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Prevalence and factors associated with vitamin c deficiency in inflammatory bowel disease

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World Journal of Gastroenterology 2022年第33期28卷 4834-4845页

作者： Benjamin langan Gordon Jonathan S Galati Stevie Yang Randy S Longman Dana Lukin Ellen J Scherl Robert Battat Department of Medicine New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10065United States Department of Gastroenterology and Hepatology New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10021United States

BAcKGROUND Patients with inflammatory bowel disease(IBD) are prone to several nutritional deficiencies. However, data are lacking on vitamin c deficiency in crohn’s disease(cD) and ulcerative colitis(Uc) patients, as well as the impact of clinical, biomarker and endoscopic disease severity on the development of vitamin c *** To determine proportions and factors associated with vitamin c deficiency in cD and Uc *** In this retrospective study, we obtained clinical, laboratory and endoscopic data from cD and Uc patients presenting to the IBD clinic at a single tertiary care center from 2014 to 2019. All patients had an available plasma vitamin c level. Of 353 subjects who met initial search criteria using a cohort discovery tool, 301ultimately met criteria for inclusion in the study. The primary aim described vitamin c deficiency(≤ 11.4 μmol/L) rates in IBD. Secondary analyses compared proportions with deficiency between active and inactive IBD. Multivariate logistic regression analysis evaluated factors associated with *** Of 301 IBD patients, 21.6% had deficiency, including 24.4% of cD patients and 16.0% of Uc patients. Patients with elevated c-reactive protein(cRP)(39.1% vs 16.9%, P cal calprotectin(50.0% vs 20.0%, P = 0.009) had significantly higher proportions of deficiency compared to those without. Penetrating disease(P = 0.03),obesity(P = 0.02) and current biologic use(P = 0.006) were also associated with deficiency on univariate analysis. On multivariate analysis, the objective inflammatory marker utilized for analysis(elevated cRP) was the only factor associated with deficiency(odds ratio = 3.1, 95%confidence interval: 1.5-6.6, P = 0.003). There was no difference in the presence of clinical symptoms of scurvy in those with vitamin c deficiency and those *** Vitamin c deficiency was common in IBD. Patients with elevated inflammatory markers and penetrating disease had higher rates of vitamin

关键词： Inflammatory bowel disease crohn’s disease Ulcerative colitis Vitamin c deficiency Scurvy Malnutrition

college writing skills, media edition / 5th ed.

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2003年

作者： John langan.

Includes index.

ISBN: (数字)0072818921

ISBN: (纸本)0072818921

Includes index.

关键词： Report writing.

college writing skills / 6th ed.

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畅想之星图书光盘版（南通市图书馆镜像）

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2005年

作者： John langan.

Includes index.

ISBN: (数字)0072871865

ISBN: (纸本)0072871865

Includes index.

关键词： English language

cOLLEGE WRITING SKILLS WITH READINGS / 5th ed.

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2001年

作者： JOHN langan.

college Writing Skills, with Readings 6th ed.

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2005年

作者： John langan

Excellent condition, rarely used, fifth edition. Ship fast from WA state.

ISBN: (数字)0072871326

ISBN: (纸本)9780072871326

Excellent condition, rarely used, fifth edition. Ship fast from WA state.

关键词： English language

college writing skills with readings

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1000年

作者： John langan

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抗-c伴随自身类抗-e的鉴定

中国输血杂志 2017年第7期30卷 693-695页

作者：皮兰敢何章勇郴州市第一人民医院检验医学中心湖南郴州423000

目的分析在院患者住院期间产生的抗体特性。方法通过进行红细胞抗体筛选、鉴定,检测不同时间段抗体变化,高速毛细管离心法分离患者红细胞测定Rh表型等多种方法对抗体特性进行多方面的探究。结果抗体产生初期检出同种抗-c和非特异性自身... 详细信息

目的分析在院患者住院期间产生的抗体特性。方法通过进行红细胞抗体筛选、鉴定,检测不同时间段抗体变化,高速毛细管离心法分离患者红细胞测定Rh表型等多种方法对抗体特性进行多方面的探究。结果抗体产生初期检出同种抗-c和非特异性自身抗体,然后自身抗体成熟为有特异性的抗-e。在住院时间段内抗-c效价均较低(<4)。结论抗体的鉴定尽可能在方法学上从各个方面进行综合分析,以便找到真正相合的血液。

关键词：抗-c同种抗体抗-e特异性自身抗体类同种抗体

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追溯轻度脑外伤患者视空间注意力缺陷的恢复

世界核心医学期刊文摘(神经病学分册) 2006年第8期 44-45页

作者： Halterman c.I. langan J. Drew A. P. Van Donkelaar 赵天智 Department of Human Physiology Institute of Neuroscience University of Oregon Eugene OR United States

The goal of the current investigation was to probe the deficits in the alerting, orienting and executive components of visuospatial attention in individuals who have recently suffered a mild traumatic brain injury (mTBI) and to assess the rate and degree of recovery for each of these components over a month postinjury. A group design was employed to assess and compare the performance of participants (12 males, 8 females; mean age: 21 ± 1.74 years) identified with mTBI relative to control subjects matched for gender, age, height, weight and activity level. Participants performed the attentional network test, designed to isolate the constituents of attention into alerting, orienting and executive components. Reaction times (RTs) and response accuracy were the main dependent variables. The results showed that the orienting and executive components were significantly affected by mTBI immediately after the injury, whereas the alerting component was not. Furthermore, participants with mTBI recovered from the deficits in the orienting component of attention within a week of their injury, whereas the deficits in the executive component remained throughout the month post- injury. In addition, the RT cost to generate accurate compared with inaccurate responses was significantly larger in participants with mTBI than in controls, and this difference was maintained throughout the I month testing period. These findings indicate that the regions of the brain associated with the orienting and executive components of visuospatial attention may be most susceptible to neural damage resulting from mTBI. Moreover, the lack of recovery in the executive component indicates that the degree and time course for recovery may be regionally specific.

关键词：脑外伤 TBI 患者

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患乙型肝炎或丙型肝炎的孕妇和新生儿的护理

中国实用乡村医生杂志 2011年第7期18卷 22-23页

作者： NGUYET-cAM VU LAM PATRIcIA B. GOTScH ROBERT c. langan 李禄增敖嫩董少华(译) St. Luke's Family Medicine Residency Bethlehem Pennsylvania 中国医科大学92期七年制

介绍美国对于患有乙型肝炎或丙型肝炎孕妇和新生儿的护理情况。

关键词：乙型肝炎丙型肝炎新生儿护理