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Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2014-2028页

作者： Mengqi Xu Cong Mao Haoting Chen Lu Liu Yabin Wang Abid Hussain Sulei Li Xu Zhang ruslan g.tuguntaev Xing-Jie Liang Weisheng guo Feng Cao Department of Cardiology National Clinical Research Center for Geriatric Diseases&Second Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Minimally Invasive Interventional Radiology Key Laboratory of Molecular Target&Clinical PharmacologySchool of Pharmaceutical Sciences&the Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China Department of Urology Chinese PLA General HospitalBeijing 100853China

Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular *** detection and precise intervention of VASP hold great clinical significance,yet remain a major *** therapy(PDT)realizes potent ablation efficacy under precise manipulation of laser *** this study,we constructed theranostic nanoprobes(NPs),which could precisely regress VASPs through a cascade of synergistic events triggered by local irradiation of lasers under the guidance of fluorescence/MR *** NPs were formulated from human serum albumin(HSA)conjugated with a high affinity-peptide targeting osteopontin(OPN)and encapsulated with photosensitizer IR780 and hypoxia-activatable tirapazamine(TPZ).After intravenous injection into atherosclerotic mice,the OPN-targeted NPs demonstrated high specific accumulation in VASPs due to the overexpression of OPN in activated foamy macrophages in the carotid *** the visible guidance of fluorescence and MR dual-model imaging,the precise near-infrared(NIR)laser irradiation generated massive reactive oxygen species(ROS),which resulted in efficient plaque ablation and amplified hypoxia within *** response to the elevated hypoxia,the initially inactive TPZ was successively boosted to present potent biological suppression of foamy *** therapeutic administration of the NPs for 2 weeks,the plaque area and the degree of carotid artery stenosis were markedly ***,the formulated NPs displayed excellent *** conclusion,the developed HSA-based NPs demonstrated appreciable specific identification ability of VASPs and realized precise synergistic regression of atherosclerosis.

关键词： Vulnerable atherosclerotic plaques Theranostic nanoprobe Human serum albumin Osteopontin Photodynamic therapy Hypoxia Reactive oxygen species Tirapazamine

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Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy

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Biophysics Reports 2020年第5期6卷 193-210页

作者： Yingsi Xie ruslan g.tuguntaev Cong Mao Haoting Chen Ying Tao Shixiang Wang Bin Yang Weisheng guo Translational Medicine Center Key Laboratory of Molecular Target & Clinical Pharmacology School of Pharmaceutical Sciences & the Second Affiliated Hospital Guangzhou Medical University Université Paris 13 99 avenue Jean Baptiste Clément Department of cardiovascular medicine the Third Affiliated Hospital Guangzhou Medical University The Sixth Affiliated Hospital Department of Biomedical Engineering School of Basic Medical Sciences Guangzhou Medical University

Rheumatoid arthritis(RA) is a long-term inflammatory disease derived from an autoimmune disorder of the synovial membrane. Current therapeutic strategies for RA mainly aim to hamper the macrophages’ proliferation and reduce the production of pro-inflammatory cytokines. Therefore, the accumulation of therapeutic agents targeted at the inflammatory site should be a crucial therapeutic strategy. Nowadays, the nanocarrier system incorporated with stimuli-responsive property is being intensively studied, showing the potentially tremendous value of specific therapy. Stimuli-responsive(i.e., p H, temperature, light, redox, and enzyme) polymeric nanomaterials, as an important component of nanoparticulate carriers, have been intensively developed for various diseases treatment. A survey of the literature suggests that the use of targeted nanocarriers to deliver therapeutic agents(nanotherapeutics) in the treatment of inflammatory arthritis remains largely unexplored. The lack of suitable stimuli-sensitive polymeric nanomaterials is one of the limitations. Herein, we provide an overview of drug delivery systems prepared from commonly used stimuli-sensitive polymeric nanomaterials and some inorganic agents that have potential in the treatment of RA. The current situation and challenges are also discussed to stimulate a novel thinking about the development of nanomedicine.

