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Editorial of special column on Drug targets and drug development for Alzheimer's disease

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1686-1687页

作者： Wen-Xing Ding russell h.swerdlow Department of Pharmacology Toxicology and TherapeuticsDepartment of Internal Medicinethe University of Kansas Medical CenterKansas CityKS 66160USA Department of Neurology the University of Kansas Medical CenterKansas CityKS 66160USA

Alzheimer's disease(AD)is the most common form of progressive dementia in people aged 65 years and *** major pathological features of AD are the accumulation of extracellularβ-amyloid plaques and intracellular neurofibrillary tangles composed of aggregated,hyperphosphorylated *** addition to an accumulation of protein aggregates,mitochondrial dysfunction,altered lipid metabolism and increased neuroinflammation also play critical roles in the pathogenesis of AD and its associated dementia.

关键词： Alzheimer metabolism inflammation

Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1685-1685页

作者： Ding, Wen-Xing swerdlow, russell Univ Kansas Dept Pharmacol Toxicol & Therapeut Med Ctr Kansas City KS 66042 USA Univ Kansas Dept Neurol Sch Med Kansas City KS USA Univ Kansas Dept Mol & Integrat Physiol Sch Med Kansas City KS USA Univ Kansas Dept Biochem & Mol Biol Sch Med Kansas City KS USA

***-Xing Ding is the William Warner Abercrombie Professor at Department of Pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center,Kansas City,KS,*** graduated from Shanghai Medical University(now Fudan University)in China in 1992 and later obtained his PhD in Molecular Toxicology in 2002 from National University of *** then did his Postdoc training at University of Pittsburgh and became an assistant professor in 2009 at The University of Kansas Medical Center.

关键词： Kansas Singapore Pittsburgh

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Utilising the scientific method to demonstrate that slender beam/column behaviour is the dominant behavioural mechanism leading to roof/rib failure

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International Journal of Mining Science and Technology 2021年第5期31卷 867-887页

作者： Mark Colwell russell Frith Colwell Geotechnical Services CaloundraQLD 4551Australia Mine Advice Pty Ltd BeresfieldNSW 2322Australia

As per most other earth science engineering problems,the underground coal geotechnical environment and the way in which roof and rib support interacts with the rock mass are complex *** is therefore generally recognised that without prudent simplification,the complexity of the problem will overwhelm all current geotechnical methods of modelling,not least for the reason that a rock mass can never be characterised to a level that allows a"non-simplified"*** fact that numerical models,which are commonly purported to be a"simulation"tool and the so-called epitome of advanced geotechnical engineering,always need to be"calibrated"to a known reality is taken to be conclusive proof of this *** the problem should not be oversimplified(*** dominant failure mechanisms or critical data input parameters should not be ignored),without question judicious simplification is at the heart of all engineering design,to the point that it has a well-established name–"reductionism".The hypothesis addressed in this paper,is that horizontal and vertical stress-driven slender beam and column behaviour(which includes unstable Euler Buckling)are respectively the dominant(but not only)roadway roof and ribline behavioural mechanism that(if not controlled)can lead to excessive deformation,failure and eventual *** a part of the Scientific Method,a hypothesis can only be tested via real-world observations,measurements and analyses in establishing it is a credible *** the Scientific Method,this paper demonstrates that slender beam/column behaviour is the dominant instability mechanism within a coal mine roof/rib subject to elevated horizontal/vertical stress conditions and therefore,must be representatively accounted for in any credible empirical,analytical,or numerical approach to coal mine roof/rib stability assessment and associated ground support design.

关键词： Prudent simplification Behavioural mechanisms Support design Delamination Axial stress Buckling

Reusing oxide-based pulverised fly ash and medical waste particles to develop electroless nickel composite coatings(Ni–P/fly ash and Ni–P/SiO2–Al2O3)

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International Journal of Minerals,Metallurgy and Materials 2020年第8期27卷 1147-1156页

作者： Franco Mayanglambam Mark russell School of Natural and Built Environment Queen’s University BelfastBelfast BT71NNUK Centre for Nanotechnology Indian Institute of Technology GuwahatiGuwahati 781038India

Recycling and reusing materials from waste have become a nexus in the development of sustainable materials,leading to more balanced *** this study,we developed a composite coating by co-depositing recycled ceramic particles,pulverised fly ash(PFA)and medical ceramics(MC),into a nickel–phosphorus matrix using a typical electroless plating *** electron microscopy(SEM)images indicated well-dispersed particles in the Ni–P ***,compared with the MC particles,the PFA particles were distributed scantily with a lower content in the matrix,which could be due to the less impingement effect during the co-deposition.A modified microstructure with refined grains was obtained for the PFA-incorporated composite coating,as seen in the SEM *** X-ray diffraction result of the MC-incorporated composite coating showed the formation of Nix Siy phases in addition to the typical Ni3 P phases for the heattreated electroless Ni–P *** heat treatment,the PFA-reinforced composite coating,due to a modified microstructure,exhibited a higher microhardness up to hK0.05818,which is comparable to that of the traditional SiC particle-embedded composite coating(hK0.05825).The findings can potentially open up a new strategy to further advance the green approach for industrial surface engineering.

关键词： electroless plating waste ceramics fly ash particles microstructure microhardness

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Beyond the Receptor

Molecular Plant 2008年第2期1卷 195-197页

作者： russell Jones

had this Special Issue on plant hormones been published 5 years ago, it is likely that details about biosynthetic pathways would have taken center stage. As articles in this issue show, however, the field of plant hor... 详细信息

关键词： BRASSINOSTEROIDS GENES