV) currently yields excellent outcomes: it allows to rescue patients with an HBV-related advanced liver disease, resulting in a demographical modification of the waiting list for liver transplant. In an age of patient-tailored treatments, in liver transplantation as well the aim is to offer the best suitable graft to the patient who can benefit from it, also expanding the criteria for organ acceptance and allocation. With the intent of developing strategies to increase the donor pool, we set-up a multicenter study involving 3 Liver Transplant Centers in Italy: patients undergoing liver transplantation between March 03, 2004, and May 21, 2010, were retrospectively evaluated. 1408 patients underwent liver transplantation during the study period, 28(2%) received the graft from hepatitis B surface antigen positive(HBs Ag)-positive deceased donors. The average follow-up after liver transplantation was 63.7 mo [range: 0.1-119.4; SD ± 35.8]. None Primary nonfunction, re-liver transplantation, early or late hepatic artery thrombosis occurred. The 1-, 3-and 5-year graft and patient survival resulted of 85.7%, 82.1%, 78.4%. Our results suggest that the use of HBs Agpositive donors liver grafts is feasible, since HBV can be controlled without affecting graft stability. However, the selection of grafts and the postoperative antiviral therapy should be managed appropriately.

关键词： Liver transplantation Hepatitis B virus Hepatitis B surface antigen Hepatocellular carcinoma Organ allocation Organ procurement Multicenter study

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