关键词： Rheumatoid arthritis Nanotechnology Stimuli-responsive polymers Drug delivery systems

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Orbital reconstruction:From simple materials to bioengineered solutions

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 98-105页

作者： Maria Cervatiuc Eldor Jonnazarov Doston Farhodovich Shukuraliev Mehrob Islomidinovich Yatimov Abdullo Hudoydodovich Bobobegov Sukhrobjon Solijonovich Tuychiev Husan Bahtiyorovich Juraev Suhrob Tulqinovich Khidiraliev Makhmudjon Burhonovich Muratov Sherali Chorshanbeevich Uralov Dilshod Uralovich Yuldashov Muslihiddin Ahmadovich Rahimov ruslan Usmonjonovich ghoziev Idibek Shamsidinovich Mainusov Department of Oncology Radiotherapy and Plastic Surgery I.M. Sechenov First Moscow State Medical University (Sechenov University) Department of Ophthalmology I.M. Sechenov First Moscow State Medical University (Sechenov University) Avicenna Tajik State Medical University (ATSMU) Tajik National University (TNU) Pacific State Medical University (PSMU)

Orbital fractures are a frequent and serious problem for practicing ophthalmologists. The complexity of the pathology is explained by the combined nature of the injuries(often associated with craniofacial injuries), multistage treatments, results that are often unsatisfactory, and a wide range of complaints about functional and cosmetic limitations. Over the years, significant progress has been made in the field of orbital reconstruction,allowing the transition from traditional methods using simple materials to innovative bioengineering *** evolution has been driven by advances in surgical technologies, imaging techniques, and biomaterials aimed at optimizing the restoration of the shape and function of the orbital region. Traditional approaches are based on the use of autologous tissues such as bone grafts and muscle flaps, which provide biocompatibility and natural integration, but have limitations in terms of customization and accessibility. The advent of patient-specific implants and 3D printing technology has revolutionized the reconstruction of the orbit, allowing implants to be precisely adapted to a patient's anatomy. Biocompatible materials, such as porous polyethylene, titanium, and silicone, have become the basis for orbital reconstruction, ensuring durability and compatibility while minimizing long-term complications. Bioengineered solutions hold promise for further advancements in orbital reconstruction. We searched Pub Med, Cyberleninka, and other verified databases for published articles on orbital reconstruction reported in the literature between 1960 and January 2024. In this article, we consider the advantages and disadvantages of each category of reconstruction materials and provide up-to-date information on the methods for modifying their properties using modern processing technologies.

关键词： Orbital reconstruction Bioengineered solutions Biomaterials Patient-specific implants Minimally invasive surgery

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Tribological study on the surface modification of metal-on-polymer bioimplants

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Frontiers of Mechanical Engineering 2022年第2期17卷 103-115页

作者： gang SHEN Jufan ZHANg David CULLITON ruslan MELENTIEV Fengzhou FANg Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) School of Mechanical and Materials EngineeringUniversity College DublinDublin 4Ireland Department of Aerospace Mechanical and Electronic EngineeringInstitute of Technology CarlowCarlowIreland State Key Laboratory of Precision Measuring Technology and Instruments Centre of Micro/Nano Manufacturing Technology(MNMT)Tianjin UniversityTianjin 300072China

The tribological performance of artificial joints is regarded as the main factor of the lifespan of implanted prostheses. The relationship between surface roughness and coefficient of friction (COF) under dry and lubricated conditions is studied. Results show that under dry test, friction coefficient is not reduced all the time with a decrease in surface roughness. On the contrary, a threshold of roughness value is observed, and frictional force increases again below this value. This critical value lies between 40 and 100 nm in Sa (roughness). This phenomenon is due to the transfer of friction mechanisms from abrasion to adhesion. Under wet test, COF always decreases with reduction in surface roughness. This result is mainly attributed to the existence of a thin layer of lubricant film that prevents the intimate contact of two articulating surfaces, thus greatly alleviating adhesion friction. Furthermore, surface texturing technology is successful in improving the corresponding tribological performance by decreasing friction force and mitigating surface deterioration. The even-distribution mode of texturing patterns is most suitable for artificial joints. By obtaining the optimal surface roughness and applying texturing technology, the tribological performance of polymer-based bioimplants can be greatly enhanced.

关键词： artificial joints surface roughness friction surface texturing

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Bibliometric analysis of micro-nano manufacturing technologies

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Nanotechnology and Precision Engineering 2019年第2期2卷 61-70页

作者： Maryna Bodnariuk ruslan Melentiev Department of Information Activity and Media Communications Odessa National Polytechnic UniversityOdessaUkraine Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) University College DublinDublinIreland

Manufacturing is the primary industry promoting economic and social *** the past 30 years,the global trends of preciseness and device miniaturisation have promoted manufacturing to the micro(μ)and nano(η)*** of themost promising micro-nano manufacturing technologies(MNMT)is of interest to industry,academia and private and national science investing *** the exponential broadening of the research area and an enormous volume of literature,providing an overview of the state of the art is far beyond the scope of a technical review *** study performs bibliometric analysis of a stream of academic literature devoted toμ-andη-*** goals of the analysis are to assess the current core and trends in the field *** and citation statistics from 1988 were collected from theWeb of Science,google Scholar,Scopus,Engineering Village,ScienceDirect and SpringerLink databases and were then analysed and illustrated with Microsoft Excel and VOSviewer *** top keywords,articles,journals,authors,universities and countrieswere identified according to different *** index of normalised influence was offered to evaluate the top element in each *** observed that the most powerful keywords were present in well-known articles published in prominent journals by authoritative scientists at leading universities in the countries that are most actively engaged in *** implications of the research outcomes for investors and academicians are summarised in the conclusion.

关键词： Bibliometric analysis Micro-machining Nano-machining Top Citations

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Nitrite pre-treatment of dewatered sludge for microbial fuel cell application

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Journal of Environmental Sciences 2019年第3期31卷 148-155页

作者： Abdul Rasyid ruslan Vel Murugan Vadivelu School of Chemical Engineering Universiti Sains MalaysiaEngineering Campus

The effect of pre-treatment of dewatered sludge using different nitrite concentrations and p H for microbial fuel cell(MFC) application was investigated. The results show that the addition of nitrite was feasible to increase the solubilization rate of the sludge and may reduce mass transfer limitation at the anode. This helped the MFC to reach higher voltage and to generate more power. The higher free nitrous acid(FNA) concentration under the acidic condition helped to increase sludge solubilization. However, under an alkaline condition, during which the FNA concentration was relatively low, the solubilization of the sludge was higher. The highest voltage and power density produced was 390 mV and 153 mW/m^2, respectively, with the addition of nitrite at 100 mg-N/L and pH 9. Furthermore,it was found that elevated levels of FNA could inhibit electrogenic bacteria thus reducing power generation.

关键词： Dewatered sludge Nitrite pre-treatment Free nitrous acid Microbial fuel cell Electricity generation

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Robot-assisted radical cystectomy for bladder cancer: single-center experience

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Frigid Zone Medicine 2022年第1期2卷 45-52页

作者： Valentin Pavlov Marat Urmantsev ruslan Safiullin Anton Denejko Rita gilmanova ruslan Abdrakhimov Bashkir State Medical University Ufa 450074Russia

Objective:Radical cystectomy remains the most effective treatment for patients with localized,invasive bladder cancer and recurrent noninvasive *** some surgeons have begun to describe outcomes associated with less invasive surgical approaches to this disease,such as laparoscopic or robotic assisted *** report our maturing experience with 100 consecutive cases of robotic assisted laparoscopic radical cystectomy regarding perioperative results,pathological outcomes,and surgical ***:A total of 100 consecutive patients(73 male and 27 female)underwent robotic radical cystectomy with intracorporeal urinary diversion at our institution from February 2018 to February 2021 for clinically localized bladder *** measures evaluated included operative variables,hospital recovery,pathological outcomes,and complication ***:The mean age of this cohort was 60.4 years(range 38 to 82).Ninety-five patients underwent ileal conduit diversion,5 received a neobladder).The mean operating room time for all patients was 184 min(min time was 160 min)and mean surgical blood loss was 286 *** surgical pathology,2%of the cases were pT1,35%were pT2,51+12%were pT3/T4 disease and 17%were node *** mean number of lymph nodes removed was 16(range 10 to 40).In no case was there a positive surgical *** mean days to flatus were 2.6,bowel movement 2.8 and discharge home *** were 21 postoperative complications in 20 patients with 4%having a major complication(Clavien grade 3 or higher)and 15%being readmitted within 30 days after *** a mean follow-up of 12 months 3 patients had disease recurrence and died 4 of ***:We report a relatively large cohort and maturing experience with robotic radical cystectomy for the treatment of bladder cancer,providing acceptable surgical and pathological *** results support continued efforts to refine the surgical management of muscle-invasive bladder cancer.

关键词： bladder cystectomy admitted

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Sparse representation for machine learning the properties of defects in 2D materials

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npj Computational Materials 2023年第1期9卷 1186-1195页

作者： Nikita Kazeev Abdalaziz Rashid Al-Maeeni Ignat Romanov Maxim Faleev ruslan Lukin Alexander Tormasov A.H.Castro Neto Kostya S.Novoselov Pengru Huang Andrey Ustyuzhanin Institute for Functional Intelligent Materials National University of Singapore4 Science Drive 2117544 SingaporeSingapore Constructor University Bremen ggmbH Campus Ring 1Bremen 28759Germany HSE University Myasnitskaya Ulitsa20101000 MoscowRussia Innopolis University Universitetskaya St1InnopolisRepublic of Tatarstan 420500Russia Centre for Advanced 2D Materials National University of Singapore6 Science Drive 2117546 SingaporeSingapore

Two-dimensional materials offer a promising platform for the next generation of(opto-)electronic devices and other high technology *** of the most exciting characteristics of 2D crystals is the ability to tune their properties via controllable introduction of ***,the search space for such structures is enormous,and ab-initio computations prohibitively *** propose a machine learning approach for rapid estimation of the properties of 2D material given the lattice structure and defect *** method suggests a way to represent configuration of 2D materials with defects that allows a neural network to train quickly and *** compare our methodology with the state-of-the-art approaches and demonstrate at least 3.7 times energy prediction error ***,our approach is an order of magnitude more resource-efficient than its contenders both for the training and inference part.

关键词： properties defects prediction

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Using Blockchain Technology in Mobile Network to create decentralized Home Location Registry(HLR)

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Computer Systems Science & Engineering 2021年第11期39卷 287-296页

作者： Behnam Kiani Kalejahi ruslan Eminov Aga guliyev Department of Computer Science School of Science and EngineeringKhazar UniversityBakuAzerbaijan Department of Biomedical Engineering Faculty of Electrical and Computer EngineeringUniversity of TabrizTabrizIran

Blockchain can mean many things to many *** is a set of protocols and encryption technologies for securely storing data on a distributed network for the *** is a distributed ledger for business and finance and the technology underlying the explosion of new digital *** technologists,it is the driving force behind the next generation of the *** the other hand,it is a transformational technology facilitating large-scale human progress in previously unimagined ways for the rest of the people,a tool for radically reshaping society and *** view it as a disruptive technology that can be the source of a great deal of fraud,illegal activity,where others see opportunities to bring into existing systems by providing decentralization,transparency,and *** complex technological,economic,and social phenomenon has been the subject of fervent *** calls into question what might have been seen to be established parameters of the modern world like currency,economics,trust,value,and *** is a revolutionary new computing paradigm and one of the most significant,fundamental digital platforms’advances since the *** is an emergent technology experiencing very rapid evolution,and so is our understanding of what it is and what it can *** paper is subject to the use of Blockchain concepts in mobile networks to strengthen the Home Location Registry(HLR)database and make it decentralized for secure transactions and in banking and financial *** also holds potential implications for global *** could make trade more efficient by removing the manual and paper-based processes and introducing streamlined and automated processes.

关键词： Blockchain Mobile Network Home Location Registry Mobile Technology

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genetic diversity and differentiation among populations of the pedunculate oak(Quercus robur)at the eastern margin of its range based on a new set of 95 SNP loci

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Journal of Forestry Research 2021年第5期32卷 2237-2243页

作者： Bernd Degen Yulai Yanbaev ruslan Ianbaev Svetlana Bakhtina Albina Tagirova Institute of Forest genetics GrosshansdorfGermany Federal State Budgetary Educational Establishment of Higher Education“Bashkir State Agrarian University” UfaRussia Federal State Budgetary Educational Establishment of Higher Education“Bashkir State University” UfaRussia

The aim of this study is to determine the genetic variability and differentiation among populations of pedunculate oak(Quercus robur)at the eastern margin of the species distribution *** applied new set of 95 geographically informative nuclear SNP(single nucleotide polymorphism)loci developed using Double Digest Restriction Site Associated DNA(ddRAD),a new generation DNA sequencing *** study area is located in the basins of the Volga River and its two main tributaries,Kama and *** the strong reduction and fragmentation of pedunculate oak forests over the last several centuries and comparatively small sizes of present stands,a relatively similar genetic diversity of seven populations was observed(on average,allelic diversity v_(a)=1.472-1.603,observed heterozygosity H_(O)=0.305-0.358,expected heterozygosity H_(E)=0.272-0.343).The genetic distances between populations vary between 0.102 and 0.170(on average,d_(0)=0.128).We have identified the absence of a spatial genetic structure and the existence of genetically peculiar populations in the territory *** genetic distances of gregorius between populations vary between 0.102 and 0.170(on average,d_(0)=0.128).genetic differentiation among populations was statistically significant with a mean of the fixation index FST of *** from the Privolzhye Upplands and from northern parts of the study area make the most contribution to overall inter-population differentiation(d_(0)=0.137).No significant differences exist among the samples at lowlands along the Volga river(d_(0)=0.110).It was concluded that the multiplicity and different ages of local populations and the complexity of migration routes of the pedunculate oak from Pleistocene refugia and secondary Holocene shelters can cause this phenomenon.

关键词： Population Quercus robur gene pool Single nucleotide polymorphism

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